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Summary. The phenomenon of cold airway hyperresponsiveness is very common among patients with bronchial asthma. Possible participation of immune mechanisms in its formation is insufficiently studied. In particular, there is no information about the interaction of Th17-related cytokines with cytokines of Th2 immune response accompanying inflammation in asthma patients with cold-induced bronchospasm. Objective. To evaluate the content of interleukins IL-17A, IL-6, IL-22, IL-4 and IL-13 in asthma patients and their role in the formation of cold airway hyperresponsiveness. Materials and Methods. Spirometric indices of forced expiratory flow were measured in 41 patients with bronchial asthma, the content of interleukins in blood serum was estimated before and after bronchoprovocation test with 3-minute isocapnic hyperventilation with cold (-20°C) air. Results. Two groups of patients were formed with presence (group 1, n=14) and absence (group 2, n=29) of cold airway hyperresponsiveness, verified by the degree of drop in forced expiratory volume in 1 sec. (∆FFV1ihca) after the cold test (-16.5[-20.0;-12.0] and -2.3[-3.5;-0.8] %, respectively; p