1. [Diagnostic value of IgG subtypes in membranous nephropathy: A case report].
- Author
-
Asmandar S, Figuères ML, Goujon JM, Noël LH, and Hummel A
- Subjects
- Adult, Autoantibodies genetics, Autoantibodies immunology, Female, Glomerulonephritis, Membranous immunology, Glomerulonephritis, Membranous metabolism, Humans, Immunoglobulin G genetics, Immunoglobulin G immunology, Kidney Glomerulus immunology, Kidney Glomerulus metabolism, Receptors, Phospholipase A2 immunology, Autoantibodies analysis, Glomerulonephritis, Membranous diagnosis, Immunoglobulin G analysis
- Abstract
The study of immunoglobulin G subtypes constituting immune deposits present in membranous nephropathy is useful to guide diagnosis. IgG4 deposits are more often seen in primitive forms of membranous nephropathy due to autoantibody (anti-phospholipase A2 receptor in a majority of cases). These deposits are polytypic. In secondary forms, deposits are constituted of IgG1, IgG2 and IgG3. We report the case of a 52-year-old woman whose renal biopsy, done for glomerular proteinuria, shows membranous nephropathy with monotypic IgG4 deposits with no overt hematologic malignancy and no anti-PLA2R antibodies., (Copyright © 2015. Published by Elsevier SAS.)
- Published
- 2015
- Full Text
- View/download PDF