1. Epidermal expression of I-TAC (Cxclll) instructs adaptive Th2-type immunity.
- Author
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Roebrock, Kirsten, Sunderkötter, Cord, Münck, Niels-Arne, Wolf, Marc, Nippe, Nadine, Barczyk, Katarzyna, Varga, Georg, Vogl, Thomas, Roth, Johannes, and Ehrchen, Jan
- Subjects
IMMUNE system ,LEISHMANIA ,CHEMOKINES ,LABORATORY mice ,MUSCLE physiology ,LYMPH nodes - Abstract
To decipher early promoters of the local microenvironment for Th2-type immunity, we wanted to identify gene patterns that were induced by Leishmania major in the infected skin of susceptible, Th2-prone BALB/c, but not of resistant, Thl-prone C57BL/6 mice. We found a marked up-regulation of the chemokine I-TAC (Cxclll) during the first 2 d of infection in the epidermis of susceptible but not of resistant mice. Accordingly, local injection of I-TAC (2x1 |xg) in resistant mice on the first day of infection resulted in a Th2-driven, sustained deterioration of disease and dramatically enhanced parasite levels. On the cellular level, I-TAC decreased IL-12 production by dendritic cells (DCs) in skindraining lymph nodes and by DCs in vitro. Thus, we demonstrate for the first time that epidermis-derived I-TAC triggers a sustained Th2-response that determines the outcome of a complex immunological process. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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