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Your search keyword '"Rao, Tata Nageswara"' showing total 2 results
Start Over Author "Rao, Tata Nageswara" Topic immune system
2 results on '"Rao, Tata Nageswara"'

1. Identification of transcriptional regulators in the mouse immune system.

Author

Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemarte-Pelletier A, Malhotra D, and Turley S

Subjects
Animals, Cell Differentiation genetics, Cell Differentiation immunology, Cell Lineage genetics, Cell Lineage immunology, DNA-Binding Proteins genetics, DNA-Binding Proteins immunology, Gene Expression Profiling, Gene Regulatory Networks immunology, Humans, Immune System cytology, Mice, Oligonucleotide Array Sequence Analysis, Receptors, Antigen, T-Cell, gamma-delta immunology, Receptors, Antigen, T-Cell, gamma-delta metabolism, Repressor Proteins genetics, Repressor Proteins immunology, T-Lymphocytes immunology, T-Lymphocytes metabolism, Trans-Activators genetics, Trans-Activators immunology, Transcription Factors genetics, Transcription Factors immunology, Transcriptome genetics, Transcriptome immunology, Algorithms, Gene Expression Regulation immunology, Immune System metabolism, Transcription, Genetic immunology
Abstract

The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. Here, the Immunological Genome Project gene-expression profiles across mouse immune lineages allowed us to systematically analyze these circuits. To analyze this data set we developed Ontogenet, an algorithm for reconstructing lineage-specific regulation from gene-expression profiles across lineages. Using Ontogenet, we found differentiation stage-specific regulators of mouse hematopoiesis and identified many known hematopoietic regulators and 175 previously unknown candidate regulators, as well as their target genes and the cell types in which they act. Among the previously unknown regulators, we emphasize the role of ETV5 in the differentiation of γδ T cells. As the transcriptional programs of human and mouse cells are highly conserved, it is likely that many lessons learned from the mouse model apply to humans.

Published
2013
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2. Identification of transcriptional regulators in the mouse immune system

Author

Jojic, Vladimir, Shay, Tal, Sylvia, Katelyn, Zuk, Or, Sun, Xin, Kang, Joonsoo, Regev, Aviv, Koller, Daphne, Immunological Genome Project Consortium, Best, Adam J, Knell, Jamie, Goldrath, Ananda, Joic, Vladimir, Cohen, Nadia, Brennan, Patrick, Brenner, Michael, Kim, Francis, Rao, Tata Nageswara, Wagers, Amy, Heng, Tracy, Ericson, Jeffrey, Rothamel, Katherine, Ortiz-Lopez, Adriana, Mathis, Diane, Benoist, Christophe, Bezman, Natalie A, Sun, Joseph C, Min-Oo, Gundula, Kim, Charlie C, Lanier, Lewis L, Miller, Jennifer, Brown, Brian, Merad, Miriam, Gautier, Emmanuel L, Jakubzick, Claudia, Randolph, Gwendalyn J, Monach, Paul, Blair, David A, Dustin, Michael L, Shinton, Susan A, Hardy, Richard R, Laidlaw, David, Collins, Jim, Gazit, Roi, Rossi, Derrick J, Malhotra, Nidhi, Kreslavsky, Taras, Fletcher, Anne, Elpek, Kutlu, Bellemarte-Pelletier, Angelique, Malhotra, Deepali, and Turley, Shannon

Subjects
1.1 Normal biological development and functioning, T-Lymphocytes, Immunology, Stem Cell Research - Embryonic - Non-Human, Regenerative Medicine, Mice, Genetic, Underpinning research, Receptors, Genetics, Animals, Humans, Cell Lineage, Gene Regulatory Networks, Oligonucleotide Array Sequence Analysis, gamma-delta, Inflammatory and immune system, Gene Expression Profiling, Cell Differentiation, Hematology, Immunological Genome Project Consortium, Stem Cell Research, T-Cell, DNA-Binding Proteins, Repressor Proteins, Gene Expression Regulation, Immune System, Antigen, Trans-Activators, Stem Cell Research - Nonembryonic - Non-Human, Transcriptome, Transcription, Algorithms, Transcription Factors
Abstract

The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. Here, the Immunological Genome Project gene-expression profiles across mouse immune lineages allowed us to systematically analyze these circuits. To analyze this data set we developed Ontogenet, an algorithm for reconstructing lineage-specific regulation from gene-expression profiles across lineages. Using Ontogenet, we found differentiation stage-specific regulators of mouse hematopoiesis and identified many known hematopoietic regulators and 175 previously unknown candidate regulators, as well as their target genes and the cell types in which they act. Among the previously unknown regulators, we emphasize the role of ETV5 in the differentiation of γδ T cells. As the transcriptional programs of human and mouse cells are highly conserved, it is likely that many lessons learned from the mouse model apply to humans.

Published
2013

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