1. BCG lymphadenitis: a potential complication of immune reconstitution following haematopoietic stem cell transplant.
- Author
-
Tsilifis C, Schim van der Loeff I, Williams E, Owens S, Powell S, Gennery A, and Slatter M
- Subjects
- BCG Vaccine adverse effects, Child, Child, Preschool, Humans, Infant, Newborn, Isoniazid therapeutic use, Male, Rifampin, Hematopoietic Stem Cell Transplantation adverse effects, Immune Reconstitution, Lymphadenitis chemically induced, Lymphadenitis therapy
- Abstract
An MHC class II deficient 2-year-old boy presented with fever and an enlarging left neck mass 100 days post allogeneic haematopoietic stem cell transplant (HSCT). Fever persisted despite treatment with broad-spectrum β-lactam antibiotics. His BCG vaccination site at presentation was quiescent. Ultrasound showed enlarged cervical lymph nodes. An incisional biopsy of the large nodal mass yielded acid-fast bacilli, identified as Mycobacterium bovis by genome sequencing. Treatment with rifampicin, isoniazid and pyridoxine was started. The mass suppurated (figure 1), before healing concurrently with T-lymphocyte reconstitution at approximately day 130 post-HSCT., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
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