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Your search keyword '"Cimaschi R"' showing total 2 results
Start Over Author "Cimaschi R" Topic imidazoles
2 results on '"Cimaschi R"'

1. Bicyclic compounds with potential antiulcer and/or antisecretory activity. I. 4,5,6,7-Tetrahydrobenzimidazoles.

Author

Scarponi U, Cimaschi R, Rusconi L, Santangelo F, Arcari G, Castello R, Toti D, and de Castiglione R

Subjects
Animals, Anti-Ulcer Agents pharmacology, Anti-Ulcer Agents toxicity, Gastric Juice metabolism, Guinea Pigs, Histamine H2 Antagonists chemical synthesis, Histamine H2 Antagonists pharmacology, Imidazoles pharmacology, Imidazoles toxicity, Lethal Dose 50, Male, Mice, Parasympatholytics chemical synthesis, Parasympatholytics pharmacology, Pyridines pharmacology, Pyridines toxicity, Rats, Rats, Inbred Strains, Structure-Activity Relationship, Anti-Ulcer Agents chemical synthesis, Gastric Juice drug effects, Imidazoles chemical synthesis, Pyridines chemical synthesis
Abstract

The remarkable antiulcer and antisecretory activity of some previously described 4,5,6,7-tetrahydroimidazo[4,5-c]pyridine derivatives prompted us to further investigate related bicyclic systems. Accordingly, a series of 5-amino- and 5-aminomethyl-4,5,6,7-tetrahydrobenzimidazoles, regiospecifically alkylated in position 1, were synthesized and tested. Only a few 1-ethyl-5-amino derivatives displayed a reasonable antiulcer activity in comparison with our former class of compounds.

Published
1985

2. Bicyclic compounds with potential antiulcer and/or antisecretory activity. II. 1(or 3),4,6,7-Tetrahydro-1(3)H-pyrano[3,4-d]imidazoles and 1(or 3),4,6,7-tetrahydro-1(3)H-thiopyrano[3,4-d]imidazoles.

Author

Scarponi U, Cimaschi R, Arcari G, Toti D, Ballabio M, Gandini E, and de Castiglione R

Subjects
Animals, Chemical Phenomena, Chemistry, Chemistry, Physical, Gastric Juice metabolism, Guinea Pigs, Imidazoles pharmacology, Mice, Pyrans pharmacology, Rats, Stomach Ulcer etiology, Stomach Ulcer physiopathology, Stress, Psychological complications, Anti-Ulcer Agents chemical synthesis, Imidazoles chemical synthesis, Pyrans chemical synthesis, Stomach Ulcer prevention & control
Abstract

Owing to our current interest in synthesizing and evaluating the antiulcer and antisecretory activity of bicyclic compounds, a series of 1(or 3),4,6,7-tetrahydropyrano- and 1(or 3),4,6,7-tetrahydrothiopyrano-[3,4-d]imidazoles was synthesized and tested. The biological results were compared with those of some previously described 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridine and 4,5,6,7-tetrahydrobenzimidazole derivatives.

Published
1986

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