1. A program to analyse optical coherence tomography images of the ciliary muscle.
- Author
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Laughton DS, Coldrick BJ, Sheppard AL, and Davies LN
- Subjects
- Adult, Female, Humans, Male, Reproducibility of Results, Software, Ciliary Body anatomy & histology, Image Processing, Computer-Assisted, Muscle, Smooth anatomy & histology, Tomography, Optical Coherence
- Abstract
Purpose: To describe and validate bespoke software designed to extract morphometric data from ciliary muscle Visante Anterior Segment Optical Coherence Tomography (AS-OCT) images., Method: Initially, to ensure the software was capable of appropriately applying tiered refractive index corrections and accurately measuring orthogonal and oblique parameters, 5 sets of custom-made rigid gas-permeable lenses aligned to simulate the sclera and ciliary muscle were imaged by the Visante AS-OCT and were analysed by the software. Human temporal ciliary muscle data from 50 participants extracted via the internal Visante AS-OCT caliper method and the software were compared. The repeatability of the software was also investigated by imaging the temporal ciliary muscle of 10 participants on 2 occasions., Results: The mean difference between the software and the absolute thickness measurements of the rigid gas-permeable lenses were not statistically significantly different from 0 (t=-1.458, p=0.151). Good correspondence was observed between human ciliary muscle measurements obtained by the software and the internal Visante AS-OCT calipers (maximum thickness t=-0.864, p=0.392, total length t=0.860, p=0.394). The software extracted highly repeatable ciliary muscle measurements (variability ≤6% of mean value)., Conclusion: The bespoke software is capable of extracting accurate and repeatable ciliary muscle measurements and is suitable for analysing large data sets., (Copyright © 2015 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2015
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