Search

Your search keyword '"Guerrini K"' showing total 2 results
Start Over Author "Guerrini K" Topic illicit drugs
2 results on '"Guerrini K"'

1. Development and validation of a reliable method for studying the distribution pattern for opiates metabolites in brain.

Author

Guerrini K, Argo A, Borroni C, Catalano D, Dell'acqua L, Farè F, Procaccianti P, Roda G, and Gambaro V

Subjects
Adult, Codeine metabolism, Drug Overdose diagnosis, Drug Overdose metabolism, Gas Chromatography-Mass Spectrometry, Heroin pharmacokinetics, Heroin Dependence diagnosis, Heroin Dependence metabolism, Humans, Illicit Drugs pharmacokinetics, Limit of Detection, Male, Molecular Structure, Morphine metabolism, Reproducibility of Results, Tissue Distribution, Brain metabolism, Codeine analysis, Heroin analysis, Illicit Drugs analysis, Morphine analysis, Substance Abuse Detection methods
Abstract

Brain distribution pattern of "street" heroin metabolites (morphine and codeine) was investigated in two fatalities due to "acute narcotism". A suitable sample pretreatment prior to solid-phase-extraction was developed to achieve a good recovery of the analytes and to eliminate the interfering species. After derivatization with MSTFA, samples were analyzed by GC/MS. Specificity, accuracy, precision and linearity of the method were evaluated; LOD and LOQ were, respectively, 10ng/25ng for morphine and 5ng/10ng for codeine. This method was applied to the analysis of six brain areas (hippocampus, frontal lobe, occipital lobe, nuclei, bulb and pons) coming from two cases of heroin-related deaths. No evidence of accumulation of metabolites in a specific brain region was found., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2013
Full Text
View/download PDF

2. Development and validation of a reliable method for studying the distribution pattern for opiates metabolites in brain

Author

Katia Guerrini, Veniero Gambaro, Fiorenza Farè, Argo A, Cristina Borroni, Gabriella Roda, Lucia Dell’Acqua, Daria Catalano, Paolo Procaccianti, Guerrini, K, Argo, A, Borroni, C, Catalano, D, Dell’Acqua, L, Farè, F, Procaccianti,P, Roda,G, and Gambaro,V

Subjects
Adult, Male, Clinical Biochemistry, Analytical chemistry, Pharmaceutical Science, Hippocampus, Gas Chromatography-Mass Spectrometry, Analytical Chemistry, Heroin, chemistry.chemical_compound, Settore MED/43 - Medicina Legale, Limit of Detection, Drug Discovery, medicine, Humans, Tissue Distribution, Derivatization, Spectroscopy, Morphine, Codeine, Post-mortem brain specimen, Chromatography, Molecular Structure, Heroin Dependence, Illicit Drugs, Brain, Reproducibility of Results, Pons, Substance Abuse Detection, chemistry, Frontal lobe, Drug Overdose, Occipital lobe, medicine.drug
Abstract

Brain distribution pattern of “street” heroin metabolites (morphine and codeine) was investigated in two fatalities due to “acute narcotism”. A suitable sample pretreatment prior to solid-phase-extraction was developed to achieve a good recovery of the analytes and to eliminate the interfering species. After derivatization with MSTFA, samples were analyzed by GC/MS. Specificity, accuracy, precision and linearity of the method were evaluated; LOD and LOQ were, respectively, 10 ng/25 ng for morphine and 5 ng/10 ng for codeine. This method was applied to the analysis of six brain areas (hippocampus, frontal lobe, occipital lobe, nuclei, bulb and pons) coming from two cases of heroin-related deaths. No evidence of accumulation of metabolites in a specific brain region was found.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results