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Universities are spaces of great cultural and religious diversity where university students are in a crucial phase of personal development and identity formation. Understanding the religiosity and spirituality of students helps foster an environment of inclusion and tolerance, and how they can be key factors in their comprehensive development. In view of its great potential, this document presents the findings of a systematic literature review following the updated guidelines of the Preferred Reporting Items for Systematic Reviews (PRISMA). This research focuses on reviewing the topics of religiosity and spirituality in university students, with the goal of identifying how they are lived and experienced during a crucial stage of personal development and identity search. The analysis includes a total of fifty-six documents in the period from 2000 to 2022 obtained from the EBSCO, Scopus, and Web of Science databases. The findings indicate that religiosity and spirituality significantly impact the lifestyle of university students. The scientific literature highlights the relationship between these dimensions and the reduction of problems such as depression and suicide. However, the conceptual difference between spirituality and religiosity is underlined, with different effects on well-being and the ability to face difficult situations. Finally, it is recommended to explore how religiosity and spirituality intersect with identity components such as gender, race, and sexual orientation, and to develop more precise measurement instruments. [ABSTRACT FROM AUTHOR]