1. Neuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial.
- Author
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Burrows K, Figueroa-Hall LK, Kuplicki R, Stewart JL, Alarbi AM, Ramesh R, Savitz JB, Teague TK, Risbrough VB, and Paulus MP
- Subjects
- Brain diagnostic imaging, Dose-Response Relationship, Drug, Double-Blind Method, Female, Gene Expression drug effects, Humans, Ibuprofen administration & dosage, Magnetic Resonance Imaging, Male, MicroRNAs genetics, MicroRNAs metabolism, MicroRNAs physiology, Placebo Effect, Brain physiology, Healthy Volunteers psychology, Ibuprofen pharmacology, Mental Processes drug effects, Motivation genetics, Reward
- Abstract
This double-blind, randomized, within-subjects design evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic changes in reward processing. Twenty healthy subjects (10 females, 10 males) underwent a functional magnetic resonance imaging scan while performing a monetary incentive delay (MID) task and provided blood samples after administration of placebo, 200 mg, or 600 mg of ibuprofen. Neuronally-enriched exosomal microRNAs were extracted from serum and sequenced. Results showed that: (1) 600 mg of ibuprofen exhibited higher miR-27b-3p, miR-320b, miR-23b and miR-203a-3p expression than placebo; (2) higher mir-27b-3p was associated with lower insula activation during MID loss anticipation; and (3) there was an inverse relationship between miR-27b-3p and MID gain anticipation in bilateral putamen during placebo, a pattern attenuated by both 200 mg and 600 mg of ibuprofen. These findings are consistent with the hypothesis that miR-27b could be an important messaging molecule that is associated with regulating the processing of positive or negative valenced information., (© 2022. The Author(s).)
- Published
- 2022
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