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Ageing is associated with chronic low-grade inflammation and with a decrease in muscle mass and strength. The aim of the study was to evaluate the effect of a resistance training programme in conditions of intermittent hypoxia on inflammatory biomarkers in older people. A total of 54 older adults (aged 65-75 years), who voluntarily participated in the study, were randomly divided into three groups: the control (CON) group, the resistance training normoxia (RTN) group that performed resistance training in normoxia and resistance training hypoxia (RTH) group that trained under hypoxic conditions at a simulated altitude of 2500 m above sea level. The training programme that was carried out during 24 weeks was similar in both experimental groups and consisted of a full-body workout with elastic bands and kettlebells (three sets x 12-15 reps). Blood inflammatory parameters (CRP, VCAM-1, IL-6, IL-8 and IL-10) were analysed before and after the intervention. After the resistance training programme, a significant decrease in CRP and IL-8 levels was observed, as well as an increase in IL-10 levels, both in normoxia and hypoxia. These results show that resistance training, either in conditions of normoxia or hypoxia, is useful to deal with the chronic inflammation associated with ageing., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)

Purpose: To investigate the training and detraining effects of two different hypoxic high-intensity protocols on cardiorespiratory fitness, maximal fat oxidation and energy contribution in obese women., Methods: 82 obese women completed a 12-week training of: (1) interval training in hypoxia (IHT; n = 19; 3 min at 90%W max : 3 min at 55-65%W max ; FiO 2  = 17.2%), (2) interval training in normoxia (INT; n = 20; 3 min at 90%W max : 3 min at 55-65%W max ), (3) repeated sprint training in hypoxia (RSH; n = 22; 30 s at 130%W max : 3 min at 55-65%W max ; FiO 2  = 17.2%), and (4) repeated sprint training in normoxia (RSN; n = 21; 30 s at 130%W max : 3 min at 55-65%W max ). VO 2max , workload, time to exhaustion and heart rate were assessed at baseline, after completion of 36 training sessions over 12 weeks and after 4 weeks of detraining., Results: Hypoxic training (IHT and RSH) showed a significant positive effect on absolute (p < 0.001) and relative maximal oxygen uptake (p < 0.001) as well as VT2 (%VO 2max ; p < 0.001). Both IHT and RSH showed significantly higher values of absolute VO 2max (IHT: + 26.63%; RSH: + 19.79%) and relative VO 2max (IHT: + 27.95%; RSH: + 19.94%) between baseline and post-exercise (p < 0.001). VO 2max (IHT: + 21.74%; RSH: + 17.65%) and relative VO 2max (IHT: + 23.53%; RSH: + 17.15%) remained significantly higher after detraining in IHT and RSH (p < 0.001)., Conclusion: A larger improvement in cardiorespiratory fitness has been observed after high-intensity interval training under normobaric hypoxia. As interval training or repeated sprint training did not show a significant effect, RSH might provide a time-metabolic effective strategy in this population.

Background: To investigate if the cyclic hypoxia exposure combined with repeat-sprints training would be more effective in reducing body fat of health women than the same protocols performed in normoxia., Methods: Twelve female volunteers were randomly divided into two groups: 1) repeated-sprint in hypoxia (RSH; N.=6; FiO2: 17.2%); and 2) repeated-sprint in normoxia (RSN; N.=6; FiO2: 20.9%). During 6 weeks, both groups undertook 30 seconds of all-out (130%Wmax) followed by 3 minutes of active recovery at 55-65%Wmax on a cycle ergometer. Anthropometric, body composition and biochemical parameters were assessed at baseline and after intervention., Results: RSH experimented a greater significant decrease of body mass index (P=0.017) and percentage of fat mass (P=0.05) respect to normoxia group. Total cholesterol of RSN experimented a significant (P=0.001) reduction (-12.66±14.35) compared with RSH (24.00±14.61)., Conclusions: Repeated-sprint training under normobaric cyclic hypoxia during 6-weeks could be a more effective prevention program because it causes a higher decrease in body mass index and fat mass compared with the same training in normoxic conditions in healthy women.

Objective: The aim of the present review is to evaluate effects of intermittent hypoxia and exercise therapy in cardiometabolic parameters on adult obese people., Database: Three well-known databases were selected: EMBASE, MEDLINE and Web of Science. Studies selection: Inclusion criteria were: (a) human healthy overweight or obese adults, (b) study randomized controlled trial, (c) original experimental study, (d) English languages and (e) therapy with intermittent hypoxia and exercise., Design: The assessment of the methodological quality of each study was based upon the risk of bias (PEDro scale) and level of evidence (CBO Guidelines)., Data Extraction: five articles clearly met inclusion criteria and were reviewed to data extraction., Results: In the hypoxia groups, weight, body mass index, waist circumference, waist-hip ratio, fat mass and lean mass improved in at least two studies in comparison with the baseline. Systolic blood pressure improved in one study. The lipid profile and the aerobic capacity were not reduced significantly., Conclusions: Results suggest that combined hypoxia with exercise may help to improve cardiometabolic parameters in obese people., (Copyright © 2018 The Authors. Publicado por Elsevier España, S.L.U. All rights reserved.)

Background: Resistance training performed under hypoxia conditions has been shown to cause major metabolic and hormonal responses. However, the influence of hypoxia on an acute session has been barely studied. The aim of this study was to evaluate the acute effects of an intermittent hypoxic resistance training (IHRT) to muscle failure on bench press performance., Methods: A randomized crossover design was performed, and 25 untrained men performed a resistance training under two different conditions: normoxia (FIO2=21%) and high-level hypoxia (FIO2=13%). Resistance training consisted of 3 sets of 75% 1RM to muscle failure, with a 2-minute rest between sets. Physical performance was assessed by quantifying total repetitions, concentric velocity and power variable during all sets. Arterial oxygen saturation, heart rate, rating of perceived exertion (RPE), capillary blood lactate and muscle soreness were also assessed after training., Results: Physical performance during bench press did not differ under hypoxic conditions (P>0.05). However, there were significant increases (P<0.05) of RPE (from 7.5±0.8 to 7.9±0.8) and blood lactate concentrations (from 5.5±1.2 to 6.2±1.5 mmol/L) in the hypoxia group., Conclusions: These findings suggest that hypoxic resistance exercise does not affect exercise performance during bench press exercise. However, influence to perceived exercise intensity and blood lactate concentrations, suggesting that hypoxic resistance training may add substantially to the training dose experienced.

Therapeutic benefits of hypoxic training have been suggested for clinical populations, such as elderly who could suffer loss of lower limb muscle strength and higher risk of falling. This study investigated the effects of 18 weeks of whole-body vibration (WBV) training in normobaric hypoxia on the strength parameters of an elderly population. Thirty-one healthy elderly participants were randomly assigned to a hypoxic whole-body vibration group (HWBV; n  = 10), normoxic whole-body vibration group (NWBV; n  = 11), or control group ( n  = 10). The experimental groups received the same vibration treatment in a hypoxia chamber (HWBV: 16.1% fraction of inspired oxygen [FiO 2 ]; NWBV: 21.0% FiO 2 ). Isokinetic leg muscle strength was evaluated using a Biodex System-3 isokinetic dynamometer. Body composition was obtained with dual-energy X-ray absorptiometry. There were no significant differences between groups in either strength or body composition parameters. The NWBV group showed statistically significant improvements in the maximal strength of knee extensors, with a small effect size ( p  = 0.004; d  = 0.54). No significant differences were found in any variable of the HWBV group. The combination of WBV training and exposure to normobaric cyclic hypoxia carried out in the present study did not have an effect on strength parameters in healthy elderly subjects.

Among other functions, hypoxia-inducible factor plays a critical role in bone-vascular coupling and bone formation. Studies have suggested that hypoxic conditioning could be a potential nonpharmacological strategy for treating skeletal diseases. However, there is no clear consensus regarding the bone metabolism response to hypoxia. Therefore, this review aims to examine the impact of different modes of hypoxia conditioning on bone metabolism. The PubMed and Web of Science databases were searched for experimental studies written in English that investigated the effects of modification of ambient oxygen on bone remodelling parameters of healthy organisms. Thirty-nine studies analysed the effect of sustained or cyclic hypoxia exposure on genetic and protein expression and mineralisation capacity of different cell models; three studies carried out in animal models implemented sustained or cyclic hypoxia; ten studies examined the effect of sustained, intermittent or cyclic hypoxia on bone health and hormonal responses in humans. Different modes of hypoxic conditioning may have different impacts on bone metabolism both in vivo and in vitro. Additional research is necessary to establish the optimal cyclical dose of oxygen concentration and exposure time.

Purpose: Promising benefits on fat mass and biochemical components may be reported after applying programs of cyclic hypoxia and HIIT., Aim: To investigate the effect of a month of detraining on cardiometabolic risk markers after active hypoxia exposure., Methods: Participants included 59 overweight/obese women, who started a 12-week program of 36 sessions, and were randomly divided into four groups: (a) aerobic interval training in hypoxia (AitH; FiO 2  = 17.2%; n = 13), (b) aerobic interval training in normoxia (AitN; n = 15), (c) sprint interval training in hypoxia (SitH; FiO 2  = 17.2%; n = 15), and (d) sprint interval training in normoxia (SitN; n = 18). Body composition, anthropometric, and biochemical parameters were assessed at baseline (A), after 36 training sessions (B) and after 4 weeks of detraining (C)., Results: Hypoxia conditions showed a significant positive effect on waist circumference (P = 0.01), WHR (P = 0.04), and percentage of trunk fat mass (P < 0.001). The percentage of trunk fat continued to decrease significantly after training cessation in both AitH and SitH groups., Conclusion: After 4 weeks of detraining with a previous 12 weeks of high-intensity interval training under cyclic normobaric hypoxia, the percentage of fat mass located in the trunk decreases significantly and this effect was not observed in the normoxia groups., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Promising benefits on cardiometabolic risk factors have been reported with prolonged programs of cyclic hypoxia. The aim of this study was to examine whether cyclic hypoxia exposure while exercising through two protocols of high-intensity interval training in overweight/obese women is more effective to improve cardiometabolic risk markers than exercising in normoxia. Participants included 86 overweight/obese women, who started a 12-week program of 36 sessions, and were randomly divided into four groups: (1) interval training in hypoxia (IHT; FIO 2  = 17.2%; n = 13), (2) interval training in normoxia (INT; n = 15), which included 3-minute high-intensity exercise (90% Wmax) followed by 3 minutes of active recovery (55%-65% Wmax), (3) repeated-sprint training in hypoxia (RSH; FIO 2  = 17.2%; n = 15), and (4) repeated-sprint training in normoxia (RSN; n = 18), which included 30 seconds of all-out effort (130% Wmax) followed by 3 minutes of active recovery (55%-65% Wmax). Body composition, anthropometric, biochemical, and clinical parameters were assessed at baseline (A), after 18 training sessions (B), and during the 7 days after the last session (C). IHT and RSH showed a significant (p < 0.001 and p = 0.016, respectively) decrease in the waist circumference at both B and C assessments compared with A. Hypoxia groups presented a significant reduction in the percentage of trunk fat with a moderate effect size (IHT: d = 0.56; RSH: d = 0.93). In the normoxia groups, total cholesterol (CHOL) tended to decrease (INT: -4.21% and RSN: -5.18%), whereas it tended to increase in the hypoxia groups (IHT: +2.91% and RSH +4.07%). An interaction effect between conditions (through pooled data) on waist circumference (p = 0.01), percentage of trunk fat mass (p < 0.001), and CHOL (p = 0.019) was observed. Both training regimens under normobaric cyclic hypoxia were more effective at causing decreased abdominal fat in overweight/obese women than the same protocols in normoxia.

Background: This pilot study had the aim to determine the effects of a new dose of maximal-intensity interval training in hypoxia in active adults., Methods: Twenty-four university student volunteers were randomly assigned to three groups: hypoxia group, normoxia group or control group. The eight training sessions consisted of 2 sets of 5 repeated sprints of 10 seconds with a recovery of 20 seconds between sprints and a recovery period of 10 minutes between sets. Body composition was measured following standard procedures. A blood sample was taken for an immediate hematocrit (HCT) and hemoglobin (Hb) concentration assessment. An all-out 3-ute test was performed to evaluate ventilation parameters and power., Results: HCT and Hb were significantly higher for the hypoxia group in Post- and Det- (P=0.01; P=0.03). Fat mass percentage was significantly lower for the hypoxia group in both assessments (P=0.05; P=0.05). The hypoxia group underwent a significant increase in mean power after the recovery period., Conclusions: A new dose of 8 sessions of maximal-intensity interval training in hypoxia is enough to decrease the percentage of fat mass and to improve HCT and Hb parameters and mean muscle power in healthy and active adults.

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