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To assess organism reaction to dosed hypoxic hypoxia in the human invividuals with pre-diabetic hydrogen metabolism disturbances.Altogether 40 subjects, age range 50-74 years, were examined, including 18 persons with pre-diabetic hydrogen metabolism disturbances and 22 essentially healthy subjects. All of them underwent dosed hypoxic test (breathing gas mixture containing 12 % of oxygen during nearly 20 min. The following monitorings were performed: blood saturation (SpO2), breathing rate, arterial blood pressure and heart rate; and standard glucose tolerance test (GTT) for blood plasma glucose and insulin concentration. The patients with prediabetic hydrogen metabolism disturbances displayed a more significant decrease of SpO2 and less effective functioning of the respiratory and cardiovascular systems during dosed hypoxic test compared with the healthy individuals without hydrogen metabolism disturbances. After redistribution of study subjects relative the degree of SpO2 decrease at dosed hypoxic test in the subgroup with satisfactory resistance to hypoxia (subgroup 1: SpO2 more than 80 %) and with reduced (subgroup 2: SpO2 80 % or less) we have found that the fasting glucose level after 2-hour GTT was significantly higher in subgroup 2 versus subgroup 1. The obtained results indicate the interrelationship between organism reaction to hypoxia, in particular between the degree of arterial hypoxemia during performance of the dosed hypoxic test and the indices of fasting glycemia and at standard GTT. The patients with pre-diabetic hydrogen metabolism disturbances are characterized with lower resistance to hypoxic hypoxia.