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Your search keyword '"Kuzenkov VS"' showing total 5 results
Start Over Author "Kuzenkov VS" Topic hypoxia
5 results on '"Kuzenkov VS"'

1. [Inhibitors of neuronal and inducible NO-syntases enhance the effect of short-term adaptation to hypoxia in rats of Krushinsky-Molodkina strain].

Author

Krushinskiĭ AL, Kuzenkov VS, D'iakonova VE, and Reutov VP

Subjects
Acclimatization drug effects, Acclimatization physiology, Animals, Guanidines administration & dosage, Indazoles administration & dosage, Male, Nitric Oxide Synthase Type I antagonists & inhibitors, Nitric Oxide Synthase Type II antagonists & inhibitors, Rats, Adaptation, Physiological drug effects, Hypoxia, Nitric Oxide Synthase Type I metabolism, Nitric Oxide Synthase Type II metabolism
Abstract

We found that selective inhibitors of neuronal and inducible NOS (7-nitroindazole and aminoguanidine) significantly enhance the protective effect of short-term adaptation to hypoxia on the development of stress lesions in rats Krushinsky-Molodkina.

Published
2015

2. Effect of hypoxia on nitric oxide formation in animal heart tissues.

Author

Kuropteva ZV, Reutov VP, Baider LM, Belaya OL, Krushinskii AL, Kuzenkov VS, and Moldaliev ZhT

Subjects
Animals, Electron Spin Resonance Spectroscopy methods, Heart drug effects, Male, Nitric Oxide Synthase antagonists & inhibitors, Nitroarginine administration & dosage, Rats, Sodium Nitrite administration & dosage, Hypoxia metabolism, Myocardium metabolism, Nitric Oxide biosynthesis
Published
2011
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3. [EPR study of the influence of hypoxia on nitric oxide formation in the blood of Krushinskii-Molodkina rats].

Author

Baĭder LM, Reutov VP, Krushinskiĭ AL, Kuzenkov VS, Sorokina EG, Koshelev VB, Fadiukov OE, Zhymabaeva TT, Lozinova TA, Komissarova LKh, Pinelis VG, Kositsin NS, and Kuropteva ZV

Subjects
Animals, Electron Spin Resonance Spectroscopy methods, Hemoglobins analysis, Male, Rats, Rats, Wistar, Species Specificity, Hemoglobins metabolism, Hypoxia blood, Nitric Oxide blood
Abstract

The influence of hypoxia on nitric oxide formation in the blood of Krushinskii-Molodkina rats has been studied by electron paramagnetic resonance. It was found that nitric oxide synthesis in Krushinskii-Molodkina rats is increased compared with that in Wistar rats. A significant enhancement of the EPR signal of Hb-NO complexes in the animal blood was observed after hypoxia simulating the altitude of 5000 m above the sea level, in particular in the presence of sodium nitrite and the NO-synthase inhibitor L-nitroarginine. It was assumed that NO synthesis and nitro-/nitrite- reductase systems are activated under hypoxic conditions.

Published
2009

4. [Nitric oxide is involved in the protective effects of short-term adaptaion to hypoxia in the course of stress-induced disorders in Krushinsky-Molodkina rats].

Author

Krushinskiĭ AL, Reutov VP, Kuzenkov VS, Sorokina EG, Koshelev VB, Fadiukova OE, Baĭder LM, Kuropteva ZV, Zhumambaeva TT, Komissarova LKh, Riasina TV, Kositsyn NS, and Pinelis VG

Subjects
Adaptation, Physiological drug effects, Animals, Electron Spin Resonance Spectroscopy, Hypoxia prevention & control, Male, Nitric Oxide Synthase metabolism, Rats, Stress, Physiological metabolism, Stress, Physiological prevention & control, Adaptation, Physiological physiology, Enzyme Inhibitors pharmacology, Hypoxia metabolism, Nitric Oxide metabolism, Nitric Oxide Synthase antagonists & inhibitors
Abstract

A possible involvement of nitric oxide in the protective effect of short-term adaptation of Krushinsky-Molodkina rats to mild hypoxia simulating 5000 m above sea level was studied. Nitric oxide proved to have a considerable protective effect on stress-induced disorders in Krushinsky-Molodkina rats as demonstrated using NO-synthase inhibitors and NO monitoring by electron spin resonance under different experimental conditions.

Published
2007

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