1. Effects of hypothyroidism on the mesenteric and omental adipose tissue in rats.
- Author
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López-Fontana CM, Pennacchio G, Zyla LE, Toneatto J, Bruna FA, Ortiz N, Sassi PL, Santiano FE, García S, Sasso CV, Pietrobon EO, Jahn GA, Pistone Creydt V, Soaje M, and Carón RW
- Subjects
- Adipocytes metabolism, Adipokines blood, Adipose Tissue, White metabolism, Adipose Tissue, White pathology, Animals, Basal Metabolism, Biomarkers metabolism, Body Weight, Corticosterone metabolism, Eating, Fatty Acids metabolism, Female, Glucose metabolism, Hypothyroidism blood, Insulin metabolism, Motor Activity, Ovary metabolism, Propylthiouracil pharmacology, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Sprague-Dawley, Adipose Tissue pathology, Hypothyroidism pathology, Mesentery pathology, Omentum pathology
- Abstract
To characterize the influence of hypothyroidism on the endocrine activity of mesenteric and omental adipose tissue (MOAT) and the peripheral regulation of energy balance (EB) in rats, we analyzed food intake (FI); basal metabolic rate (BMR); locomotor activity; body weight (BW); serum hormone concentrations and the expression of their receptors in MOAT. We evaluated the morphology and differentiation of adipocytes. Hypothyroidism decreased FI, BMR and BW. The percentage of visceral white adipose tissue (WAT) depots and the morphology of adipocytes were similar to euthyroid rats. Serum leptin and adiponectin expression in MOAT were altered by hypothyroidism. The expression of Perilipin 1, HSL, UCP1 and PRDM16 was significantly lower in MOAT of hypothyroid animals. Hypothyroidism in rats leads to a compensated EB by inducing a white adipocyte dysfunction and a decrease in BW, BMR, FI and adipokine secretions without changing the percentage of WAT depots and the morphology of the MOAT., (Copyright © 2019. Published by Elsevier B.V.)
- Published
- 2019
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