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Your search keyword '"Settembrini S"' showing total 3 results
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3 results on '"Settembrini S"'

1. The basal to total insulin ratio in outpatients with diabetes on basal-bolus regimen

Author

Castellano, Elena, Attanasio, R., Giagulli, V. A., Boriano, A., Terzolo, M., Papini, E., Guastamacchia, E., Monti, S., Aglialoro, A., Agrimi, D., Ansaldi, E., Babini, A. C., Blatto, A., Brancato, D., Casile, C., Cassibba, S., Crescenti, C., De Feo, M. L., Del Prete, A., Disoteo, O., Ermetici, F., Fiore, V., Fusco, A., Gioia, D., Grassi, A., Gullo, D., Lo Pomo, F., Miceli, A., Nizzoli, M., Pellegrino, M., Pirali, B., Santini, C., Settembrini, S., Tortato, E., Triggiani, V., Vacirca, A., Borretta, G., and all on behalf of Associazione Medici Endocrinologi (AME)

Published
2018
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2. The basal to total insulin ratio in outpatients with diabetes on basal-bolus regimen

Author

Castellano, E, Attanasio, R, Giagulli, Va, Boriano, A, Terzolo, M, Papini, E, Guastamacchia, E, Monti, S, Aglialoro, A, Agrimi, D, Ansaldi, E, Babini, Ac, Blatto, A, Brancato, D, Casile, C, Cassibba, S, Crescenti, C, De Feo ML, Del Prete, A, Disoteo, O, Ermetici, F, Fiore, V, Fusco, A, Gioia, D, Grassi, A, Gullo, D, Lo Pomo, F, Miceli, A, Nizzoli, M, Pellegrino, M, Pirali, B, Santini, C, Settembrini, S, Tortato, E, Triggiani, V, Vacirca, A, Borretta, G, and all on behalf of Associazione Medici Endocrinologi, (AME).

Subjects
musculoskeletal diseases, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Type 2 diabetes, Hypoglycemia, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Basal bolus, Internal Medicine, medicine, 030212 general & internal medicine, Type 1 diabetes, business.industry, Insulin, medicine.disease, Metformin, Regimen, Basal (medicine), Insulin therapy, business, medicine.drug, Research Article
Abstract

Objective To evaluate the basal/total ratio of daily insulin dose (b/T) in outpatients with diabetes type 1 (DM1) and type 2 (DM2) on basal-bolus regimen, by investigating whether there is a relationship with HbA1c and episodes of hypoglycemia. Methods Multicentric, observational, cross-sectional study in Italy. Adult DM1 (n = 476) and DM2 (n = 541) outpatients, with eGFR >30 mL/min/1.73 m2, on a basal-bolus regimen for at least six months, were recruited from 31 Italian Diabetes services between March and September 2016. Clinicaltrials.govID: NCT03489031. Results Total daily insulin dose was significantly higher in DM2 patients (52.3 ± 22.5 vs. 46 ± 20.9 U/day), but this difference disappeared when insulin doses were normalized for body weight. The b/T ratio was lower than 0.50 in both groups: 0.46 ± 0.14 in DM1 and 0.43 ± 0.15 in DM2 patients (p = 0.0011). The b/T was significantly higher in the patients taking metformin in both groups, and significantly different according to the type of basal insulin (Degludec, 0.48 in DM1 and 0.44 in DM2; Glargine, 0.44 in DM1 and 0.43 in DM2; Detemir, 0.45 in DM1 and 0.39 in DM2). The b/T ratio was not correlated in either group to HbA1c or incidence of hypoglycemia (

Published
2018

3. Glifozines and cardiorenal outcomes

Author

Biagio Di Iorio, Vincenzo Triggiani, Carlo Lavalle, Silvio Settembrini, Edoardo Guastamacchia, Gaetano La Manna, Claudio Ronco, Luca Di Lullo, Domenico Russo, Giuseppe Cianciolo, Antonio Bellasi, Di Lullo L., Bellasi A., Guastamacchia E., Triggiani V., Ronco C., Lavalle C., Di Iorio B.R., Russo D., Cianciolo G., La Manna G., and Settembrini S.

Subjects
Diabetes mellitu, medicine.medical_specialty, Renal function, 030204 cardiovascular system & hematology, Hypoglycemia, 03 medical and health sciences, Health problems, 0302 clinical medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Hypoglycemic drugs, 030212 general & internal medicine, Adverse effect, Intensive care medicine, Sodium-Glucose Transporter 2 Inhibitors, Gliflozin, business.industry, medicine.disease, Diabetes Mellitus, Type 2, Cardiology and Cardiovascular Medicine, business, Diabetic cardionephropathy, Developed country
Abstract

Diabetes mellitus, with its complications, is one of the major health problems in economically developed countries and its prevalence is constantly increasing. Kidneys and heart involvement represent main comorbidities in diabetic patients often leading to organ failure. The treatments available until a few years ago are often associated with hypoglycemia, weight gain, gastro-intestinal disorders and other side effects together with serious adverse effects on renal function. The new frontiers of diabetic cardionephropathy treatment are mainly focused on delay of heart and renal failure both on diabetic and nondiabetic patients ad it was shown by last data reports. In the following review, we will focus on Gliflozins, one of the newest classes of hypoglycemic drugs that have shown to hold peculiar pharmacological properties in managing cardiac and renal complications.

Published
2020
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