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Unlabelled: WHAT IS NEW AND OBJECTIVE: Some evidence suggests that angiotensin-converting enzyme insertion/deletion (I/D) polymorphism may play a role in endothelium-dependent vasodilatation. However, the impact of I/D polymorphism on endogenous nitric oxide production, which may be of great therapeutic significance, has scarcely been studied. This study aimed to investigate this in hypertensives and hypercholesterolaemics., Methods: Adult Han subjects were recruited by cluster sampling from two communities in Shunde, Guangdong province, China. Plasma nitrite and nitrate (NO(x)) levels were determined by colorimetry assay and angiotensin II and 6-keto-prostaglandin F1-alpha by radioimmunoassay. Angiotensin-converting enzyme gene I/D polymorphism were genotyped by polymer chain reaction-amplified fragment length polymorphism., Results and Discussion: Of the 779 subjects who met our inclusion criteria, 502 were with normotensive and normocholesterolaemic, 76 had hypertension only, 146 hypercholesterolaemia only, and 55 had both hypertension and hypercholesterolaemia. Among subjects with hypertension only, the plasma levels of NO(x) for genotype DD were significantly lower than those for genotype II (P = 0·034). And the plasma levels of NO(x) for genotype DD was significantly higher than those for genotype II (P = 0·040) in subjects with hypercholesterolaemia only., What Is New and Conclusion: Our results suggest that I/D polymorphism has an impact on in vivo NO production in hypertensives and hypercholesterolaemics at the population level. Hypertensives with allele D may be benefit from L-arginine supplementation and hypercholesterolaemics with allele D may respond better to statins or antioxidants., (© 2010 Blackwell Publishing Ltd.)

Objective: This study collected on from all research relating to health education and hypertension in China and, with the aid of meta-analysis tools, assessed the outcomes of such health education. The analysis provides a basis for the further development of health-education programmes for patients with hypertension. Methods: Literature searches were carried out to identify studies that had evaluated the impact of health education on hypertension in China. The time interval searched was from 1 January 1991 to 31 December 2010. We searched the databases of PubMed, CBM, CNKI and VIP. Strict inclusion and exclusion criteria were used to screen the literature. We generated meta-analyses, using Cochrane RevMan 5.0 software, of outcomes of systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results: Fourteen studies met the inclusion criteria. Results show that, after health education for patients with hypertension, SBP and DBP is substantially lowered; the effect was statistically significant (P < 0.001). We extended subgroup analyses of the separate effects on SBP and DBP with respect to follow-up time, intervention site, intervention method and age. Conclusion: This review confirms that health education plays an important role in blood pressure control in hypertensive patients (especially the elderly): short-term follow-up intervention was more effective, and the effects were similar whether intervention was at the hospital or at the community level.