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Objective: To explore the association of renal surface nodularity (RSN) with the increased adverse vascular event (AVE) risk in patients with arterial hypertension., Methods: This cross-sectional study included patients with arterial hypertension aged 18-60 years who underwent contrasted computed tomography (CT) of kidney from January 2012 to December 2020. The subjects were classified into AVE or not (non-AVE) matched with age (≤5 years) and sex. Their CT images were analyzed using both qualitative (semiRSN) and quantitative RSN (qRSN) methods, respectively. Their clinical characteristics included age, sex, systolic blood pressure (SBP), diastolic blood pressure, hypertension course, diabetes history, hyperlipidemia, and estimated glomerular filtration rate (eGFR)., Results: Compared with non-AVE group ( n  = 91), AVE ( n  = 91) was at lower age, higher SBP, and fewer rate of diabetes and hyperlipidemia history (all P  < .01). Rate of positive semiRSN was higher in AVE than non-AVE (49.45% vs 14.29%, P  < .001). qRSN was larger in AVE than non-AVE [1.03 (0.85, 1.33) vs 0.86 (0.75,1.03), P  < .001]. The increased AVE was associated with semiRSN (odds ratio = 7.04, P  < .001) and qRSN (odds ratio = 5.09, P  = .003), respectively. For distinguishing AVE from non-AVE, the area under receiver operating characteristic was bigger in the models combining the clinical characteristics with either semiRSN or qRSN than that of semiRSN or qRSN alone ( P ≤.01)., Conclusion: Among the patients with arterial hypertension aged 18-60 years, CT imaging-based RSN was associated with increased AVE risk.

Background: Renal surface nodularity (RSN) is a subclinical biomarker of renal injury and may be associated with arterial hypertension., Purpose: To explore the association of RSN with arterial hypertension compared to normotensive patients., Material and Methods: A total of 205 inpatients with or without high blood pressure (HBP vs. control group) who underwent abdominal computed tomography (CT) scans were included. Their clinical characteristics included age, sex, HBP course, HBP grade, history of diabetes mellitus (DM), and renal function (estimated glomerular filtration rate [eGFR]). The HBP group included HBP/+DM and HBP/-DM based on the presence or absence of DM. The CT-based RSN grade was scored from 0 to 2 by two radiologists, respectively, where RSN grade 0 indicated smooth renal surface, grade 1 was mild RSN, and grade 2 was marked RSN., Results: The inter-rater agreement on RSN was good (Kappa = 0.76). The age-specific rate of RSN grade 1-2 was bigger in the HBP group than in the control group (42.86% [40%-49.22%] vs. 2.18% [0.00%-22.5%]; P  = 0.005). RSN grade was associated with HBP course ( P  < 0.02). The rates of RSN grade 1-2 and of RSN grade 2 were bigger in the HBP/+DM group than those in the HBP/-DM group (48.84% vs. 37.84%, and 18.61% vs. 1.35%, respectively; all P  = 0.001). Neither HBP course nor HBP grade correlated with rate of RSN grade ( P  > 0.05). The eGFR was similar among the RSN grades in HBP or between the HBP and control groups ( P  > 0.05)., Conclusion: RSN was associated with HBP compared to normotensive patients.

Background. This study sought to explore the association between quantitative classification of renal surface nodularity (qRSN) based on computed tomography (CT) imaging and early renal injury (ERI) in patients with arterial hypertension. Methods. A total of 143 patients with a history of hypertension were retrospectively enrolled; clinical information (age, sex, hypertension grade, and hypertension course), laboratory tests, and qRSN were collected or assessed. The subjects were divided into an ERI group (n = 60) or a control group (CP, n = 83) according to ERI diagnosis based on the following criteria: cystatin C > 1.02 mg/L. Univariate analysis and multiple logistic regression were used to assess the association between ERI and qRSN. A receiver operating characteristic curve (ROC) was performed to compare multiple logistic regression models with or without qRSN for differentiating the ERI group from the control group. Results. In univariate analysis, hypertension grade, hypertension course, triglycerides (TG), and qRSN were related to ERI in patients with arterial hypertension (all P < 0.1), with strong interrater agreement of qRSN. Multiple logistic regression analysis showed an area under the ROC curve of 0.697 in the model without qRSN and 0.790 in the model with qRSN, which was significantly different (Z = 2.314, P = 0.021). Conclusion. CT imaging-based qRSN was associated with ERI in patients with arterial hypertension and may be an imaging biomarker of early renal injury. [ABSTRACT FROM AUTHOR]