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This study aims to analyze the behaviour of cardiac autonomic modulation in adolescents with a family history of hypertension along with polymorphism of the ACE gene (rs1799752). The study involved 141 adolescents, with a mean age of 14.89, divided into the following six groups: offspring of normotensive parents (ONP): DD, DI and II; and offspring of hypertensive parents (OHP): DD, DI and II. Blood pressure, body composition, family history of hypertension, sleep disorder, and sexual maturation were assessed for the groups' characterization. Afterwards, an electrocardiogram was performed, and oral mucosal cells were collected to analyze heart rate variability and genotypic research of angiotensin‐converting enzyme. The main finding of this study was the decrease of vagal action in group OHP (genotype DD) relative to group ONP (genotype II): LF (%), 54.25 ± 3.14 vs 39.33 ± 3.80; HF (%), 45.74 ± 3.14 vs 60.66 ± 3.80; LF/HF, 1.48 ± 0.23 vs 0.68 ± 0.19. The results also showed changes in the variable diastolic blood pressure (DBP) in OHP (genotype DI) to ONP (genotype II) groups: 72.99 ± 2.33 vs 63.27 ± 1.72; and OHP (genotype DI) to ONP (genotype DD) groups. Adolescents with genotype DD and a family history of arterial hypertension present chances in cardiac autonomic modulation, the cardiac parasympathetic modulation is lower in these adolescents in comparison to participants of ONP + II group. [ABSTRACT FROM AUTHOR]

The purpose of this study was to evaluate the behavior of the cardiac autonomic nervous system in adolescents with family history of hypertension at different levels of physical activity. The sample was composed for 162 adolescents who were divided into 2 groups: (a) offspring of normotensive; and (b) offspring of hypertensive that were subdivided into low and high levels of physical activity. The subjects underwent the following evaluations: anthropometric, level of physical activity, sexual maturation, sleep quality index, blood pressure, and heart rate variability. Significant differences (P<0.05) was observed at RMSSD, PNN50, Total Variance, HF, and LF. The findings indicate the practice of physical activity has a protector function on the cardiovascular system, which was linked to the decrease in sympathetic modulation along with a greater vagal response in adolescents with normotensive or hypertensive parents. [ABSTRACT FROM AUTHOR]

To analyze the effect of the use of carvacrol in the cardiovascular system of spontaneously hypertensive rats (SHR). Methods: Methods: Twenty animals were allocated in four groups, one group control Wistar receiving only sorbitol, used as vehicle of administration of the carvacrol (Wistar-Vehicle), one control group SHR, also receive only sorbitol (SHR-Vehicle), a third, treated with losartan (SHR-Losartan/50 mg/kg), and the fourth, treated with carvacrol (SHR - Carvacrol/20 mg/kg). Sorbitol, losartan and carvacrol were administered by oral gavage daily for 30-day. Hemodynamic variables, vascular reactivity, biochemical parameters, and expression of Mas and AT1 receptors in kidney tissues were analyzed. SHR- Carvacrol group showed a maximal effect of inhibition of 56% in the curve of norepinephrine. The E max of the curves with Ca2+ were smaller in the groups SHR-losartan (40.17%) and SHR-carvacrol (35.71%) when compared to the SHR-Vehicle. The carvacrol increased the expression of the MAS receptors in kidney tissue. Thirty days of treatment with carvacrol showed an antihypertensive effect associated with less peripheral vascular resistance. Also, treatment with carvacrol increased the expression of MAS receptors in kidney tissue. [ABSTRACT FROM AUTHOR]