Search

Nebivolol was given for 8 weeks to 34 menopausal women with grade 1 and 2 hypertension. Monotherapy was effective in 66,7% of patients, while in other patients combination with hydrochlorothiazide (12.5 mg) was required. The use of nebivolol was associated with decreased rate and severity of vasomotion reactions and thus with positive effect on menopausal syndrome. Nebivolol appeared to be safe and metabolically neutral.

Investigations were carried out at rest and after physical exercise (50 and 75% from maximum) with pressor Fl-alpha and F2 alpha and depressor (A, E) fraction of prostaglandins (PG) in 10 healthy individuals, in 10 patients with neurocirculatory dystoniaa with hypertension and in 10 patients with neurocirculatory dystonia with hypotension. In patients with hypertension at rest as compared to the healthy individuals there was increase of content of pressor and decrease of depressor fractions of PG, in patients with hypotension changes in PG were of the reverse type. In adaptation to physical load at different stage of load levels definite trends in changes in the PG content have been recorded, close to such changes in the healthy subjects and patients with hypotension, and a reverse trend in persons with hypertension.

Renin activity, aldosterone, prostaglandin (PGF2 alpha and PGB) and cyclic nucleotide levels and catecholamine excretion were measured in 165 essentially hypertensive patients exposed to therapeutic effects of "running" impulse magnetic field (RIMF). The correction of arterial blood pressure in RIMF-treated patients is shown to be mediated by BP-controlling humoral factors, the magnitude and direction of changes in levels and activity of biologically-active substances and hormones being determined by their respective baselines. A decrease of hyperfunction, as reflected in elevated hormonal production, and an increase of hypofunction were the most common therapeutic effect of RIMF exposure.