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Your search keyword '"Guinosso CJ"' showing total 3 results
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3 results on '"Guinosso CJ"'

1. N-(aminophenyl)oxamic acids and esters as potent, orally active antiallergy agents.

Author

Klaubert DH, Sellstedt JH, Guinosso CJ, Capetola RJ, and Bell SC

Subjects
Administration, Oral, Animals, Male, Oxamic Acid administration & dosage, Oxamic Acid chemical synthesis, Oxamic Acid pharmacology, Passive Cutaneous Anaphylaxis drug effects, Rats, Structure-Activity Relationship, Amino Acids, Hypersensitivity drug therapy, Oxamic Acid analogs & derivatives
Published
1981
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2. Oxanilic acids, a new series of orally active antiallergic agents.

Author

Sellstedt JH, Guinosso CJ, Begany AJ, Bell SC, and Rosenthale M

Subjects
Animals, Male, Oxamic Acid analogs & derivatives, Oxamic Acid therapeutic use, Passive Cutaneous Anaphylaxis drug effects, Rats, Skin Tests, ortho-Aminobenzoates chemical synthesis, ortho-Aminobenzoates pharmacology, ortho-Aminobenzoates therapeutic use, Amino Acids chemical synthesis, Hypersensitivity drug therapy, Oxamic Acid chemical synthesis
Abstract

A large number of oxanilic acid esters and N-heteroaryl oxamic acid esters were prepared and found to have antiallergic activity using the rat passive cutaneous anaphylaxis (PCA) test. Many of the oxanilic acid esters are active orally, with the most active species having an aryl 2'-carbamoyl group and a 3'-methoxy group. Hydrolysis of the ester from the oxanilic ester moiety causes a loss of oral activity.

Published
1975
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3. 5-Tetrazolecarboxamides and their salts: new orally active antiallergy agents.

Author

Klaubert DH, Sellstedt JH, Guinosso CJ, Bell SC, and Capetola RJ

Subjects
Administration, Oral, Animals, Passive Cutaneous Anaphylaxis drug effects, Rats, Structure-Activity Relationship, Tetrazoles administration & dosage, Tetrazoles chemical synthesis, Time Factors, Azoles pharmacology, Hypersensitivity drug therapy, Tetrazoles pharmacology
Published
1981
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