1. Prevalence of confirmed immediate type drug hypersensitivity reactions among school children.
- Author
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Erkoçoğlu M, Kaya A, Civelek E, Ozcan C, Cakır B, Akan A, Toyran M, Ginis T, and Kocabas CN
- Subjects
- Adolescent, Age Factors, Biomarkers blood, Chi-Square Distribution, Child, Cross-Sectional Studies, Drug Hypersensitivity blood, Drug Hypersensitivity diagnosis, Drug Hypersensitivity immunology, Female, Health Surveys, Humans, Hypersensitivity, Immediate blood, Hypersensitivity, Immediate diagnosis, Hypersensitivity, Immediate immunology, Immunoglobulin E blood, Intradermal Tests, Male, Predictive Value of Tests, Prevalence, Surveys and Questionnaires, Telephone, Turkey epidemiology, Drug Hypersensitivity epidemiology, Hypersensitivity, Immediate epidemiology
- Abstract
Background: Despite drug-related hypersensitivity reactions are an important health problem, epidemiologic data on drug allergy and hypersensitivity are limited, and studies including diagnostic work-up are scarce. The aim of this study was to determine the actual frequency of immediate type drug hypersensitivity using diagnostic tests in school children with parent-reported drug allergies., Methods: This study involved three phases. The first phase is a survey of children with a mean age of 12.9 yrs attending grades 6-8 of primary schools with a questionnaire asking drug-related symptoms within 2 h of ingestion. The total population of sixth to eight grade school children was 210,000, and a sample size of 9096 was deemed to be representative of Ankara [(p) = 1.0%, α < 0.05, β = 0.8, (d) = 0.2.] During the second phase, a detailed clinical history was obtained by phone from the parents of children who had positive parent-reported drug allergy. The final stage of the study consisted of a detailed diagnostic work-up of children with a clinical history consistent with immediate type drug hypersensitivity reaction., Results: Overall, 11,233 questionnaires were distributed, 10,096 of which were retrieved after completion by parents. The rate of parent-reported immediate type drug hypersensitivity was 7.87% (792 children). However, phone survey revealed a clinical history suggestive of drug allergy in only 117 children (1.16%). After further diagnostic work-up, the true frequency of immediate type drug hypersensitivity was 0.11%., Conclusion: Our results suggest that a positive clinical history is not enough to make a diagnosis of drug allergy, which highlights the significance of undertaking further diagnostic evaluation., (© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.)
- Published
- 2013
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