1. Apoptosis in Primary Hyperparathyroidism.
- Author
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Segiet OA, Mielańczyk Ł, Piecuch A, Michalski M, Tyczyński S, Brzozowa-Zasada M, Deska M, and Wojnicz R
- Subjects
- Apoptosis Regulatory Proteins metabolism, Biomarkers analysis, Biomarkers metabolism, Humans, Hyperparathyroidism, Primary diagnosis, Hyperplasia diagnosis, Hyperplasia pathology, Parathyroid Glands cytology, Parathyroid Neoplasms diagnosis, Apoptosis, Apoptosis Regulatory Proteins analysis, Hyperparathyroidism, Primary pathology, Parathyroid Glands pathology, Parathyroid Neoplasms pathology
- Abstract
Primary hyperparathyroidism (PHPT) is defined by inappropriate elevation of parathormone, caused by parathyroid hyperplasia, also known as multi-gland disease (MGD), parathyroid adenoma (PA), or parathyroid carcinoma (PC). Although several studies have already been conducted, there is a lack of a definite diagnostic marker, which could unambiguously distinguish MGD from PA or PC. The accurate and prompt diagnosis has the key meaning for effective treatment and follow-up. This review paper presents the role of apoptosis in PHPT. The comparison of the expression of Fas, TRAIL, BCL-2 family members, p53 in MGD, PA, and PC, among others, was described. The expression of described factors varies among proliferative lesions of parathyroid gland; therefore, these could serve as additional markers to assist in the diagnosis.
- Published
- 2018
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