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Start Over Author "PERMANA, H." Topic hyperglycemia
4 results on '"PERMANA, H."'

1. The association of admission random blood glucose concentration and body-mass index with mortality in COVID-19 patients.

Author

Permana H, Huang I, Susandi E, and Wisaksana R

Subjects
Adult, Aged, Body Mass Index, COVID-19 blood, COVID-19 diagnosis, COVID-19 virology, Comorbidity, Female, Heart Rate physiology, Hospitalization trends, Humans, Indonesia epidemiology, Length of Stay statistics & numerical data, Male, Middle Aged, Oxygen Saturation, Platelet Count, Respiratory Rate physiology, Retrospective Studies, Risk Factors, SARS-CoV-2 genetics, Blood Glucose analysis, COVID-19 mortality, Hospitalization statistics & numerical data, Hyperglycemia complications, Obesity complications
Abstract

Objective: This study aimed to investigate the association between hyperglycemia and body mass index (BMI), along with other associated comorbidities in hospitalized COVID-19 patients among the Indonesian population., Patients and Methods: This was a retrospective study conducted at Hasan Sadikin Hospital, Bandung between March 1, 2020, and August 30, 2020. Data were analyzed using the chi-square test for categorical data and unpaired t-test and Mann-Whitney alternative test for numerical data using SPSS version 24.0 (IBM SPSS Statistics for Windows, Version 24.0. IBM, Armonk, NY, USA) and GraphPad Prism version 7.0 for Windows., Results: A total of 142 hospitalized COVID-19 patients were documented between March and August 2020 at the Hasan Sadikin Hospital. Among the 142 patients, 116 (81.7%) survived, while 26 (18.3%) died. Sex, age, BMI, number of comorbidities, heart rate, respiratory rate, peripheral oxygen saturation, platelet count, random blood glucose (RBG), and length of stay (LOS) were significantly associated with mortality. Multivariate analyses demonstrated that admission RBG levels > 140 mg/dl were independently associated with an increased risk of mortality in COVID-19 patients (OR 4.3, 95% CI 1.1-17.5, p = 0.043), while BMI > 25 kg/m2 was significantly associated with reduced mortality (OR, 0.22; 95% CI 0.05-0.88, p = 0.033)., Conclusions: Admission hyperglycemia, indicated by an increase in RBG levels >140 mg/dL, is independently associated with an increased risk of mortality in hospitalized COVID-19 patients, while obesity (BMI >25 kg/m2) might have protective properties against the risk of death.

Published
2021
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2. Is subcutaneous insulin administration adequate for the management of hyperglycemic crisis in COVID-19?

Author

Permana H and Soetedjo NNM

Subjects
COVID-19, Coronavirus Infections epidemiology, Coronavirus Infections transmission, Coronavirus Infections virology, Disease Management, Humans, Hyperglycemia epidemiology, Hyperglycemia virology, Injections, Subcutaneous, Pandemics, Pneumonia, Viral epidemiology, Pneumonia, Viral transmission, Pneumonia, Viral virology, SARS-CoV-2, Betacoronavirus isolation & purification, Coronavirus Infections complications, Hyperglycemia drug therapy, Hypoglycemic Agents administration & dosage, Insulin administration & dosage, Pneumonia, Viral complications
Abstract

There is a desperate need to explore different insulin administration strategies, particularly in coronavirus disease 2019 (COVID-19) patients with hyperglycemic crisis. Noteworthily, diabetes mellitus (DM) and poorly controlled blood glucose increase the risk of mortality and severity of COVID-19. Intravenous (IV) insulin administration with hourly monitoring of blood glucose is the ideal approach in managing patients with hyperglycemic crisis, but it is not judicious to be applied in developing countries where shortage of personal protective equipment (PPE) is a major issue. Furthermore, increasing the probability of "already greater risks" for doctors or other healthcare workers contracting COVID-19 seems inappropriate. Thus, an alternative administration strategy and more moderate glucose monitoring to reduce the contact exposure of healthcare workers with COVID-19 patients, by ensuring appropriate blood glucose levels, needs to be performed in this critical pandemic era. Subcutaneous (SC) rapid-acting insulin analog administration could presumably be a solution to this contentious issue., Competing Interests: Declaration of competing interest None to declare., (Copyright © 2020. Published by Elsevier Ltd.)

Published
2020
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3. Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries

Author

Huangfu, P., Laurence, Y.V., Alisjahbana, B., Ugarte-Gil, C., Riza, A.L., Walzl, G., Ruslami, R., Moore, D.A.J., Ioana, M., McAllister, S., Ronacher, K., Koesoemadinata, R.C., Grint, D., Kerry, S., Coronel, J., Malherbe, S.T., Griffiths, U., Dockrell, H.M., Hill, P.C., Crevel, R. van, Pearson, F., Critchley, J.A., Cliff, J.M., Eckold, C., Moore, D.A., Griffiths, U.K., Kerry, S.R., Anmontse, R., Netea, M.N., Ruesen, C., Lachmandas, E., Joosten, S.A., Ottenhoff, T.H.M., Vrieling, F., Haks, M.C., Kumar, V., Wijmenga, C., Kaufmann, S.H.E., Beigier, M., Golinski, R., Kleynhans, L., Smith, B., Stanley, K., Spuy, G.D. van der, Loxton, A.G., Chegou, N.N., Bosman, M., Thiart, L., Wagman, C., Tshivhula, H., Selamolela, M., Prins, N., Plessis, W.J. du, Rensburg, I.C. van, Toit, L. du, McAllister, S.M., Verrall, A.E., Cimpoeru, A., Ciocoiu, A., Dorobantu, S.C., Plesea, R.M., Popescu, E., Cucu, M.G., Streata, I., Burada, F., Serban-Sosoi, S., Nicoli, E.R., Panduru, M.N., Cioboata, R., Dudau, M.O., Nitu, F.M., Bazavan, I.C., Olteanu, M., Editoiu, C.D., Florescu, A., Ciontea, M.S., Capitanescu, I.D., Olaru, M., Tataru, T., Papurica, M.D., Valutanu, I., Dubreu, V., Stamatoiu, L., Enoiu, C., Mota, M., Popa, S., Firanescu, A.G., Popa, A., Gheonea, I.A., Bicuti, S., Lepadat, A., Streba, C., Demetrian, A.D., Ciurea, M., Vladu, I.M., Clenciu, D., Bicu, M.L., Lopez, S., Limascca, R., Villaizan, K., Castro, B., Flores, J., Solano, W., Soetedjo, N.N.M., Santoso, P., Chaidir, L., Susilawati, N., Annisa, J., Livia, R., Yunivita, V., Soeroto, A.Y., Permana, H., Imaculata, S., Gunawan, Y., Dewi, N.F., Apriani, L.A., and TANDEM Consortium

Subjects
endocrine system diseases, Epidemiology, diagnostic error, 0302 clinical medicine, middle aged, patient safety, DM, middle income country, 030212 general & internal medicine, hemoglobin A1c, Public health, Human immunodeficiency virus, adult, public health, anemia, female, Infectious Diseases, TB, priority journal, tuberculosis, diabetes mellitus, diagnostic accuracy, disease severity, epidemiology, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tuberculosis, HbA1c, high performance liquid chromatography, Anemia, Point-of-care testing, prevalence, 030231 tropical medicine, purl.org/pe-repo/ocde/ford#3.03.08 [https], Article, 03 medical and health sciences, male, treatment refusal, Diabetes mellitus, Internal medicine, medicine, sex, human, infection risk, Point of care, point of care testing, hemoglobin blood level, business.industry, screening, nutritional and metabolic diseases, Likert scale, medicine.disease, major clinical study, body mass, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], age, purl.org/pe-repo/ocde/ford#3.02.07 [https], hyperglycemia, business, Body mass index
Abstract

Contains fulltext : 202938.pdf (Publisher’s version ) (Closed access) BACKGROUND: Diabetes mellitus (DM) is common among tuberculosis (TB) patients and often undiagnosed or poorly controlled. We compared point of care (POC) with laboratory glycated haemoglobin (HbA1c) testing among newly diagnosed TB patients to assess POC test accuracy, safety and acceptability in settings in which immediate access to DM services may be difficult. METHODS: We measured POC and accredited laboratory HbA1c (using high-performance liquid chromatography) in 1942 TB patients aged 18 years recruited from Peru, Romania, Indonesia and South Africa. We calculated overall agreement and individual variation (mean +/- 2 standard deviations) stratified by country, age, sex, body mass index (BMI), HbA1c level and comorbidities (anaemia, human immunodeficiency virus [HIV]). We used an error grid approach to identify disagreement that could raise significant concerns. RESULTS: Overall mean POC HbA1c values were modestly higher than laboratory HbA1c levels by 0.1% units (95%CI 0.1-0.2); however, there was a substantial discrepancy for those with severe anaemia (1.1% HbA1c, 95%CI 0.7-1.5). For 89.6% of 1942 patients, both values indicated the same DM status (no DM, HbA1c

Published
2019

4. Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis

Author

Eckold, C, Kumar, V, Weiner, J, Alisjahbana, B, Riza, A-L, Ronacher, K, Coronel, J, Kerry-Barnard, S, Malherbe, ST, Kleynhans, L, Stanley, K, Soeroto, A, Permana, H, Imaculata, S, Apriani, L, Ugarte-Gil, C, Walzl, G, van Crevel, R, Wijmenga, C, Critchley, JA, Dockrell, HM, Haks, M, Cliff, JM, Malherbe, S, Dockrell, H, Cliff, J, Moore, D, Griffiths, U, Laurence, Y, Aarnouste, R, Netea, M, Ruesen, C, Lachmandas, E, Kaufmann, S, Beigier, M, Golinski, R, Joosten, S, Ottenhoff, T, Vrieling, F, Smith, B, van der Spuy, G, Loxton, A, Chegou, N, Bosman, M, Thiart, L, Nitu, F, Wagman, C, Editoiu, C, Tshivhula, H, Selamolela, M, Prins, N, du Plessis, W, van Rensburg, I, du Toit, L, Critchley, J, Bazavan, I, Pearson, F, Grint, D, Florescu, A, McAllister, S, Hill, P, Verrall, A, Ioana, M, Riza, A, Cioboata, R, Dudau, M, Olteanu, M, Mota, M, Popa, SG, Firanescu, A, Popa, A, Gheonea, I, Bicuti, S, Lepadat, A, Capitanescu, I, Vladu, I, Papurica, M, Clenciu, D, Bicu, M, Streba, C, Demetrian, A, Ciurea, M, Cimpoeru, A, Ciocoiu, A, Dorobantu, S, Olaru, M, Plesea, R, Popescu, EL, Valutanu, I, Cucu, M, Streata, I, Burada, F, Serban-Sosoi, S, Panduru, N, Nicoli, E, Ciontea, M, Tataru, T, Dubreu, V, Stamatoiu, L, Lopez, S, Gunawan, Y, Limascca, R, Ruslami, R, Villaizan, K, Castro, B, Flores, J, Solano, W, Soetedjo, N, Santoso, P, Dewi, N, Chaidir, L, Koesoemadinata, R, Susilawati, N, Annisa, J, Livia, R, Yunivita, V, TANDEM (Concurrent Tuberculosis and Diabetes Mellitus, and unraveling the causal link, and improving care) Consortium

Subjects
0301 basic medicine, Microbiology (medical), Tuberculosis, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Inflammation, Transcriptome, 03 medical and health sciences, chemistry.chemical_compound, South Africa, 0302 clinical medicine, Immune system, Diabetes mellitus, Peru, Diabetes Mellitus, Medicine, Humans, 030212 general & internal medicine, Articles and Commentaries, Tuberculosis, Pulmonary, Whole blood, diabetes, business.industry, Mycobacterium tuberculosis, medicine.disease, Comorbidity, 3. Good health, 030104 developmental biology, Infectious Diseases, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], AcademicSubjects/MED00290, chemistry, tuberculosis, inflammation, Indonesia, Hyperglycemia, Immunology, hyperglycemia, Glycated hemoglobin, medicine.symptom, business
Abstract

Background People with diabetes have an increased risk of developing active tuberculosis (TB) and are more likely to have poor TB-treatment outcomes, which may impact on control of TB as the prevalence of diabetes is increasing worldwide. Blood transcriptomes are altered in patients with active TB relative to healthy individuals. The effects of diabetes and intermediate hyperglycemia (IH) on this transcriptomic signature were investigated to enhance understanding of immunological susceptibility in diabetes-TB comorbidity. Methods Whole blood samples were collected from active TB patients with diabetes (glycated hemoglobin [HbA1c] ≥6.5%) or IH (HbA1c = 5.7% to, Our study shows that people with diabetes and tuberculosis have altered peripheral immune profiles compared to people with only tuberculosis, and that these differences also exist in patients with intermediate hyperglycemia.

Published
2021

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