1. Organic reactions promoted by mucin glycoproteins
- Author
-
Shraga, Natalie, Belgorodsky, Bogdan, and Gozin, Michael
- Subjects
Diels-Alder reaction -- Analysis ,Esters -- Chemical properties ,Glycoproteins -- Structure ,Glycoproteins -- Chemical properties ,Hydrolysis -- Analysis ,Hydrophobic effect -- Analysis ,Chemistry - Abstract
Bovine submaxillary mucin and porcine gastric mucin have accelerated the rate of fatty acid p-nitrophenol ester hydrolysis up to 337 times and a carbon-carbon bond-forming Diels-Alder reaction between N-propylmaleimide and anthracene up to 200 times relative to the rates of the reference processes. The new properties of mucins to accelerate organic reactions have provided a new example of natural nonenzymatic proteins capable of promoting reactions of hydrophobic materials in aqueous solution.
- Published
- 2009