1. Antimicrobial Effect of Calcium Hydroxide Combined with Electrolyzed Superoxidized Solution at Neutral pH on Enterococcus faecalis Growth.
- Author
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Jimenez-Gonzalez, Héctor Armando, Nakagoshi-Cepeda, María Argelia Akemi, Nakagoshi-Cepeda, Sergio Eduardo, Urrutia-Baca, Víctor Hugo, De La Garza-Ramos, Myriam Angélica, Solis-Soto, Juan Manuel, Gomez-Flores, Ricardo, and Tamez-Guerra, Patricia
- Subjects
ANTIMICROBIAL stewardship ,STATISTICS ,HYDROGEN-ion concentration ,ANALYSIS of variance ,HYDROXIDES ,TIME ,ANTI-infective agents ,TOOTH roots ,HEALTH outcome assessment ,ENTEROCOCCUS ,DESCRIPTIVE statistics ,STATISTICAL sampling ,HYPERTONIC saline solutions ,DATA analysis software ,DATA analysis ,PHARMACODYNAMICS - Abstract
Objective. To evaluate the effect of the combination of calcium hydroxide (Ca(OH)
2 ) and a novel electrolyzed superoxidized solution at neutral pH, known as OxOral® on Enterococcus faecalis growth in root canals. Methods. Sixty human teeth were used, from which root canals were infected and randomly divided into the following treatment groups: saline solution, saline solution plus Ca(OH)2 , OxOral®, and OxOral® plus Ca(OH)2 . Results. A permanent reduction in bacterial growth was observed at days 1, 6, 12, and 18 after OxOral® plus Ca(OH)2 treatment from 4.4 ± 0.074 log 10 CFU / mL to 0.0 ± 0.001 log 10 CFU / mL. In addition, alkaline conditions maintenance was observed from application time (pH = 12.2 ± 0.033) to 18 d posttreatment (pH = 12.6 ± 0.083). Conclusion. The combination of OxOral® and Ca(OH)2 provides an alkaline pH and inhibits E. faecalis growth into the root canals. Our study opens the possibility for further research on the use of OxOral® in endodontic therapy. [ABSTRACT FROM AUTHOR]- Published
- 2021
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