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Manufacturing facile and low-cost wound dressings that simultaneously meet the needs of the entire repair process remains the major challenge of effective wound healing. Herein, a series of curdlan-tannic acid hybrid hydrogels were successfully fabricated through the annealing technique. Notedly, when the mixing weigh ratio was 1:1, the hydrogel exhibited excellent physicochemical properties, including swellability, degradability, water retention, porosity, and rheology. Additionally, the hydrogel did not display significant cytotoxicity to fibroblasts and the hemolysis rate at 12 h was 3%. Interestingly, the hybrid hydrogel showed multifunctional properties, including remarkable antioxidant, antibacterial, and rapid hemostasis effects reduce blood loss by 0.35 g, that were achieved through the temperature-dependent release of tannic acid. Moreover, a full-thickness skin defect animal model was used to verify that the multifunctional hydrogel could accelerate wound healing in vivo. These results suggest that this hybrid hydrogel is a promising candidate for the clinical treatment of full-thickness wounds., (Copyright © 2021. Published by Elsevier Ltd.)

The development of cheap and easily available injectable hydrogel is an urgent problem in the field of biomedical engineering. Herein, we used chitosan quaternary ammonium salt and sodium alginate to prepare a dual crosslinking hydrogel. The hydrogel formed in-situ crosslinking and can be injected continuously. Interestingly, the formed hydrogel possessed a homogeneous 3D network structure and exhibited reasonable mechanical properties. Moreover, the hydrogels had excellent injectability, and the compression strength of the hydrogel (Gel-0.5) was up to 27.65 kPa. Additionally, the hydrogel showed good biocompatibility that evaluated by cytotoxicity. Notably, the hydrogel was nontoxic toward NIH-3T3 cells. In summary, the hydrogel we produced can be used as an ideal biomaterial for further applications in the field of biomedical engineering., (Copyright © 2021 Elsevier Ltd. All rights reserved.)