1. Nephrogenic diabetes insipidus: treat with caution.
- Author
-
Boussemart T, Nsota J, Martin-Coignard D, and Champion G
- Subjects
- Combined Modality Therapy, Diabetes Insipidus, Nephrogenic congenital, Diabetes Insipidus, Nephrogenic genetics, Drug Therapy, Combination, Genetic Diseases, X-Linked, Humans, Infant, Male, Mutation, Receptors, Vasopressin genetics, Treatment Outcome, Urination drug effects, Water Intoxication drug therapy, Water Intoxication etiology, Amiloride therapeutic use, Cyclooxygenase Inhibitors therapeutic use, Diabetes Insipidus, Nephrogenic therapy, Diet, Sodium-Restricted, Diuretics therapeutic use, Hydrochlorothiazide therapeutic use, Indomethacin therapeutic use
- Abstract
Current therapy for congenital nephrogenic diabetes insipidus consists of appropriate water intake coupled with decreased urine output obtained by means of a low-sodium diet and a combination of thiazide diuretics with renal prostaglandins inhibitors or amiloride. We report a case of congenital nephrogenic diabetes insipidus that was complicated by paradoxical water intoxication secondary to liberal water intake and the initiation of hydrochlorothiazide and indomethacin combination therapy. This report emphasizes the importance of evaluating the water balance and of a quick response with strict protocols following the initiation of indomethacin and thiazide diuretics in nephrogenic diabetes insipidus.
- Published
- 2009
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