1. A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community‐dwelling Mexican Americans and non‐Hispanic Whites: A method for increasing representation of diverse populations in clinical research
- Author
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O'Bryant, Sid E, Zhang, Fan, Petersen, Melissa, Hall, James R, Johnson, Leigh A, Yaffe, Kristine, Mason, David, Braskie, Meredith, Barber, Robert A, Rissman, Robert A, Mapstone, Mark, Mielke, Michelle M, Toga, Arthur W, and Team, for the HABLE Study
- Subjects
Dementia ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurosciences ,Behavioral and Social Science ,Aging ,Neurodegenerative ,Prevention ,Acquired Cognitive Impairment ,Brain Disorders ,Clinical Research ,Alzheimer's Disease ,Neurological ,Aged ,Alzheimer Disease ,Biomarkers ,Cognitive Dysfunction ,Female ,Humans ,Independent Living ,Male ,Mass Screening ,Mexican Americans ,Neuropsychological Tests ,Patient Selection ,Proteomics ,White People ,Alzheimer&apos ,s disease ,diversity ,Hispanic ,inclusion ,Mexican American ,mild cognitive impairment ,screening tool ,HABLE Study Team ,Alzheimer's disease ,Clinical Sciences ,Geriatrics - Abstract
IntroductionRepresentation of Mexican Americans in Alzheimer's disease (AD) clinical research has been extremely poor.MethodsData were examined from the ongoing community-based, multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Participants underwent functional exams, clinical labs, neuropsychological testing, and 3T magnetic resonance imaging of the brain. Fasting proteomic markers were examined for predicting mild cognitive impairment (MCI) and AD using support vector machine models.ResultsData were examined from n = 1649 participants (Mexican American n = 866; non-Hispanic White n = 783). Proteomic profiles were highly accurate in detecting MCI (area under the curve [AUC] = 0.91) and dementia (AUC = 0.95). The proteomic profiles varied significantly between ethnic groups and disease state. Negative predictive value was excellent for ruling out MCI and dementia across ethnic groups.DiscussionA blood-based screening tool can serve as a method for increasing access to state-of-the-art AD clinical research by bridging between community-based and clinic-based settings.
- Published
- 2022