1. Successful Intensive Care Treatment of Severe Lactic Acidosis and Tumor Lysis Syndrome Related to Intravascular Lymphoma
- Author
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Yuki Genda, Yutaro Ogawa, Jumpei Takeuchi, Hiroshi Mase, Atsuhiro Sakamoto, and Shingo Ichiba
- Subjects
Male ,Critical Care ,Multiple Organ Failure ,Prednisolone ,medicine.medical_treatment ,Severity of Illness Index ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Medicine ,Lactic Acid ,Renal replacement therapy ,Cyclophosphamide ,business.industry ,Organ dysfunction ,General Medicine ,Middle Aged ,medicine.disease ,Intensive care unit ,Vascular Neoplasms ,Renal Replacement Therapy ,Tumor lysis syndrome ,Respiratory failure ,Doxorubicin ,Vincristine ,030220 oncology & carcinogenesis ,Lactic acidosis ,Anesthesia ,030211 gastroenterology & hepatology ,Hyperlactatemia ,Lymphoma, Large B-Cell, Diffuse ,medicine.symptom ,Acidosis ,Rituximab ,Tumor Lysis Syndrome ,business ,Severe lactic acidosis - Abstract
Intravascular lymphoma is a rare disease that progresses to multiple organ dysfunction caused primarily by tumor cell proliferation in small blood vessels. Few studies have investigated critical care management of intravascular lymphoma. We describe a rare case of multiple organ failure due to intravascular lymphoma with severe lactic acidosis in a patient who survived. A 64-year-old man with impaired consciousness was diagnosed as having intravascular large B-cell lymphoma by means of a random skin biopsy. The patient arrived at our hospital's intensive care unit (ICU) with impaired consciousness, respiratory failure that required mechanical ventilation, and lactic acidosis that required renal replacement therapy. Mechanical ventilation and renal replacement therapy were continued in the ICU, and his respiratory status and circulatory dynamics eventually stabilized. However, his impaired consciousness and hyperlactatemia did not improve until after the start of chemotherapy with doxorubicin, cyclophosphamide, vincristine, prednisolone, and rituximab. Although he developed tumor lysis syndrome immediately after chemotherapy, his systemic condition was gradually stabilized by continued critical care management primarily comprising renal replacement therapy. He was weaned from ventilator support after a tracheotomy and moved to the general ward. Hematopoietic malignancy with hyperlactatemia has a very poor prognosis; however, hyperlactatemia and impaired consciousness were dramatically improved in this patient by critical care management and chemotherapy.
- Published
- 2020