1. The role of Fas expression on the occurrence of immunosuppression in severe acute pancreatitis
- Author
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Xi-han Zhou, Yanwu You, Sien Song, Suren R. Sooranna, Zhansong Huang, Yueqiu Qin, Yi-xia Yin, and Liao Pinhu
- Subjects
Adult ,CD4-Positive T-Lymphocytes ,Male ,Physiology ,medicine.medical_treatment ,Lymphocyte ,CD4-CD8 Ratio ,CD8-Positive T-Lymphocytes ,Monocytes ,Sepsis ,Medicine ,Humans ,RNA, Messenger ,fas Receptor ,business.industry ,Monocyte ,Gastroenterology ,Immunosuppression ,HLA-DR Antigens ,Middle Aged ,Fas receptor ,medicine.disease ,medicine.anatomical_structure ,Gene Expression Regulation ,Pancreatitis ,Apoptosis ,Immunology ,Acute pancreatitis ,Female ,business - Abstract
Severe acute pancreatitis (SAP) is a dangerous illness with high mortality where most patients do not die of excessive inflammation, but die of immunosuppression and multiple infections at a later stage. The mechanism of immunosuppression in SAP is unknown. The purpose of this study was to analyze the role of Fas expression on the occurrence of immunosuppression in patients with SAP. Forty-eight patients with pancreatitis were divided into two groups: 20 cases with SAP (7 cases with sepsis, 13 cases without sepsis) and 28 cases with mild acute pancreatitis (MAP). Twenty-eight healthy volunteers were selected as controls. Fas mRNA expression in peripheral blood was detected by qPCR and Fas protein of lymphocyte membranes; T lymphocyte subsets and expression of monocyte Human leukocyte antigen DR (HLA-DR) in peripheral blood were detected by flow cytometry. Compared with MAP and control groups, expression level of Fas mRNA and lymphocyte Fas protein in peripheral blood were significantly increased in the SAP group (all P
- Published
- 2013