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1. Prevalence and clinical profile of metabolic syndrome in longevity: study from Guangxi Zhuang Autonomous Region, China

Author

Caiyou Hu, Yuan Lv, Ze Yang, Wei Zhang, Xiang-hua He, and Guofang Pang

Subjects
Adult, Male, Gerontology, China, Cross-sectional study, media_common.quotation_subject, Longevity, Population, lcsh:Geriatrics, 030204 cardiovascular system & hematology, Fasting glucose, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Prevalence, Humans, Medicine, 030212 general & internal medicine, Risk factor, education, National Cholesterol Education Program, Abdominal obesity, Aged, media_common, Aged, 80 and over, Metabolic Syndrome, education.field_of_study, Chinese, business.industry, Middle Aged, medicine.disease, lcsh:RC952-954.6, Cross-Sectional Studies, Cardiovascular Diseases, Female, Geriatrics and Gerontology, medicine.symptom, Metabolic syndrome, business, Research Article, Demography
Abstract

Background Metabolic syndrome (MetS) was a risk factor for cardiovascular diseases, yet the prevalence of MetS among nonagenarians and centenarians was rarely reported. Here we investigated the prevalence of MetS and its components among nonagenarians and centenarians in our Zhuang population from Bama, Guangxi Zhuang Autonomous Region, China. Method In Bama area, there registered 881 individuals who lived more than 90 years old in 269,800 local residents and our study involved 307 long-lived participants and 486 local younger (35–68 years) persons, as controls. MetS was defined according to the revised National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATPIII) criteria. Results The overall prevalence estimates of MetS among longevity group were 28.0% based on NCEP ATPIII criteria. The most common metabolic component was elevated blood pressure (61.1%), followed by raised fasting glucose (39.1%) and low high-density lipoprotein cholesterol (low HDL-C) (28.0%). The prevalence of MetS and abdominal obesity in women (33.6% and 22.1% respectively) was higher than that of men (19.8% and 3.7% respectively) (Prange

Published
2017
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2. Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis

Author

Hui Juan, Caiyou Hu, Zhu Xiaoquan, Zeping Lv, Wang Nana, Zhao Fan, Yi-Ge Yang, Chenguang Zheng, Shenghang Pang, Weidong Zheng, Chu-yu Yang, Guofang Pang, Ze Yang, WenyYu Jiang, Liang Sun, Mian Fu, Fabiana Michelsen de Andrade, Haiqun Xie, Qin Zhou, Xiaohong Shi, Wandong Zhang, and Xiang-hua He

Subjects
Oncology, Linkage disequilibrium, Apolipoprotein E4, lcsh:Medicine, genetic risk, ethnic group, Cognition, Gene Frequency, Polymorphism (computer science), Risk Factors, Genotype, genetic variability, lcsh:Science, African American, Genetics, Multidisciplinary, APOC1 gene, disease course, pathogenesis, allele, Caribbean Hispanic, Hispanic or Latino, protein function, Neurology, Meta-analysis, Medicine, Hispanic Americans, gene insertion, Research Article, Asian Continental Ancestry Group, medicine.medical_specialty, Clinical Research Design, Cognitive Neuroscience, European Continental Ancestry Group, disease classification, Biology, Caucasian, Polymorphism, Single Nucleotide, White People, Asian People, Meta-Analysis as Topic, Alzheimer Disease, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Allele, Allele frequency, Genetic Association Studies, Genetic association, Aged, Apolipoprotein C-I, Asian, lcsh:R, disease association, disease predisposition, Case-control study, Human Genetics, apolipoprotein C1, heterozygote, Black or African American, DNA polymorphism, Case-Control Studies, Genetics of Disease, Linear Models, Genetic Polymorphism, lcsh:Q, Dementia, Meta-Analyses, Population Genetics, Neuroscience
Abstract

Background Previous association studies examining the relationship between the APOC1 polymorphism and susceptibility to Alzheimer’s disease (AD) have shown conflicting results, and it is not clear if an APOC1 variant acts as a genetic risk factor in AD etiology across multiple populations. Methods To confirm the risk association between APOC1 and AD, we designed a case-control study and also performed a meta-analysis of previously published studies. Results Seventy-nine patients with AD and one hundred fifty-six unrelated controls were included in case-control study. No association was found between the variation of APOC1 and AD in stage 1 of our study. However, our meta-analysis pooled a total of 2092 AD patients and 2685 controls. The APOC1 rs11568822 polymorphism was associated with increased AD risk in Caucasians, Asians and Caribbean Hispanics, but not in African Americans. APOE e4 carriers harboring the APOC1 insertion allele, were more prevalent in AD patients than controls (χ2 = 119.46, OR = 2.79, 95% CI = 2.31–3.36, P

Published
2013

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