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3 results on '"Walter MP"'

1. Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease

Author

F Bloget, Anne Janin, J P Jouet, Francis Bauters, Thierry Facon, and Noel-Walter Mp

Subjects
Adult, Pathology, medicine.medical_specialty, medicine.medical_treatment, Graft vs Host Disease, chemical and pharmacologic phenomena, Pathogenesis, Fatal Outcome, immune system diseases, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Biopsy, Macrophage, Medicine, Humans, Child, Bone Marrow Transplantation, Transplantation, medicine.diagnostic_test, business.industry, Tumor Necrosis Factor-alpha, Macrophages, Hematology, Middle Aged, medicine.disease, Leukemia, Leukemia, Myeloid, Acute, surgical procedures, operative, medicine.anatomical_structure, Cytokine, Graft-versus-host disease, Immunology, Tumor necrosis factor alpha, Female, Bone marrow, business
Abstract

We report three patients with lethal forms of acute GVHD in whom all biopsy specimens showed a striking preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha. The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the existence of primary macrophagic forms of GVHD is discussed.

Published
1997

2. Feasibility of autologous bone marrow transplantation for early consolidation of follicular non-Hodgkin's lymphoma

Author

J P Jouet, Francis Bauters, J.Ph. Laporte, Marcelo F. Lopez, Norbert-Claude Gorin, Pierre Fenaux, Albert Najman, Pierre Morel, Walter Mp, L. Fouillard, Luc Douay, Stachowiak J, A. Devidas, Françoise Isnard, and M Aoudjhane

Subjects
Adult, Male, medicine.medical_specialty, Follicular lymphoma, Transplantation, Autologous, chemistry.chemical_compound, Mafosfamide, Lomustine, Follicular phase, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Thioguanine, Cyclophosphamide, Bone Marrow Transplantation, Neoplasm Staging, Marrow transplantation, business.industry, Lymphoma, Non-Hodgkin, Cytarabine, Hematology, General Medicine, Autologous bone, medicine.disease, Surgery, Regimen, medicine.anatomical_structure, chemistry, Toxicity, Feasibility Studies, Female, Bone marrow, business, Follow-Up Studies
Abstract

In contrast to intermediate- and high-grade non-Hodgkin's lymph-omas (NHL), patients with follicular lymphomas retain a poor prognosis in the long run. Several reports suggested that they are incurable by conventional chemotherapy. 10 patients with follicular NHL were autografted for consolidation of early remission. One of these patients treated in 1979 received the TACC regimen with unpurged marrow. The other 9 (8 in first, 1 in second remission) treated since July 1987 received the BEAM regimen followed by autologous bone marrow transplantation (ABMT) with marrow purged in vitro by mafosfamide at levels individually adjusted. There were no toxic deaths. 8 patients remain in unmaintained CR 15 to 43 months post-ABMT - 2 are beyond 2 years. The patient autografted in 1979 has relapsed 9 yr later. ABMT is feasible with no indue toxicity for consolidation of follicular NHL early in first remission, as an alternative aggressive strategy. Further studies and a longer follow-up will be needed to evaluate its antitumor efficacy.

Published
1991

3. Biopterin and organ transplantation

Author

Walter Mp, J.L. Dhondt, F. Bauters, and Jean-Pierre Jouet

Subjects
medicine.medical_specialty, Pathology, business.industry, Biopterin, General Medicine, Neopterin, Organ transplantation, chemistry.chemical_compound, chemistry, medicine, Humans, business, Bone Marrow Transplantation
Published
1988

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