33 results on '"Vishal, Thakur"'
Search Results
2. Pachydermoperiostosis with Hearing Loss
- Author
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Dilbag, Singh, Ritu, Rawat, and Vishal, Thakur
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Adult ,Male ,Young Adult ,Osteoarthropathy, Primary Hypertrophic ,Face ,Humans ,Hearing Loss ,Arthralgia ,Skin - Abstract
A 21-year-old unmarried man, born of a non-consanguineous marriage, presented to the dermatology department with progressive thickening of the facial skin and eyelids, plus increased folds over his forehead for the last 5 months. He also complained of progressive enlargement of his hands and feet, with intermittent joint pains in his wrists, elbows, and ankles, along with occasional abdominal pain. He had a hearing loss and increased sweating. (
- Published
- 2022
3. Do unmanned aerial vehicles reduce the duration and costs in transporting sputum samples? A feasibility study conducted in Himachal Pradesh, India
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Vishal Thakur, Parasuraman Ganeshkumar, Sundaramoorthy Lakshmanan, and Polani Rubeshkumar
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Unmanned Aerial Devices ,Infectious Diseases ,Sputum ,Public Health, Environmental and Occupational Health ,Feasibility Studies ,Humans ,India ,Transportation ,Parasitology ,General Medicine - Abstract
Background The feasibility of and advantages of using an unmanned aerial vehicle (UAV) for sputum transportation for TB in Chamba, Himachal Pradesh, India, were evaluated. Methods We conducted a non-randomized interventional study and compared the advantages of sputum transport between UAVs and motorbikes (conventional). Results We completed 151 transportations. Transportation by UAV (7.1±0.8 min) was faster than by motorbike (22.7±4.6 min, p Conclusions Sputum transportation by UAVs was feasible, cheaper and an efficacious potential alternative to conventional modes of transportation.
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- 2022
4. Nevoid acanthosis nigricans: a case series of nine patients
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Rajat Choudhary, Vishal Thakur, Vinod Hanumanthu, Debajyoti Chatterjee, Muthu Sendhil Kumaran, and Keshavamurthy Vinay
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Humans ,Dermatology ,Acanthosis Nigricans - Published
- 2022
5. Onychocryptosis – decrypting the controversies
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Keshavamurthy Vinay, Eckart Haneke, and Vishal Thakur
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medicine.medical_specialty ,Ingrown toenail ,medicine.medical_treatment ,Cautery ,Treatment outcome ,Nails, Ingrown ,Dermatology ,Conservative Treatment ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Phenol ,business.industry ,General surgery ,Treatment method ,Treatment options ,Surgical procedures ,medicine.disease ,Treatment Outcome ,Nails ,030220 oncology & carcinogenesis ,Practice Guidelines as Topic ,Cauterization ,business ,Nail matrix - Abstract
Onychocryptosis, or ingrown toenail, is a frequent, painful condition affecting young individuals. Controversies still exist regarding its etiopathogenesis and treatment options, including conservative and surgical techniques. The choice of treatment method depends on the stage of disease as conservative measures are mostly effective in early stages and surgical procedures are required in the later stages. Among surgical techniques, phenol cauterization of lateral nail matrix has been the most effective, safe, and commonly performed method. Other more destructive surgical procedures are rarely done nowadays. In this review, we briefly discuss the etiopathogenesis, clinical features, and different treatment options of ingrown toenail.
- Published
- 2020
6. Dopamine toxicity contributes to melanocyte loss via melanocytorrhagy: an in vitro study
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Sushma Tanwar, Vishal Thakur, and Davinder Parsad
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Norepinephrine ,Epinephrine ,Dopamine ,Vitiligo ,Humans ,Melanocytes ,Dermatology - Abstract
Catecholamines (epinephrine, norepinephrine, and dopamine) have been proposed as a possible cause of melanocyte loss. Dopamine has been observed to cause apoptosis in melanocytes via reactive oxygen species development, but the effect on melanocyte adhesion and proliferation still remains to be elucidated. Thus, we explored the dose- and time-dependent toxicity of catecholamines and the effect of dopamine on the proliferation and adhesion potential of melanocytes.Primary culture of melanocytes was investigated in vitro for toxic effects of epinephrine, norepinephrine, and dopamine on metabolic activity via MTT [3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide) assay. Cells were observed microscopically for any phenotypic changes. Further cell proliferation, cell adhesion, and cell death pathway were explored under dopamine toxicity in dose- and time-dependent manner with RNase/PI method of cell cycle analysis, cell adhesion assay, and Annexin V-FITC/PI assay, respectively. Altered gene expressions were confirmed with a real-time polymerase chain reaction.Metabolic activity of cells varied with time and different doses of epinephrine, norepinephrine, and dopamine. Dopamine was observed to be more toxic than epinephrine and norepinephrine. Melanocytes were observed to follow different cell death pathways at comparatively lower and higher concentrations of dopamine. Persistent exposure to dopamine resulted in decreased cell proliferation and adhesion potential with apoptotic changes. Gene expression changes also confirmed the weak adhesion and survival potential of cells under the toxic effects of dopamine.Dopamine can alter melanocytes' adhesion and survival potential, leading to apoptotic cell death or melanocytorrhagic loss.
- Published
- 2021
7. A randomised clinical trial to assess the adjuvant potential of methotrexate to corticosteroids in mucosal or limited mucocutaneous pemphigus vulgaris
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Khimit Jain, Vishal Thakur, Sanjeev Handa, Neha Thakur, null Shilpa, Naresh Sachdeva, Rahul Mahajan, and Dipankar De
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Multidisciplinary ,Methotrexate ,Adjuvants, Immunologic ,Adrenal Cortex Hormones ,Prednisolone ,Humans ,Prospective Studies ,Pemphigus ,Retrospective Studies - Abstract
Glucocorticoids are the mainstay of treatment for pemphigus vulgaris (PV). However, the requirement of high doses for long durations often leads to serious adverse events. Methotrexate as an adjuvant has shown potential in retrospective studies but randomized trials are lacking. The objective of the study was to assess the adjuvant potential of methotrexate in mucosal/limited mucocutaneous PV. In this randomised prospective study, 44 patients with mucosal/limited mucocutaneous PV were randomised (1:1) to receive either prednisolone 1 mg/kg/day (later fixed at a maximum dose of 60 mg/day) alone or with methotrexate 0.3 mg/kg/week for 9-months study period. Prednisolone dose was tapered once there was an 80% reduction in Pemphigus Disease Activity Index. Outcome measures were total cumulative dose of prednisolone, the proportion of patients achieving disease control, time taken for disease control and remission on minimal treatment, and adverse effects. No significant difference in the total cumulative dose of prednisolone among the groups was observed (p = 0.68). Disease control was achieved in 95.5% and 86.4% of patients in the prednisolone alone group, and prednisolone and methotrexate group respectively (p = 0.61). No statistically significant difference was observed among the groups with respect to the proportion of patients achieving remission, time taken for disease control and remission, and the number of adverse events. Our study showed no additional benefit of methotrexate to prednisolone in the treatment of mucosal/limited mucocutaneous PV.Trial registration: CTRI/2018/07/015002; Registered on 23/07/2018]; Trial Registered Retrospectively. http://ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=24964&EncHid=&modid=&compid=%27,%2724964det%27.
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- 2021
8. Clinicodemographic features of mixed vitiligo: a case-control study
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Sheetanshu Kumar, Keshavamurthy Vinay, Rajat Choudhary, Vishal Thakur, Anuradha Bishnoi, Muthu Sendhil Kumaran, and Davinder Parsad
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Case-Control Studies ,Vitiligo ,Humans ,Dermatology ,Hair Color ,Hair Diseases ,Retrospective Studies - Abstract
Mixed vitiligo (MV) is the coexistence of segmental vitiligo (SV) and non-segmental vitiligo (NSV). The literature on MV is sparse.To assess the clinicodemographic and treatment parameters in MV and compare them with SV.Clinical data of MV and SV patients enrolled in our pigmentary clinic from July 2015 to December 2019 were reviewed retrospectively and compared.Out of a total of 4,371 vitiligo patients, 293 (6.7%) were SV while 74 (1.69%) were MV. As compared to SV, MV had significantly lower mean age of onset of segmental component (SC) (13.33 ± 9.01 vs. 15.70 ± 8.60 years, P = 0.03) and significantly higher proportion of patients with more than 1% body surface involvement by SC (66.2% vs. 51.5%, P = 0.03) and presence of leukotrichia in the SC (66.2% vs. 51.5%, P = 0.03). Topical agents and systemic immunosuppressive agents were significantly more effective in non-segmental component (NSC) as compared to SC of MV. Surgical modalities were the only effective treatment modality for SC.Retrospective design, heterogeneity of treatment regimens.Early age of onset, larger (1%) body surface area involvement, and leukotrichia in SV predict its progression into MV with time. Treatment response to different modalities varies significantly between SC and NSC of MV.
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- 2021
9. Lobulated swelling of the ear: a diagnostic challenge
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Rajat Choudhary, Keshavamurthy Vinay, Vishal Thakur, Divya Aggarwal, and Debajyoti Chatterjee
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Mice, Inbred BALB C ,medicine.medical_specialty ,business.industry ,Dermatology ,Mice ,Text mining ,Animals ,Edema ,Humans ,Medicine ,Radiology ,Ear, External ,Swelling ,medicine.symptom ,business - Published
- 2021
10. Comparison of the efficacy and safety of minocycline and clofazimine in chronic and recurrent erythema nodosum leprosum-A randomized clinical trial
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Vishal Thakur, Sunil Dogra, Vinod Hanumanthu, and Tarun Narang
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medicine.medical_specialty ,business.industry ,Outcome measures ,Leprostatic Agents ,Minocycline ,Dermatology ,General Medicine ,Clofazimine ,law.invention ,Leprosy, Lepromatous ,Erythema nodosum leprosum ,Erythema Nodosum ,Randomized controlled trial ,law ,Internal medicine ,Prednisolone ,Medicine ,Humans ,Corticosteroid use ,Prospective Studies ,business ,Adverse effect ,medicine.drug - Abstract
Management of chronic/recurrent erythema nodosum leprosum (ENL) is challenging. The majority of these patients become steroid-dependent and suffer from the adverse effects of long-term corticosteroid use. Minocycline has shown promising results in a small series of chronic/recurrent ENL patients. The aim of this study was to compare the efficacy and safety of minocycline and clofazimine in patients with chronic/recurrent ENL. In this prospective randomized clinical trial, 60 participants with chronic/recurrent ENL were randomized (1:1) to receive either minocycline 100 mg once daily or clofazimine 100 mg thrice daily for 12 weeks along with prednisolone according to WHO protocol and followed up for 6 months. The outcome measures were mean time for initial control of ENL, proportion of patients having a recurrence of ENL, mean time for recurrence after initial control, additional prednisolone requirement, and frequency of adverse events. Initial control of ENL was achieved earlier in the minocycline group as compared to the clofazimine group (2.97 ± 1.9 weeks vs. 4 ± 1.96 weeks, respectively; p-0.048). The number of participants having ENL flares/recurrences during the study period was comparable in both groups (71.4% in clofazimine vs. 55.2% in minocycline group; p-0.2). The participants in the minocycline group remained in remission for a longer duration after initial control of ENL as compared to the clofazimine group (p-0.001). Mean additional prednisolone dose required for control of ENL flares/recurrences was also comparable in both groups (p-0.09). The minocycline group had fewer side effects than the clofazimine group (p-0.047). Minocycline led to a rapid and sustained improvement of ENL episodes with fewer adverse events showing a superior efficacy to clofazimine.
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- 2021
11. Equal rates of drug resistance in leprosy cases with relapse and recurrent/chronic Type 2 reaction: time to revise the guidelines for drug-resistance testing in leprosy?
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Tarun Narang, Madhvi Ahuja, Sunil Dogra, Divya Kamat, Vishal Thakur, Itu Singh, and M. Lavania
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Adult ,Male ,medicine.medical_specialty ,Endemic Diseases ,Leprostatic Agents ,Dermatology ,Drug resistance ,Dapsone ,Recurrence ,Internal medicine ,Drug Resistance, Multiple, Bacterial ,Leprosy ,Drug Resistance, Bacterial ,medicine ,Humans ,Mycobacterium leprae ,biology ,medicine.diagnostic_test ,business.industry ,Middle Aged ,biology.organism_classification ,medicine.disease ,Multiple drug resistance ,Cross-Sectional Studies ,Skin biopsy ,Chronic Disease ,Female ,Ofloxacin ,business ,Rifampicin ,medicine.drug - Abstract
BACKGROUND Leprosy relapse/recurrence is a serious concern particularly in a leprosy-endemic nation such as India. It is believed that bacilli persisting even after multidrug therapy can cause relapse; recently, however, drug resistance as a cause for recurrences and chronic erythema nodosum leprosum (ENL) has been speculated. AIM To study drug-resistance patterns in cases of leprosy relapse and chronic/recurrent (c/r)ENL. METHODS This cross-sectional study conducted over a period of 1 year included patients diagnosed as having leprosy relapse and those with c/rENL. Skin biopsy specimens were examined by conventional PCR for resistance testing for rifampicin, dapsone and ofloxacin, respectively targeting the rpoB, folP and gyrA genes of Mycobacterium leprae. RESULTS In total, 61 patients (25 smear-negative) were included in the study. Of these, 37 were diagnosed as having leprosy relapse and 24 as having c/rENL. Drug resistance to at least one drug was identified in 10 cases (16.4%). Rates of drug resistance were 5.4% (2 of 37) for dapsone, 10.8% (4 of 37) for rifampicin and 2.7% (1 of 37) for ofloxacin among cases of relapse, whereas it was 12.5% (3 of 24) and 8.3% (2 of 24) for dapsone and rifampicin respectively among those with c/rENL. Multidrug resistance was seen in 3.3% patients (2 of 61). CONCLUSION Drug-resistance rate among those with c/rENL was almost equalled that of relapse. Smear-negative leprosy relapse cases also had resistance to bactericidal drugs. These findings call for modifications in criteria for testing under leprosy drug-resistance surveillance and all cases of relapse and those with recalcitrant c/rENL should be tested.
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- 2021
12. Periocular cutaneous amyloidosis in multiple myeloma
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Keshavamurthy Vinay, Vinod Hanumanthu, Debajyoti Chatterjee, and Vishal Thakur
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medicine.medical_specialty ,business.industry ,MEDLINE ,Cutaneous amyloidosis ,Skin Diseases, Genetic ,General Medicine ,Amyloidosis ,medicine.disease ,Dermatology ,Amyloidosis lichen ,medicine ,Humans ,business ,Multiple Myeloma ,Amyloidosis, Familial ,Multiple myeloma - Published
- 2021
13. Vitiligo: Translational research and effective therapeutic strategies
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Vishal Thakur, Anuradha Bishnoi, Keshavamurthy Vinay, Sendhil M. Kumaran, and Davinder Parsad
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0301 basic medicine ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Vitiligo ,Autoimmunity ,Dermatology ,Disease ,Severity of Illness Index ,General Biochemistry, Genetics and Molecular Biology ,Surgical methods ,Translational Research, Biomedical ,03 medical and health sciences ,0302 clinical medicine ,Depigmentation ,Medicine ,Humans ,Stable phase ,skin and connective tissue diseases ,integumentary system ,business.industry ,Phototherapy ,medicine.disease ,Oxidative Stress ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,medicine.symptom ,business - Abstract
This is an exciting phase of vitiligo research with the current understanding of vitiligo pathogenesis and its translation to successful treatment. The pathogenetic origin of vitiligo revolves around autoimmunity with supporting role from many other factors like oxidative stress, inherent melanocyte defects, or defective keratinocytes and fibroblasts. Vitiligo can be classified into segmental or non-segmental depending upon the clinical presentation, or it can be classified as progressing or stable based on the activity of the disease. Vitiligo treatments need to be stratified depending upon which type of vitiligo we are treating and at which phase the vitiligo patient presents to us. There are two different aims of treatment of vitiligo. The first involves rescuing the melanocytes from the damage to arrest the depigmentation. The second strategy focuses on replenishing the melanocytes so that successful repigmentation is achieved. It is also important to maintain the disease in a stable phase or prevent relapse. As stability in non-segmental vitiligo is a dynamic process, maintenance of the stability of repigmentation is also an important consideration in the management of vitiligo. In this review, we shall briefly discuss the current options and future insight into the management of vitiligo.
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- 2021
14. Comparison of the Efficacy and Safety of Apremilast and Methotrexate in Patients with Palmoplantar Psoriasis: A Randomized Controlled Trial
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Sanjeev Handa, Sunil Dogra, Tarun Narang, Soufila Kt, and Vishal Thakur
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Adult ,Male ,medicine.medical_specialty ,Palmoplantar pustulosis ,Dermatology ,Severity of Illness Index ,law.invention ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Interquartile range ,law ,Psoriasis ,Internal medicine ,medicine ,Humans ,Prospective Studies ,business.industry ,General Medicine ,Dermatology Life Quality Index ,Middle Aged ,medicine.disease ,Confidence interval ,Thalidomide ,Methotrexate ,Treatment Outcome ,Female ,Apremilast ,Dermatologic Agents ,business ,medicine.drug - Abstract
Placebo-controlled studies have reported the efficacy of apremilast in the management of palmoplantar psoriasis but studies comparing efficacy with a conventional agent are lacking. The objective of this article was to compare the efficacy and safety of apremilast and methotrexate in patients with palmoplantar psoriasis. In this prospective, randomized, active-controlled, observer-blinded clinical trial, conducted at a psoriasis clinic of a tertiary care institute in India from 1 July, 2019 to 1 June, 2020, 84 patients with palmoplantar psoriasis were randomized (1:1) to receive either methotrexate (0.4 mg/kg/week orally) or apremilast (30 mg twice daily). The treatment protocol was continued for 16 weeks or until achieving a ≥ 75% improvement in the Modified Palmoplantar Psoriasis Area and Severity Index (m-PPPASI 75), whichever was earlier. Changes in m-PPPASI and Dermatology Life Quality Index scores from baseline, the proportion of patients achieving m-PPPASI 75, and adverse events were assessed. Eighty-four patients were included (76 palmoplantar psoriasis and 8 palmoplantar pustulosis). The mean age (standard deviation) was 44.5 (12.9) years and 53 (63%) were women. The m-PPPASI score [median (interquartile range)] after 16 weeks of treatment showed a significant improvement from baseline in both apremilast [− 6.3 (10.9), p < 0.001] and methotrexate groups [− 8.5 (9.9), p < 0.001]. The estimated median difference between the groups was − 1.2 (p = 0.39, 95% confidence interval − 4.2 to 2.1). At 16 weeks, m-PPPASI 75 was achieved by 14/42 (33%) and 17/42 (41%) patients in the apremilast and methotrexate groups, respectively (p = 0.49). A significant reduction in the Dermatology Life Quality Index score [median (interquartile range)] was observed in both groups [apremilast: − 3.0 (6.0), p < 0.001; methotrexate: − 3.0 (6.3), p < 0.001] with an estimated median difference of 0.0 (p = 0.99, 95% confidence interval − 1.0 to 2.0). The proportion of patients experiencing adverse events was comparable (p = 0.49). Apremilast showed a comparable efficacy and safety profile to methotrexate in the management of palmoplantar psoriasis. CTRI/2019/06/019830, date of registration: 24 June, 2019; trial registered prospectively.
- Published
- 2021
15. Dermoscopic features of post kala azar dermal leishmaniasis
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Vishal Thakur, Keshavamurthy Vinay, and Priyansh Gupta
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Post-kala-azar dermal leishmaniasis ,medicine.medical_specialty ,business.industry ,Leishmaniasis, Cutaneous ,Leishmaniasis ,Dermatology ,medicine.disease ,Infectious Diseases ,medicine ,Humans ,Leishmaniasis, Visceral ,Leprosy ,business - Published
- 2021
16. Apremilast in treatment of palmoplantar pustulosis – a case series
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Vishal Thakur, Sunil Dogra, Tarun Narang, Sanjeev Handa, and Soufila Kt
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medicine.medical_specialty ,Palmoplantar pustulosis ,Skin Diseases, Vesiculobullous ,business.industry ,Dermatology ,Exanthema ,Thalidomide ,Humans ,Psoriasis ,Medicine ,Apremilast ,business ,medicine.drug - Published
- 2021
17. A prospective, randomized clinical study to compare the efficacy of recipient site preparation using dermabrasion, cryoblister, and dermaroller in autologous noncultured epidermal cell suspension in stable vitiligo
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Vishal Thakur, Niharika Srivastava, Davinder Parsad, Kiruthika Subburaj, Muthu Sendhil Kumaran, and Keshavamurthy Vinay
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Vitiligo ,Skin Pigmentation ,Dermatology ,Transplantation, Autologous ,law.invention ,Clinical study ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,Randomized controlled trial ,law ,medicine ,Humans ,Prospective Studies ,Recipient site ,Patient satisfaction score ,business.industry ,Dermabrasion ,General Medicine ,medicine.disease ,Hyperpigmentation ,Surgery ,Treatment Outcome ,Epidermal Cells ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,business - Abstract
Noncultured epidermal cell suspension (NCES) is a well-established surgical treatment modality for stable vitiligo. The outcome of this procedure significantly depends on the method of recipient site preparation, a critical step to achieve cosmetically acceptable repigmentation. To compare the efficacy of recipient site preparation using three methods namely, dermabrasion, cryoblister, and dermaroller followed by NCES in stable vitiligo. In this single-center, prospective, intra-patient, randomized clinical trial; 36 participants having at least three vitiligo patches in same anatomic region with minimum lesional stability of 1 year were randomized 1:1:1 for recipient site preparation using manual dermabrasion, cryoblister, and dermaroller followed by NCES. Patients were followed up at 4, 8, and 12 weeks and assessment of extent and pattern of repigmentation, color match and patient satisfaction were done. Among 36 patients, 22 (61.1%) were females; mean (SD) age was 28.33 (9.4) years. Dermabrasion and cryoblister techniques showed equal efficacy with respect to extent of repigmentation (>75% repigmentation; 55.6% vs 47.2%; P = .63) and patient satisfaction score (20.2 ± 9.6 vs 19.9 ± 7.9, P = .194). However, dermabrasion was superior to cryoblister in terms of rapidity (65% vs 32.5% at 4 weeks, P = .04) and color match (47.2% vs 19.4%, P = .004). Dermaroller had poor repigmentation outcomes compared to both dermabrasion and cryoblister. Cryoblister as a method of recipient site preparation is equally effective as manual dermabrasion in NCES for attaining good to excellent repigmentation, but with risk of hyperpigmentation. However, dermaroller is inferior to both dermabrasion and cryoblister.
- Published
- 2020
18. Photosensitivity during apremilast treatment in patients with palmoplantar psoriasis
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Tarun Narang, Sanjeev Handa, Soufila Kt, Sunil Dogra, and Vishal Thakur
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medicine.medical_specialty ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Treatment outcome ,MEDLINE ,Dermatology ,Severity of Illness Index ,Thalidomide ,Treatment Outcome ,Photosensitivity ,Severity of illness ,medicine ,Humans ,Psoriasis ,In patient ,Palmoplantar psoriasis ,Apremilast ,business ,medicine.drug - Published
- 2020
19. Persistent plaques after release from treatment in slit-skin smear negative leprosy patients: Wait and watch or adopt a proactive approach?
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Sunil Dogra, Tarun Narang, Anuradha Bishnoi, Vishal Thakur, Debajyoti Chatterjee, Muhammad Razmi T, and Divya Kamat
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Slit skin smear ,medicine.medical_specialty ,Leprostatic Agents ,Minocycline ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Leprosy ,medicine ,Humans ,Adverse effect ,business.industry ,General Medicine ,medicine.disease ,Hyperpigmentation ,030220 oncology & carcinogenesis ,Quality of Life ,Drug Therapy, Combination ,Active treatment ,Once daily ,medicine.symptom ,business ,medicine.drug - Abstract
A subset of leprosy patients has clinical and histopathological activity in the form of persistent plaques and granulomas after completion of multidrug therapy (MDT) which can have significant impact on their quality of life. In the absence of clear guidelines regarding management of such patients, majority of the times they are treated either as late reversal reaction with corticosteroids or no active treatment is offered. We observed 11 patients of leprosy with persistent plaques after completing the 6/12-months MDT who were treated favorably with minocycline 100 mg once daily for 16 weeks. Complete clinical resolution was observed in 9/11 patients while two patients had partial improvement. Histopathological improvement in the form of disappearance of granulomas corroborated with the clinical improvement. All the patients tolerated the treatment well and hyperpigmentation was the only adverse effect noted. Minocycline may be considered as a useful and well tolerated therapeutic option for this subset of leprosy patients due to its immune modulatory and anti-inflammatory effects.
- Published
- 2020
20. Response to 'Three drugs are unnecessary for treating paucibacillary leprosy-A critique of the WHO guidelines'
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Vishal Thakur, Sunil Dogra, Bhushan Kumar, and Tarun Narang
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Bacterial Diseases ,medicine.medical_specialty ,Clinical Research Design ,RC955-962 ,Paucibacillary Leprosy ,MEDLINE ,Research and Analysis Methods ,Pathology and Laboratory Medicine ,Microbiology ,Pharmacotherapy ,Signs and Symptoms ,Drug Therapy ,Diagnostic Medicine ,Arctic medicine. Tropical medicine ,Leprosy ,Microbial Control ,Epidemiology ,medicine ,Medicine and Health Sciences ,Humans ,Chemotherapy ,Intensive care medicine ,Adverse effect ,Pharmacology ,Treatment Guidelines ,Health Care Policy ,business.industry ,Pharmaceutics ,Antimicrobials ,Public Health, Environmental and Occupational Health ,Drugs ,Biology and Life Sciences ,medicine.disease ,Tropical Diseases ,Viewpoints ,Health Care ,Infectious Diseases ,Research Design ,Who guidelines ,Lesions ,Antibacterials ,Drug Therapy, Combination ,Leprosy, Paucibacillary ,Adverse Events ,Public aspects of medicine ,RA1-1270 ,business ,Neglected Tropical Diseases - Published
- 2020
21. Response to ‘Folliculitis decalvans‐like pustular plaques on the limbs sparing the scalp’
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Divya Aggarwal, Vishal Thakur, Keshavamurthy Vinay, Sheetanshu Kumar, Anuradha Bishnoi, and Bishan Dass Radotra
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Folliculitis ,medicine.medical_specialty ,Scalp ,business.industry ,Alopecia ,Dermatology ,medicine.disease ,medicine.anatomical_structure ,medicine ,Humans ,business ,Folliculitis decalvans - Published
- 2020
22. A prospective study to assess the efficacy of various surgical modalities in treatment of stable vitiligo patches over resistant sites
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Vishal Thakur, Davinder Parsad, Keshavamurthy Vinay, Muthu Sendhil Kumaran, and Amit Dalla
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Vitiligo ,Skin Pigmentation ,Dermatology ,Color matching ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Patient satisfaction ,Statistical significance ,Medicine ,Humans ,Prospective Studies ,skin and connective tissue diseases ,Prospective cohort study ,integumentary system ,business.industry ,Skin Transplantation ,medicine.disease ,Treatment efficacy ,Suction blister ,Clinical trial ,Treatment Outcome ,Epidermal Cells ,Patient Satisfaction ,030220 oncology & carcinogenesis ,Female ,business - Abstract
Background Despite advances in surgical management of vitiligo, lesions on acral areas and bony prominences remain treatment refractory. There is lack of literature on the treatment efficacy of various surgical modalities over these treatment refractory sites. Objective To compare the efficacy of three common methods of grafting in vitiligo in known resistant areas. Methods A single-center interventional clinical trial involving 30 patients of stable vitiligo (disease stability ≥1 year) located over bony prominences and acral areas. All patients were treated with noncultured epidermal cell suspension (NCES), suction blister epidermal grafting (SBEG), and mini punch grafting (MPG) on three separate patches. Extent of repigmentation was assessed at 12 and 24 weeks, color matching and patient satisfaction were evaluated at 24 weeks. Results Among 30 participants, 22 (73%) were females, mean age was 27.4 (±10.7) years, and the majority (93.3%) had nonsegmental vitiligo. At 12 weeks, repigmentation >75% was noted in 56.6, 60, and 16.6% of patches treated by NCES, SBEG, and MPG, respectively. At 24 weeks, results remained the same in both the NCES and SBEG groups, while the number of patches with >75% repigmentation increased to 23.3% in the MPG group. The difference in repigmentation rate between NCES and MPG as well as between SBEG and MPG achieved statistical significance. Color matching of treated area and patient satisfaction were better in NCES and SBEG groups compared to MPG. Conclusion NCES and SBEG are superior to MPG with reasonably good efficacy and can be offered as a therapeutic modality for stable vitiligo patches over these sites.
- Published
- 2020
23. Leiomyoma cutis of breast
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Bishan Dass Radotra, Divya Aggarwal, Sheetanshu Kumar, Vishal Thakur, and Anuradha Bishnoi
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medicine.medical_specialty ,Skin Neoplasms ,Leiomyoma ,business.industry ,Breast Neoplasms ,Dermatology ,Leiomyoma Cutis ,Oncology ,Internal Medicine ,Medicine ,Humans ,Surgery ,Female ,Breast ,business - Published
- 2019
24. Ipsilateral linear genital plaque and plantar pits in a girl
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Keshavamurthy Vinay, Manoj Gopal Madakshira, Vishal Thakur, and Anuradha Bishnoi
- Subjects
Foot ,business.industry ,media_common.quotation_subject ,Dermatology ,Plantar pits ,Anatomy ,Groin ,Porokeratosis ,Vulva ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Humans ,Medicine ,Female ,Sex organ ,Vulvar Diseases ,Girl ,business ,media_common - Published
- 2020
25. Adalimumab-induced photosensitivity and oral erosions in rheumatoid arthritis
- Author
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Anuradha Bishnoi, Shirin Bakshi, and Vishal Thakur
- Subjects
Adult ,medicine.medical_specialty ,Erythema ,Mucocutaneous zone ,030204 cardiovascular system & hematology ,Arthritis, Rheumatoid ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Adalimumab ,Humans ,Medical history ,Photosensitivity Disorders ,030212 general & internal medicine ,skin and connective tissue diseases ,Nose ,Lupus erythematosus ,business.industry ,General Medicine ,medicine.disease ,Dermatology ,Rheumatology ,medicine.anatomical_structure ,Antirheumatic Agents ,Rheumatoid arthritis ,Female ,medicine.symptom ,Mouth Diseases ,business ,medicine.drug - Abstract
Tumour necrosis factor-alpha (TNF-α) inhibitors have been successfully used in the treatment of various immune-mediated inflammatory diseases. However, these agents are frequently associated with mucocutaneous adverse effects.1 Anti-TNF-α-induced lupus erythematosus (LE) represents an uncommon adverse effect and has implications on patient management.2 Herein, we report a female patient who developed cutaneous LE after treatment with adalimumab for her rheumatoid arthritis (RA). A woman aged 40 years presented with photosensitivity and painless oral ulcers of 1-month duration. On examination, ill-defined erythema was present over her nose extending to malar area. Well-defined erythematous ulcers were present over buccal mucosae, lips and hard palate (figure 1A,B). Chillblain-like lesions were present over both ears (figure 1C). Her medical history was significant for the presence of RA, for which she had received four doses of …
- Published
- 2020
26. Comparison of efficacy of cold trypsinization versus warm trypsinization in preparation of autologous non-cultured epidermal cell suspension for treatment of stable vitiligo
- Author
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A. J. Kanwar, Keshavamurthy Vinay, Anantha Prasad Holla, Davinder Parsad, Vishal Thakur, S. Awasti, Rajesh Kumar, and K. Sahni
- Subjects
Adult ,Male ,Hot Temperature ,Adolescent ,business.industry ,Cell Transplantation ,Vitiligo ,Dermatology ,medicine.disease ,Molecular biology ,Transplantation, Autologous ,Trypsinization ,Cold Temperature ,Young Adult ,Infectious Diseases ,Treatment Outcome ,Epidermal Cells ,medicine ,Humans ,Female ,Trypsin ,Suspension (vehicle) ,business - Published
- 2019
27. Calcinosis cutis universalis
- Author
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Sheetanshu Kumar, Vishal Thakur, and Anuradha Bishnoi
- Subjects
medicine.medical_specialty ,Skin Neoplasms ,business.industry ,Calcinosis ,General Medicine ,medicine.disease ,Skin Diseases ,Dermatology ,Calcinosis cutis ,medicine ,Humans ,business ,Skin - Published
- 2020
28. Cutaneous manifestations as a clue to the diagnosis of POEMS syndrome
- Author
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Vishal Thakur, Mandeep Singh, Debajyoti Chatterjee, Manish Modi, Sheetanshu Kumar, Dipankar De, and Sanjeev Handa
- Subjects
Hypertrichosis ,Electrophoresis ,Male ,medicine.medical_specialty ,Neurology ,Hepatosplenomegaly ,Neural Conduction ,Physical examination ,Asymptomatic ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,POEMS syndrome ,Skin ,medicine.diagnostic_test ,business.industry ,General Medicine ,Blood Proteins ,Middle Aged ,medicine.disease ,Dermatology ,Trunk ,body regions ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Scalp ,POEMS Syndrome ,medicine.symptom ,business - Abstract
Dermatology consultation was sought for a middle-aged man with multiple asymptomatic skin nodules all over the body. The patient was admitted with neurology inpatient services for altered sensorium and loss of vision for the last 2 days. He also suffered from hyperaesthesia and weakness of limbs for the last 2 years. On physical examination, hepatosplenomegaly was also detected along with neurological and visual abnormalities. Multiple cutaneous erythematous to skin-coloured, dome-shaped, exophytic, sessile as well as pedunculated, soft to firm asymptomatic nodules were observed on trunk, limbs and scalp (figure …
- Published
- 2018
29. Burning red hot feet
- Author
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Vishal Thakur and Dipankar De
- Subjects
Male ,Foot ,business.industry ,Internal Medicine ,MEDLINE ,Humans ,Medicine ,Middle Aged ,Erythromelalgia ,business ,Archaeology - Published
- 2019
30. Papulopustules and paronychia in a lung carcinoma
- Author
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Vishal Thakur, Muthu Sendhil Kumaran, and Manju Daroach
- Subjects
Male ,medicine.medical_specialty ,Lung Neoplasms ,Lung ,business.industry ,Antineoplastic Agents ,Gefitinib ,Syndrome ,Middle Aged ,medicine.disease ,Dermatology ,Paronychia ,medicine.anatomical_structure ,Carcinoma, Non-Small-Cell Lung ,Internal Medicine ,Carcinoma ,Humans ,Medicine ,business ,Protein Kinase Inhibitors - Published
- 2019
31. Hydroxychloroquine induced cutaneous pigmentation: a unique pattern
- Author
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Muthu Sendhil Kumaran, Sheetanshu Kumar, Divya Aggarwal, Vishal Thakur, Bishan Dass Radotra, and Amit Dalla
- Subjects
medicine.medical_specialty ,Biopsy ,030204 cardiovascular system & hematology ,Diagnosis, Differential ,Granuloma Annulare ,03 medical and health sciences ,0302 clinical medicine ,Dermis ,medicine ,Humans ,030212 general & internal medicine ,Enzyme Inhibitors ,Granuloma annulare ,Aged ,medicine.diagnostic_test ,business.industry ,Erythematous papule ,Hydroxychloroquine ,General Medicine ,medicine.disease ,Dermatology ,Lymphohistiocytic infiltrate ,medicine.anatomical_structure ,Female ,sense organs ,business ,Pigmentation Disorders ,medicine.drug - Abstract
An elderly woman presented with 6 months history of skin coloured to erythematous papules in annular pattern over extremities, upper back and neck. The patient was diagnosed with granuloma annulare (GA) and started on hydroxychloroquine (HCQ) 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin (figure 1A,B). There was no pigmentation at other body sites. Biopsy from the plaque showed necrobiotic collagen with intradermal mucin and perivascular lymphohistiocytic infiltrate accompanied by brown coarse pigment in the dermis …
- Published
- 2019
32. Efficacy of Transplantation of Combination of Noncultured Dermal and Epidermal Cell Suspension vs Epidermal Cell Suspension Alone in Vitiligo
- Author
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Hitaishi Kaushik, Davinder Parsad, Vishal Thakur, Sheetanshu Kumar, Muthu Sendhil Kumaran, and Niharika Srivastava
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Cell Transplantation ,Vitiligo ,India ,Pilot Projects ,Skin Pigmentation ,Dermatology ,Color matching ,Risk Assessment ,Transplantation, Autologous ,law.invention ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Biopsy ,Humans ,Medicine ,In patient ,Young adult ,Trial registration ,Original Investigation ,medicine.diagnostic_test ,business.industry ,Biopsy, Needle ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Transplantation ,Treatment Outcome ,Epidermal Cells ,Langerhans Cells ,030220 oncology & carcinogenesis ,Melanocytes ,Female ,business ,Follow-Up Studies - Abstract
Importance Surgical interventions, notably noncultured epidermal suspension (NCES), are the next line of treatment in patients with vitiligo who fail to respond to medical therapy. Noncultured epidermal suspension is usually performed in patients with vitiligo with duration of clinical stability (DS) of 12 months or longer because DS is a vital parameter in determining outcome of NCES. In this pilot study, we planned to assess the efficacy of a novel combination of noncultured epidermal cell suspension and noncultured dermal cell suspension (NCES and NDCS) in patients with vitiligo with shorter DS (3-6 months). Objective To compare the efficacy of transplantation of NCES and NDCS vs NCES alone in patients with vitiligo with DS of 3 to 6 months. Design, Setting, and Participants A single-center randomized clinical trial including 40 patients with focal, segmental, or generalized vitiligo with DS of 3 to 6 months or more than 12 months was carried out. Based on DS, 2 groups including 20 patients each were recruited (DS in group 1, 3 to 6 months; DS in group 2, more than 12 months). Each group was further randomized into 2 subgroups, A and B. Intervention Patients in subgroups 1A and 2A underwent NCES alone, whereas patients in subgroups 1B and 2B underwent NCES and NDCS. Main Outcomes and Measures Extent of repigmentation, color match, and pattern of repigmentation at 24 weeks. Results Of the 40 study participants, mean (SD) age was 24.9 (4.0) years and 24 (60%) were women; in group 1 with DS for 3 to 6 months, more than 75% repigmentation at 24 weeks was observed in all 10 patients in subgroup 1B (NCES and NDCS) compared with 3 of 10 patients in subgroup 1A (NCES) (100% vs 30%,P = .003). In group 2 (DS > 12 months), the same was observed in 6 of 10 patients in subgroup 2A and 7 of 10 patients in subgroup 2B (NCES) (60% vs 70%,P > .99). The 2 groups and subgroups did not show any significant differences with respect to color matching and pattern of repigmentation. Conclusions and Relevance Combination of NCES and NDCS resulted in excellent response in patients with vitiligo with shorter duration of clinical stability compared with NCES alone. This combination may be used early in the course of stable vitiligo without waiting for a period of 12 months or more since last clinical activity. Trial Registration ClinicalTrials.gov identifier:NCT03013049
- Published
- 2019
33. Gossypibomas in India - A systematic literature review
- Author
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Vishal Thakur, M Sharma, NK Vijhay Ganesun, and Tushar Patial
- Subjects
medicine.medical_specialty ,MEDLINE ,India ,lcsh:Medicine ,Gossypiboma ,Review Article ,retained foreign body ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,systematic review ,medicine ,Humans ,gauzoma ,030212 general & internal medicine ,Cottonoma ,Surgical approach ,business.industry ,pathogenesis ,retained surgical item ,General surgery ,Gossypibomas ,lcsh:R ,General Medicine ,Foreign Bodies ,medicine.disease ,textiloma ,Surgery ,Systematic review ,030220 oncology & carcinogenesis ,Vomiting ,Palpable mass ,medicine.symptom ,Complication ,business ,gossypiboma ,retained surgical sponge - Abstract
Purpose of Review: Gossypibomas remain a dreaded and unwanted complication of surgical practice. Despite significant interest and numerous guidelines, the number of reported cases remains sparse due to various factors, including potential legal implications. Herein, we review related data from India to ascertain if the problem is better or worse than that reported in world literature. Materials and Methods: A literature search was performed on PubMed and Google Scholar, to collect and analyze all case reports and case reviews regarding the condition in India. Results: On analysis of the results, there were 100 publications reporting a total of 126 events. The average patient age was 38.65 years. Average time to discovery was 1225.62 days. Forty-nine percent of reported cases were discovered within the 1 st year. The most common clinical features were pain (73.8%), palpable mass (47.6%), vomiting (35%), abdominal distention (26%), and fever (12.6%). Spontaneous expulsion of the gossypiboma was noted in five cases (3.96%). Transmural migration was seen in 36 cases (28.57%). Conclusions: Despite advancements in surgical approaches and preventive measures, gossypibomas continue to be a cause of significant morbidity. A safe working culture, open communication, teamwork, and an accurate sponge count remain our best defence against this often unpredictable complication of surgery.
- Published
- 2017
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