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1. Characterising the background incidence rates of adverse events of special interest for covid-19 vaccines in eight countries: multinational network cohort study

Author

Li, Xintong, Ostropolets, Anna, Makadia, Rupa, Shoaibi, Azza, Rao, Gowtham, Sena, Anthony G, Martinez-Hernandez, Eugenia, Delmestri, Antonella, Verhamme, Katia, Rijnbeek, Peter R, Duarte-Salles, Talita, Suchard, Marc A, Ryan, Patrick B, Hripcsak, George, and Prieto-Alhambra, Daniel

Subjects
Prevention, Aging, Aetiology, 2.4 Surveillance and distribution, Good Health and Well Being, Adolescent, Anaphylaxis, COVID-19, COVID-19 Vaccines, Cohort Studies, Female, Humans, Incidence, Male, United States, Venous Thrombosis, Clinical Sciences, Public Health and Health Services, General & Internal Medicine
Abstract

ObjectiveTo quantify the background incidence rates of 15 prespecified adverse events of special interest (AESIs) associated with covid-19 vaccines.DesignMultinational network cohort study.SettingElectronic health records and health claims data from eight countries: Australia, France, Germany, Japan, the Netherlands, Spain, the United Kingdom, and the United States, mapped to a common data model.Participants126 661 070 people observed for at least 365 days before 1 January 2017, 2018, or 2019 from 13 databases.Main outcome measuresEvents of interests were 15 prespecified AESIs (non-haemorrhagic and haemorrhagic stroke, acute myocardial infarction, deep vein thrombosis, pulmonary embolism, anaphylaxis, Bell's palsy, myocarditis or pericarditis, narcolepsy, appendicitis, immune thrombocytopenia, disseminated intravascular coagulation, encephalomyelitis (including acute disseminated encephalomyelitis), Guillain-Barré syndrome, and transverse myelitis). Incidence rates of AESIs were stratified by age, sex, and database. Rates were pooled across databases using random effects meta-analyses and classified according to the frequency categories of the Council for International Organizations of Medical Sciences.ResultsBackground rates varied greatly between databases. Deep vein thrombosis ranged from 387 (95% confidence interval 370 to 404) per 100 000 person years in UK CPRD GOLD data to 1443 (1416 to 1470) per 100 000 person years in US IBM MarketScan Multi-State Medicaid data among women aged 65 to 74 years. Some AESIs increased with age. For example, myocardial infarction rates in men increased from 28 (27 to 29) per 100 000 person years among those aged 18-34 years to 1400 (1374 to 1427) per 100 000 person years in those older than 85 years in US Optum electronic health record data. Other AESIs were more common in young people. For example, rates of anaphylaxis among boys and men were 78 (75 to 80) per 100 000 person years in those aged 6-17 years and 8 (6 to 10) per 100 000 person years in those older than 85 years in Optum electronic health record data. Meta-analytic estimates of AESI rates were classified according to age and sex.ConclusionThis study found large variations in the observed rates of AESIs by age group and sex, showing the need for stratification or standardisation before using background rates for safety surveillance. Considerable population level heterogeneity in AESI rates was found between databases.

Published
2021

2. Genome‐wide association study of inhaled corticosteroid response in admixed children with asthma

Author

Hernandez‐Pacheco, Natalia, Farzan, Niloufar, Francis, Ben, Karimi, Leila, Repnik, Katja, Vijverberg, Susanne J, Soares, Patricia, Schieck, Maximilian, Gorenjak, Mario, Forno, Erick, Eng, Celeste, Oh, Sam S, Pérez‐Méndez, Lina, Berce, Vojko, Tavendale, Roger, Samedy, Lesly‐Anne, Hunstman, Scott, Hu, Donglei, Meade, Kelley, Farber, Harold J, Avila, Pedro C, Serebrisky, Denise, Thyne, Shannon M, Brigino‐Buenaventura, Emerita, Rodriguez‐Cintron, William, Sen, Saunak, Kumar, Rajesh, Lenoir, Michael, Rodriguez‐Santana, Jose R, Celedón, Juan C, Mukhopadhyay, Somnath, Potočnik, Uroš, Pirmohamed, Munir, Verhamme, Katia M, Kabesch, Michael, Palmer, Colin NA, Hawcutt, Daniel B, Flores, Carlos, der Zee, Anke H Maitland‐van, Burchard, Esteban G, and Pino‐Yanes, Maria

Subjects
Biomedical and Clinical Sciences, Immunology, Human Genome, Asthma, Genetics, Clinical Research, Lung, Respiratory, Administration, Inhalation, Adolescent, Adrenal Cortex Hormones, Child, Cytidine Deaminase, DNA-Binding Proteins, Female, GTPase-Activating Proteins, Genome-Wide Association Study, Humans, Male, Minor Histocompatibility Antigens, African American, childhood asthma, exacerbations, Latino, pharmacogenomics, Nutrition and Dietetics, Public Health and Health Services, Allergy
Abstract

BackgroundInhaled corticosteroids (ICS) are the most widely prescribed and effective medication to control asthma symptoms and exacerbations. However, many children still have asthma exacerbations despite treatment, particularly in admixed populations, such as Puerto Ricans and African Americans. A few genome-wide association studies (GWAS) have been performed in European and Asian populations, and they have demonstrated the importance of the genetic component in ICS response.ObjectiveWe aimed to identify genetic variants associated with asthma exacerbations in admixed children treated with ICS and to validate previous GWAS findings.MethodsA meta-analysis of two GWAS of asthma exacerbations was performed in 1347 admixed children treated with ICS (Hispanics/Latinos and African Americans), analysing 8.7 million genetic variants. Those with P ≤ 5 × 10-6 were followed up for replication in 1697 asthmatic patients from six European studies. Associations of ICS response described in published GWAS were followed up for replication in the admixed populations.ResultsA total of 15 independent variants were suggestively associated with asthma exacerbations in admixed populations (P ≤ 5 × 10-6 ). One of them, located in the intergenic region of APOBEC3B and APOBEC3C, showed evidence of replication in Europeans (rs5995653, P = 7.52 × 10-3 ) and was also associated with change in lung function after treatment with ICS (P = 4.91 × 10-3 ). Additionally, the reported association of the L3MBTL4-ARHGAP28 genomic region was confirmed in admixed populations, although a different variant was identified.Conclusions and clinical relevanceThis study revealed the novel association of APOBEC3B and APOBEC3C with asthma exacerbations in children treated with ICS and replicated previously identified genomic regions. This contributes to the current knowledge about the multiple genetic markers determining responsiveness to ICS which could lead in the future the clinical identification of those asthma patients who are not able to respond to such treatment.

Published
2019

3. Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors

Author

Connolly, Stuart J, Milling, Truman J, Eikelboom, John W, Gibson, C Michael, Curnutte, John T, Gold, Alex, Bronson, Michele D, Lu, Genmin, Conley, Pamela B, Verhamme, Peter, Schmidt, Jeannot, Middeldorp, Saskia, Cohen, Alexander T, Beyer-Westendorf, Jan, Albaladejo, Pierre, Lopez-Sendon, Jose, Goodman, Shelly, Leeds, Janet, Wiens, Brian L, Siegal, Deborah M, Zotova, Elena, Meeks, Brandi, Nakamya, Juliet, Lim, W Ting, and Crowther, Mark

Subjects
Hematology, Clinical Research, Cardiovascular, Acute Disease, Aged, Aged, 80 and over, Cardiovascular Diseases, Enoxaparin, Factor Xa, Factor Xa Inhibitors, Female, Gastrointestinal Hemorrhage, Hemorrhage, Humans, Infusions, Intravenous, Intracranial Hemorrhages, Male, Prospective Studies, Pyrazoles, Pyridones, Recombinant Proteins, Rivaroxaban, Thrombosis, ANNEXA-4 Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundAndexanet alfa (andexanet) is a recombinant modified human factor Xa decoy protein that has been shown to reverse the inhibition of factor Xa in healthy volunteers.MethodsIn this multicenter, prospective, open-label, single-group study, we evaluated 67 patients who had acute major bleeding within 18 hours after the administration of a factor Xa inhibitor. The patients all received a bolus of andexanet followed by a 2-hour infusion of the drug. Patients were evaluated for changes in measures of anti-factor Xa activity and were assessed for clinical hemostatic efficacy during a 12-hour period. All the patients were subsequently followed for 30 days. The efficacy population of 47 patients had a baseline value for anti-factor Xa activity of at least 75 ng per milliliter (or ≥0.5 IU per milliliter for those receiving enoxaparin) and had confirmed bleeding severity at adjudication.ResultsThe mean age of the patients was 77 years; most of the patients had substantial cardiovascular disease. Bleeding was predominantly gastrointestinal or intracranial. The mean (±SD) time from emergency department presentation to the administration of the andexanet bolus was 4.8±1.8 hours. After the bolus administration, the median anti-factor Xa activity decreased by 89% (95% confidence interval [CI], 58 to 94) from baseline among patients receiving rivaroxaban and by 93% (95% CI, 87 to 94) among patients receiving apixaban. These levels remained similar during the 2-hour infusion. Four hours after the end of the infusion, there was a relative decrease from baseline of 39% in the measure of anti-factor Xa activity among patients receiving rivaroxaban and of 30% among those receiving apixaban. Twelve hours after the andexanet infusion, clinical hemostasis was adjudicated as excellent or good in 37 of 47 patients in the efficacy analysis (79%; 95% CI, 64 to 89). Thrombotic events occurred in 12 of 67 patients (18%) during the 30-day follow-up.ConclusionsOn the basis of a descriptive preliminary analysis, an initial bolus and subsequent 2-hour infusion of andexanet substantially reduced anti-factor Xa activity in patients with acute major bleeding associated with factor Xa inhibitors, with effective hemostasis occurring in 79%. (Funded by Portola Pharmaceuticals; ANNEXA-4 ClinicalTrials.gov number, NCT02329327 .).

Published
2016

4. Electrodiagnosis of Guillain-Barre syndrome in the International GBS Outcome Study: Differences in methods and reference values

Author

Samuel Arends, Judith Drenthen, Peter van den Bergh, Hessel Franssen, Robert D.M. Hadden, Badrul Islam, Satoshi Kuwabara, Ricardo C. Reisin, Nortina Shahrizaila, Hiroshi Amino, Giovanni Antonini, Shahram Attarian, Claudia Balducci, Fabio Barroso, Tulio Bertorini, Davide Binda, Thomas H. Brannagan, Jan Buermann, Carlos Casasnovas, Guido Cavaletti, Chi-Chao Chao, Mazen M. Dimachkie, Ernesto A. Fulgenzi, Giuliana Galassi, Gerardo Gutiérrez Gutiérrez, Thomas Harbo, Hans-Peter Hartung, Sung-Tsang Hsieh, Lynette Kiers, Helmar C. Lehmann, Fiore Manganelli, Girolama A. Marfia, Giorgia Mataluni, Julio Pardo, Yann Péréon, Yusuf A. Rajabally, Lucio Santoro, Yukari Sekiguchi, Beth Stein, Mark Stettner, Antonino Uncini, Christine Verboon, Camiel Verhamme, Michal Vytopil, Waqar Waheed, Min Wang, Sasha Zivkovic, Bart C. Jacobs, David R. Cornblath, J.M. Addington, S. Ajroud-Driss, H. Andersen, G. Antonini, S. Attarian, U.A. Badrising, G. Balloy, F.A. Barroso, K. Bateman, I.R. Bella, L. Benedetti, P. van den Bergh, T.E. Bertorini, R. Bhavaraju-Sanka, M. Bianco, T.H. Brannagan, C. Briani, null Buerrmann, M. Busby, S. Butterworth, C. Casasnovas, G. Cavaletti, C.C. Chao, G. Chavada, S. Chen, K.G. Claeys, M.E. Conti, D.R. Cornblath, J.S. Cosgrove, M.C. Dalakas, P. van Damme, E. Dardiotis, A. Davidson, M.A. Derejko, G.W. van Dijk, M.M. Dimachkie, P.A. van Doorn, C. Dornonville de la Cour, A. Echaniz-Laguna, F. Eftimov, C.G. Faber, R. Fazio, T.E. Feasby, C. Fokke, T. Fujioka, E.A. Fulgenzi, G. Galassi, T. Garcia-Sobrino, M.P.J. Garssen, C.J. Gijsbers, J.M. Gilchrist, H.J. Gilhuis, J.M. Goldstein, K.C. Gorson, N.A. Goyal, V. Granit, S.T.E. Grisanti, null Gutiérrez-Gutiérrez, L. Gutmann, R.D.M. Hadden, T. Harbo, H.P. Hartung, J.V. Holbech, J.K.L. Holt, S.T. Hsieh, M. Htut, R.A.C. Hughes, I. Illa, B. Islam, Z. Islam, B.C. Jacobs, J. Fehmi, K. Jellema, I. Jerico Pascual, K. Kaida, S. Karafiath, H.D. Katzberg, M.A. Khoshnoodi, L. Kiers, K. Kimpinski, R.P. Kleyweg, N. Kokubun, N.A. Kolb, R. van Koningsveld, A.J. van der Kooi, J.C.H.M. Kramers, K. Kuitwaard, S. Kusunoki, S. Kuwabara, J.Y. Kwan, S.S. Ladha, L. Landschoff Lassen, V. Lawson, H.C. Lehmann, E. Lee Pan, M.P.T. Lunn, H. Manji, G.A. Marfia, C. Márquez Infante, L. Martin-Aguilar, E. Martinez Hernandez, G. Mataluni, M. Mattiazi, C.J. McDermott, G.D. Meekins, J.A.L. Miller, Q.D. Mohammad, M.S. Monges, G. Moris de la Tassa, C. Nascimbene, F.J. Navacerrada-Barrero, E. Nobile-Orazio, R.J. Nowak, P.J. Orizaola, M. Osei-Bonsu, A.M. Pardal, J. Pardo, R.M. Pascuzzi, Y. Péréon, M.T. Pulley, L. Querol, S.W. Reddel, T. van der Ree, R.C. Reisin, S. Rinaldi, R.C. Roberts, I. Rojas-Marcos, null Rudnicki, G.M. Sachs, J.P.A. Samijn, L. Santoro, A. Schenone, M.J. Sedano Tous, N. Shahrizaila, K.A. Sheikh, N.J. Silvestri, S.H. Sindrup, C.L. Sommer, B. Stein, Y. Song, A.M. Stino, H. Tankisi, M.R. Tannemaat, P. Twydell, P.V. Vélez-Santamaria, J.D. Varrato, F.H. Vermeij, L.H. Visser, M.V. Vytopil, W. Waheed, C. Walgaard, Y.Z. Wang, H.J. Willison, P.W. Wirtz, Y. Yamagishi, L. Zhou, S.A. Zivkovic, Neurology, ANS - Neuroinfection & -inflammation, EURO-NMD, Immunology, Arends, S., Drenthen, J., van den Bergh, P., Franssen, H., Hadden, R. D. M., Islam, B., Kuwabara, S., Reisin, R. C., Shahrizaila, N., Amino, H., Antonini, G., Attarian, S., Balducci, C., Barroso, F., Bertorini, T., Binda, D., Brannagan, T. H., Buermann, J., Casasnovas, C., Cavaletti, G., Chao, C. -C., Dimachkie, M. M., Fulgenzi, E. A., Galassi, G., Gutierrez Gutierrez, G., Harbo, T., Hartung, H. -P., Hsieh, S. -T., Kiers, L., Lehmann, H. C., Manganelli, F., Marfia, G. A., Mataluni, G., Pardo, J., Pereon, Y., Rajabally, Y. A., Santoro, L., Sekiguchi, Y., Stein, B., Stettner, M., Uncini, A., Verboon, C., Verhamme, C., Vytopil, M., Waheed, W., Wang, M., Zivkovic, S., Jacobs, B. C., Cornblath, D. R., Arends, S, Drenthen, J, van den Bergh, P, Franssen, H, Hadden, R, Islam, B, Kuwabara, S, Reisin, R, Shahrizaila, N, Amino, H, Antonini, G, Attarian, S, Balducci, C, Barroso, F, Bertorini, T, Binda, D, Brannagan, T, Buermann, J, Casasnovas, C, Cavaletti, G, Chao, C, Dimachkie, M, Fulgenzi, E, Galassi, G, Gutierrez Gutierrez, G, Harbo, T, Hartung, H, Hsieh, S, Kiers, L, Lehmann, H, Manganelli, F, Marfia, G, Mataluni, G, Pardo, J, Pereon, Y, Rajabally, Y, Santoro, L, Sekiguchi, Y, Stein, B, Stettner, M, Uncini, A, Verboon, C, Verhamme, C, Vytopil, M, Waheed, W, Wang, M, Zivkovic, S, Jacobs, B, Cornblath, D, UCL - (SLuc) Centre de référence neuromusculaire, and UCL - (SLuc) Service de neurologie

Subjects
Nerve conduction studie, Electrodiagnòstic, Malalties autoimmunitàries, Electromyography, Electrodiagnosis, Autoimmune diseases, Neural Conduction, Medizin, Settore MED/26, Guillain-Barre Syndrome, AIDP, AMSAN, Sensory Systems, Reference values, Clinical trials, AMAN, Neurology, Physiology (medical), Outcome Assessment, Health Care, Humans, Nerve conduction studies, Neurology (clinical), Reference value, Assaigs clínics
Abstract

Objective: To describe the heterogeneity of electrodiagnostic (EDx) studies in Guillain-Barre syndrome (GBS) patients collected as part of the International GBS Outcome Study (IGOS). Methods: Prospectively collected clinical and EDx data were available in 957 IGOS patients from 115 centers. Only the first EDx study was included in the current analysis. Results: Median timing of the EDx study was 7 days (interquartile range 4-11) from symptom onset. Methodology varied between centers, countries and regions. Reference values from the responding 103 centers were derived locally in 49%, from publications in 37% and from a combination of these in the remaining 15%. Amplitude measurement in the EDx studies (baseline-to-peak or peak-to-peak) differed from the way this was done in the reference values, in 22% of motor and 39% of sensory conduction. There was marked variability in both motor and sensory reference values, although only a few outliers accounted for this. Conclusions: Our study showed extensive variation in the clinical practice of EDx in GBS patients among IGOS centers across the regions. Significance: Besides EDx variation in GBS patients participating in IGOS, this diversity is likely to be present in other neuromuscular disorders and centers. This underlines the need for standardization of EDx in future multinational GBS studies.(c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Published
2022

5. Venous or arterial thrombosis and deaths among COVID-19 cases

Author

Edward Burn, Talita Duarte-Salles, Sergio Fernandez-Bertolin, Carlen Reyes, Kristin Kostka, Antonella Delmestri, Peter Rijnbeek, Katia Verhamme, Daniel Prieto-Alhambra, and Medical Informatics

Subjects
Cohort Studies, Male, Venous Thrombosis, Infectious Diseases, SDG 3 - Good Health and Well-being, SARS-CoV-2, COVID-19, Humans, Venous Thromboembolism
Abstract

Background: There are few data on the incidence of thrombosis among COVID-19 cases, with most research concentrated on hospitalised patients. We aimed to estimate the incidence of venous thromboembolism, arterial thromboembolism, and death among COVID-19 cases and to assess the impact of these events on the risks of hospitalisation and death. Methods: We conducted a distributed network cohort study using primary care records from the Netherlands, Italy, Spain, and the UK, and outpatient specialist records from Germany. The Spanish database was linked to hospital admissions. Participants were followed up from the date of a diagnosis of COVID-19 or positive RT-PCR test for SARS-CoV-2 (index date) for 90 days. The primary study outcomes were venous thromboembolic events, arterial thromboembolic events, and death, all over the 90 days from the index date. We estimated cumulative incidences for the study outcomes. Multistate models were used to calculate adjusted hazard ratios (HRs) for the association between venous thromboembolism or arterial thromboembolism occurrence and risks of hospitalisation or COVID-19 fatality. Findings: Overall, 909 473 COVID-19 cases and 32 329 patients hospitalised with COVID-19 on or after Sept 1, 2020, were studied. The latest index dates across the databases ranged from Jan 30, 2021, to July 31, 2021. Cumulative 90-day incidence of venous thromboembolism ranged from 0·2% to 0·8% among COVID-19 cases, and up to 4·5% for those hospitalised. For arterial thromboembolism, estimates ranged from 0·1% to 0·8% among COVID-19 cases, increasing to 3·1% among those hospitalised. Case fatality ranged from 1·1% to 2·0% among patients with COVID-19, rising to 14·6% for hospitalised patients. The occurrence of venous thromboembolism in patients with COVID-19 was associated with an increased risk of death (adjusted HRs 4·42 [3·07–6·36] for those not hospitalised and 1·63 [1·39–1·90] for those hospitalised), as was the occurrence of arterial thromboembolism (3·16 [2·65–3·75] and 1·93 [1·57–2·37]). Interpretation: Risks of venous thromboembolism and arterial thromboembolism were up to 1% among COVID-19 cases, and increased with age, among males, and in those who were hospitalised. Their occurrence was associated with excess mortality, underlying the importance of developing effective treatment strategies that reduce their frequency. Funding: European Medicines Agency.

Published
2022

6. Statin use and 30‐day mortality in patients with acute symptomatic pulmonary embolism

Author

Carmine Siniscalchi, Alfonso Muriel, Jose Maria Suriñach Caralt, Behnood Bikdeli, David Jiménez, José Luis Lobo, Cristina Amado, Aída Gil‐Díaz, Egidio Imbalzano, Manuel Monreal, Paolo Prandoni, Benjamin Brenner, Dominique Farge‐Bancel, Raquel Barba, Pierpaolo Di Micco, Laurent Bertoletti, Sebastian Schellong, Inna Tzoran, Abilio Reis, Marijan Bosevski, Henri Bounameaux, Radovan Malý, Peter Verhamme, Joseph A Caprini, and Hanh My Bui

Subjects
Neoplasms, Acute Disease, Humans, Registries, Hematology, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Pulmonary Embolism
Abstract

Statins possess antithrombotic and profibrinolytic properties. The association between statin use and short-term outcomes in patients with acute pulmonary embolism (PE) remains unknown.We used the data from the Registro Informatizado de Pacientes con Enfermedad TromboEmbólica registry to compare the 30-day all-cause mortality in patients with acute PE according to the use of statins. Secondary outcome was fatal PE. We used cancer-related mortality as a falsification endpoint.From January 2009 to April 2021, 31 169 patients with PE were recruited. Of these, 5520 (18%) were using statins at baseline: low intensity: 829, moderate: 3636, high intensity: 1055. Statin users were older and had a higher frequency of diabetes, hypertension, or atherosclerotic disease than non-users (P0.001 for all comparisons). During the first 30 days, 1475 patients died (fatal PE, 255). On multivariable analysis, statin users had a lower risk of all-cause death (odds ratio [OR]: 0.65; 95% confidence interval [CI]: 0.56-0.76) and fatal PE (OR: 0.42; 95% CI: 0.28-0.62) than non-users. The risk for death was lower in patients using either low- (OR: 0.51; 95% CI: 0.34-0.77), moderate- (OR: 0.68; 95% CI: 0.57-0.81), or high-intensity statins (OR: 0.68; 95% CI: 0.51-0.92). Results did not change in mixed effects logistic regression models with hospitals as a random effect. Statins were not associated with a significant chance in cancer mortality (falsification endpoint).PE patients using statins at baseline had a significantly lower risk of dying within the first 30 days than non-users. Randomized trials are needed to confirm these data.

Published
2022

7. Ten-year retrospective evaluation of therapeutic choices and related satisfaction in patients with auricular deformities

Author

M.A. Vijverberg, I. Siemann, L. Verhamme, H. Eising, G.W.J.A. Damen, and M.K.S. Hol

Subjects
Dental Implants, Personal Satisfaction, Hearing loss, Plastic Surgery Procedures, Auricle, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], Bone conduction device, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], All institutes and research themes of the Radboud University Medical Center, Otorhinolaryngology, Atresia, Patient Satisfaction, Microtia, Humans, Surgery, Oral Surgery, Reconstruction, Congenital Microtia, Retrospective Studies
Abstract

To adequately counsel future patients with auricular abnormalities, this study aimed to analyze the therapeutic choices patients make after consultation concerning their auricle and/or hearing. All patients who visited the auricle consultation between January 2010 and January 2020 were included. This comprises patients with all types of auricular anomalies of both congenital and acquired etiology. Follow-up was performed by telephone to obtain informed consent and to take a short nonvalidated questionnaire regarding their therapeutic choices and satisfaction with these choices. Patient characteristics and information regarding therapeutic choices after consultation were subsequently obtained from the patients' medical files. The main outcome parameters were the patients’ therapeutic choices regarding the auricle and hearing. A total of 134 patients (61.2%) were included with a mean follow-up of 3.85 years. For congenital and acquired etiologies, 72.8% and 18.2% declined reconstruction, 14.0% and 18.2% chose autologous, 5.3% and 0% chose alloplastic, 6.1% and 45.4% chose prosthetic, and 1.8% and 18.2% chose another type of reconstruction, respectively. A total of 54.9% declined hearing rehabilitation, while 38.2% chose percutaneous bone conduction device (BCD), 2.0% transcutaneous BCD, and 4.9% BCD on a softband. The overall satisfaction score was 8.7/10 concerning the auricle and 8.3/10 regarding hearing. In conclusion, most patients with a congenital etiology chose to wait or decided against auricular reconstruction, while patients with acquired etiologies mostly opted for reconstruction by a prosthesis. Patients or their caregivers were very satisfied with their choice, regardless of whether this implies reconstruction or no reconstruction, which emphasizes the importance of shared decision-making and thorough counseling.

Published
2022

8. Using Iterative Pairwise External Validation to Contextualize Prediction Model Performance: A Use Case Predicting 1-Year Heart Failure Risk in Patients with Diabetes Across Five Data Sources

Author

Ross Williams, Jenna M. Reps, Jan A. Kors, Patrick B. Ryan, Ewout Steyerberg, Katia M. Verhamme, Peter R. rijnbeek, Medical Informatics, and Public Health

Subjects
Heart Failure, Pharmacology, SDG 3 - Good Health and Well-being, Databases, Factual, Diabetes Mellitus, Type 2, Humans, Pharmacology (medical), Toxicology, Prediction, machine learning, diabetes, heart failure, Software
Abstract

INTRODUCTION: External validation of prediction models is increasingly being seen as a minimum requirement for acceptance in clinical practice. However, the lack of interoperability of healthcare databases has been the biggest barrier to this occurring on a large scale. Recent improvements in database interoperability enable a standardized analytical framework for model development and external validation. External validation of a model in a new database lacks context, whereby the external validation can be compared with a benchmark in this database. Iterative pairwise external validation (IPEV) is a framework that uses a rotating model development and validation approach to contextualize the assessment of performance across a network of databases. As a use case, we predicted 1-year risk of heart failure in patients with type 2 diabetes mellitus.METHODS: The method follows a two-step process involving (1) development of baseline and data-driven models in each database according to best practices and (2) validation of these models across the remaining databases. We introduce a heatmap visualization that supports the assessment of the internal and external model performance in all available databases. As a use case, we developed and validated models to predict 1-year risk of heart failure in patients initializing a second pharmacological intervention for type 2 diabetes mellitus. We leveraged the power of the Observational Medical Outcomes Partnership common data model to create an open-source software package to increase the consistency, speed, and transparency of this process.RESULTS: A total of 403,187 patients from five databases were included in the study. We developed five models that, when assessed internally, had a discriminative performance ranging from 0.73 to 0.81 area under the receiver operating characteristic curve with acceptable calibration. When we externally validated these models in a new database, three models achieved consistent performance and in context often performed similarly to models developed in the database itself. The visualization of IPEV provided valuable insights. From this, we identified the model developed in the Commercial Claims and Encounters (CCAE) database as the best performing model overall.CONCLUSION: Using IPEV lends weight to the model development process. The rotation of development through multiple databases provides context to model assessment, leading to improved understanding of transportability and generalizability. The inclusion of a baseline model in all modelling steps provides further context to the performance gains of increasing model complexity. The CCAE model was identified as a candidate for clinical use. The use case demonstrates that IPEV provides a huge opportunity in a new era of standardised data and analytics to improve insight into and trust in prediction models at an unprecedented scale.

Published
2022

9. Prevalence of Acute Pulmonary Embolism at Autopsy in Patients With COVID-19

Author

Marco Zuin, Matthias M. Engelen, Claudio Bilato, Thomas Vanassche, Gianluca Rigatelli, Peter Verhamme, Christophe Vandenbriele, Giovanni Zuliani, and Loris Roncon

Subjects
SARS-CoV-2, Acute Disease, Prevalence, COVID-19, Humans, Autopsy, Middle Aged, Pulmonary Embolism, Cardiology and Cardiovascular Medicine
Abstract

To date, the actual prevalence of acute pulmonary embolism (PE) in patients with SARS-CoV-2 infection remains unknown, as systematic screening for PE is cumbersome. We performed a systematic review and meta-analysis on autoptic data to estimate the prevalence of histopathologic findings of acute PE and its relevance as a cause of death on patients with COVID-19. We searched MEDLINE-PubMed and Scopus to locate all articles published in the English language, up to August 10, 2021, reporting the autoptic prevalence of acute PE and evaluating PE as the underlying cause of death in patients with COVID-19. The pooled prevalence for both outcomes was calculated using a random-effects model and presenting the related 95% confidence interval (CI). Statistical heterogeneity was measured using the Higgins I

Published
2022

10. Background rates of five thrombosis with thrombocytopenia syndromes of special interest for <scp>COVID</scp> ‐19 vaccine safety surveillance: Incidence between 2017 and 2019 and patient profiles from 38.6 million people in six European countries

Author

Edward Burn, Xintong Li, Kristin Kostka, Henry Morgan Stewart, Christian Reich, Sarah Seager, Talita Duarte‐Salles, Sergio Fernandez‐Bertolin, María Aragón, Carlen Reyes, Eugenia Martinez‐Hernandez, Edelmira Marti, Antonella Delmestri, Katia Verhamme, Peter Rijnbeek, Scott Horban, Daniel R. Morales, Daniel Prieto‐Alhambra, and Medical Informatics

Subjects
COVID-19 Vaccines, SDG 3 - Good Health and Well-being, Epidemiology, Incidence, COVID-19, Humans, Thrombosis, Pharmacology (medical), Syndrome, Thrombocytopenia
Abstract

Background:Thrombosis with thrombocytopenia syndrome (TTS) has been reported among individuals vaccinated with adenovirus-vectored COVID-19 vaccines. In this study, we describe the background incidence of non-vaccine induced TTS in six European countries. Methods:Electronic medical records from France, the Netherlands, Italy, Germany, Spain, and the United Kingdom informed the study. Incidence rates of cerebral venous sinus thrombosis (CVST), splanchnic vein thrombosis (SVT), deep vein thrombosis (DVT), pulmonary embolism (PE), and myocardial infarction or ischemic stroke, all with concurrent thrombocytopenia, were estimated among the general population of persons in a database between 2017 and 2019. A range of additional potential adverse events of special interest for COVID-19 vaccinations were also studied in a similar manner. Findings:A total of 38 611 617 individuals were included. Background rates ranged from 1.0 (95% CI: 0.7–1.4) to 8.5 (7.4–9.9) per 100 000 person-years for DVT with thrombocytopenia, from 0.5 (0.3–0.6) to 20.8 (18.9–22.8) for PE with thrombocytopenia, from 0.1 (0.0–0.1) to 2.5 (2.2–2.7) for SVT with thrombocytopenia, and from 1.0 (0.8–1.2) to 43.4 (40.7–46.3) for myocardial infarction or ischemic stroke with thrombocytopenia. CVST with thrombocytopenia was only identified in one database, with incidence rate of 0.1 (0.1–0.2) per 100 000 person-years. The incidence of non-vaccine induced TTS increased with age, and was typically greater among those with more comorbidities and greater medication use than the general population. It was also more often seen in men than women. A large proportion of those affected were seen to have been taking antithrombotic and anticoagulant therapies prior to their event. Interpretation:Although rates vary across databases, non-vaccine induced TTS has consistently been seen to be a very rare event among the general population. While still remaining very rare, rates were typically higher among older individuals, and those affected were also seen to generally be male and have more comorbidities and greater medication use than the general population.

Published
2022

11. Open-Angle Glaucomatous Optic Neuropathy Is Related to Dips Rather Than Increases in the Mean Arterial Pressure Over 24-H

Author

Jesus D Melgarejo, Jan V Eijgen, Gladys E Maestre, Lama A Al-Aswad, Lutgarde Thijs, Luis J Mena, Joseph H Lee, Joseph D Terwilliger, Michele Petitto, Carlos A Chávez, Miguel Brito, Gustavo Calmon, Egle Silva, Dong-Mei Wei, Ella Cutsforth, Karel V Keer, C Gustavo De Moraes, Thomas Vanassche, Stefan Janssens, Ingeborg Stalmans, Peter Verhamme, Jan A Staessen, and Zhen-Yu Zhang

Subjects
Original Contributions, open-angle glaucoma, Optic Nerve, Middle Aged, dips, ambulatory blood pressure monitoring, population science, Case-Control Studies, Optic Nerve Diseases, Internal Medicine, glaucomatous optic neuropathy, Humans, Arterial Pressure, Female, blood pressure variability, Glaucoma, Open-Angle, Intraocular Pressure
Abstract

BACKGROUND Mean arterial pressure (MAP) drives ocular perfusion. Excessive 24-h MAP variability relates to glaucoma, however, whether this is due to dips or increases in the blood pressure (BP) is undocumented. We investigated the association of open-angle glaucoma (OAG) in relation to the 5 largest MAP dips/increases over 24-h, henceforth called dips/blips. METHODS In the Maracaibo Aging Study (MAS), 93 participants aged ≥40 y (women, 87.1%; mean age, 61.9 y) underwent baseline ophthalmological and 24-h ambulatory BP monitoring assessments. OAG was the presence of optic nerve damage and visual field defects. Statistical methods included logistic regression and the generalized R2 statistic. For replication, 48 OAG cases at the Leuven Glaucoma Clinic were matched with 48 controls recruited from Flemish population. RESULTS In the MAS, 26 participants had OAG. OAG compared to non-OAG participants experienced longer and deeper dips (116.5 vs. 102.7 minutes; to 60.3 vs. 66.6 mm Hg; −21.0 vs. −18.0 mm Hg absolute or 0.79 vs. 0.81 relative dip compared to the preceding reading). The adjusted odds ratios associated with dip measures ranged from 2.25 (95% confidence interval [CI], 1.31–4.85; P = 0.009) to 3.39 (95% CI, 1.36–8.46; P = 0.008). On top of covariables and 24-MAP level/variability, the dip measures increased the model performance (P ≤ 0.025). Blips did not associate with OAG. The case–control study replicated the MAS observations. CONCLUSIONS Dips rather than increases in the 24-h MAP level were associated with increased risk for OAG. An ophthalmological examination combined with 24-h BP monitoring might be precautious steps required in normotensive and hypertensive patients at risk of OAG.

Published
2022

12. Improving appropriate use of anticoagulants in hospitalised patients: A pharmacist‐led Check of Medication Appropriateness intervention

Author

Charlotte Quintens, Peter Verhamme, Thomas Vanassche, Christophe Vandenbriele, Bart Van den Bosch, Willy E. Peetermans, Lorenz Van der Linden, and Isabel Spriet

Subjects
Pharmacology, Anticoagulant prescribing, clinical decision rules, Anticoagulants, Humans, clinical pharmacists, Inappropriate Prescribing, Interrupted Time Series Analysis, Pharmacology (medical), medication review, Pharmacists
Abstract

AIM: Inappropriate anticoagulant use increases the risk of bleeding and thrombotic events. We implemented clinical decision rules to promote judicious medication use, as part of the 'Check of Medication Appropriateness' (CMA). The CMA concerns a pharmacist-led review service, targeting potentially inappropriate prescriptions (PIPs). In this analysis, we aimed to evaluate the impact of the CMA on anticoagulant prescribing. METHODS: The number of anticoagulant-related PIPs was evaluated before and after implementation of the intervention in a quasi-experimental interrupted time series analysis. The pre-implementation cohort received usual care. The anticoagulant-focused CMA, comprising 13 clinical rules pertaining to anticoagulation therapies, was implemented in the post-implementation cohort. Segmented regression analysis was used to assess the impact of the intervention on the number of residual PIPs. A residual PIP was defined as a PIP which persisted up to 48h after the CMA intervention. Total number of recommendations and acceptance rate were documented for the 2-year post-implementation period. RESULTS: Pre-implementation, we observed 501 PIPs in 466 inpatients on 36 days, with a median proportion of 78.5% (range: 46.2%-100%) residual PIPs per day. Post-implementation, 538 PIPs were detected in 485 patients over the same number of days. The CMA intervention reduced the median proportion to 18.2% (range: 0-100%) per day. The effect coincided with an immediate relative reduction of 70% (95%CI 0.19-0.46) in anticoagulant-related residual PIPs. Post-implementation, 2778 recommendations were provided and 75.1% were accepted. CONCLUSION: Our CMA approach significantly reduced anticoagulant-related PIPs. Implementing a pharmacist-led intervention, based on clinical rules, may support safer prescribing of anticoagulants. ispartof: British Journal Of Clinical Pharmacology vol:88 issue:6 pages:2959-2968 ispartof: location:England status: accepted

Published
2022

13. Does initial buccal crest thickness affect final buccal crest thickness after flapless immediate implant placement and provisionalization

Author

Tristan Ariaan Staas, Edith Groenendijk, Ewald Bronkhorst, Luc Verhamme, Gerry Max Raghoebar, Gerrit Jacobus Meijer, Personalized Healthcare Technology (PHT), and Man, Biomaterials and Microbes (MBM)

Subjects
Immediate Dental Implant Loading, CBCT analysis, SOFT-TISSUE ALTERATIONS, RIDGE PRESERVATION, Esthetics, Dental, FRESH EXTRACTION SOCKETS, Cohort Studies, Dental Implants, Single-Tooth, AESTHETIC ZONE, Maxilla, Animals, Humans, flapless immediate implant placement, BONE WALL, Prospective Studies, immediate restoration, General Dentistry, RESTORATION, Dental Implants, SINGLE-TOOTH IMPLANTS, POST-EXTRACTION, Cone-Beam Computed Tomography, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], ANTERIOR MAXILLA, aesthetic outcome, Cattle, Oral Surgery, DIMENSIONAL CHANGES
Abstract

Contains fulltext : 288300.pdf (Publisher’s version ) (Open Access) BACKGROUND: Flapless immediate implant placement and provisionalization (FIIPP) in the aesthetic zone is still controversial. Especially, an initial buccal crest thickness (BCT) of ≤1 mm is thought to be disruptive for the final buccal crest stability jeopardizing the aesthetic outcome. PURPOSE: To radiographically assess the BCT and buccal crest height (BCH) after 1 year and to calculate the correlation between initial and final achieved BCT. MATERIALS AND METHODS: The study was designed as a prospective study on FIIPP. Only patients were included in whom one maxillary incisor was considered as lost. In six centers, 100 consecutive patients received FIIPP. Implants were placed in a maximal palatal position of the socket, thereby creating a buccal space of at least 2 mm, which was subsequently filled with a bovine bone substitute. Files of preoperative (T0), peroperative (T1) and 1-year postoperative (T3) cone beam computed tomogram (CBCT) scans were imported into the Maxillim™ software to analyze the changes in BCT-BCH over time. RESULTS: Preoperatively, 85% of the cases showed a BCT ≤1 mm, in 25% of the patients also a small buccal defect (≤5 mm) was present. Mean BCT at the level of the implant-shoulder increased from 0.6 mm at baseline to 3.3 mm immediate postoperatively and compacted to 2.4 mm after 1 year. Mean BCH improved from 0.7 to 3.1 mm peroperatively, and resorbed to 1.7 mm after 1 year. The Pearson correlation of 0.38 between initial and final BCT was significant (p = 0.01) and therefore is valued as moderate. If only patients (75%) with an intact alveolus were included in the analysis, still a "moderate correlation" of 0.32 (p = 0.01) was calculated. CONCLUSIONS: A "moderate correlation" was shown for the hypothesis that "thinner preoperative BCT's deliver thinner BCT's" 1 year after performing FIIPP.

Published
2022

14. Overview of the European post-authorisation study register post-authorization studies performed in Europe from September 2010 to December 2018

Author

Janet, Sultana, Salvatore, Crisafulli, Mariana, Almas, Ippazio Cosimo, Antonazzo, Esme, Baan, Claudia, Bartolini, Maria Paola, Bertuccio, Fedele, Bonifazi, Annalisa, Capuano, Antonella, Didio, Vera, Ehrenstein, Mariagrazia, Felisi, Carmen, Ferrajolo, Andrea, Fontana, Remy, Francisca, Annie, Fourrier-Reglat, Joan, Fortuny, Rosa, Gini, Giulia, Hyeraci, Christel, Hoeve, Christos, Kontogiorgis, Valentina, Isgrò, Panagiotis-Nikolaos, Lalagkas, Luca, L'Abbate, Deborah, Layton, Annalisa, Landi, Silvia, Narduzzi, Leonardo, Roque Pereira, Georgios, Poulentzas, Concetta, Rafaniello, Giuseppe, Roberto, Giulia, Scondotto, Liberata, Sportiello, Maddalena, Toma, Massoud, Toussi, Katia, Verhamme, Elisabetta, Volpe, Gianluca, Trifirò, Sultana, Janet, Crisafulli, Salvatore, Almas, Mariana, Antonazzo, Ippazio Cosimo, Baan, Esme, Bartolini, Claudia, Bertuccio, Maria Paola, Bonifazi, Fedele, Capuano, Annalisa, Didio, Antonella, Ehrenstein, Vera, Felisi, Mariagrazia, Ferrajolo, Carmen, Fontana, Andrea, Francisca, Remy, Fourrier-Reglat, Annie, Fortuny, Joan, Gini, Rosa, Hyeraci, Giulia, Hoeve, Christel, Kontogiorgis, Christo, Isgrò, Valentina, Lalagkas, Panagiotis-Nikolao, L'Abbate, Luca, Layton, Deborah, Landi, Annalisa, Narduzzi, Silvia, Roque Pereira, Leonardo, Poulentzas, Georgio, Rafaniello, Concetta, Roberto, Giuseppe, Scondotto, Giulia, Sportiello, Liberata, Toma, Maddalena, Toussi, Massoud, Verhamme, Katia, Volpe, Elisabetta, Trifirò, Gianluca, Medical Informatics, Sultana, J, Crisafulli, S, Almas, M, Antonazzo, I, Baan, E, Bartolini, C, Bertuccio, M, Bonifazi, F, Capuano, A, Didio, A, Ehrenstein, V, Felisi, M, Ferrajolo, C, Fontana, A, Francisca, R, Fourrier-Reglat, A, Fortuny, J, Gini, R, Hyeraci, G, Hoeve, C, Kontogiorgis, C, Isgro, V, Lalagkas, P, L'Abbate, L, Layton, D, Landi, A, Narduzzi, S, Roque Pereira, L, Poulentzas, G, Rafaniello, C, Roberto, G, Scondotto, G, Sportiello, L, Toma, M, Toussi, M, Verhamme, K, Volpe, E, and Trifiro, G

Subjects
post-authorization studies, Databases, Factual, Epidemiology, Pharmacoepidemiology, Reproducibility of Result, Reproducibility of Results, post-authorization studie, EU PAS register, Observational Studies as Topic, Research Design, Surveys and Questionnaires, multi-database studies, Surveys and Questionnaire, Humans, Pharmacology (medical), multi-database studie, Human
Abstract

Background: The European post-authorisation study (EU PAS) register is a repository launched in 2010 by the European Medicines Agency (EMA). All EMA-requested PAS, commonly observational studies, must be recorded in this register. Multi-database studies (MDS) leveraging secondary data have become an important strategy to conduct PAS in recent years, as reflected by the type of studies registered in the EU PAS register. Objectives: To analyse and describe PAS in the EU PAS register, with focus on MDS. Methods: Studies in the EU PAS register from inception to 31st December 2018 were described concerning transparency, regulatory obligations, scope, study type (e.g., observational study, clinical trial, survey, systematic review/meta-analysis), study design, type of data collection and target population. MDS were defined as studies conducted through secondary use of >1 data source not linked at patient-level. Data extraction was carried out independently by 14 centres with expertise in pharmacoepidemiology, using publicly available information in the EU PAS register including study protocol, whenever available, using a standardised data collection form. For validation purposes, a second revision of key fields for a 15% random sample of studies was carried out by a different centre. The inter-rater reliability (IRR) was then calculated. Finally, to identify predictors of primary data collection-based studies/versus those based on secondary use of healthcare databases) or MDS (vs. non-MDS), odds ratios (OR) and 95% confidence intervals (CI) were calculated fitting univariate logistic regression models. Results: Overall, 1426 studies were identified. Clinical trials (N = 30; 2%), systematic reviews/meta-analyses (N = 16; 1%) and miscellaneous study designs (N = 46; 3%) were much less common than observational studies (N = 1227; 86%). The protocol was available for 63% (N = 360) of 572 observational studies requested by a competent authority. Overall, 36% (N = 446) of observational studies were based fully or partially on primary data collection. Of 757 observational studies based on secondary use of data alone, 282 (37%) were MDS. Drug utilisation was significantly more common as a study scope in MDS compared to non-MDS studies. The overall percentage agreement among collaborating centres that collected the data concerning study variables was highest for study type (93.5%) and lowest for type of secondary data (67.8%). Conclusions: Observational studies were the most common type of studies in the EU PAS register, but 30% used primary data, which is more resource-intensive. Almost half of observational studies using secondary data were MDS. Data recording in the EU PAS register may be improved further, including more widespread availability of study protocols to improve transparency.

Published
2021

15. Onset of labor and use of analgesia in women using thromboprophylaxis with 2 doses of low-molecular-weight heparin: insights from the Highlow study

Author

Ingrid M. Bistervels, Hanke M.G. Wiegers, Fionnuala Ní Áinle, Suzanne M. Bleker, Céline Chauleur, Jennifer Donnelly, Anne F. Jacobsen, Marc A. Rodger, Maria T. DeSancho, Peter Verhamme, Anette T. Hansen, Roman G. Shmakov, Wessel Ganzevoort, Andrea Buchmüller, Saskia Middeldorp, Graduate School, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, Amsterdam Reproduction & Development (AR&D), Amsterdam Cardiovascular Sciences, Obstetrics and Gynaecology, and APH - Quality of Care

Subjects
Male, anesthesia and analgesia, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], venous thromboembolism, labor, Hematology, heparin, All institutes and research themes of the Radboud University Medical Center, Anticoagulants/therapeutic use, Heparin, Low-Molecular-Weight/therapeutic use, Pregnancy, low-molecular-weight, obstetric, Humans, Female, pregnancy, Analgesia, Venous Thromboembolism/drug therapy
Abstract

Item does not contain fulltext BACKGROUND: Peripartum management of women using low-molecular-weight heparin (LMWH) varies widely. Minimum time intervals are required between LMWH injection and neuraxial procedure, and they differ by dose. OBJECTIVES: The objective of this study was to describe the onset of labor and use of analgesia in women using LMWH and to compare practices between intermediate-dose and low-dose LMWH. METHODS: In the Highlow study (NCT01828697), 1110 women were randomized to intermediate-dose or low-dose LMWH and were instructed to discontinue LMWH when labor commenced unplanned or 24 hours prior to planned delivery. The required time interval since last injection to receive a neuraxial procedure was ≥24 hours for intermediate-dose LMWH or ≥12 hours for low-dose LMWH. RESULTS: In total, 1018 women had an ongoing pregnancy for ≥24 weeks. Onset of labor was spontaneous in 198 of 509 (39%) women on intermediate-dose LMWH and in 246 of 509 (49%) on low-dose LMWH. With unplanned onset, a neuraxial procedure was performed in 37% on intermediate-dose and in 48% on low-dose LMWH (risk difference -11%, 95% CI -20% to -2%). Based on time interval, 61% on intermediate-dose and 82% on low-dose LMWH were eligible for a neuraxial procedure. With planned onset, 68% on intermediate-dose and 66% on low-dose LMWH received a neuraxial procedure, whereas 81% and 93%, respectively, were eligible for a neuraxial procedure (risk difference -13%, 95% CI -18% to -8%). CONCLUSION: With spontaneous onset of labor, neuraxial procedures were performed less often in women using intermediate-dose LMWH. Irrespective of onset, fewer women on intermediate-dose LMWH than those on low-dose LMWH were eligible for neuraxial procedures based on required time intervals since the last LMWH injection. 01 januari 2023

Published
2023

16. Strength testing of low-cost 3D-printed transtibial prosthetic socket

Author

Cornelis H. Slump, L.M. Verhamme, Thomas Jj Maal, Lars Brouwers, Merel van der Stelt, Oral and Maxillofacial Surgery, Digital Society Institute, and Robotics and Mechatronics

Subjects
3d printed, 3D-printing, Computer science, medicine.medical_treatment, Mechanical engineering, 3D printing, Artificial Limbs, Fused filament fabrication, Prosthesis Design, Prosthesis, Prosthesis Implantation, low-cost, ISO 527, medicine, Humans, Strength testing, Standard test, business.industry, Mechanical Engineering, Structural integrity, General Medicine, Prosthetic socket, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], strength testing, Printing, Three-Dimensional, Computer-Aided Design, transtibial prosthetic socket, fused filament fabrication, business, NLA, ISO 10328
Abstract

Item does not contain fulltext Measurement and production of traditional prosthetic sockets are time-consuming, labor-intensive, and highly dependent on the personnel involved. An alternative way to make prostheses is using computer-aided design (CAD) and computer-aided manufacturing (CAM). Fused Filament Fabrication (FFF) may be an alternative to make low-cost prosthetic sockets. This study investigates the tensile properties of potential printing materials suitable for FFF according to ISO527 (Standard Test Method for Tensile Properties of Plastics). To ensure that FFF-printed sockets are safe for patient usage, the structural integrity of the 3D-printed prosthesis will be investigated according to ISO10328 (International Standard Structural Testing of Lower Limb Prostheses). Tough PLA was the most suitable print material according to ISO 527 testing. The Tough PLA printed socket completed 2.27 million cycles and a static test target value of 4025 N. Future research remains necessary to continue testing new potential materials, improve print settings, and improve the socket design for the production of FFF-printed transtibial prosthetic sockets. FFF using Tough PLA can be used to create transtibial prostheses that almost comply with the International Standard for Structural Testing of Lower Limb Prostheses.

Published
2021

17. Maxillofacial and oral surgery in patients with thrombophilia: safe territory for the oral surgeon? A single-center retrospective study

Author

An-Sofie Vandeput, Lisa De Kock, Elien Janssens, Peter Verhamme, Constantinus Politis, Katrien Brijs, and Hilde Peeters

Subjects
Adult, Male, medicine.medical_specialty, Oral Surgeon, Oral Surgical Procedures, Single Center, Thrombophilia, Pathology and Forensic Medicine, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Antiphospholipid syndrome, Factor V Leiden, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Dentistry (miscellaneous), Protein S deficiency, Oral and Maxillofacial Surgeons, Aged, Retrospective Studies, business.industry, Retrospective cohort study, 030206 dentistry, Middle Aged, medicine.disease, Surgery, Oral, Surgery, 030220 oncology & carcinogenesis, Female, Oral Surgery, Complication, business
Abstract

Objective The aim of this study was to analyze patients with thrombophilia who underwent oral and/or maxillofacial surgery at our center. Study Design We performed a retrospective analysis of patients with hereditary or acquired thrombophilia who had undergone oral/maxillofacial surgery between January 1, 2000 and December 31, 2019. Data regarding demographic and patient characteristics, surgical treatment modalities, antithrombotic therapies, and complications were analyzed. Results A total of 76 eligible patients (26 male, 50 female) were included in this study, with a mean follow-up period of 3.8 months (range, 0-51 months). The mean age at time of surgery was 44.7 ± 19.4 years. Seven different hereditary and acquired thrombophilia were identified: factor V Leiden (n = 31; 40.8%), prothrombin G20210A mutation (n = 5; 6.6%), protein C deficiency (n = 4; 5.3%), protein S deficiency (n = 11; 14.5%), antiphospholipid syndrome (n = 10; 13.2%), hyperhomocysteinemia (n = 8; 10.5%), and elevated factor VIII (n = 2; 2.6%). Complications occurred in 9 patients (11.8%) and included postoperative infections (n = 6; 7.9%) and postoperative bleeding (n = 3; 3.9%). Conclusion Our data suggest that oral and/or maxillofacial surgery in patients with a confirmed diagnosis of thrombophilia is not associated with a burden of thrombosis or high complication rates. Furthermore, we formulated a guideline for preoperative antithrombotic therapy for patients with thrombophilia undergoing oral and/or maxillofacial surgery.

Published
2021

19. Thrombosis and thrombocytopenia after vaccination against and infection with SARS-CoV-2 in Catalonia, Spain

Author

Edward Burn, Elena Roel, Andrea Pistillo, Sergio Fernández-Bertolín, Maria Aragón, Berta Raventós, Carlen Reyes, Katia Verhamme, Peter Rijnbeek, Xintong Li, Victoria Y. Strauss, Daniel Prieto-Alhambra, Talita Duarte-Salles, and Medical Informatics

Subjects
Multidisciplinary, COVID-19 Vaccines, SARS-CoV-2, Vaccination, General Physics and Astronomy, COVID-19, Thrombosis, General Chemistry, Venous Thromboembolism, Thrombocytopenia, General Biochemistry, Genetics and Molecular Biology, SDG 3 - Good Health and Well-being, Spain, Humans, BNT162 Vaccine
Abstract

Population-based studies can provide important evidence on the safety of COVID-19 vaccines. Here we compare rates of thrombosis and thrombocytopenia following vaccination against SARS-CoV-2 with the background (expected) rates in the general population. In addition, we compare the rates of the same adverse events among persons infected with SARS-CoV-2 with background rates. Primary care and linked hospital data from Catalonia, Spain informed the study, with participants vaccinated with BNT162b2 or ChAdOx1 (27/12/2020-23/06/2021), COVID-19 cases (01/09/2020-23/06/2021) or present in the database as of 01/01/2017. We included 2,021,366 BNT162b2 (1,327,031 with 2 doses), 592,408 ChAdOx1, 174,556 COVID-19 cases, and 4,573,494 background participants. Standardised incidence ratios for venous thromboembolism were 1.18 (95% CI 1.06-1.32) and 0.92 (0.81-1.05) after first- and second dose BNT162b2, and 0.92 (0.71-1.18) after first dose ChAdOx1. The standardised incidence ratio for venous thromboembolism in COVID-19 was 10.19 (9.43-11.02). Standardised incidence ratios for arterial thromboembolism were 1.02 (0.95-1.09) and 1.04 (0.97-1.12) after first- and second dose BNT162b2, 1.06 (0.91-1.23) after first-dose ChAdOx1 and 4.13 (3.83-4.45) for COVID-19. Standardised incidence ratios for thrombocytopenia were 1.49 (1.43-1.54) and 1.40 (1.35-1.45) after first- and second dose BNT162b2, 1.28 (1.19-1.38) after first-dose ChAdOx1 and 4.59 (4.41- 4.77) for COVID-19. While rates of thrombosis with thrombocytopenia were generally similar to background rates, the standardised incidence ratio for pulmonary embolism with thrombocytopenia after first-dose BNT162b2 was 1.70 (1.11-2.61). These findings suggest that the safety profiles of BNT162b2 and ChAdOx1 are similar, with rates of adverse events seen after vaccination typically similar to background rates. Meanwhile, rates of adverse events are much increased for COVID-19 cases further underlining the importance of vaccination.

Published
2022

20. Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial

Author

Ingrid M Bistervels, Andrea Buchmüller, Hanke M G Wiegers, Fionnuala Ní Áinle, Bernard Tardy, Jennifer Donnelly, Peter Verhamme, Anne F Jacobsen, Anette T Hansen, Marc A Rodger, Maria T DeSancho, Roman G Shmakov, Nick van Es, Martin H Prins, Céline Chauleur, Saskia Middeldorp, Eline S van den Akker, Mireille N Bekker, Thomas van Bemmel, Laurent Bertoletti, Julie Blanc, Suzanne M Bleker, Aude Bourtembourg-Matras, Florence Bretelle, Bridgette Byrne, Francis Couturaud, Pierre Delorme, Elise S Eerenberg, Maureen TM Franssen, Jens Fuglsang, Wessel Ganzevoort, François Goffinet, Jiska M de Haan-Jebbink, Wieteke Heidema, Monique A Hertzberg, Marcel MC Hovens, Menno V Huisman, Leonie de Jong-Speksnijder, Pieter-Willem Kamphuisen, Denis J O'Keeffe, Karine Lacut, Josje Langenveld, M Simone Lunshof, Caroline P Martens, Adel Merah, Emmanuelle Le Moigne, Dimitri NM Papatsonis, Gilles Pernod, Franck Perrotin, Edith Peynaud-Debayle, Fabrice Pierre, Geneviève Plu Bureau, Tiphaine Raia-Barjat, Robbert JP Rijnders, Roger Rosario, Marc Ruivard, Jeannot Schmidt, Marieke Sueters, Thomas Vanassche, Marie-Noëlle Varlet, Alexandre J Vivanti, Matthieu Y van der Vlist, Lucet F van der Voet, Karlijn C Vollebregt, Johanna IP de Vries, Sabina de Weerd, Peter E Westerweel, Lia DE Wijnberger, Marije ten Wolde, Paula F Ypma, Catherine Zuily-Lamy, Joost J Zwart, Alexandra Benachi, Gaël Beucher, Holy Bezanahary, Karin de Boer, Marjon A. de Boer, Frantz Bousquet, Henk A. Bremer, Luc Bressollette, Aurélie Brossard, Cécile Chau, Brian Cleary, Fabienne Comte, Thomas Corsini, Anne Coustel, Barbara Debaveye, Raoul Desbrière, Cécile Duvillard, Astrid Eckman, Jeroen Eikenboom, Antoine Elias, Laura M. Faber, Emile Ferrari, Denis Gallot, Emilie Gauchotte, Ingrid Gaugler, Abby E. Geerlings, Audrey O'Gorman, Vincent Grobost, Pieter-Kees de Groot, David P. van der Ham, Brenda Hermsen, Kim Kamphorst, Alan Karovitch, Gunilla Kleiverda, Aiste Kloster, Annemarieke Koops, Inneke Krabbendam, Marieke J.H.A. Kruip, Saskia Kuipers, Judith van Laar, Damien Laneelle, Suzanne Lima, Peter MacMahon, Laurent Mandelbrot, Claudia A. van Meir, Caroline Menez, Leonard P. Morssink, Nathalie Moulin, Eve Mousty, Matthieu Muller, Lucy Murphy, Kathelijne Peerlinck, Alma O'Reilly, Maartje de Reus, Magali Hilmi Le Roux, Kevin Ryan, Bettina Samren, Daniela Schippers, Nico Schuitemaker, Chloé Schweizer, Hanneke van der Straaten, Cécile Tromeur, Kristine Vanheule, Tamara Verhagen, Jantien Visser, Michael Watts, Wim J. van Wijngaarden, Mallory Woiski, Maartje Zelis, Obstetrics and gynaecology, AMS - Rehabilitation & Development, Amsterdam Reproduction & Development (AR&D), VU University medical center, Cardiology, ACS - Heart failure & arrhythmias, Graduate School, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, ARD - Amsterdam Reproduction and Development, ACS - Amsterdam Cardiovascular Sciences, CCA -Cancer Center Amsterdam, Obstetrics and Gynaecology, APH - Quality of Care, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Digital Health, ACS - Atherosclerosis & ischemic syndromes, RS: CAPHRI - R5 - Optimising Patient Care, MUMC+: KIO Kemta (9), Surgery, Public Health, Obstetrics & Gynecology, Hematology, and Epidemiology

Subjects
Low-Molecular-Weight/adverse effects, Male, Heparin, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Postpartum Period, Postpartum Hemorrhage, Heparin, Low-Molecular-Weight/adverse effects, Obstetrics and Gynecology, Anticoagulants, General Medicine, Venous Thromboembolism, Heparin, Low-Molecular-Weight, Pregnancy, Humans, Pulmonary Embolism/prevention & control, Female, Anticoagulants/adverse effects, Pulmonary Embolism, Venous Thromboembolism/drug therapy
Abstract

Item does not contain fulltext BACKGROUND: Pregnancy-related venous thromboembolism is a leading cause of maternal morbidity and mortality, and thromboprophylaxis is indicated in pregnant and post-partum women with a history of venous thromboembolism. The optimal dose of low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy and the post-partum period is uncertain. METHODS: In this open-label, randomised, controlled trial (Highlow), pregnant women with a history of venous thromboembolism were recruited from 70 hospitals in nine countries (the Netherlands, France, Ireland, Belgium, Norway, Denmark, Canada, the USA, and Russia). Women were eligible if they were aged 18 years or older with a history of objectively confirmed venous thromboembolism, and with a gestational age of 14 weeks or less. Eligible women were randomly assigned (1:1), before 14 weeks of gestational age, using a web-based system and permuted block randomisation (block size of six), stratified by centre, to either weight-adjusted intermediate-dose or fixed low-dose low-molecular-weight heparin subcutaneously once daily until 6 weeks post partum. The primary efficacy outcome was objectively confirmed venous thromboembolism (ie, deep-vein thrombosis, pulmonary embolism, or unusual site venous thrombosis), as determined by an independent central adjudication committee, in the intention-to-treat (ITT) population (ie, all women randomly assigned to treatment). The primary safety outcome was major bleeding which included antepartum, early post-partum (within 24 h after delivery), and late post-partum major bleeding (24 h or longer after delivery until 6 weeks post partum), assessed in all women who received at least one dose of assigned treatment and had a known end of treatment date. This study is registered with ClinicalTrials.gov, NCT01828697, and is now complete. FINDINGS: Between April 24, 2013, and Oct 31, 2020, 1339 pregnant women were screened for eligibility, of whom 1110 were randomly assigned to weight-adjusted intermediate-dose (n=555) or fixed low-dose (n=555) low-molecular-weight heparin (ITT population). Venous thromboembolism occurred in 11 (2%) of 555 women in the weight-adjusted intermediate-dose group and in 16 (3%) of 555 in the fixed low-dose group (relative risk [RR] 0·69 [95% CI 0·32-1·47]; p=0·33). Venous thromboembolism occurred antepartum in five (1%) women in the intermediate-dose group and in five (1%) women in the low-dose group, and post partum in six (1%) women and 11 (2%) women. On-treatment major bleeding in the safety population (N=1045) occurred in 23 (4%) of 520 women in the intermediate-dose group and in 20 (4%) of 525 in the low-dose group (RR 1·16 [95% CI 0·65-2·09]). INTERPRETATION: In women with a history of venous thromboembolism, weight-adjusted intermediate-dose low-molecular-weight heparin during the combined antepartum and post-partum periods was not associated with a lower risk of recurrence than fixed low-dose low-molecular-weight heparin. These results indicate that low-dose low-molecular-weight heparin for thromboprophylaxis during pregnancy is the appropriate dose for the prevention of pregnancy-related recurrent venous thromboembolism. FUNDING: French Ministry of Health, Health Research Board Ireland, GSK/Aspen, and Pfizer.

Published
2022

21. Non-invasive early exclusion of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: The InShape II study

Author

Boon, G.J.A.M., Ende-Verhaar, Y.M., Bavalia, R., Bouazzaoui, L.H. el, Delcroix, M., Dzikowska-Diduch, O., Huisman, M.V., Kurnicka, K., Mairuhu, A.T.A., Middeldorp, S., Pruszczyk, P., Ruigrok, D., Verhamme, P., Vliegen, H.W., Noordegraaf, A.V., Vriend, J.W.J., Klok, F.A., InShape II Study Grp, Graduate School, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, ARD - Amsterdam Reproduction and Development, Epidemiology and Data Science, APH - Aging & Later Life, APH - Societal Participation & Health, and Pulmonary medicine

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Delayed Diagnosis, Overdiagnosis, medicine.drug_class, Hypertension, Pulmonary, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Internal medicine, medicine, Natriuretic peptide, Humans, Prospective Studies, business.industry, Incidence (epidemiology), Non invasive, medicine.disease, Pulmonary hypertension, Pulmonary embolism, Pre- and post-test probability, Chronic Disease, Cardiology, Chronic thromboembolic pulmonary hypertension, business, Pulmonary Embolism
Abstract

BackgroundThe current diagnostic delay of chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism (PE) is unacceptably long, causing loss of quality-adjusted life years and excess mortality. Validated screening strategies for early CTEPH diagnosis are lacking. Echocardiographic screening among all PE survivors is associated with overdiagnosis and cost-ineffectiveness. We aimed to validate a simple screening strategy for excluding CTEPH early after acute PE, limiting the number of performed echocardiograms.MethodsIn this prospective, international, multicentre management study, consecutive patients were managed according to a screening algorithm starting 3 months after acute PE to determine whether echocardiographic evaluation of pulmonary hypertension (PH) was indicated. If the ‘CTEPH prediction score’ indicated high pretest probability or matching symptoms were present, the ‘CTEPH rule-out criteria’ were applied, consisting of ECG reading and N-terminalpro-brain natriuretic peptide. Only if these results could not rule out possible PH, the patients were referred for echocardiography.Results424 patients were included. Based on the algorithm, CTEPH was considered absent in 343 (81%) patients, leaving 81 patients (19%) referred for echocardiography. During 2-year follow-up, one patient in whom echocardiography was deemed unnecessary by the algorithm was diagnosed with CTEPH, reflecting an algorithm failure rate of 0.29% (95% CI 0% to 1.6%). Overall CTEPH incidence was 3.1% (13/424), of whom 10 patients were diagnosed within 4 months after the PE presentation.ConclusionsThe InShape II algorithm accurately excluded CTEPH, without the need for echocardiography in the overall majority of patients. CTEPH was identified early after acute PE, resulting in a substantially shorter diagnostic delay than in current practice.

Published
2021

22. Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial: rational and protocol

Author

Lutgarde Thijs, Katarzyna Stolarz-Skrzypek, Gladys E. Maestre, Luk Buyse, Carina Mels, Zhenyu Zhang, Upright-Htm Investigators, Thomas Vanassche, Natasza Gilis-Malinowska, Advisors, Elisabeth S Muxfeldt, Marek Rajzer, Raymond Vanholder, Urinary Proteomics Centres, Peter Verhamme, Jesus D. Melgarejo, and Recruiting, Krzysztof Narkiewicz, Ruan Kruger, Fabio de Souza, Jana Brguljan-Hitij, Aletta E. Schutte, Jan A. Staessen, Yi-Wen Tsai, Tine W. Hansen, Dong-Mei Wei, Kalina Kawecka-Jaszcz, Gontse G. Mokwatsi, Hao-Min Cheng, Augustine N. Odili, Harald Mischak, Logistic Coordinating, Kei Asayama, Physiotherapy, Human Physiology and Anatomy, and Human Physiology and Sports Physiotherapy Research Group

Subjects
Proteomics, medicine.medical_specialty, hypertension, Urinary system, Diastole, Blood Pressure, Diabetic nephropathy, left ventricular function, Chronic kidney disease, Internal medicine, Diabetes mellitus, Medicine and Health Sciences, MANAGEMENT, Internal Medicine, home blood pressure telemonitoring, Humans, Medicine, Renal Insufficiency, Chronic, Aged, Randomized Controlled Trials as Topic, RISK, Science & Technology, OFFICE, business.industry, diabetic nephropathy, Type 2 Diabetes Mellitus, type-2 diabetes mellitus, KIDNEY-DISEASE, DIASTOLIC DYSFUNCTION, ASSOCIATION, General Medicine, Middle Aged, medicine.disease, SPIRONOLACTONE, Blood pressure, Peripheral Vascular Disease, Health Care Reform, Hypertension, Cardiovascular System & Cardiology, ANTIHYPERTENSIVE DRUGS, HEART-FAILURE, sense organs, Health care reform, Cardiology and Cardiovascular Medicine, business, Life Sciences & Biomedicine, Kidney disease
Abstract

BACKGROUND: Hypertension and diabetes cause chronic kidney disease (CKD) and diastolic left ventricular dysfunction (DVD) as forerunners of disability and death. Home blood pressure telemonitoring (HTM) and urinary peptidomic profiling (UPP) are technologies enabling prevention. METHODS: UPRIGHT-HTM (Urinary Proteomics Combined with Home Blood Pressure Telemonitoring for Health Care Reform [NCT04299529]) is an investigator-initiated 5-year clinical trial with patient-centred design, which will randomise 1148 patients to be recruited in Europe, sub-Saharan Africa and South America. During the whole study, HTM data will be collected and freely accessible for patients and caregivers. The UPP, measured at enrolment only, will be communicated early during follow-up to 50% of patients and their caregivers (intervention), but only at trial closure in 50% (control). The hypothesis is that early knowledge of the UPP risk profile will lead to more rigorous risk factor management and result in benefit. Eligible patients, aged 55-75 years old, are asymptomatic, but have ≥5 CKD- or DVD-related risk factors, preferably including hypertension, type-2 diabetes, or both. The primary endpoint is a composite of new-onset intermediate and hard cardiovascular and renal outcomes. Demonstrating that combining UPP with HTM is feasible in a multicultural context and defining the molecular signatures of early CKD and DVD are secondary endpoints. EXPECTED OUTCOMES: The expected outcome is that application of UPP on top of HTM will be superior to HTM alone in the prevention of CKD and DVD and associated complications and that UPP allows shifting emphasis from treating to preventing disease, thereby empowering patients. ispartof: BLOOD PRESSURE vol:30 issue:5 pages:269-281 ispartof: location:England status: published

Published
2021

23. Quantitative magnetic resonance imaging of the brachial plexus shows specific changes in nerve architecture in chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy and motor neuron disease

Author

Jeroen Hendrikse, H. Stephan Goedee, Marieke H J van Rosmalen, Fay-Lynn Asselman, Rosina Derks, Martijn Froeling, Camiel Verhamme, Alberto De Luca, W. Ludo van der Pol, Neurology, ANS - Neuroinfection & -inflammation, and EURO-NMD

Subjects
medicine.medical_specialty, multifocal motor neuropathy, Mismatch negativity, Chronic inflammatory demyelinating polyneuropathy, Gastroenterology, Polyneuropathies, 03 medical and health sciences, chronic inflammatory demyelinating polyneuropathy, 0302 clinical medicine, Internal medicine, Fractional anisotropy, medicine, Humans, magnetic resonance imaging, Brachial Plexus, 030212 general & internal medicine, Motor Neuron Disease, pathophysiology, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Motor neuron, medicine.disease, diffusion tensor imaging, Neuropathies, medicine.anatomical_structure, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Neurology, Original Article, Neurology (clinical), business, Brachial plexus, 030217 neurology & neurosurgery, Multifocal motor neuropathy, Diffusion MRI
Abstract

Background The immunological pathophysiologies of chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) differ considerably, but neither has been elucidated completely. Quantitative magnetic resonance imaging (MRI) techniques such as diffusion tensor imaging, T2 mapping, and fat fraction analysis may indicate in vivo pathophysiological changes in nerve architecture. Our study aimed to systematically study nerve architecture of the brachial plexus in patients with CIDP, MMN, motor neuron disease (MND) and healthy controls using these quantitative MRI techniques. Methods We enrolled patients with CIDP (n = 47), MMN (n = 29), MND (n = 40) and healthy controls (n = 10). All patients underwent MRI of the brachial plexus and we obtained diffusion parameters, T2 relaxation times and fat fraction using an automated processing pipeline. We compared these parameters between groups using a univariate general linear model. Results Fractional anisotropy was lower in patients with CIDP compared to healthy controls (p, With this study, we show that quantitative MRI techniques reveal differences in the brachial plexus between patients with CIDP, MMN, MND and healthy controls. CIDP is characterized by lower FA and higher RD than MMN, MND and healthy controls, whilst MMN is characterized by higher FA values than CIDP and MND. These differences between CIDP and MMN are the most remarkable and important finding as they emphasize important differences in the underlying pathophysiologies.

Published
2021

24. Comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with different covid-19 vaccines

Author

Li, X, Burn, E, Duarte-Salles, T, Yin, C, Reich, C, Delmestri, A, Verhamme, K, Rijnbeek, P, Suchard, MA, Li, K, Mosseveld, M, John, LH, Mayer, M-A, Ramirez-Anguita, J-M, Cohet, C, Strauss, V, Prieto-Alhambra, D, Medical Informatics, and Epidemiology

Subjects
Adult, Venous Thrombosis, COVID-19 Vaccines, Adolescent, Ad26COVS1, COVID-19, Thrombosis, General Medicine, Thrombocytopenia, Cohort Studies, SDG 3 - Good Health and Well-being, Thromboembolism, Humans, BNT162 Vaccine
Abstract

Objective To quantify the comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with use of adenovirus based covid-19 vaccines versus mRNA based covid-19 vaccines. Design International network cohort study. Setting Routinely collected health data from contributing datasets in France, Germany, the Netherlands, Spain, the UK, and the US. Participants Adults (age ≥18 years) registered at any contributing database and who received at least one dose of a covid-19 vaccine (ChAdOx1-S (Oxford-AstraZeneca), BNT162b2 (Pfizer-BioNTech), mRNA-1273 (Moderna), or Ad26.COV2.S (Janssen/Johnson & Johnson)), from December 2020 to mid-2021. Main outcome measures Thrombosis with thrombocytopenia syndrome or venous or arterial thromboembolic events within the 28 days after covid-19 vaccination. Incidence rate ratios were estimated after propensity scores matching and were calibrated using negative control outcomes. Estimates specific to the database were pooled by use of random effects meta-analyses. Results Overall, 1 332 719 of 3 829 822 first dose ChAdOx1-S recipients were matched to 2 124 339 of 2 149 679 BNT162b2 recipients from Germany and the UK. Additionally, 762 517 of 772 678 people receiving Ad26.COV2.S were matched to 2 851 976 of 7 606 693 receiving BNT162b2 in Germany, Spain, and the US. All 628 164 Ad26.COV2.S recipients from the US were matched to 2 230 157 of 3 923 371 mRNA-1273 recipients. A total of 862 thrombocytopenia events were observed in the matched first dose ChAdOx1-S recipients from Germany and the UK, and 520 events after a first dose of BNT162b2. Comparing ChAdOx1-S with a first dose of BNT162b2 revealed an increased risk of thrombocytopenia (pooled calibrated incidence rate ratio 1.33 (95% confidence interval 1.18 to 1.50) and calibrated incidence rate difference of 1.18 (0.57 to 1.8) per 1000 person years). Additionally, a pooled calibrated incidence rate ratio of 2.26 (0.93 to 5.52) for venous thrombosis with thrombocytopenia syndrome was seen with Ad26.COV2.S compared with BNT162b2. Conclusions In this multinational study, a pooled 30% increased risk of thrombocytopenia after a first dose of the ChAdOx1-S vaccine was observed, as was a trend towards an increased risk of venous thrombosis with thrombocytopenia syndrome after Ad26.COV2.S compared with BNT162b2. Although rare, the observed risks after adenovirus based vaccines should be considered when planning further immunisation campaigns and future vaccine development.

Published
2022

25. Lipoprotein profiles of fat distribution and its association with insulin sensitivity

Author

Dongmei Wei, Vannina González Marrachelli, Jesus D. Melgarejo, Chia-Te Liao, Stefan Janssens, Peter Verhamme, Thomas Vanassche, Lucas Van Aelst, Daniel Monleon, Josep Redón, and Zhen-Yu Zhang

Subjects
cardiovascular risk, Male, PARTICLE NUMBER, Lipoproteins, Endocrinology, Diabetes and Metabolism, LOW-DENSITY-LIPOPROTEIN, waist-to-hip ratio, ALL-CAUSE, CORONARY EVENTS, Endocrinology & Metabolism, insulin resistance, Humans, Obesity, INCREASED RISK, Science & Technology, lipoprotein, Cholesterol, HDL, Cholesterol, LDL, SUBCLASS PROFILE, Middle Aged, BODY-MASS INDEX, SIZE, Cholesterol, CARDIOVASCULAR-DISEASE, ABDOMINAL OBESITY, Female, Insulin Resistance, Life Sciences & Biomedicine
Abstract

BackgroundFat deposition is associated with adverse outcomes. Waist-to-hip (WHR) ratio is a simple feasible index to assess fat distribution. Lipoprotein particle composition in relation to WHR and to what extent their association is mediated by insulin sensitivity are less investigated.MethodsIn 504 randomly recruited Flemish (mean age: 48.9 years; women: 51.6%), we analyzed the lipoprotein particle constitutions using nuclear magnetic resonance spectroscopy. WHR obesity described a WHR of ≥ 0.85 for women or 0.9 for men. Insulin sensitivity was evaluated by the homeostasis model assessment-estimated insulin resistance (HOMA-IR). SCORE-2 risk algorithm was applied to estimate 10-year cardiovascular risk. Statistical methods included multivariable-adjusted linear regression analysis, logistic regression analysis, and mediation analysis.ResultsThe prevalence of WHR obesity was 54.6%, approximately 3 times of BMI-determined obesity (19.1%). Individuals with WHR obesity had significantly higher metabolic complications, such as hypertension (57.1%), dyslipidemia (61.8%), and insulin resistance (14.2%). WHR and WHR obesity were positively associated with total very-low-density lipoprotein (VLDL) particle concentration, remnant cholesterol, and triglycerides, but were negatively associated with VLDL particle size (P ≤ 0.027), independent of body mass index and other covariates. WHR was inversely associated with total high-density lipoprotein (HDL) particle concentration, whereas WHR obesity was inversely associated with HDL cholesterol (P ≤ 0.039). Neither WHR nor WHR obesity was associated with the concentration of total low-density lipoprotein (LDL) particles, LDL particle size, and LDL cholesterol (P ≥ 0.089). In the mediation analysis, insulin sensitivity significantly mediated the effect of WHR on total VLDL particle concentration (mediation percentage: 37.0%), remnant cholesterol (47.7%), and HDL cholesterol (41.1%). Individuals with WHR obesity were at increased cardiovascular risk, regardless of LDL cholesterol (P ≤0.028). In WHR obesity, higher total VLDL particle concent36ration and remnant cholesterol, and lower HDL cholesterol were associated with an increased cardiovascular risk (P≤ 0.002).ConclusionsUpper-body fat deposition was independently associated with an unfavorable lipoprotein profile, and insulin sensitivity significantly mediated this association. LDL cholesterol might underestimate lipid abnormality for people with upper-body obesity and lowering VLDL particles and remnant cholesterol might potentially reduce the residual cardiovascular risk.

Published
2022

26. TreatmentPatterns: An R package to facilitate the standardized development and analysis of treatment patterns across disease domains

Author

Markus, Aniek F., Verhamme, Katia M.C., Kors, Jan A., Rijnbeek, Peter R., and Medical Informatics

Subjects
Treatment pathways, Observational data, Databases, Factual, Diabetes Mellitus, Type 2, SDG 3 - Good Health and Well-being, R package, Medicine and Health Sciences, Humans, Health Informatics, Current treatment practices, Software, Computer Science Applications
Abstract

Background and objectives:There is an increasing interest to use real-world data to illustrate how patients with specific medical conditions are treated in real life. Insight in the current treatment practices helps to improve and tailor patient care, but is often held back by a lack of data interoperability and a high-level of required resources. We aimed to provide an easy tool that overcomes these barriers to support the standardized development and analysis of treatment patterns for a wide variety of medical conditions. Methods:We formally defined the process of constructing treatment pathways and implemented this in an open-source R package TreatmentPatterns (https://github.com/mi-erasmusmc/TreatmentPatterns) to enable a reproducible and timely analysis of treatment patterns. Results:The developed package supports the analysis of treatment patterns of a study population of interest. We demonstrate the functionality of the package by analyzing the treatment patterns of three common chronic diseases (type II diabetes mellitus, hypertension, and depression) in the Dutch Inte- grated Primary Care Information (IPCI) database. Conclusion:TreatmentPatterns is a tool to make the analysis of treatment patterns more accessible, more standardized, and more interpretation friendly. We hope it thereby contributes to the accumulation of knowledge on real-world treatment patterns across disease domains. We encourage researchers to further adjust and add custom analysis to the R package based on their research needs.

Published
2022

27. Development and external validation of prediction models for adverse health outcomes in rheumatoid arthritis: A multinational real-world cohort analysis

Author

Cynthia Yang, Ross D. Williams, Joel N. Swerdel, João Rafael Almeida, Emily S. Brouwer, Edward Burn, Loreto Carmona, Katerina Chatzidionysiou, Talita Duarte-Salles, Walid Fakhouri, Antje Hottgenroth, Meghna Jani, Raivo Kolde, Jan A. Kors, Lembe Kullamaa, Jennifer Lane, Karine Marinier, Alexander Michel, Henry Morgan Stewart, Albert Prats-Uribe, Sulev Reisberg, Anthony G. Sena, Carmen O. Torre, Katia Verhamme, David Vizcaya, James Weaver, Patrick Ryan, Daniel Prieto-Alhambra, Peter R. Rijnbeek, and Medical Informatics

Subjects
Infections, Prediction models, Arthritis, Rheumatoid, Cohort Studies, Stroke, Cardiovascular diseases, Methotrexate, Anesthesiology and Pain Medicine, Rheumatology, SDG 3 - Good Health and Well-being, Antirheumatic Agents, Outcome Assessment, Health Care, Humans, Rheumatoid arthritis
Abstract

Background:Identification of rheumatoid arthritis (RA) patients at high risk of adverse health outcomes remains a major challenge. We aimed to develop and validate prediction models for a variety of adverse health outcomes in RA patients initiating first-line methotrexate (MTX) monotherapy. Methods:Data from 15 claims and electronic health record databases across 9 countries were used. Models were developed and internally validated on Optum®De-identified Clinformatics®Data Mart Database using L1- regularized logistic regression to estimate the risk of adverse health outcomes within 3 months (leukopenia, pancytopenia, infection), 2 years (myocardial infarction (MI) and stroke), and 5 years (cancers [colorectal, breast, uterine] after treatment initiation. Candidate predictors included demographic variables and past medical history. Models were externally validated on all other databases. Performance was assessed using the area under the receiver operator characteristic curve (AUC) and calibration plots. Findings:Models were developed and internally validated on 21,547 RA patients and externally validated on 131,928 RA patients. Models for serious infection (AUC: internal 0.74, external ranging from 0.62 to 0.83), MI (AUC: internal 0.76, external ranging from 0.56 to 0.82), and stroke (AUC: internal 0.77, external ranging from 0.63 to 0.95), showed good discrimination and adequate calibration. Models for the other outcomes showed modest internal discrimination (AUC Interpretation:We developed and validated prediction models for a variety of adverse health outcomes in RA patients initiating first-line MTX monotherapy. Final models for serious infection, MI, and stroke demonstrated good performance across multiple databases and can be studied for clinical use. Funding:This activity under the European Health Data&Evidence Network (EHDEN) has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 806968. This Joint Under- taking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

Published
2022

28. Fully digital workflow for producing implant-supported overdentures milled from PMMA on titanium bars using PEEK as the female part/sliding mechanism in three clinical visits: A case report

Author

Thomas, Van de Winkel, Frans, Delfos, Olleke, van der Heijden, Luc, Verhamme, and Gert, Meijer

Subjects
Dental Implants, Titanium, Benzophenones, Polymers, Humans, Jaw, Edentulous, Polymethyl Methacrylate, Female, Dental Prosthesis, Implant-Supported, Ketones, Middle Aged, Denture, Overlay, Workflow
Abstract

To prove that a fully digital workflow, even for registration of the maxillomandibular relationship, can be employed to produce implant-supported overdentures and demonstrate that CAD/CAM techniques can be used to mill permanent implant-supported overdentures from polymethylmethacrylate discs, using polyetheretherketone as the sliding mechanism.An edentulous 64-year-old woman received six implants in the maxilla after a bone augmentation procedure and two implants in the mandible. Five months after implant placement, intraoral scans were taken of her original complete dentures, of each prosthesis individually, and of both in centric relation, and another was taken of both edentulous arches, including the scan bodies. Along with facial photographs, sufficient digital data were gathered to design and mill titanium bars, polyetheretherketone female parts and a trial implant-supported overdenture. The tooth positions and colour were discussed with the patient using Smile Design software (3Shape, Copenhagen, Denmark). In the second session, the bars and trial implant-supported overdenture were inserted and checked, and in the third session, the final implant-supported overdentures were inserted.The milled titanium bar exhibited a passive fit, as did the implant-supported overdentures. After 1 year, no prosthetic complications were noted; the measured pockets were all less than 4 mm in depth. On a visual analogue scale from 0 to 10, with 0 being the worst and 10 being the best, the patient awarded a score of 9 for her satisfaction with the implant-supported overdentures.A fully digital workflow enables the production of robust wear-resistant implant-supported overdentures milled from polymethylmethacrylate, using polyetheretherketone female parts as the sliding mechanism, in just three clinical sessions.

Published
2022

29. Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19

Author

Caroline P. Martens, Pierre Van Mol, Joost Wauters, Els Wauters, Tanja Gangnus, Bernard Noppen, Hanne Callewaert, Jean H.M. Feyen, Laurens Liesenborghs, Elisabeth Heylen, Sander Jansen, Leydi Carolina Velásquez Pereira, Sirima Kraisin, Ipek Guler, Matthias M. Engelen, Anna Ockerman, Anke Van Herck, Robin Vos, Christophe Vandenbriele, Philippe Meersseman, Greet Hermans, Alexander Wilmer, Kimberly Martinod, Bjoern B. Burckhardt, Marc Vanhove, Marc Jacquemin, Peter Verhamme, Johan Neyts, and Thomas Vanassche

Subjects
Kallikrein-Kinin System, ACE2, COAGULATION, Kinins, Research & Experimental Medicine, Bradykinin, General Biochemistry, Genetics and Molecular Biology, ACTIVATION, Medicine, General & Internal, General & Internal Medicine, Humans, Peroxidase, Science & Technology, Thromboinflammation, SARS-CoV-2, COVID-19, General Medicine, Extracellular traps, IN-VITRO, DNA, Medicine, Research & Experimental, Kallikreins, Angiotensin-Converting Enzyme 2, Bronchoalveolar Lavage Fluid, Tissue Kallikreins, Life Sciences & Biomedicine
Abstract

Summary Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein-kinin system. Its dysregulation may lead to increased vascular permeability and release of inflammatory chemokines. Interactions between the kallikrein-kinin and the coagulation system might further contribute to thromboembolic complications in COVID-19. Methods In this observational study, we measured plasma and tissue kallikrein hydrolytic activity, levels of kinin peptides, and myeloperoxidase (MPO)-DNA complexes as a biomarker for neutrophil extracellular traps (NETs), in bronchoalveolar lavage (BAL) fluid from patients with and without COVID-19. Findings In BAL fluid from patients with severe COVID-19 (n = 21, of which 19 were mechanically ventilated), we observed higher tissue kallikrein activity (18·2 pM [1·2-1535·0], median [range], n = 9 vs 3·8 [0·0-22·0], n = 11; p = 0·030), higher levels of the kinin peptide bradykinin-(1-5) (89·6 [0·0-2425·0], n = 21 vs 0·0 [0·0-374·0], n = 19, p = 0·001), and higher levels of MPO-DNA complexes (699·0 ng/mL [66·0-142621·0], n = 21 vs 70·5 [9·9-960·0], n = 19, p < 0·001) compared to patients without COVID-19. Interpretation Our observations support the hypothesis that dysregulation of the kallikrein-kinin system might occur in mechanically ventilated patients with severe pulmonary disease, which might help to explain the clinical presentation of patients with severe COVID-19 developing pulmonary oedema and thromboembolic complications. Therefore, targeting the kallikrein-kinin system should be further explored as a potential treatment option for patients with severe COVID-19. Funding Research Foundation-Flanders (G0G4720N, 1843418N), KU Leuven COVID research fund. Summary Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein-kinin system. Its dysregulation may lead to increased vascular permeability and release of inflammatory chemokines. Interactions between the kallikrein-kinin and the coagulation system might further contribute to thromboembolic complications in COVID-19. Methods In this observational study, we measured plasma and tissue kallikrein hydrolytic activity, levels of kinin peptides, and myeloperoxidase (MPO)-DNA complexes as a biomarker for neutrophil extracellular traps (NETs), in bronchoalveolar lavage (BAL) fluid from patients with and without COVID-19. Findings In BAL fluid from patients with severe COVID-19 (n = 21, of which 19 were mechanically ventilated), we observed higher tissue kallikrein activity (18·2 pM [1·2-1535·0], median [range], n = 9 vs 3·8 [0·0-22·0], n = 11; p = 0·030), higher levels of the kinin peptide bradykinin-(1-5) (89·6 [0·0-2425·0], n = 21 vs 0·0 [0·0-374·0], n = 19, p = 0·001), and higher levels of MPO-DNA complexes (699·0 ng/mL [66·0-142621·0], n = 21 vs 70·5 [9·9-960·0], n = 19, p < 0·001) compared to patients without COVID-19. Interpretation Our observations support the hypothesis that dysregulation of the kallikrein-kinin system might occur in mechanically ventilated patients with severe pulmonary disease, which might help to explain the clinical presentation of patients with severe COVID-19 developing pulmonary oedema and thromboembolic complications. Therefore, targeting the kallikrein-kinin system should be further explored as a potential treatment option for patients with severe COVID-19. Funding Research Foundation-Flanders (G0G4720N, 1843418N), KU Leuven COVID research fund. ispartof: Ebiomedicine vol:83 pages:104195- ispartof: location:Netherlands status: published

Published
2022

30. Early high antibody titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma

Author

Devos, Timothy, Van Thillo, Quentin, Compernolle, Veerle, Najdovski, Tomé, Romano, Marta, Dauby, Nicolas, Jadot, Laurent, Leys, Mathias, Maillart, Evelyne, Loof, Sarah, Seyler, Lucie, Moonen, Martial, Moutschen, Michel, Van Regenmortel, Niels, Ariën, Kevin K., Barbezange, Cyril, Betrains, Albrecht, Garigliany, Mutien, Engelen, Matthias M., Gyselinck, Iwein, Maes, Piet, Schauwvlieghe, Alexander, Liesenborghs, Laurens, Belmans, Ann, Verhamme, Peter, Meyfroidt, Geert, DAWn-plasma investigators, [ missing ], Gyselinck, Iwein/0000-0002-4068-7228, Barbezange, Cyril/0000-0001-9606-2983, Dauby, Nicolas/0000-0002-7697-6849, Liesenborghs, Laurens/0000-0001-5616-8548, Devos , Timothy, Van Thillo, Quentin, Compernolle, Veerle, Najdovski, Tome, Romano, Marta, Dauby, Nicolas, Jadot, Laurent, Leys, Mathias, Maillart, Evelyne, Loof, Sarah, Seyler , Lucie, Moonen , Martial, Moutschen, Michel, Van Regenmortel, Niels, Arien, Kevin K., Barbezange, Cyril, Betrains, Albrecht, Garigliany, Mutien, Engelen, Matthias M., Gyselinck, Iwein, Maes, Piet, Schauwvlieghe, Alexander, Liesenborghs, Laurens, Belmans, Ann, Verhamme, Peter, Meyfroidt, Geert, DAWn-plasma investigators, Faculty of Sciences and Bioengineering Sciences, Internal Medicine, Internal Medicine Specializations, and Clinical sciences

Subjects
Pulmonary and Respiratory Medicine, Adult, medicine.medical_specialty, Convalescent plasma, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Antibodies, Viral, Antibodies, Viral/blood, Internal medicine, medicine, Medicine and Health Sciences, Humans, Prospective Studies, Antibodies, Neutralizing/blood, Adverse effect, Mechanical ventilation, biology, business.industry, Immunization, Passive, COVID-19, Odds ratio, Sciences bio-médicales et agricoles, Antibodies, Neutralizing, Clinical trial, Hospitalization, Treatment Outcome, DAWn-plasma investigators, biology.protein, Human medicine, Antibody, business, COVID-19/therapy
Abstract

Background Several randomised clinical trials have studied convalescent plasma (CP) for COVID-19 using different protocols, with different SARS-CoV-2 neutralising-antibody-titres, at different time-points and severities of illness. Methods In the prospective multicentre DAWN-plasma trial, adult patients hospitalised with COVID-19 were randomised to 4 units of open-label convalescent plasma combined with standard of care (intervention group) or standard of care alone (control group). Plasma from donors with neutralising-antibody-titres (NT50) ≥1/320 was the product of choice for the study. Results Between May 2nd, 2020 and January 26th, 2021, 320 patients were randomised to convalescent plasma and 163 patients to the control group according to a 2:1 allocation scheme. A median volume of 884 mL convalescent plasma (IQR 806–906 mL) was administered, and 80.68% of the units came from donors with neutralising-antibody-titres (NT50) ≥1/320. Median time from onset of symptoms to randomisation was 7 days. The proportion of patients alive and free of mechanical ventilation on Day 15 was not different between both groups (convalescent plasma: 83.74% (n=267) versus control: 84.05% (n=137) – Odds ratio 0.99 (0.59–1.66) – p-value=0.9772). The intervention did not change the natural course of antibody titres. The number of serious or severe adverse events was similar in both study arms, and transfusion-related side effects were reported in 19/320 patients in the intervention group (5.94%). Conclusions Transfusion of 4 units of convalescent plasma with high neutralising-antibody-titres early in hospitalised COVID-19 patients did not result in a significant improvement of the clinical status, or a reduced mortality., info:eu-repo/semantics/published

Published
2022

31. Association of colorectal cancer with genetic and epigenetic variation in PEAR1-A population-based cohort study

Author

Yang, Wen-Yi, Izzi, Benedetta, Bress, Adam P., Thijs, Lutgarde, Citterio, Lorena, Wei, Fang-Fei, Salvi, Erika, Delli Carpini, Simona, Manunta, Paolo, Cusi, Daniele, Hoylaerts, Marc F., Luttun, Aernout, Verhamme, Peter, Hardikar, Sheetal, NAWROT, Tim, Staessen, Jan A., Zhang , Zhen-Yu, Mischak, Harald, Citterio, Lorena/0000-0001-6455-2291, Hoylaerts, Marc/0000-0002-6474-3933, Zhenyu/0000-0002-3785-7417, Cusi, Daniele/0000-0002-1006-7597, Yang, Wen-Yi, Izzi, Benedetta, Bress, Adam P, Thijs, Lutgarde, Citterio, Lorena, Wei, Fang-Fei, Salvi, Erika, Delli Carpini, Simona, Manunta, Paolo, Cusi, Daniele, Hoylaerts, Marc F, Luttun, Aernout, Verhamme, Peter, Hardikar, Sheetal, Nawrot, Tim S, Staessen, Jan A, and Zhang, Zhen-Yu

Subjects
Adult, Cohort Studies, Male, Multidisciplinary, Humans, Female, Genetic Predisposition to Disease, Receptors, Cell Surface, DNA Methylation, Colorectal Neoplasms, Epigenesis, Genetic
Abstract

Platelet Endothelial Aggregation Receptor 1 (PEAR1) modulates angiogenesis and platelet contact-induced activation, which play a role in the pathogenesis of colorectal cancer. We therefore tested the association of incident colorectal cancer and genetic and epigenetic variability in PEAR1 among 2532 randomly recruited participants enrolled in the family-based Flemish Study on Environment, Genes and Health Outcomes (51.2% women; mean age 44.8 years). All underwent genotyping of rs12566888 located in intron 1 of the PEAR1 gene; in 926 participants, methylation at 16 CpG sites in the PEAR1 promoter was also assessed. Over 18.1 years (median), 49 colorectal cancers occurred, all in different pedigrees. While accounting for clustering of risk factors within families and adjusting for sex, age, body mass index, the total-to-HDL cholesterol ratio, serum creatinine, plasma glucose, smoking and drinking, use of antiplatelet and nonsteroidal anti-inflammatory drug, the hazard ratio of colorectal cancer contrasting minor-allele (T) carriers vs. major-allele (GG) homozygotes was 2.17 (95% confidence interval, 1.18-3.99; P = 0.013). Bootstrapped analyses, from which we randomly excluded from two to nine cancer cases, provided confirmatory results. In participants with methylation data, we applied partial least square discriminant analysis (PLS-DA) and identified two methylation sites associated with higher colorectal cancer risk and two with lower risk. In-silico analysis suggested that methylation of the PEAR1 promoter at these four sites might affect binding of transcription factors p53, PAX5, and E2F-1, thereby modulating gene expression. In conclusion, our findings suggest that genetic and epigenetic variation in PEAR1 modulates the risk of colorectal cancer in white Flemish. To what extent, environmental factors as exemplified by our methylation data, interact with genetic predisposition and modulate penetrance of colorectal cancer risk is unknown. The European Union (HEALTH-F7-305507 HOMAGE), the European Research Council (Advanced Researcher Grant 2011-294713-EPLORE and Proof-of-Concept Grant 713601-uPROPHET), the European Research Area Net for Cardiovascular Diseases (JTC2017-046-PROACT), and the Research Foundation Flanders, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13, G.0A65.14N, 1508715N, and 12M2715N) supported FLEMENGHO; grants 1508715N and 12M2715N supported the epigenetic analyses. The data for external replication analyses in the current publication were obtained from the dbGaP web site, under phs001078.v1.p1 (https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001078.v1.p1). Funding for Genetics & Epidemiology of Colorectal Cancer Consortium (GECCO), PHS, and DALS was provided by the National Institutes of Health of the United States of America (NIH, U01 CA137088, R01 CA059045, R01 CA042182, R01 CA137178, P50 CA127003, and R01 CA48998). The study also receives funding from Science and Technology Commission of Shanghai Municipality, Shanghai, China (21TS1400300 and Shanghai Pujiang Program-20PJ1412700). The funding sources had no role in study design, data extraction, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had responsibility for the decision to submit for publication.The authors gratefully acknowledge the approval of Drs. Ulrike Peters and Martha Slattery for the access to the PHS and DALS data and the clerical assistance of Renilde Wolfs.

Published
2022

32. Consensus validation of a screening tool for cardiovascular pharmacotherapy in geriatric patients: the RASP_CARDIO list (Rationalization of Home Medication by an Adjusted STOPP list in Older Patients)

Author

Hannah De Schutter, Julie Hias, Laura Hellemans, Karolien Walgraeve, Jos Tournoy, Peter Verhamme, Peter Sinnaeve, Rik Willems, Walter Droogné, Christophe Vandenbriele, Lucas Van Aelst, Thomas Vanassche, and Lorenz Van der Linden

Subjects
Rationalization, Consensus, Humans, Inappropriate Prescribing, Cardiovascular Agents, Potentially Inappropriate Medication List, Aged
Abstract

Cardiovascular agents commonly used in geriatric patients, are linked to potentially avoidable harm and might hence be a suitable substrate for medication review practices. Therefore, we sought to update and validate the content of the cardiovascular segment of the previously published Rationalization of Home Medication by an Adjusted STOPP list in Older Patients (RASP) List.A three-step study was conducted by the pharmacy department in collaboration with the geriatric medicine and cardiology department at the University Hospitals Leuven, Belgium. First, the cardiovascular segment of the RASP list version 2014 was updated taking into account published research, other screening tools and the input of end-users. Secondly, this draft was reviewed during three panel discussions with five expert cardiologists and three clinical pharmacists, all of whom had relevant expertise in geriatric pharmacotherapy. Thirdly, the content was validated using a modified Delphi Technique by a panel of European hospital pharmacists, cardiologists, geriatricians and an internal medicine physician.After the first and second step, the RASP_CARDIO list comprised 94 statements. Consensus (≥ 80% agreement) of all statements and one new statement about gliflozins in heart failure was achieved by a panel of seventeen experts across four European countries after two validation rounds. The final construct comprised a list of 95 statements related to potentially inappropriate prescribing of cardiovascular agents.The RASP_CARDIO list is an updated and validated explicit screening tool to optimize cardiovascular pharmacotherapy in geriatric patients.

Published
2022

33. Rivaroxaban 2.5 mg Twice Daily Plus Aspirin Reduces Venous Thromboembolism in Patients With Chronic Atherosclerosis

Author

Nana Pogosova, Jacqueline Bosch, Deepak L. Bhatt, Keith A.A. Fox, Stuart J. Connolly, Marco Alings, Peter Verhamme, Eva Muehlhofer, Olga Shestakovska, Salim Yusuf, and John W. Eikelboom

Subjects
Peripheral Arterial Disease, Aspirin, Rivaroxaban, Physiology (medical), Humans, Drug Therapy, Combination, Venous Thromboembolism, Cardiology and Cardiovascular Medicine, Atherosclerosis, Platelet Aggregation Inhibitors, Factor Xa Inhibitors
Published
2022

34. Reduced-Dose Intravenous Thrombolysis for Acute Intermediate–High-risk Pulmonary Embolism: Rationale and Design of the Pulmonary Embolism International THrOmbolysis (PEITHO)-3 trial

Author

Marc Philip Righini, Klaus Empen, Stavros Konstantinides, Kerstin de Wit, Antoniu Petris, Andreas Zirlik, Harald Binder, David Jiménez, Peter Verhamme, Piotr Pruszczyk, Philippe Girard, Mareike Lankeit, Walter Ageno, Melanie Ferreira, Eric Vicaut, Stefano Barco, Sebastian Schellong, Olivier Sanchez, Nicolas Meneveau, Daniel Duerschmied, Menno V. Huisman, Guy Meyer, Gilles Chatellier, Sandrine Katsahian, Branislav Stefanovic, Stephan Rosenkranz, Matija Kozak, Anais Charles-Nelson, University of Zurich, and Konstantinides, Stavros V

Subjects
medicine.medical_specialty, pulmonary embolism, Ventricular Dysfunction, Right, medicine.medical_treatment, 2720 Hematology, Hemodynamics, Hemorrhage, 610 Medicine & health, 030204 cardiovascular system & hematology, intermediate-high-risk, prognosis, randomized trial, reduced-dose thrombolysis, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Internal medicine, medicine, Humans, Thrombolytic Therapy, Decompensation, Stroke, Heparin, business.industry, 10031 Clinic for Angiology, Hematology, Thrombolysis, medicine.disease, 3. Good health, Pulmonary embolism, Regimen, Treatment Outcome, Blood pressure, 030228 respiratory system, Tissue Plasminogen Activator, Heart failure, Acute Disease, Cardiology, business
Abstract

Intermediate-high-risk pulmonary embolism (PE) is characterized by right ventricular (RV) dysfunction and elevated circulating cardiac troponin levels despite apparent hemodynamic stability at presentation. In these patients, full-dose systemic thrombolysis reduced the risk of hemodynamic decompensation or death but increased the risk of life-threatening bleeding. Reduced-dose thrombolysis may be capable of improving safety while maintaining reperfusion efficacy. The Pulmonary Embolism International THrOmbolysis (PEITHO)-3 study (ClinicalTrials.gov Identifier: NCT04430569) is a randomized, placebo-controlled, double-blind, multicenter, multinational trial with long-term follow-up. We will compare the efficacy and safety of a reduced-dose alteplase regimen with standard heparin anticoagulation. Patients with intermediate-high-risk PE will also fulfill at least one clinical criterion of severity: systolic blood pressure ≤110 mm Hg, respiratory rate >20 breaths/min, or history of heart failure. The primary efficacy outcome is the composite of all-cause death, hemodynamic decompensation, or PE recurrence within 30 days of randomization. Key secondary outcomes, to be included in hierarchical analysis, are fatal or GUSTO severe or life-threatening bleeding; net clinical benefit (primary efficacy outcome plus severe or life-threatening bleeding); and all-cause death, all within 30 days. All outcomes will be adjudicated by an independent committee. Further outcomes include PE-related death, hemodynamic decompensation, or stroke within 30 days; dyspnea, functional limitation, or RV dysfunction at 6 months and 2 years; and utilization of health care resources within 30 days and 2 years. The study is planned to enroll 650 patients. The results are expected to have a major impact on risk-adjusted treatment of acute PE and inform guideline recommendations. ispartof: THROMBOSIS AND HAEMOSTASIS vol:122 issue:05 pages:857-866 ispartof: location:Germany status: published

Published
2022

35. Comparative clinical prognosis of massive and non-massive pulmonary embolism: A registry-based cohort study

Author

Marc Blondon, David Jimenez, Helia Robert‐Ebadi, Jorge Del Toro, Luciano Lopez‐Jimenez, Conxita Falga, Andris Skride, Llorenç Font, Fernando Javier Vazquez, Henri Bounameaux, Manuel Monreal, Paolo Prandoni, Benjamin Brenner, Dominique Farge‐Bancel, Raquel Barba, Pierpaolo Di Micco, Laurent Bertoletti, Sebastian Schellong, Inna Tzoran, Abilio Reis, Marijan Bosevski, Radovan Malý, Peter Verhamme, Joseph A Caprini, Hanh My Bui, MD Adarraga, M Agud, J Aibar, MA Aibar, J Alfonso, C Amado, JI Arcelus, C Baeza, A Ballaz, R Barba, C Barbagelata, M Barrón, B Barrón‐Andrés, A Blanco‐Molina, E Botella, AM Camon, J Castro, MA Caudevilla, P Cerdà, L Chasco, J Criado, C de Ancos, J de Miguel, P Demelo‐Rodríguez, JA Díaz‐Peromingo, J Díez‐Sierra, R Díaz‐Simón, IM Domínguez, M Encabo, JC Escribano, C Falgá, AI Farfán, C Fernández‐Capitán, JL Fernández‐Reyes, MA Fidalgo, K Flores, C Font, I Francisco, C Gabara, F Galeano‐Valle, MA García, F García‐Bragado, MM García‐Mullor, O Gavín‐Blanco, O Gavín‐Sebastián, A Gil‐Díaz, C Gómez‐Cuervo, J González‐Martínez, E Grau, L Guirado, J Gutiérrez, L Hernández‐Blasco, L Jara‐Palomares, MJ Jaras, D Jiménez, MD Joya, I Jou, B Lacruz, R Lecumberri, J Lima, JL Lobo, H López‐Brull, L López‐Jiménez, P López‐Miguel, JJ López‐Núñez, R López‐Reyes, JB López‐Sáez, MA Lorente, A Lorenzo, M Loring, O Madridano, A Maestre, PJ Marchena, M Martín del Pozo, F Martín‐Martos, C Martínez‐Baquerizo, C Mella, M Mellado, MI Mercado, J Moisés, MV Morales, A Muñoz‐Blanco, D Muñoz‐Guglielmetti, N Muñoz‐Rivas, E Nart, JA Nieto, MJ Núñez, MC Olivares, C Ortega‐Michel, MD Ortega‐Recio, J Osorio, S Otalora, R Otero, P Parra, V Parra, JM Pedrajas, G Pellejero, A Pérez‐Jacoiste, ML Peris, D Pesántez, JA Porras, J Portillo, L Reig, A Riera‐Mestre, A Rivas, A Rodríguez‐Cobo, C Rodríguez‐Matute, J Rogado, V Rosa, CM Rubio, P Ruiz‐Artacho, N Ruiz‐Giménez, J Ruiz‐Ruiz, P Ruiz‐Sada, JC Sahuquillo, G Salgueiro, A Sampériz, JF Sánchez‐Muñoz‐Torrero, T Sancho, P Sigüenza, M Sirisi, S Soler, S Suárez, JM Suriñach, G Tiberio, MI Torres, C Tolosa, J Trujillo‐Santos, F Uresandi, E Usandizaga, R Valle, JR Vela, G Vidal, C Vilar, P Villares, C Zamora, P Gutiérrez, FJ Vázquez, T Vanassche, C Vandenbriele, P Verhamme, J Hirmerova, R Malý, E Salgado, I Benzidia, L Bertoletti, A Bura‐Riviere, B Crichi, P Debourdeau, O Espitia, D Farge‐Bancel, H Helfer, I Mahé, F Moustafa, G Poenou, S Schellong, A Braester, B Brenner, I Tzoran, M Amitrano, F Bilora, C Bortoluzzi, B Brandolin, M Ciammaichella, D Colaizzo, F Dentali, P Di Micco, E Giammarino, E Grandone, S Mangiacapra, D Mastroiacovo, R Maida, N Mumoli, F Pace, R Pesavento, F Pomero, P Prandoni, R Quintavalla, A Rocci, C Siniscalchi, A Tufano, A Visonà, N Vo Hong, B Zalunardo, RV Kalejs, K Maķe, M Ferreira, S Fonseca, F Martins, J Meireles, M Bosevski, M Zdraveska, L Mazzolai, JA Caprini, AJ Tafur, I Weinberg, H Wilkins, HM Bui, Blondon, M., Jimenez, D., Robert-Ebadi, H., Del Toro, J., Lopez-Jimenez, L., Falga, C., Skride, A., Font, L., Vazquez, F. J., Bounameaux, H., Monreal, M., Prandoni, P., Brenner, B., Farge-Bancel, D., Barba, R., Di Micco, P., Bertoletti, L., Schellong, S., Tzoran, I., Reis, A., Bosevski, M., Maly, R., Verhamme, P., Caprini, J. A., My Bui, H., Adarraga, M. D., Agud, M., Aibar, J., Aibar, M. A., Alfonso, J., Amado, C., Arcelus, J. I., Baeza, C., Ballaz, A., Barbagelata, C., Barron, M., Barron-Andres, B., Blanco-Molina, A., Botella, E., Camon, A. M., Castro, J., Caudevilla, M. A., Cerda, P., Chasco, L., Criado, J., de Ancos, C., de Miguel, J., Demelo-Rodriguez, P., Diaz-Peromingo, J. A., Diez-Sierra, J., Diaz-Simon, R., Dominguez, I. M., Encabo, M., Escribano, J. C., Farfan, A. I., Fernandez-Capitan, C., Fernandez-Reyes, J. L., Fidalgo, M. A., Flores, K., Font, C., Francisco, I., Gabara, C., Galeano-Valle, F., Garcia, M. A., Garcia-Bragado, F., Garcia-Mullor, M. M., Gavin-Blanco, O., Gavin-Sebastian, O., Gil-Diaz, A., Gomez-Cuervo, C., Gonzalez-Martinez, J., Grau, E., Guirado, L., Gutierrez, J., Hernandez-Blasco, L., Jara-Palomares, L., Jaras, M. J., Joya, M. D., Jou, I., Lacruz, B., Lecumberri, R., Lima, J., Lobo, J. L., Lopez-Brull, H., Lopez-Miguel, P., Lopez-Nunez, J. J., Lopez-Reyes, R., Lopez-Saez, J. B., Lorente, M. A., Lorenzo, A., Loring, M., Madridano, O., Maestre, A., Marchena, P. J., Martin del Pozo, M., Martin-Martos, F., Martinez-Baquerizo, C., Mella, C., Mellado, M., Mercado, M. I., Moises, J., Morales, M. V., Munoz-Blanco, A., Munoz-Guglielmetti, D., Munoz-Rivas, N., Nart, E., Nieto, J. A., Nunez, M. J., Olivares, M. C., Ortega-Michel, C., Ortega-Recio, M. D., Osorio, J., Otalora, S., Otero, R., Parra, P., Parra, V., Pedrajas, J. M., Pellejero, G., Perez-Jacoiste, A., Peris, M. L., Pesantez, D., Porras, J. A., Portillo, J., Reig, L., Riera-Mestre, A., Rivas, A., Rodriguez-Cobo, A., Rodriguez-Matute, C., Rogado, J., Rosa, V., Rubio, C. M., Ruiz-Artacho, P., Ruiz-Gimenez, N., Ruiz-Ruiz, J., Ruiz-Sada, P., Sahuquillo, J. C., Salgueiro, G., Samperiz, A., Sanchez-Munoz-Torrero, J. F., Sancho, T., Siguenza, P., Sirisi, M., Soler, S., Suarez, S., Surinach, J. M., Tiberio, G., Torres, M. I., Tolosa, C., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valle, R., Vela, J. R., Vidal, G., Vilar, C., Villares, P., Zamora, C., Gutierrez, P., Vanassche, T., Vandenbriele, C., Hirmerova, J., Salgado, E., Benzidia, I., Bura-Riviere, A., Crichi, B., Debourdeau, P., Espitia, O., Helfer, H., Mahe, I., Moustafa, F., Poenou, G., Braester, A., Amitrano, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., Colaizzo, D., Dentali, F., Giammarino, E., Grandone, E., Mangiacapra, S., Mastroiacovo, D., Maida, R., Mumoli, N., Pace, F., Pesavento, R., Pomero, F., Quintavalla, R., Rocci, A., Siniscalchi, C., Tufano, A., Visona, A., Vo Hong, N., Zalunardo, B., Kalejs, R. V., Maie, K., Ferreira, M., Fonseca, S., Martins, F., Meireles, J., Zdraveska, M., Mazzolai, L., Tafur, A. J., Weinberg, I., Wilkins, H., and Bui, H. M.

Subjects
Registrie, medicine.medical_specialty, pulmonary embolism, Prognosi, Hemodynamics, 030204 cardiovascular system & hematology, Cohort Studies, 03 medical and health sciences, Clinical prognosis, 0302 clinical medicine, Recurrence, Internal medicine, Case fatality rate, medicine, Humans, hemorrhage, mortality, prognosis, thrombolytic therapy, Registries, cardiovascular diseases, business.industry, Anticoagulant, Anticoagulants, Hematology, Venous Thromboembolism, Prognosis, medicine.disease, Confidence interval, Pulmonary embolism, Discontinuation, Cohort Studie, business, Venous thromboembolism, Cohort study, Human
Abstract

Aims Little is known about the prognosis of patients with massive pulmonary embolism (PE) and its risk of recurrent venous thromboembolism (VTE) compared with non-massive PE, which may inform clinical decisions. Our aim was to compare the risk of recurrent VTE, bleeding, and mortality after massive and non-massive PE during anticoagulation and after its discontinuation. Methods and results We included all participants in the RIETE registry who suffered a symptomatic, objectively confirmed segmental or more central PE. Massive PE was defined by a systolic hypotension at clinical presentation (

Published
2021

36. Hospital antibiotic prescribing patterns in adult patients according to the WHO Access, Watch and Reserve classification (AWaRe): results from a worldwide point prevalence survey in 69 countries

Author

Pauwels, Ines, Versporten, Ann, Drapier, Nico, Vlieghe, Erika, Goossens, Herman, Koraqi, Andi, Hoxha, Iris, Tafaj, Silva, Cornistein, Wanda, Quiros, Rodolfo, Hojman, Martin, Ghazaryan, Lilit, Horne, Kylie, Cairns, Kelly, Doukas, Fiona, Gottlieb, Thomas, Sermijn, Erica, Verhamme, Katia, Brands, Christiane, Van Herendael, Bruno, Filippin, Lorenzo, Vandewal, Wouter, Konopnicki, Deborah, Maillart, Evelyne, Teixeira Lopes, Liliana, Papin, Pauline, Smits, Ilse, Jansens, Hilde, Bartholomeus, Sofie, Van den Abeele, Anne-Marie, Steyaert, Sophia, Piette, Anne, Buyle, Franky, Cartuyvels, Reinoud, Jonckheere, Stijn, Wybo, Ingrid, Vanneste, Lorenz, Mathieu, Delphine, Firre, Eric, Westelinck, Veerle, Gadisseux, Philippe, Dugernier, Thierry, Bafort, Kristof, Gonissen, Viviane, Vanderper, Vanessa, Gabriels, Patrick, Weekers, Frank, Michel, Philippe, Van Liedekerke, Ann, Costers, Michiel, Catry, Boudewijn, Dedeic-Ljubovic, Amela, Gales, Ana C., Matos Porto, Ana Paula, Figueiredo Costa, Silvia, Keuleyan, Emma, Beidi, Apollinaire, Cissohko, Youssouph, Blakwe, Habsatou, Batchaya Basile, Ngassa, German, Greg J., Lutes, Sarah, Boswell, Jennifer, Mertz, Dominik, Nguyen, Tuyen, MacLaggan, Timothy, Landry, Daniel, Ang, Anita, Thirion, Daniel J.G., Frenette, Charles, Émond, Yannick, Roberts, Jacqueline, Chang, Sandra, Kosar, Justin, Valiquette, Louis, Dutrisac, Ginette, Afra, Kevin, McGeer, Allison, Carrier, Marie, Grant, Jennifer, Labarca, Jaime, Carvajal, Camila, Lin, HongYi, Wang, Qiang, Yang, Jing, Yang, Wenjie, Cortes, Jorge A., Villalobos-Vindas, Juan, Ramírez-Valverde, Carlos, Horvatic, Jasminka, Pristas, Irina, Paphitou, Niki, Rummukainen, Maija-Liisa, Froissart, Antoine, Vanhems, Philippe, Pagava, Karaman, Korinteli, Irma, Brandt, Tobias, Gaertner, Johannes, Enimil, Anthony, Roilides, Emmanuel, Hajdú, Edit, Sengupta, Sharmila, Singh, Sanjeev, Patil, Priyanka, Poojary, Aruna, Soltani, Jafar, Pouladfar, Gholamreza, Jafarpour, Zahra, Alinia, Cyrus, Ameen, Hadi, Fitzgerald, David, Paul, Mical, Maor, Yasmin, Strahilevitz, Jacob, Chowers, Michal, Temkin, Elizabeth, Luca, Arnoldo, Ishibashi, Noriomi, Gu, Yoshiaki, Darwish Elhajji, Feras, Karabukayeva, Aizhan, Raka, Denis, Kambaralieva, Baktygul, Zarakauska, Lelde, Zarb, Peter, Hernandez Chena, Blanca Estela, Gonzalez-Diaz, Esteban, Corona-Meléndez, JuanCarlos, Torres Erazo, Darwin Stalin, Loza-Jalil, Suria Elizabeth, Molina, Julio, Candelas, Jose Antonio, Mijovic, Gordana, Duborija-Kovacevic, Natasa, Jong, Eefje, Kluytmans, Jan, van Elzakker, Erika, Schweitzer, Valentijn, Davies, Nicola, Iregbu, Kenneth, Nwajiobi-Princewill, Philip, Nwafia, Ifeyinwa, Fasuyi, Temitayo, Aboderin, Aaron, Elikwu, Charles John, Fadeyi, Abayomi, Ola-Bello, Olafoyekemi, Oduyebo, Oyinlola, Adedosu, Akin Nelson, Ekuma, Agantem, Shaqiri, Erjona, Saleem, Zikria, De Los Reyes, Mari Rose, Tavares, Luis, Kim, Nam Joong, Rachina, Svetlana, Alharthi, Alwaleed R., Enani, Mushira, Faried, Osama, Mirghani, Mohamed, Carevic, Biljana, Radulovic, Lili, Dragovac, Gorana, Tan, Sock Hoon, Taljaard, Jantjie, Chibabhai, Vindana, Joiner, Jennifer, Caston, Juan Jose, Núñez-Núñez, María, Martínez-Marcos, Francisco Javier, Ojeda-Burgos, Guillermo, Menendez, Maria Dolores, Retamar, Pilar, Corzo, Juan E., Rattanaumpawan, Pinyo, Salou, Mounerou, Mnif, Basma, Oncul, Ahsen, Babigumira, Peter Ahabwe, Olweny, James, Marshall, Emily, McCorry, Ann, Aldeyab, Mamoon, Khanna, Priya, Gormley, Cairine, Maloney, Sara, Cooper, Mandelin, Blackburn, Laura, Gessner-Wharton, Mallory, Vu, Lam, Greer, Nickie, Gawrys, Gerard, Kronmann, Lisha, Rios, Edgar, Hudson, Melissa, Lindholm, David A., The Global-PPS network, Vriendenkring VUB, Clinical sciences, Microbiology and Infection Control, and Clinical Biology

Subjects
Adult, Microbiology (medical), Point prevalence survey, Latin Americans, education, Population, MEDLINE, World Health Organization, Essential medicines, Antibiotic prescribing, Anti-Infective Agents, Environmental health, Prevalence, Humans, AcademicSubjects/MED00740, Medicine, Pharmacology (medical), Medical prescription, Biology, Original Research, Pharmacology, education.field_of_study, Adult patients, business.industry, Pharmacology. Therapy, Hospitals, Anti-Bacterial Agents, Anti-Bacterial Agents/therapeutic use, AcademicSubjects/MED00290, Infectious Diseases, Human medicine, AcademicSubjects/MED00230, business
Abstract

ObjectivesThe WHO Access, Watch and Reserve (AWaRe) classification has been developed to support countries and hospitals in promoting rational use of antibiotics while improving access to these essential medicines. We aimed to describe patterns of worldwide antibiotic use according to the AWaRe classification in the adult inpatient population.MethodsThe Global Point Prevalence Survey on Antimicrobial Consumption and Resistance (Global-PPS) collects hospital antibiotic use data using a standardized PPS methodology. Global-PPS 2015, 2017 and 2018 data, collected by 664 hospitals in 69 countries, were categorized into AWaRe groups to calculate proportional AWaRe use, Access-to-Watch ratios and the most common indications for treatment with selected Watch antibiotics. Only prescriptions for systemic antibiotics on adult inpatient wards were analysed.ResultsRegional Access use ranged from 28.4% in West and Central Asia to 57.7% in Oceania, whereas Watch use was lowest in Oceania (41.3%) and highest in West and Central Asia (66.1%). Reserve use ranged from 0.03% in sub-Saharan Africa to 4.7% in Latin America. There were large differences in AWaRe prescribing at country level. Watch antibiotics were prescribed for a range of very different indications worldwide, both for therapeutic and prophylactic use.ConclusionsWe observed considerable variations in AWaRe prescribing and high use of Watch antibiotics, particularly in lower- and upper-middle-income countries, followed by high-income countries. The WHO AWaRe classification has an instrumental role to play in local and national stewardship activities to assess prescribing patterns and to inform and evaluate stewardship activities.

Published
2021

37. Combined analysis of transcriptomic and genetic data for the identification of loci involved in glucocorticosteroid response in asthma

Author

Mario Gorenjak, Vojko Berce, Maximilian Schieck, Martin Kerick, Steve Turner, Munir Pirmohamed, Leila Karimi, Almudena Corrales, Staša Jurgec, Marialbert Acosta-Herrera, Katia M.C. Verhamme, Carlos Flores, Natalia Hernandez-Pacheco, Susanne J. H. Vijverberg, Roger Tavendale, Michael Kabesch, Colin N. A. Palmer, Lesly-Anne Samedy-Bates, Jesús Villar, Somnath Mukhopadhyay, Andrea L. Jorgensen, Esteban G. Burchard, Daniel B Hawcutt, Anke H. Maitland-van der Zee, Uroš Potočnik, Maria Pino-Yanes, Pulmonology, AII - Inflammatory diseases, APH - Personalized Medicine, Paediatric Pulmonology, and Medical Informatics

Subjects
pharmacogenomics, Childhood asthma, asthma treatment, Immunology, Asthma treatment, Genetic data, Computational biology, Biology, medicine.disease, Polymorphism, Single Nucleotide, Article, Asthma, Transcriptome, exacerbations, childhood asthma, Pharmacogenomics, medicine, Humans, Immunology and Allergy, genetic polymorphism, Identification (biology), Genome-Wide Association Study
Published
2021

38. Intravenous immunoglobulins as first-line treatment in idiopathic inflammatory myopathies

Author

Anneke J. van der Kooi, Filip Eftimov, Rob J. de Haan, Eleonora Aronica, Christiaan G J Saris, Jessica E. Hoogendijk, Ivo N. van Schaik, Joost Raaphorst, Marianne de Visser, Esther Brusse, Camiel Verhamme, Johan Lim, Neurology, Graduate School, AII - Inflammatory diseases, ANS - Neuroinfection & -inflammation, ANS - Neurodegeneration, Clinical Research Unit, APH - Methodology, Pathology, ANS - Cellular & Molecular Mechanisms, and EURO-NMD

Subjects
Adult, Male, Weakness, medicine.medical_specialty, myositis and muscle disease, Pilot Projects, Loading dose, Drug Administration Schedule, 03 medical and health sciences, 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, Rheumatology, Internal medicine, medicine, Humans, Pharmacology (medical), Adverse effect, Creatine Kinase, Myositis, AcademicSubjects/MED00360, Aged, 030203 arthritis & rheumatology, Folliculitis, Muscle Weakness, Dose-Response Relationship, Drug, business.industry, Standard treatment, Immunoglobulins, Intravenous, Middle Aged, Clinical Science, medicine.disease, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], Pulmonary embolism, Regimen, Ceiling effect, Female, immunotherapy, medicine.symptom, business, Pulmonary Embolism, 030217 neurology & neurosurgery
Abstract

Objectives We explored efficacy and safety of IVIg as first-line treatment in patients with an idiopathic inflammatory myopathy. Methods In this investigator-initiated phase 2 open-label study, we included 20 adults with a newly diagnosed, biopsy-proven idiopathic inflammatory myopathy, and a disease duration of less than 9 months. Patients with IBM and prior use of immunosuppressants were excluded. The standard treatment regimen consisted of IVIg (Privigen) monotherapy for 9 weeks: a loading dose (2 g/kg body weight) and two subsequent maintenance doses (1 g/kg body weight) with a 3-week interval. The primary outcome was the number of patients with at least moderate improvement on the 2016 ACR/EULAR Total Improvement Score. Secondary outcomes included time to improvement, the number of patients requiring rescue medication and serious adverse events. Results We included patients with DM (n = 9), immune-mediated necrotizing myopathy (n = 6), non-specific myositis/overlap myositis (n = 4) and anti-synthetase syndrome (n = 1). One patient was excluded from analyses because of minimal weakness resulting in a ceiling effect. Eight patients (8/19 = 42.0%; Clopper–Pearson 95% CI: 19.6, 64.6) had at least moderate improvement by 9 weeks. Of these, six reached improvement by 3 weeks. Seven patients required rescue medication due to insufficient efficacy and prematurely ended the study. Three serious adverse events occurred, of which one was pulmonary embolism. Conclusion First-line IVIg monotherapy led to at least moderate improvement in nearly half of patients with a fast clinical response in the majority of responders. Trial registration Netherlands Trial Register identifier, NTR6160.

Published
2021

39. Women are started on a lower daily dose of metoprolol than men irrespective of dose recommendations

Author

Loes E. Visser, Linda C. Hendriksen, Bruno H. Stricker, Paul D. van der Linden, Katia M.C. Verhamme, Epidemiology, Medical Informatics, and Pharmacy

Subjects
Male, medicine.medical_specialty, Epidemiology, Population, 030226 pharmacology & pharmacy, Cohort Studies, 03 medical and health sciences, Rotterdam Study, 0302 clinical medicine, Internal medicine, Medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, education, Contraindication, Antihypertensive Agents, Metoprolol, education.field_of_study, evidence‐based medicine, business.industry, Contraindications, Pharmacoepidemiology, Confounding, prescribing, Original Articles, medicine.disease, Comorbidity, 3. Good health, Female, Original Article, business, drug utilization, medicine.drug, Cohort study
Abstract

Purpose Current guidelines have no sex‐specific dosage advice for metoprolol. To evaluate whether women and men are prescribed the same dose a cohort analysis was performed in the population‐based Rotterdam Study (RS). Results were replicated in the Integrated Primary Care Information (IPCI) database of automated general practice data. Methods The mean daily starting doses of metoprolol in both sexes were compared with independent‐samples t‐tests and a linear regression analysis was used to adjust in the RS for co‐variables, notably, cardiovascular comorbidity, migraine, age, SBP, DBP, BMI, socioeconomic status, use of other antihypertensive drugs, smoking, and alcohol. In the IPCI‐database, adjustment was for age only. Results The mean daily starting dose was statistically significantly lower in women than in men in both the RS and IPCI database, with a mean difference of 4.8 mg (95%CI −7.8, −1.8) and 4.6 mg (95%CI −5.3,‐4.0), respectively. Statistical significance remained after adjustment in both databases. Conclusions Women received lower starting doses of metoprolol than men in two independent data collections despite non‐sex specific cardiovascular guideline recommendations. This example of real‐life pharmacotherapy can lead to a form of confounding by contraindication in pharmacoepidemiology.

Published
2021

40. Pharmacogenetics of inhaled corticosteroids and exacerbation risk in adults with asthma

Author

Guy Brusselle, Kelan G. Tantisira, Meng Lu, Michael J. McGeachie, Ahmed Edris, Carlos Iribarren, Lies Lahousse, Emmely W de Roos, Katia M.C. Verhamme, Ann Chen Wu, Bruno H. Stricker, Epidemiology, Medical Informatics, and Pulmonary Medicine

Subjects
Adult, medicine.medical_specialty, Exacerbation, business.industry, Incidence (epidemiology), Immunology, Single-nucleotide polymorphism, medicine.disease, Asthma, Minor allele frequency, Rotterdam Study, Adrenal Cortex Hormones, Pharmacogenetics, Internal medicine, Administration, Inhalation, Cohort, Medicine and Health Sciences, medicine, Humans, Immunology and Allergy, Anti-Asthmatic Agents, business
Abstract

Background: Inhaled corticosteroids (ICS) are a cornerstone of asthma treatment. However, their efficacy is characterized by wide variability in individual responses. Objective: We investigated the association between genetic variants and risk of exacerbations in adults with asthma and how this association is affected by ICS treatment. Methods: We investigated the pharmacogenetic effect of 10 single nucleotide polymorphisms (SNPs) selected from the literature, including SNPs previously associated with response to ICS (assessed by change in lung function or exacerbations) and novel asthma risk alleles involved in inflammatory pathways, within all adults with asthma from the Dutch population–based Rotterdam study with replication in the American GERA cohort. The interaction effects of the SNPs with ICS on the incidence of asthma exacerbations were assessed using hurdle models adjusting for age, sex, BMI, smoking and treatment step according to the GINA guidelines. Haplotype analyses were also conducted for the SNPs located on the same chromosome. Results: rs242941 (CRHR1) homozygotes for the minor allele (A) showed a significant, replicated increased risk for frequent exacerbations (RR = 6.11, P

Published
2021

41. Hemostatic Efficacy and Anti-FXa (Factor Xa) Reversal with Andexanet Alfa in Intracranial Hemorrhage: ANNEXA-4 Substudy

Author

John W. Eikelboom, Elena Zotova, Saskia Middeldorp, Andrew M. Demchuk, Pamela B. Conley, Tomoyuki Ohara, John T. Curnutte, Truman J. Milling, Mark Crowther, Stuart J. Connolly, Lizhen Xu, Peter Verhamme, Juliet Nakamya, Patrick Yue, Jose Lopez-Sendon, Joshua N. Goldstein, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, and ARD - Amsterdam Reproduction and Development

Subjects
Male, Pyridones, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 030204 cardiovascular system & hematology, Pharmacology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Rivaroxaban, law, Humans, Medicine, Aged, Aged, 80 and over, Advanced and Specialized Nursing, Hemostasis, Blood Coagulation Factor Inhibitors, business.industry, Anti fxa, Recombinant Proteins, andexanet alfa, Factor Xa, Recombinant DNA, Pyrazoles, direct factor Xa inhibitor reversal, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Intracranial Hemorrhages, 030217 neurology & neurosurgery, intracranial hemorrhage, Andexanet alfa, medicine.drug
Abstract

Background and Purpose: Andexanet alfa is a recombinant modified human FXa (factor Xa) developed to reverse FXa inhibition from anticoagulants. Hemostatic efficacy and reversal of anti-FXa activity with andexanet were assessed in patients from the ANNEXA-4 study (Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of FXa Inhibitors) with intracranial hemorrhage (ICrH). Methods: ANNEXA-4 was a single-arm study evaluating andexanet in patients presenting with major bleeding ≤18 hours after taking an FXa inhibitor. Patients received a bolus plus 2-hour infusion of andexanet. Brain imaging in patients with ICrH was performed at baseline and at 1 and 12 hours postandexanet infusion. Coprimary efficacy outcomes were change in anti-FXa activity and hemostatic efficacy at 12 hours (excellent/good efficacy defined as ≤35% increase in hemorrhage volume/thickness). Safety outcomes included occurrence of thrombotic events and death at 30 days. Results: A total of 227 patients with ICrH were included in the safety population (51.5% male; mean age 79.3 years) and 171 in the efficacy population (99 spontaneous and 72 traumatic bleeds). In efficacy evaluable patients, excellent/good hemostasis 12 hours postandexanet occurred in 77 out of 98 (78.6%) and in 58 out of 70 (82.9%) patients with spontaneous and traumatic bleeding, respectively. In the subanalysis by FXa inhibitor treatment group in the efficacy population, median of percent change in anti-FXa from baseline to nadir showed a decrease of 93.8% for apixaban-treated patients (n=99) and by 92.6% for rivaroxaban-treated patients (n=59). Within 30 days, death occurred in 34 out of 227 (15.0%) patients and thrombotic events occurred in 21 out of 227 (9.3%) patients (safety population). Conclusions: Andexanet reduced anti-FXa activity in FXa inhibitor-treated patients with ICrH, with a high rate of hemostatic efficacy. Andexanet may substantially benefit patients with ICrH, the most serious complication of anticoagulation. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02329327.

Published
2021

42. Management and outcomes of cancer patients with venous thromboembolism presenting with thrombocytopenia

Author

Ido Weinberg, Giovanni Barillari, Justo Ruiz-Ruiz, Manuel Alejandro Lorente, Javier Trujillo-Santos, Riete Investigators, Ramón Lecumberri, Peter Verhamme, Manuel Monreal, Benjamin Brenner, Pedro Ruiz-Artacho, and Fernando J. Vazquez

Subjects
medicine.medical_specialty, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Internal medicine, Humans, Medicine, Platelet, In patient, cardiovascular diseases, Inverse correlation, business.industry, Anticoagulants, Cancer, Venous Thromboembolism, Hematology, Heparin, Heparin, Low-Molecular-Weight, equipment and supplies, medicine.disease, Thrombocytopenia, Severe thrombocytopenia, 030220 oncology & carcinogenesis, business, Venous thromboembolism, medicine.drug
Abstract

Introduction Treatment of venous thromboembolism (VTE) in cancer patients with thrombocytopenia is challenging due to perceived higher risk of bleeding. Material and methods We used the RIETE registry to compare the 10- and 30-day outcomes in cancer patients with acute VTE, according to platelet count at baseline. Results As of December 2018, 15,337 cancer patients with VTE were included: 166 (1.1%) had Conclusions Cancer patients with acute VTE and baseline thrombocytopenia often receive initial lower-than recommended doses of LMWH. Although caution is required, this practice seems to be safe in patients with severe thrombocytopenia. Nonetheless, there was an inverse correlation between baseline platelet count and mortality.

Published
2020

43. Urinary Proteomic Profile of Arterial Stiffness Is Associated With Mortality and Cardiovascular Outcomes

Author

Dongmei Wei, Jesus D. Melgarejo, Lutgarde Thijs, Xander Temmerman, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Jan A. Staessen, Peter Verhamme, and Zhen‐Yu Zhang

Subjects
Male, Proteomics, pulse wave velocity, biomarkers, Middle Aged, Pulse Wave Analysis, Cardiovascular System, arterial stiffness, proteomics, Vascular Stiffness, population science, Cardiovascular Diseases, Risk Factors, cardiovascular system, Humans, Female, cardiovascular diseases, Cardiology and Cardiovascular Medicine, circulatory and respiratory physiology
Abstract

Background The underlying mechanisms of arterial stiffness remain not fully understood. This study aimed to identify a urinary proteomic profile to illuminate its pathogenesis and to determine the prognostic value of the profile for adverse outcomes. Methods and Results We measured aortic stiffness using pulse wave velocity (PWV) and analyzed urinary proteome using capillary electrophoresis coupled with mass spectrometry in 669 randomly recruited Flemish patients (mean age, 50.2 years; 51.1% women). We developed a PWV‐derived urinary proteomic score (PWV‐UP) by modeling PWV with proteomics data at baseline through orthogonal projections to latent structures. PWV‐UP that consisted of 2336 peptides explained the 65% variance of PWV, higher than 36% explained by clinical risk factors. PWV‐UP was significantly associated with PWV (adjusted β=0.73 [95% CI, 0.67–0.79]; P P ≤0.031). For PWV, the corresponding estimates were 1.25 (95% CI, 0.97–1.60), 1.35 (95% CI, 0.85–2.15), and 1.22 (95% CI, 1.02–1.47), respectively ( P ≥0.033). Pathway analysis revealed that the peptides in PWV‐UP mostly involved multiple pathways, including collagen turnover, cell adhesion, inflammation, and lipid metabolism. Conclusions PWV‐UP was highly associated with PWV and could be used as a biomarker of arterial stiffness. PWV‐UP, but not PWV, was associated with all‐cause mortality and cardiovascular mortality, implying that PWV‐UP–associated peptides may be multifaceted and involved in diverse pathological processes beyond arterial stiffness.

Published
2022

44. [Reconstruction after facial trauma with dento-alveolar injury]

Author

J.H.F. Liebregts, T. Xi, L. Verhamme, B. Kramer, M. Wouters, and G.J. Meijer

Subjects
Adult, Dental Implants, Bone Transplantation, Dental Implantation, Endosseous, Alveolar Process, Gingiva, Humans, Female, General Medicine, Mandible
Abstract

While abroad, a healthy 36-year-old woman slammed head-on into a rock wall at high speed, resulting in significant facial trauma. The initial trauma care and first aid took place abroad. In the Netherlands, the woman was referred to the Department of Oral and Maxillofacial Surgery (OMFS) for reconstruction of her face and alveolar processes, gingiva and dentition. In view of the seriousness of the injuries, a 3D treatment plan was drawn up in a multidisciplinary collaboration with an OMF surgeon, an implantologist, dentist and dental technician. By making a digital setup of both the top and bottom front in advance, it was possible to work predictably. The first step consisted of bone augmentation by means of an iliac crest graft to reconstruct the major bone defects of the superior and inferior alveolar processes. Implants were then placed in the upper and lower jaws in the ideal position for the suprastructure by means of drill jigs. Within 10 months after the trauma, the implant bridges could be placed on individual zirconia frameworks to optimally restore oral function and aesthetics, completing the reconstruction.Een gezonde 36-jarige vrouw klapte in het buitenland met hoge snelheid frontaal tegen een rotswand, met als gevolg een flink trauma van het aangezicht. De initiële opvang en eerste hulp vond in het buitenland plaats. In Nederland werd de vrouw verwezen naar de afdeling Mondziekten, Kaak- en Aangezichtschirurgie voor reconstructie van haar gelaat en processus alveolaris, gingiva en dentitie. Gezien de ernst van de letsels werd in een multidisciplinair samenwerkingsverband met een mka-chirurg, implantoloog, tandarts en tandtechnieker een 3D-behandelplan opgesteld. Door vooraf een digitale setup van zowel het boven- als onderfront te maken, kon er voorspelbaar gewerkt worden. De eerst stap bestond uit een botaugmentatie door middel van een crista iliaca bottransplantaat om de forse botdefecten van de processus alveolaris superior en inferior te reconstrueren. Vervolgens werden door middel van boormallen implantaten in de maxilla en mandibula geplaatst op de voor de suprastructuur ideale positie. Binnen 10 maanden na het trauma konden de implantaatbruggen op individuele zirkoniumdioxide onderstructuren geplaatst worden om de orale functie en esthetiek optimaal te herstellen, waarna de reconstructie compleet was.

Published
2022

45. Dutch injection versus surgery trial in patients with carpal tunnel syndrome (DISTRICTS)

Author

Wijnand A C Palmbergen, Rob M A de Bie, Tim W H Alleman, Esther Verstraete, Korne Jellema, Wim I M Verhagen, Geert J F Brekelmans, Godard C W de Ruiter, Diederik van de Beek, Corianne A J M de Borgie, Rob de Haan, Roy Beekman, Camiel Verhamme, Graduate School, Neurology, ANS - Neurodegeneration, APH - Aging & Later Life, ANS - Neuroinfection & -inflammation, Clinical Research Unit, APH - Methodology, and EURO-NMD

Subjects
Treatment Outcome, Adrenal Cortex Hormones, Quality of Life, Humans, Multicenter Studies as Topic, General Medicine, Wrist, Adult neurology, Neuromuscular disease, Carpal Tunnel Syndrome, NEUROLOGY, Injections, Randomized Controlled Trials as Topic
Abstract

IntroductionCarpal tunnel syndrome (CTS) is the most common peripheral neuropathy. The optimal treatment strategy is still unknown. The objective of the Dutch Injection versus Surgery TRIal in patients with CTS (DISTRICTS) is to investigate if initial surgery of CTS results in a better clinical outcome and is more cost-effective when compared with initial treatment with corticosteroid injection.Methods and analysisThe DISTRICTS is an ongoing multicenter, open-label randomised controlled trial. Participants with CTS are randomised to treatment with surgery or with a corticosteroid injection. If needed, any additional treatments after this first treatment are allowed and these are not dictated by the study protocol. The primary outcome is the difference between the groups in the proportion of participants recovered at 18 months. Recovery is defined as having no or mild symptoms as measured with the 6-item carpal tunnel symptoms scale. Secondary outcome measurements are among others: time to recovery, hand function, patient satisfaction, quality of life, additional treatments, adverse events, and use of care and health-related costs.Ethics and disseminationThe study was approved by the Medical Ethical Committee of the Amsterdam University Medical Centers (study number 2017-171). Study results will be disseminated in peer-reviewed journals and conferences.Trial registration numberISRCTN Registry: 13164336.

Published
2022

46. The novel proteomic signature for cardiac allograft vasculopathy

Author

Dongmei Wei, Sander Trenson, Jan M. Van Keer, Jesus Melgarejo, Ella Cutsforth, Lutgarde Thijs, Tianlin He, Agnieszka Latosinska, Agnieszka Ciarka, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Johan Van Cleemput, Harald Mischak, Jan A. Staessen, Peter Verhamme, and Zhen‐Yu Zhang

Subjects
Adult, Male, Proteomics, CORONARY ENDOTHELIAL DYSFUNCTION, GROWTH-FACTOR, Cardiac & Cardiovascular Systems, BIOMARKERS, HEART-TRANSPLANTATION, INTERNATIONAL SOCIETY, PROGRESSION, Pilot Projects, Heart transplantation, Coronary Angiography, DISEASE, Diagnosis, Humans, Vascular Diseases, Aged, Science & Technology, Cardiac allograft vasculopathy, Middle Aged, Allografts, C-REACTIVE PROTEIN, SUBSEQUENT DEVELOPMENT, MARKER, Cardiovascular System & Cardiology, cardiovascular system, Heart Transplantation, Female, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine
Abstract

AIMS: Cardiac allograft vasculopathy (CAV) is the major long-term complication after heart transplantation, leading to mortality and re-transplantation. As available non-invasive biomarkers are scarce for CAV screening, we aimed to identify a proteomic signature for CAV. METHODS AND RESULTS: We measured urinary proteome by capillary electrophoresis coupled with mass spectrometry in 217 heart transplantation recipients (mean age: 55.0 ± 14.4 years; women: 23.5%), including 76 (35.0%) patients with CAV diagnosed by coronary angiography. We randomly and evenly grouped participants into the derivation cohort (n = 108, mean age: 56.4 ± 13.8 years; women: 22.2%; CAV: n = 38) and the validation cohort (n = 109, mean age: 56.4 ± 13.8 years; women: 24.8%, CAV: n = 38), stratified by CAV. Using the decision tree-based machine learning methods (extreme gradient boost), we constructed a proteomic signature for CAV discrimination in the derivation cohort and verified its performance in the validation cohort. The proteomic signature that consisted of 27 peptides yielded areas under the curve of 0.83 [95% confidence interval (CI): 0.75-0.91, P

Published
2022

47. Mechanical properties and cellular content of leukocyte- and platelet-rich fibrin membranes of patients on antithrombotic drugs

Author

Anna Ockerman, Amber Hendrickx, Wouter Willekens, Heleen Fehervary, Julie Vastmans, Wim Coucke, Peter Verhamme, Constantinus Politis, Thomas Vanassche, Annabel Braem, Marc Quirynen, and Reinhilde Jacobs

Subjects
Blood Platelets, Fibrinolytic Agents, Platelet-Rich Fibrin, Leukocytes, Periodontics, Anticoagulants, Humans
Abstract

The aim of this study was to examine the potential influence of antithrombotics on leukocyte- and platelet-rich fibrin (L-PRF) membranes.Tensile tests and cell counts were performed with L-PRF membranes originating from patients on anticoagulants and antiplatelets versus patients not taking antithrombotics.For the tensile tests, 13 control patients, 12 on anticoagulants, and 10 on antiplatelets donated blood. Compared to controls, membranes from anticoagulated donors were weaker (strength 0.57 ± 0.24 MPa vs. 0.80 ± 0.27 MPa, p = .03) and could not be stretched as far (1.8 ± 0.3 vs. 2.1 ± 0.3 times the initial length, p = .01). For the cell counting, 23 control patients, 16 on anticoagulants, and 16 on antiplatelets donated blood. The percentage of platelets was ±50% in the three groups. The percentage of leukocytes was lower in the anticoagulant group compared with controls (69 ± 10% vs. 78 ± 8%, p = .04). However, because of the unknown error of method, it is questionable whether the statistical significance is meaningful. There was no difference between membranes from the control group and the group on antiplatelets.Our results indicate that L-PRF membranes originating from patients on anticoagulants are weaker, stretch less far, and contain less leukocytes than L-PRF membranes of patients not taking these drugs.

Published
2022

48. Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans

Author

Nepogodiev D., Omar O. M., Glasbey J. C., Li E., Simoes J. F. F., Abbott T. E. F., Ademuyiwa A. O., Biccard B. M., Chaudhry D., Davidson G. H., Di Saverio S., Gallo G., Ghosh D., Harrison E. M., Hutchinson P. J., Kamarajah S. K., Keller D. S., Lawani I., Minaya-Bravo A., Moore R., Morton D. G., Ntirenganya F., Pata F., Pearse R. M., la Medina A. R. -D., Tabiri S., Venn M. L., Omar A. B. O. M., Bhangu A., Siaw-Acheampong K., Adamina M., Agarwal A., Alameer E., Alderson D., Alakaloko F., Alser O., Arnaud A. P., Augestad K. M., Bankhead-Kendall B. K., Barlow E., Benson R. A., Blanco-Colino R., Brar A., Breen K. A., Buarque I. L., Caruana E. J., Chakrabortee S., Cox D., Cunha M. F., Dawson B. E., Desai A., Drake T. D., Edwards J. G., Elhadi M., Evans J. P., Farik S., Fiore M., Fitzgerald J. E., Ford S., Gomes G. M. A., Griffiths E. A., Gujjuri R. R., Halkias C., Heritage E., Isik A., Jenkinson M. D., Jones C. S., Khatri C., Keatley J. M., Kolias A., Lawday S., Lederhuber H., Leventoglu S., LAffler M. W., Martin J., Mashbari H. N., Mazingi D., Mckay S. C., Metallidis S., Mohan H. M., Moszkowicz D., Moug S., Ng-Kamstra J. S., Niquen M., Outani O., Pellino G., Pinkney T. D., Pockney P., Radenkovic D., Roberts K., Roslani A. C., Santos I., Schache A., Schnitzbauer A. A., Stewart G. D., Shaw R., Shu S., Soreide K., Spinelli A., Sundar S., Tiwari A., Townend P., Trout I. M., Tsoulfas G., van Ramshorst G. H., Vidya R., Vimalachandran D., Warren O., Wilkin R. J. W., Wright N., Hoste E., Huyghens L., Jacobs R., Opdenacker G., Poelaert J., Rijckaert D., De Decker K., Foubert L., De Neve N., Biston P., Piagnerelli M., Collin V., den Blauwen N., Clauwaert C., De Crop L., Verbeke A., Derumeaux P., Gardin C., Kindt S., Louage S., Verhamme B., DruwACopyright P., Lahaye I., Rosseel F., Rutsaert R., Vanlinthout L., De Kock M., Forget P., Kahn D., Lois F., Momeni M., Yemnga A. P. B., Jadoul J. -L., Malbrain M., Bosinceanu D., Collard E., Jorens P., Reyntiens D., Smitz C., Vercauteren M., Fagnoul D., Toplice K., OremuA¡ K., BeA¡lic G., Duzel V., Hauptman A., Peremin S., Aribar A., Aupcic M., Brod S., Mirkovic I., Bauer Z. A., Belavic M., BlaA¾anin B., KatuA¡in M. L., Krijan A. B., MiA¡kovic P., Aimic-Korac N., Topic J., Ailic A., Aunic J., Acan I., Adanic M., Ivanov N., Aaric J. P., Tomulic K., Viskovic N., BoA¡njak S., Drenjancevic I. H., Kristek G., Kvolik S., Markic S., Rakipovic A. S., Tot O. K., Fabris L. K., Bacak-Kocman I., Balenovic I., Bandic D., Deutsch P. A. J., Divjak L., Filipovic I. G., GuA¾vinec Z., Krznaric Z., Loncaric Y., MagaA¡ J. V., Mitrovic M., Okic M., Pavlek M., Ramov E., Rezek K., Sekulic A., Tomasevic B., Miric M., TomaA¡evic A., Mahecic T. T., Vrbanovic V., Bobinac M., BoA¾ic A., Debelic D., Frkovic V., Batinica I. M., Baranovic S., Gavranovic A., Kikec M., Maldini B., Maric S., Agnic I., Delic N., Dropulic N., GaA¡pic T. K., Ilic D., Ivancev B., Karanovic N., KuA¡cevic D., Marovic Z., Milic M., NeveA¡canin A., Petkovic T., Smoje M., Brozovic G., Goranovic T., Jelisavac M., Matolic M., Mazul-Sunko B., Oberhofer D., Pavicic A. M., Aakic K., Bozovic M. D., Krecek Z. K., Krobot R., Andabaka T., Bratanic M., Dzepina O., Kraljev M., Aeric J., Aimurina T., Grujic R., Nacevski-Bulaja B., BariA¾on M., Danira V., DraA¾en B., DuA¡anka K., HaluA¾an M. B., JoA¡ko A., Katica R., Labor M., Marinkovic T. G., Mihovilcevic D., Marija B., Srecko M., Drab M., Hudacek K., Krikava I., Stourac P., BrabcovA¡ M., KlozovA¡ R., Vajter J., Vymazal T., Toft P., Blichfeldt L., Hansen B. D., Moller K., Nielsen J. S., Frederiksen J., Andersen J. D., KA¼hne J. P., Leivdal S., Stendell L., Simonsen M., Zoltowski M. K., Ali Z. S., Freundlich M., Pilypaite J., Clausen N. G., Thorup L., Hansen F., Bestle M., Hansen C. S., Afshari A., Bille A. B., Lefort M., Secher E. L., Liboriussen L., Herodes V., HA¤rma E., Marvet K., Pool K., Kallas P., MA¤gi T. -K., SA¼tt J., Vijar K., Visk E., Vinnal M., Ellermaa J., Liibusk L., Hovilehto S., Kirsi A., Mustola S., Tiainen P., Toivonen J., Dabnell S., Kaminski T., Sysimetsa A., Kaukonen M., Silvasti P., Vainio K., Lund V., SjAvall S., Saarinen K., Viitanen M., Ahonen T., AlaspA¤A¤ A., Zittling R., Saarinen A., Moisander A., Wagner B., Laru-Sompa R., Elomaa E., Lavonen L., Nevantaus J., Geier K., Kavasmaa T., Koorits U., Kubjas M., Lauritsalo S., Ottelin L., Palve M., PynnAnen J., RA¤A¤bis I., Saarelainen M., HeikkilA¤ T., Kontula T., LehtimA¤ki M., Liimatainen J., Moilanen-Oikarinen M., Pakarinen M., Palanne R., SeppA¤nen H., Pulkkinen A., VA¤A¤rA¤niemi H., Kajaani, Paananen S., Koskenkari J., SA¤lkiA S., Vakkala M., Koskue T., Loisa P., Laitio R., HautamA¤ki R., Koivisto S. -P., Leon A., Bonnet F., Marret E., Spielvogel C., Papageorgiou C., Szymkiewicz O., Tounou-Akue F., Aubrun F., Bonnet A., Gazon M., Guiraud M., Laurent V., Tachon G., Demars N., Dumenil A. -S., Mercier F. J., Landais A., Mentec H., Bazin M., Futier E., Gonnu S., Petit A., Albaladejo P., Almeras L., Rossi-Blancher A. B. M., Lefrant J. Y., Barthel F., Hallel D., Sbai H., Khalifeh P., Lidzborski L., Jully M., Platon E., Pottecher J., Baumgarten R., Schultz C., ElMiloudi F., Lefebvre J., Waton K., Sprunck A., Steib A., Thibaud A., Thuet V., Kieffer V., Dubois-Vallaud D., Jacob L., Becanne X., Cherfaoui S., Gauzit R., Godier A., Lakhdari M., Samma C. M., Halchini C., Lacroix M., Pinna F., Barbes A., Just B., Mateu P., Benayoun L., Berger P., Granier N., Perrigault P. F., Libert N., De Rudnicki S., Merat S., Bourdet B., FerrACopyright F., Minville V., Piriou V., Rague P., Wallet F., Lebuffe G., Desbordes J., Robin E., Ichai C., Orban J. -C., Gottschalk A., Piontek A., Unterberg M., Hilpert J., Kees M., Triltsch A., Wiegand-LAhnert C., GlAckner C., Hohn A., Rose E., SchrAder S., Wiese O., Awlakpui E., Hoeft A., Scheidemann M., Wittmann M., Ramminger A., Dresden C., de Abreu M. G., Heller A. R., Marx C., Neidel J., Goldmann A., von Heymann C., Laetsch B., Maahs E., Scholz L., Frenzel D., Massarat K., Lenhart F. -P., Reichle F., Rudlof K., Borchers F., Buettner C., Schmutzler M., Lucht A., Wagner J., Wuppertal H. K., Pilge S., Schneider G., Untergehrer G., Bis B., Krassler J., Dittmann J., Haberkorn J., Eberitsch J., Eberitsch K., Nippraschk T., Wepler U., Engelen W. -C., Nau C., Scholler A., SchA¼ttler J., Wintzheimer S., Bloos F., Braune A., Fergen D., Ludewig K., Paxian M., Reinhart K., Graf N., Schwarzkopf K., Berger K., Habicher M., Kasperiunaite R., Savelsberg S., Krep H., Reindl M., Bauer W., Bingold F., Christ S., Friederich P., Kaviani R., Auer P., BonnlA¤nder G., Drescher J., Braun R., Eichenauer T., Kerner J., Bierbaum K., BrA¼nner H., Grond S., Perez-Platz U., Andresen B., Linstedt U., Stegmann N., Erkens U., Kopcke J., Meyer A., Brestrich H., Ernst S., Merkel S., Krieger L., Luers F., Weyland A., Noeldge-Schomburg G., Wasmund C., Bredtmann R. -D., Erler I., Haumann C., MAllemann A., Oehmichen U., Sergejewa O., Lehning B., Czeslick E., Geyer M., Malcharek M., Sablotzki A., Stier M., Feld F., Marx G., Rossaint R., Simon V., Armaganidis A., Kotanidou A., Nanas S., Papastylianou A., Psevdi A., Stathopoulos A., Voulas A., Kanna E., Koutsikou A., Moustaka A., Chovas A., Komnos A., Zafiridis T., Franses J., Lavrentieva A., Koraki E., Katsenos C., Kasianidou M. F., Nasopoulou P., Spyropoulou E., Gousia C., Katsanoulas C., Lathyris D., Kyriazopoulos G., Sfyras D., Tsirogianni A., Kostopanagiotou G., Koulenti D., Lignos M., Matsota P., Christopoulos C., Mouratidou A., Vrettou E., Boufidis S., Moka E., Arnaoutoglou E., Koulouras V., Nakos G., Papathanakos G., Anthopoulos G., Choutas G., Karapanos D., Tzani V., Gkiokas G., Nastos K., Nikolakopoulos F., Dragoumanis C., Nikitidis N., Pneumatikos I., Theodorou V., Zacharouli D., Kandi S., Tasopoulos K., Arvaniti K., Matamis D., Mplougoura E., Petropoulou P., Soumpasis I., Amaniti E., Giannakou-Peftoulidou M., Gkeka E., Soultati I., Kokinou M., Papatheodorou L., Stafylaraki M., Giasnetsova T., Gritsi-Gerogianni N., Kydona C., Kiskira O., Koulentis I., Apsokardos A., Dimitropoulos K., Soldatou O., Nathanail C., Papazotos A., Tsakas P., Clouva-Molyvdas P. -M., Kolotoura A., Sartzi M., Papanikolaou S., Polakis P., Karatzas S., Kyparissi A., Papavasilopoulou T., Koukoubani T., Mastora E., Nyktari V., Malliotakis P., Papaioannou A., Bekos V., Maragkou E., Spring A., Ioakeimidou S. E. A., Noulas N., MolnA¡r Z., CsA¼llAg E., Elekes E., MolnA¡r T., Katona Z., Kremer I., Miko A., Budapest, Csomos A., Galambos Z., Szucs A., Szekeres G., Szabo E., Kranitz K., Simon M., Szigeti J., GaA¡l E., Havas A., Ille A., Miskolc, BrA¡z K., Nagy G., Hafeez P., Hanumanthaiah D., Brohan J., O'Chroinin D., Bailey K., Ramamoorthy K. G., Doyle Y., Freir N., O'Rourke J., Jonson P., Saeed S., Hayes I., Loughrey J., Frohlich S., McCauley N., Ryan D., Fitzpatrick G., Kevin L., Thomas J., Warde B., Woolhead A., Duggan M., Egan C., Crowley S., Lebese S., Bergin A., Westbrook A., Page R., Collins D., McKenny M., Bresciani A., Carmino L., Ghelfi S., Lorenzelli L., Novelli M. T., Pescarmona C., Roasio A., Gatta A., Nastasi M., Sanseverino M., Tinti C., Bianchin A., Tormena M. P., Franco A., Marini F., Di Mauro P., Rapido F., Tommasino C., Bellotti F., Boninsegna D., Castellani G., Sances D., Spano G., Tredici S., Vezzoli D., Fucecchio I., Bacci A., Coppini R., Dell'unto S., Mori E., Stanzani M. R., Tosi M., Collareta M., Forfori F., Franchi M., Mancino G., Battistella M., Baricocchi E., Bona F., Debernardi F., Giacoletto G., Iacobellis A., Massucco P., Moselli N., Muratore A., Palomba G., Sardo E., Suita L., Zocca E., Bucci B., Corte F. D., Piciucco T., Viarengo V., Cantarini E., Giampieri M., Tanfani A., Recchia E., Bignami E., Bruno G., Costagliola R., Gandolfi A., Greco M., Lembo R., Monti G., Nicelli E., Pasculli N., Turi S., Rocca G. D., Baroselli A., Brazzoni M., Buttazzoni M., Buttera S., Centonze C., Serena G., Spagnesi L., Toretti I., Vilardi A., Zearo E., Arpino I., Baraldi S., Guarnerio C., Molene V., Monea M. C., Vaccarisi E., Vicari L., Albante A., Aversano M., Loiacono C., Marandola M., Fusari M., Petrucci N., Galla A., Mascia A., Primieri P., Di Noto A., Gratarola A., Molin A., Pelosi P., Spagnolo L., Spena C., Calligaro P., Marchiotto S., Merlini A., Pedrazzoli E., Perina G., Visentin R., Fumagalli R., Garbagnati A., Manetti B., Snaier C., Somaini M., Farnia A., Nani R., Pierantonio N., Grasso S., Gazzanelli S., Pugliese F., Ruberto F., Bergamini E., Tassinati T., Capuzzo M., Cirillo V., Tufano R., Oggioni R., Parrini V., Brunori E., Capone M., Carbone L., Corradetti F., Elisei D., Fiorentino S., Francesconi M., Gattari D., Gorgoglione M., Iacobone E., Minnucci F., Montironi C., Riccioni G., Tappata G., Zompanti V., Verdenelli P., Cerutti E., Ranieri V. M., Grigorjevs S., Rikmane M., Rozkalne D., Stepanovs J., Suba O., Golubovska I., Kazune S., Miscuk A., Nemme J., Oss P., Sipylaite J., Macas A., Ragaisis V., Kontrimaviciute E., Tomkute G., Boerma E. C., Leeuwarden M. C., Kramer I. F., Poeze M., Maria J., Pelzer G., Nijsten M., Schoorl M., Spanjersberg R., Buhre W., Dieleman S., van Klei W. A., Bouw M., Pickkers P., Schreiner F., Zandvliet R., van den Berg R., De Wit E., Keijzer C., Hollmann M. W., Preckel B., van Acker G. J. D., Dennesen P. J. W., Kuijpers-Visser A. G., Inan T., Gemert A. W. M. M. K. -V., Ponssen H. H., Brouwer T., Koopmans M., van Bommel J., van Duijn D., van der Hoven B., Ormskerk P., Beck O., Schiere S., Reidinga A. C., Venema A., Jammer I., Dokka V., Monsen S. A., Ytrebo L. M., Noursadeghi M., Shahzad A., Boksasp O. D., Roiss C., Strietzel H. F., Berntsen A. G. S., Haugland H., Vingsnes S. O., Axelsson P., Risom Olsen T. C., Katre S., Aakeroey K., Tamowicz B., Bozilow D., Goch R., Grabowski P., Kupisiak J., Mallek M., Szyca R., Kostyrka W., Choma R., Jankowski G., Koscielniak W., Pietraszek P., Szarowar B., FranA§a C., Lacerda A. P., Ormonde L., Rosa R., Pereira I., Vitor P., Bento H. C., Carvalho M. R. L. M., Faria M., Almeida E., Mealha R., Vicente R., Monte R., Rua F., Barros N., Esteves F., Pinheiro C. M. G., Real V., Oliveira V. M., Oliveira M. F., Martins I., Saraiva J. P., AssunA§A£o J. P., BA¡rtolo A., Carvalho A., Correia C., Martins S., Milheiro R., Diaz A., GonA§alves M. I., Ribeiro R., Estilita J., GlAria C., de Almeida J., Barros F., Ramos A., Camara M., Maul E. R., Nobrega J., Langner A., Maia D. F., Afonso O., Faria F., Serra S., Botelho M. M., Ferreira P., MourA£o L., Oliveira A. V., Resende M., Aleman M., Fonseca J., Isidoro M., de Meneses H., PAªgas A., Pereira J., Pereira L., Ramos B., Matos F., Matos R., de Lurdes GonA§alves Castro M., Martins A., Ramos C., de Sousa M., Bento L., Botas C., Lopes V., Mendes R., Blaj M., Damian M., Lupusoru A., Ristescu I., Codreanu M., Diaconescu C., Nistor A., Stelian D. S., Streanga L., Berneanu M., Bordeianu C., Florenta C., Iacob A., Lupu M. N., Mocanu I., Moraru C., Meran C., Nicolae B., Sandu M., Turcanu R., Epure F., Grigore M., Hotaranu C., Popescu N., Baban O., Baciu M., Ciobanu A., Maftei I., Moldovan I., Ungureanu L., Bogdan P., Corneci D., Dinu M., Madalina D., Rely M., Silvius N., Tomescu D., Gabriela D., Dinescu S. A., Calin M., Ionescu D., Margarit S., Vasian H., Albu C., Balasa C., Cadrigati A., Dragulescu D., Gavra L., Hentia C., Macarie C., Manescu M., Nediglea I., Ocica D., Ovidiu B., Papurica M., Plavat C., Popa C., Ramneantu M., Sandesc D., Sandici Z., Sarandan M., Belciu I., Tincu E., Aignatoaie M., Huzuneanu M., Cocu S., Hagau N., Ciubotaru R., Copotoiu S. -M., Copotoiu R., Ioana G., Kovacs J., Leonard A., Szederjesi I., Genoveva V., Mosnegutu S., Djordjevic D., Djordjevic B., Grujic K., Jovanovic D., Obradovic J., Zeba S., Jevdjic J., Miletic M., Zunic F., Bulasevic A., Brko R., Gazibegovic N., Kendrisic M., Vojinovic R., CapkovA¡ J., Firment J., Grochova M., Trenkler S., Griger M., Zahorec R., Bakosova E., Kvasnica M., Saniova B., Sulaj M., Zacharovska A., Simkova A., CA­kovA¡ A., Gebhardtova A., HanuljakovA¡ S., Koutun J., MartonovA¡ A., AilincA¡rovA¡ V., Galkova K., Krbila S., Sobona V., Ocenasova M., Novak-Jankovic V., Stecher A., Stivan F., Grynyuk A., Damjanovska M., Kostadinov I., Knezevic M., Malivojevic M., Borovsak Z., Kamenik M., MekiA¡ D., KapA¡ S. O., Aleksic D., Gerjevic B., Kalan K., Ursic T., Artigas A., Garcia A., Lisi A., Perez I., Perez G., Poch N., Vaquer S., Balciscueta G., Barrasa H., Cabanes S., Maynar J., Poveda Y., Rodero A. Q., Vallejo A., Duque P., Garcia-Bunger B., Elvira M. A., Lajara A. M., Palencia M., Ramos R., Fernandez A. S., LeAn J. P. T., LApez J. I., Murillo F. J. Y., Ramirez E. T., Rico P. U., Patricia M., VizcaA­no M., Alvarez M. J. B., Real K. P., Serra A. M., Aracil N., Bodega B. M., GarcA­a R. F., GarcA­a M. A., de la Quintana Gordon B., JodrA¡ A. G., LApez A. D. S., Ros J. J. L., Soto R. A., SepAºlveda I., DA­ez E. P., FernA¡ndez L. F., Gulina C. S., Arviza L. P., Fernandez L. M., GAmez A. R., MartA­nez C. A., RodrA­guez A. B. R., Soto C. L., Aldecoa C., Garcia C., Lorenzo M., Pinilla E., Rico J., Ruperez I., Alonso E., Leira F., Maseda D. P. E., Royo C., Villagran J., Candi G. M., Esteva G. E., Folgado R. M., Fornaguera N. J., Montse P. C., Prat A. S., Sintes D., Arteta D. A., Delgado H. G., LApez-Cuervo J. F., LApez M. C., RamA­rez A., SaldaA+/-a F. J., Aliste P., Anchuelo A. H., Campos A. G., CatalA¡n M., GAmez M. G., Gonzalaez O. G., LApez E. L., Navacerrada I. R., de Quevedo S. A., Serrano M. G., Silvestre F. P. -C., Torrente F. M., Arocas B., Martinez E. P., Soro M., Maroto F., Algarra R. R., Aleixandre I. S., Argente G. R., LleA A. B., Rubio A. V., SA¡nchez J. L. V., ValcA¡rcel I. E., Balust C., Balust J., Borrat X., Carretero M. J., Gracia I., Matute P., Mercadal J., Pujol R., Tena B., Ubre M., Albalad D. D., Alcaide C. M., Caballero J., Cervantes A. C., de Nadal Clanchet M., Estruch N. M., Ferrer M. B., Fornells A. L., Galera E. T., Martinez I. G., MuA+/-oz S. M., Pelavski A., Perez P. T., Posada M. A. G., de Prat I. C., Rello J., Serrano L. G., Sieiro J. M. N., Silva L., Sole M. J. C., SuA+/-ACopyright A. B., Villach I. R., Herreras J. I. G., Poves R., Rafael B. M., Almeida I. M., Collates A. F., BartolomACopyright M. J., Cimadevilla B., GonzA¡lez A. M. G., Llevot J. M. R., de TerA¡n Mira J. C. D., Molina B. G., Pardo S., SA¡nchez C. L., Williams M., Zaldibar E., Corsini L. M., Fraile J. R. R., de la Lastra M., Sacramento M. K., SaA+/-a F. J. L., Alvarez J. T., Bulnes M. L. C., Carrasco V. G., del RocA­o MA­guez Crespo M., Cubillos D. N., Laza E. L., del Pino Heredia PACopyrightrez M., Seisdedos A. A., Torres B. F., Ampuero M. S., Llano M. C., Mata E., Munoz M., Orts M., Planas A., Ramasco F., Roman C., DurA¡n M. V., del RA­o Fernandez S., Otero Y. S., Pineiro S. L., Pardal C. B., Alcantud J. F., Antolinos M. A., Barrios F., Casanova A. C., Castro M. R., Crespo B. I., Felipe U. L., Fuster M. L., GarcA­a M. S., Garrote B. H., Gonzalez R. M., Granero M. J. M., de la GuA­a C. L., LApez R. C., de Frutos LApez S., Martinez J. J. M., Mostaza A. G., Moreno A. J., Osado I. R., PACopyrightrez M. R., PiA+/-a M. A., Romero C. A., RodrA­guez E. R., Salvan J. H., Sampedro M. G., de la Torre P. A., Toro J. P., UnzAºe C. L., Vargas M. J., Bernal D. 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M., CerdeiriA+/-a A. P., de la Torre Concostrina M., Cristina M. V., DA­az T. D., Esteruelas J. A., Ingelmo I. I., Insuga P. D., Llamas E. C., Lopez J. J. M., MartA­n M. B., MartA­n E. E., Mesa E. U., Monterde M. L., Montoiro P. A., MAstoles M. L. G., Olarte E. V., PACopyrightrez A. M., Perez F. D., Romero A. S., Rous D. P., Ruiz N. M., Ruiz J. A. P., Saiz A. R., de la Vega Terol A., Toha A. C., Utrera F. A., Alberdi F., ElAsegui I., GarcA­a J., Garde P. M., Mintegui E. I., SA¡ez I. G., Salas E., Zabarte M., Diaz-Boladeras R. -M., Mora-Guevara E., Zamora J. F., Bonet A., Salo L., Salinas U., Zaballos J. M., Alvarez A. A., Garrido C. J., Roa J. R. H., Vidal F. G., Garcia-Egea J., Elson M. Z., Seron-Arbeloa C., Asensio M. A. M., SimeAn R. G., Alameda L. E. M., Angulo G. O., Aranzubia M., Arcas J. J., Arevalo J., Belvert B. Q., Calvo C. P., Cremades M., Crespo P., Cuarental A., Del Olmo M., FernA¡ndez P. T., Vega J. L. F. G. I. G., Herrera E., Llorente M. A. A., Rabes C. M., de Maeyer A. 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D., Ekwen G., Kaggya M., Constance N., Samuel N., Akanyun S., Freeman T., Royas L., Tchoupa M., Simo W. A. G., Ngouane D., Tanjong B. N., Bouya A. P., Carlos F., Gallou P. D., Prosper A., Athombo J. S., Sanduku D. K., Mampangula Y., Nziene V. N., Odia P. K., Mbombo W. D., Wms M., Mukuna P. M., Boloko P. M., Mvwama N. M., Jjn I., Manzombi J. K., Mvwala K. R., Ilunga J. P. M., Mawisa T., Kilembe A. M., Bikuelo C. J., Mwepu I. M., Mwaluka C. N., Sarah H. N., Kukembila A. M., Diyoyo M. P., Ngalala A. M., Kabango R., Kongolo M., Mbayabu M., Namegabe E. S., Bula Bula I. M., Likongo T. B., Pengemale G. N., Bingidimi S. S., Imposo D. H., Matondo P. M., Lelo S. N., Kamanda R. J., Kady N., Ntueba B., Christian M., Badianga E. K., Clc L., Mubeya F. K., Bahta M. T., Kassa S. K., Assefa S. B., Girmaye G. T., Samateh A. L., Janneh L., Sanyang L. N., Nyassi M. T., Grey-Johnson S. V., Villarreal R., AntAnez O., Jallow C. S., Roberts C. A., Clegg-Lamptey J. N., Kutor Y. Y., Adu-Aryee N. A., Domoyyeri D. P., Atito-Narh E., Anabah T. W. A., Ndonga A. K. N., Ngumi Z. W. W., Bitta C., Nyawanda H. O., Oduor O. E. O., Okelo O. S., Ogendo S. W. O., Ngari N. B. M., Nyokabi N. N., Chokwe T. M., Gacii V. M., Githae B., Gatheru A. P., Maranga O., Muriithi J. M., Mwangi C. M., Mwiti T. M., Nabulindo S. M., Ndung'u C., Mugambi J., Mtongwe V. M., Kiprop B., Mbadi R., Wambugu P. K., Hersi S., Mutahi S., Aluvale J. S., Gitau S., Kariuki K., Ngatia E., Sitima S., Obadiah S., Mwenda V., Iraya A. M., Waweru E. N., Muturi A., Miima S., Ojujo M., Mossy P., Macharia I., Gakenia A., Mitema F., Manvinder M., Kipng'etich B., Njoroge M., Ndegwa D., Karanja J. K., Muchiri K., Makori O., Kibochi W., Mathangani W., Swaleh A., Wafula A., Maina S. N., Njenga P. W., Okonu N., Maghrabi M., Saed S. S., al Shams E. S., Shkirban A. S., Alakkari E. A., Gweder M. G., Baghni R. B., Alsabri S. A., Hebli S. H., Elghandouri M., Shanin S. H., Rokhsi S., Hensheri M. E. L., Eltaguri M., Elyasir I. E., Alwahedi H. W., Almoraid F., Anjar N., Alkilani A., Ghnain A., Senusi F. S., Elsaity R., Almajbery A., Abokris A., Montenegro L., Mohammed F. A. M., Hammouda M., Elsaadi G., Makhlouf N. M., Elzoway A. Z., Abuzalout T. S., Elmehdawi H., Alhendery A. A., Tarhuni A., Feituri A., Benamour A. S. B., Alkobty F. A., Azzaidey H. M. Z., Mohammed N. M., Elghazal Z. S. E., Alhoty F. F. H., Abugassa S. O. A., Al-Zubaidy K., Ilbarasi M. N., Alalem R., Swayeb E., Zubia N. Z., Mohamed P., Teeka M. O., Sohoub A., Abushnaf A., Mohamed A., Ramadan L., Shubba A., Huwidi O., Al-Serksi M., Eshtiwi M., Hadia E., Ahmed A. -J., Mansour I., Rian J. R., Yousef G., Mohamed S., Ahmed E. -Z., Ahmed B., Jamal Z., Abujanah S. A., Amer A. -A., Yousef O., Abozaid W., Elfagieh M. A., Ali A., Zoobei N. Z., Juwid A., Wafa A., Alatresh O. A., Alashhab M., Elzufri A. M., Aldarrat A. D., Matoug F., Alsellabi B., Alkesa T., Addanfour A., Badi H. B., Elfaghi I. E., Salaheddin E., Hamadi L., Hashmi H., Abd-rouf A., Ahmed M., Karar M., Zidan A., Alraheem A. A., Attia A., Yahya A. A., Otman F., Elmadany H., Gerbel G., Saleh M., Eurayet O., Almesmary R., Mostafa H., Abdurazig S., Dahim L., Jermi K., Koraz M. Y. K., Elghallal A. M., Eshwehdi A. A., Elwerfelli A., Elharati F. T., Elrafifi D., Algbali M., Abuhdema F., Elmadani L., Algedar H. A., Shefren I., Abdulrahman A., Najat N. Z., Elkhwildi R. M., Elgelany S., Abduljalil A., Hdud A., Zentuti H. Z., Khetrish S. B., Zeiton A. Z., Altagazi A. A., Almisslati S. H. A., Gandy Y. G., Jasim I., Alghafoud I. A., Hokoma M., Abusnina S. A., Gwila M., Yahya A. I., Mohammed M., Alqawi O. A., Hasan S. H., Rakotoarison S. R., Albert F., Hery A. H., Mamy R. M., Andriamampionona A. G. B., JudicaA«l M., Ramilson H. E., Eloi H., Athanse V., Zo A., Andrianina L., Judicael R. M., Rakotoarisoa A. H. N., Rakotoarijaona A. H. R., Ramananasoa M. L. R., Angelin R., Hanta R., Raherison R. A. R., Rija F. R., Fanjandrainy R. F., Coulibaly Y., Zie S. Z., Gangaly D., Mahamane D. D., Toure Mamadou K., Simaga Abdoul K., Ibrahim T., Abdoulaye T., Alioune B. S., Souleymane T., Oumar O., Sogoba G., Amadou M., Moussa K., Veerasamy B., Heerah H. M. S. N., Limbajee M. L., Alleesaib S. B. M., Ramchurn T. P. R., Mandarry M. T. M., Joomye S., Thakoor B., Aungraheeta M., Sookun S. S., Lumbala K. F., Ikandi K., Kabongo L. T., Garcia M., Izquirdo P., Castro A. C., Ilunga I. B. B., Imbangu N. A. V., Nakandungile F., Mmasi J. E., Tobiko O., Polishchuk O., Kashuupulwa P. N. K., Kalume S., Sihope S. E., Arrey O., Kakololo S. I., Taiwo N. A., Kairuki P. C. K., Gazmuri O. G. G., Imene A. M., Umenushkin U. A., Kibandwa A., Cisekedi J. C., Nakangombe P., Musiba V. E. M., Gama G. G. N., Mwanga H. A. M., Mgonja L., Rink B., Amisi B. T., Bangure L., Rois W., Rois I., Sabwa H. K., Barongo M. L., Tshisekedi S. M., Mbuyi T., Lyimo T. S. K., Munyika A. A., Kornilov A. A., Rwehumbiza S. S. R., Kumar M., Makopa E. K., Njuguna W., Mavesere H. P., Kabongo A. N., Mutasiigwa M. G. H., Yangazov Y. M., Masiyambiri A. T. M., Jannetjies M. J., Dibwe D. F., Manyere D. V., Gorelyk O., Kabangu J. K., Gagara M., Salaou H., Moutari M., Bori I., Ogboli-Nwasor E. O., Aghadi K., Mohammed I., Sarkin-Pawa A., Yunus A. A., Ibrahim A. I., Edaigbini S. A., Yakubu Y., Sholadoye T., Koledale A. K., Anyanwu L. J. C., Salisu-Kabara H. M., Sheshe A. A., Ekwunife N. C., Ike I. A. R., Anele A., Isiguzo M., Ihezie O., Onyegbule A., Enendu E. O., Akhideno I., Desalu I. S., Bankole O. B., Ojewola R. W., Osinowo A. O., Afolabi B. B., Menkiti I. D., Mofikoya B. O., Osazuwa M. O., Yusuf A. S., Adamu Y. B., Alatise O. I., Arowolo O. A., Adisa A. O., Etuk E. B., Eyelade O. R., Ogunbode O., Shittu O. B., Idowu O. K., Ayandipo O. O., Lawal T. A., Echem R. C., Otokwala J., Jamabo S., Gueye S., Allopi K., Singh U., Bester J. J. A., Saaiman C. R., Alli A., Bischof K. E., Hurri H., Smith O. I., Elghobashy A. M., Omoshoro-Jones J., Murray R., Basson C. H., de Wet J. B., Skinner G. C., Kransingh S., Kuhn W., Madsen A. S. M., Matubatuba J. T., Mayeza S., Naidoo L. C., Narain S. J., Nkuebe T. N., Nabela L., Nkunjana M., Mhatu S., Thomas B. P., Wynne E. E., Davids J. G., GrA¼newald K. K., Kruger S., Ras W. A. P., Venter P. J., Cacala S. R. C., Kruse C., Mahomva O., Marais L. C., Semenya E. M., Rayne S. R., Alphonsus C. S., Mbuyisa M. W., Torborg A. M., De Lange J. T., Drummond L. W., Dullab K. D., Enicker B. C., Gigabhoy R., Hardcastle T. C., Maharaj A., Majola N., Moopanar M., Mukama I. F., Naicker K., Ngcobo G. K., Ramnarain H., Rocher A. G. L., Singh S., Stoltenkamp H. L., Alberts A. N. J. D., Luthuli L., Lumbamba A. J. M., Anderson P. G. R., du Plessis W. M., Ellis S., Ford L. M., Rousseau F. J., Rousseau N., Steyn G., Steyn H. C., Weideman M., Church B., Holford E. B., Szpytko A. J., Brouckaert N. T., Freeman Y. B. M., Ehouni A., Jithoo S., Naidoo L., Peter A. M., Belhaj S., Tun M., Kapp P., Bwambale Y. B., Holder H., Kasongo K. J. P., Makhanya V., Morapedi M., Mahomedy N. A., Pillay V., Reddy S. R., Mgoqo N., Mrara B., Nibe Z., Ninise E., Pahlana S. M., Usenbo A. O., Malongwe S. M., Giles D. G., Porrill O. S., Reed A. R., Visser J., Davies G. L., Koller V. L., Moodie Q. K., Spicer J. M., Van Dyk J. G., Diedericks B. J. S., Esterhuizen J. L., Mavhungu R., Mhlari T. M., Akhter M., Baloyi A. M., Bamuza K. A., Bamuza M. I., Bashiya L., Blignaut F., Machowski A. Z., Madzivhe L. J., Mafafo S. C., Mashile M. V., Masia O. R., Masipa J. N., Matenchi M. W., Mathe R. C., Mogale J. O., Mohlala M. P., Mongwe K. N., Morulana T. G., Motloutsi S. P., Mphephu P. E., Muroonga M. P., Mzezewa S. Z., Neil M. C., Neluheni E. V., Nesengani D. S., Nesengani N. T., Netshimboni L. E., Notoane I., Omoding S., Orjiako O., Perez N., Pheeha R. M., Pilusa K. A., Pochana M. P., Pupyshev M., Rambau M., Ramuntshi R., Roura H., Ryabchiy B. B., Ryndine V., Sebei M. P., Moses V. L., Mungherera A. R. W., Pansegrouw J., Nepogodiev D., Omar O.M., Glasbey J.C., Li E., Simoes J.F.F., Abbott T.E.F., Ademuyiwa A.O., Biccard B.M., Chaudhry D., Davidson G.H., Di Saverio S., Gallo G., Ghosh D., Harrison E.M., Hutchinson P.J., Kamarajah S.K., Keller D.S., Lawani I., Minaya-Bravo A., Moore R., Morton D.G., Ntirenganya F., Pata F., Pearse R.M., la Medina A.R.-D., Tabiri S., Venn M.L., Omar A.B.O.M., Bhangu A., Siaw-Acheampong K., Adamina M., Agarwal A., Alameer E., Alderson D., Alakaloko F., Alser O., Arnaud A.P., Augestad K.M., Bankhead-Kendall B.K., Barlow E., Benson R.A., Blanco-Colino R., Brar A., Breen K.A., Buarque I.L., Caruana E.J., Chakrabortee S., Cox D., Cunha M.F., Dawson B.E., Desai A., Drake T.D., Edwards J.G., Elhadi M., Evans J.P., Farik S., Fiore M., Fitzgerald J.E., Ford S., Gomes G.M.A., Griffiths E.A., Gujjuri R.R., Halkias C., Heritage E., Isik A., Jenkinson M.D., Jones C.S., Khatri C., Keatley J.M., Kolias A., Lawday S., Lederhuber H., Leventoglu S., Loffler M.W., Martin J., Mashbari H.N., Mazingi D., Mckay S.C., Metallidis S., Mohan H.M., Moszkowicz D., Moug S., Ng-Kamstra J.S., Niquen M., Outani O., Pellino G., Pinkney T.D., Pockney P., Radenkovic D., Roberts K., Roslani A.C., Santos I., Schache A., Schnitzbauer A.A., Stewart G.D., Shaw R., Shu S., Soreide K., Spinelli A., Sundar S., Tiwari A., Townend P., Trout I.M., Tsoulfas G., van Ramshorst G.H., Vidya R., Vimalachandran D., Warren O., Wilkin R.J.W., Wright N., Hoste E., Huyghens L., Jacobs R., Opdenacker G., Poelaert J., Rijckaert D., De Decker K., Foubert L., De Neve N., Biston P., Piagnerelli M., Collin V., den Blauwen N., Clauwaert C., De Crop L., Verbeke A., Derumeaux P., Gardin C., Kindt S., Louage S., Verhamme B., Druwe P., Lahaye I., Rosseel F., Rutsaert R., Vanlinthout L., De Kock M., Forget P., Georges P., Grosu I., Kahn D., Lois F., Momeni M., Yemnga A.P.B., Jadoul J.-L., Malbrain M., Bosinceanu D., Collard E., Jorens P., Reyntiens D., Smitz C., Vercauteren M., Fagnoul D., Toplice K., Oremus K., Beslic G., Duzel V., Hauptman A., Peremin S., Sribar A., Zupcic M., Brod S., Mirkovic I., Bauer Z.S., Belavic M., Blazanin B., Katusin M.L., Krijan A.B., Miskovic P., Simic-Korac N., Topic J., Zilic A., Zunic J., Acan I., Adanic M., Ivanov N., Saric J.P., Tomulic K., Viskovic N., Bosnjak S., Drenjancevic I.H., Kristek G., Kvolik S., Markic S., Rakipovic A.S., Tot O.K., Fabris L.K., Bacak-Kocman I., Balenovic I., Bandic D., Deutsch P.A.J., Divjak L., Filipovic I.G., Guzvinec Z., Krznaric Z., Loncaric Y., Magas J.V., Mitrovic M., Okic M., Pavlek M., Ramov E., Rezek K., Sekulic A., Tomasevic B., Miric M., Tomasevic A., Mahecic T.T., Vrbanovic V., Bobinac M., Bozic A., Debelic D., Frkovic V., Batinica I.M., Baranovic S., Gavranovic Z., Kikec M., Maldini B., Maric S., Agnic I., Delic N., Dropulic N., Gaspic T.K., Ilic D., Ivancev B., Karanovic N., Kuscevic D., Marovic Z., Milic M., Nevescanin A., Petkovic T., Smoje M., Brozovic G., Goranovic T., Jelisavac M., Matolic M., Mazul-Sunko B., Oberhofer D., Pavicic A.M., Sakic K., Bozovic M.D., Krecek Z.K., Krobot R., Andabaka T., Bratanic M., Dzepina O., Kraljev M., Seric J., Simurina T., Grujic R., Nacevski-Bulaja B., Barizon M., Danira V., Drazen B., Dusanka K., Haluzan M.B., Josko Z., Katica R., Labor M., Marinkovic T.G., Mihovilcevic D., Marija B., Srecko M., Drab M., Hudacek K., Krikava I., Stourac P., Brabcova M., Klozova R., Vajter J., Vymazal T., Toft P., Blichfeldt L., Hansen B.D., Moller K., Nielsen J.S., Frederiksen J., Andersen J.D., Kuhne J.P., Leivdal S., Stendell L., Simonsen M., Zoltowski M.K., Ali Z.S., Freundlich M., Pilypaite J., Clausen N.G., Thorup L., Hansen F., Bestle M., Hansen C.S., Afshari A., Bille A.B., Lefort M., Secher E.L., Liboriussen L., Herodes V., Harma E., Marvet K., Pool K., Kallas P., Magi T.-K., Sutt J., Vijar K., Visk E., Vinnal M., Ellermaa J., Liibusk L., Hovilehto S., Kirsi A., Mustola S., Tiainen P., Toivonen J., Dabnell S., Kaminski T., Sysimetsa A., Kaukonen M., Silvasti P., Vainio K., Lund V., Sjovall S., Saarinen K., Viitanen M., Ahonen T., Alaspaa A., Zittling R., Saarinen A., Moisander A., Wagner B., Laru-Sompa R., Elomaa E., Lavonen L., Nevantaus J., Geier K., Kavasmaa T., Koorits U., Kubjas M., Lauritsalo S., Ottelin L., Palve M., Pynnonen J., Raabis I., Saarelainen M., Heikkila T., Kontula T., Lehtimaki M., Liimatainen J., Moilanen-Oikarinen M., Pakarinen M., Palanne R., Seppanen H., Pulkkinen A., Vaaraniemi H., Kajaani, Paananen S., Koskenkari J., Salkio S., Vakkala M., Koskue T., Loisa P., Laitio R., Hautamaki R., Koivisto S.-P., Leon A., Bonnet F., Marret E., Spielvogel C., Papageorgiou C., Szymkiewicz O., Tounou-Akue F., Aubrun F., Bonnet A., Gazon M., Guiraud M., Laurent V., Tachon G., Demars N., Dumenil A.-S., Mercier F.J., Landais A., Mentec H., Bazin M., Futier E., Gonnu S., Petit A., Albaladejo P., Almeras L., Rossi-Blancher A.B.M., Lefrant J.Y., Barthel F., Hallel D., Sbai H., Khalifeh P., Lidzborski L., Jully M., Platon E., Pottecher J., Baumgarten R., Schultz C., ElMiloudi F., Lefebvre J., Waton K., Sprunck A., Steib A., Thibaud A., Thuet V., Kieffer V., Dubois-Vallaud D., Jacob L., Becanne X., Cherfaoui S., Gauzit R., Godier A., Lakhdari M., Samma C.M., Halchini C., Lacroix M., Pinna F., Barbes A., Just B., Mateu P., Benayoun L., Berger P., Granier N., Perrigault P.F., Libert N., De Rudnicki S., Merat S., Bourdet B., Ferre F., Minville V., Piriou V., Rague P., Wallet F., Lebuffe G., Desbordes J., Robin E., Ichai C., Orban J.-C., Gottschalk A., Piontek A., Unterberg M., Hilpert J., Kees M., Triltsch A., Wiegand-Lohnert C., Glockner C., Hohn A., Rose E., Schroder S., Wiese O., Awlakpui E., Hoeft A., Scheidemann M., Wittmann M., Ramminger A., Dresden C., de Abreu M.G., Heller A.R., Marx C., Neidel J., Goldmann A., von Heymann C., Laetsch B., Maahs E., Scholz L., Frenzel D., Massarat K., Lenhart F.-P., Reichle F., Rudlof K., Borchers F., Buettner C., Schmutzler M., Lucht A., Wagner J., Wuppertal H.K., Pilge S., Schneider G., Untergehrer G., Bis B., Krassler J., Dittmann J., Haberkorn J., Eberitsch J., Eberitsch K., Nippraschk T., Wepler U., Engelen W.-C., Nau C., Scholler A., Schuttler J., Wintzheimer S., Bloos F., Braune A., Fergen D., Ludewig K., Paxian M., Reinhart K., Graf N., Schwarzkopf K., Berger K., Habicher M., Kasperiunaite R., Savelsberg S., Krep H., Reindl M., Bauer W., Bingold F., Christ S., Friederich P., Kaviani R., Auer P., Bonnlander G., Drescher J., Braun R., Eichenauer T., Kerner J., Bierbaum K., Brunner H., Grond S., Perez-Platz U., Andresen B., Linstedt U., Stegmann N., Erkens U., Kopcke J., Meyer A., Brestrich H., Ernst S., Merkel S., Krieger L., Luers F., Weyland A., Noeldge-Schomburg G., Wasmund C., Bredtmann R.-D., Erler I., Haumann C., Mollemann A., Oehmichen U., Sergejewa O., Lehning B., Czeslick E., Geyer M., Malcharek M., Sablotzki A., Stier M., Feld F., Marx G., Rossaint R., Simon V., Armaganidis A., Kotanidou A., Nanas S., Papastylianou A., Psevdi A., Stathopoulos A., Voulas A., Kanna E., Koutsikou A., Moustaka A., Chovas A., Komnos A., Zafiridis T., Franses J., Lavrentieva A., Koraki E., Katsenos C., Kasianidou M.F., Nasopoulou P., Spyropoulou E., Gousia C., Katsanoulas C., Lathyris D., Kyriazopoulos G., Sfyras D., Tsirogianni A., Kostopanagiotou G., Koulenti D., Lignos M., Matsota P., Christopoulos C., Mouratidou A., Vrettou E., Boufidis S., Moka E., Arnaoutoglou E., Koulouras V., Nakos G., Papathanakos G., Anthopoulos G., Choutas G., Karapanos D., Tzani V., Gkiokas G., Nastos K., Nikolakopoulos F., Dragoumanis C., Nikitidis N., Pneumatikos I., Theodorou V., Zacharouli D., Kandi S., Tasopoulos K., Arvaniti K., Matamis D., Mplougoura E., Petropoulou P., Soumpasis I., Amaniti E., Giannakou-Peftoulidou M., Gkeka E., Soultati I., Kokinou M., Papatheodorou L., Stafylaraki M., Giasnetsova T., Gritsi-Gerogianni N., Kydona C., Kiskira O., Koulentis I., Apsokardos A., Dimitropoulos K., Soldatou O., Nathanail C., Papazotos A., Tsakas P., Clouva-Molyvdas P.-M., Kolotoura A., Sartzi M., Papanikolaou S., Polakis P., Karatzas S., Kyparissi A., Papavasilopoulou T., Koukoubani T., Mastora E., Nyktari V., Malliotakis P., Papaioannou A., Bekos V., Maragkou E., Spring A., Ioakeimidou S.E.A., Noulas N., Molnar Z., Csullog E., Elekes E., Molnar T., Katona Z., Kremer I., Miko A., Budapest, Csomos A., Galambos Z., Szucs A., Szekeres G., Szabo E., Kranitz K., Simon M., Szigeti J., Gaal E., Havas A., Ille A., Miskolc, Braz K., Nagy G., Hafeez P., Hanumanthaiah D., Brohan J., O'Chroinin D., Bailey K., Ramamoorthy K.G., Doyle Y., Freir N., O'Rourke J., Jonson P., Saeed S., Hayes I., Loughrey J., Frohlich S., McCauley N., Ryan D., Fitzpatrick G., Kevin L., Thomas J., Warde B., Woolhead A., Duggan M., Egan C., Crowley S., Lebese S., Bergin A., Westbrook A., Page R., Collins D., McKenny M., Bresciani A., Carmino L., Ghelfi S., Lorenzelli L., Novelli M.T., Pescarmona C., Roasio A., Gatta A., Nastasi M., Sanseverino M., Tinti C., Bianchin A., Tormena M.P., Franco A., Marini F., Di Mauro P., Rapido F., Tommasino C., Bellotti F., Boninsegna D., Castellani G., Sances D., Spano G., Tredici S., Vezzoli D., Fucecchio I., Bacci A., Coppini R., Dell'unto S., Mori E., Stanzani M.R., Tosi M., Collareta M., Forfori F., Franchi M., Mancino G., Battistella M., Baricocchi E., Bona F., Debernardi F., Giacoletto G., Iacobellis A., Massucco P., Moselli N., Muratore A., Palomba G., Sardo E., Suita L., Zocca E., Bucci B., Corte F.D., Piciucco T., Viarengo V., Cantarini E., Giampieri M., Tanfani A., Recchia E., Bignami E., Bruno G., Costagliola R., Gandolfi A., Greco M., Lembo R., Monti G., Nicelli E., Pasculli N., Turi S., Rocca G.D., Baroselli A., Brazzoni M., Buttazzoni M., Buttera S., Centonze C., Serena G., Spagnesi L., Toretti I., Vilardi A., Zearo E., Arpino I., Baraldi S., Guarnerio C., Molene V., Monea M.C., Vaccarisi E., Vicari L., Albante A., Aversano M., Loiacono C., Marandola M., Fusari M., Petrucci N., Galla A., Mascia A., Primieri P., Di Noto A., Gratarola A., Molin A., Pelosi P., Spagnolo L., Spena C., Calligaro P., Marchiotto S., Merlini A., Pedrazzoli E., Perina G., Visentin R., Fumagalli R., Garbagnati A., Manetti B., Snaier C., Somaini M., Farnia A., Nani R., Pierantonio N., Grasso S., Gazzanelli S., Pugliese F., Ruberto F., Bergamini E., Tassinati T., Capuzzo M., Cirillo V., Tufano R., Oggioni R., Parrini V., Brunori E., Capone M., Carbone L., Corradetti F., Elisei D., Fiorentino S., Francesconi M., Gattari D., Gorgoglione M., Iacobone E., Minnucci F., Montironi C., Riccioni G., Tappata G., Zompanti V., Verdenelli P., Cerutti E., Ranieri V.M., Grigorjevs S., Rikmane M., Rozkalne D., Stepanovs J., Suba O., Golubovska I., Kazune S., Miscuk A., Nemme J., Oss P., Sipylaite J., Macas A., Ragaisis V., Kontrimaviciute E., Tomkute G., Boerma E.C., Leeuwarden M.C., Kramer I.F., Poeze M., Maria J., Pelzer G., Nijsten M., Schoorl M., Spanjersberg R., Buhre W.F., Dieleman S., van Klei W.A., Bouw M., Pickkers P., Schreiner F., Zandvliet R., van den Berg R., De Wit E., Keijzer C., Hollmann M.W., Preckel B., van Acker G.J.D., Dennesen P.J.W., Kuijpers-Visser A.G., Inan T., Gemert A.W.M.M.K.-V., Ponssen H.H., Brouwer T., Koopmans M., van Bommel J., van Duijn D., van der Hoven B., Ormskerk P., Beck O., Schiere S., Reidinga A.C., Venema A., Jammer I., Dokka V., Monsen S.A., Ytrebo L.M., Noursadeghi M., Shahzad A., Boksasp O.D., Roiss C., Strietzel H.F., Berntsen A.G.S., Haugland H., Vingsnes S.O., Axelsson P., Risom Olsen T.C., Katre S., Aakeroey K., Tamowicz B., Bozilow D., Goch R., Grabowski P., Kupisiak J., Mallek M., Szyca R., Kostyrka W., Choma R., Jankowski G., Koscielniak W., Pietraszek P., Szarowar B., Franca C., Lacerda A.P., Ormonde L., Rosa R., Pereira I., Vitor P., Bento H.C., Carvalho M.R.L.M., Faria M., Almeida E., Mealha R., Vicente R., Monte R., Rua F., Barros N., Esteves F., Pinheiro C.M.G., Real V., Oliveira V.M., Oliveira M.F., Martins I., Saraiva J.P., Assuncao J.P., Bartolo A., Carvalho A., Correia C., Martins S., Milheiro R., Diaz A., Goncalves M.I., Ribeiro R., Estilita J., Gloria C., de Almeida J., Barros F., Ramos A., Camara M., Maul E.R., Nobrega J., Langner A., Maia D.F., Afonso O., Faria F., Serra S., Botelho M.M., Ferreira P., Mourao L., Oliveira A.V., Resende M., Aleman M., Fonseca J., Isidoro M., de Meneses H., Pegas A., Pereira J., Pereira L., Ramos B., Matos F., Matos R., de Lurdes Goncalves Castro M., Martins A., Ramos C., de Sousa M., Bento L., Botas C., Lopes V., Mendes R., Blaj M., Damian M., Lupusoru A., Ristescu I., Codreanu M., Diaconescu C., Nistor A., Stelian D.S., Streanga L., Berneanu M., Bordeianu C., Florenta C., Iacob A., Lupu M.N., Mocanu I., Moraru C., Meran C., Nicolae B., Sandu M., Turcanu R., Epure F., Grigore M., Hotaranu C., Popescu N., Baban O., Baciu M., Ciobanu A., Maftei I., Moldovan I., Ungureanu L., Bogdan P., Corneci D., Dinu M., Madalina D., Rely M., Silvius N., Tomescu D., Gabriela D., Dinescu S.A., Calin M., Ionescu D., Margarit S., Vasian H., Albu C., Balasa C., Cadrigati A., Dragulescu D., Gavra L., Hentia C., Macarie C., Manescu M., Nediglea I., Ocica D., Ovidiu B., Papurica M., Plavat C., Popa C., Ramneantu M., Sandesc D., Sandici Z., Sarandan M., Belciu I., Tincu E., Aignatoaie M., Huzuneanu M., Cocu S., Hagau N., Ciubotaru R., Copotoiu S.-M., Copotoiu R., Ioana G., Kovacs J., Leonard A., Szederjesi I., Genoveva V., Mosnegutu S., Djordjevic D., Djordjevic B., Grujic K., Jovanovic D., Obradovic J., Zeba S., Jevdjic J., Miletic M., Zunic F., Bulasevic A., Brko R., Gazibegovic N., Kendrisic M., Vojinovic R., Capkova J., Firment J., Grochova M., Trenkler S., Griger M., Zahorec R., Bakosova E., Kvasnica M., Saniova B., Sulaj M., Zacharovska A., Simkova A., Cikova A., Gebhardtova A., Hanuljakova S., Koutun J., Martonova A., Zilincarova V., Galkova K., Krbila S., Sobona V., Ocenasova M., Novak-Jankovic V., Stecher A., Stivan F., Grynyuk A., Damjanovska M., Kostadinov I., Knezevic M., Malivojevic M., Borovsak Z., Kamenik M., Mekis D., Kaps S.O., Aleksic D., Gerjevic B., Kalan K., Ursic T., Artigas A., Garcia A., Lisi A., Perez I., Perez G., Poch N., Vaquer S., Balciscueta G., Barrasa H., Cabanes S., Maynar J., Poveda Y., Rodero A.Q., Vallejo A., Duque P., Garcia-Bunger B., Elvira M.A., Lajara A.M., Palencia M., Ramos R., Fernandez A.S., Leon J.P.T., Lopez J.I., Murillo F.J.Y., Ramirez E.T., Rico P.U., Patricia M., Vizcaino M., Alvarez M.J.B., Real K.P., Serra A.M., Aracil N., Bodega B.M., Garcia R.F., Garcia M.A., de la Quintana Gordon B., Jodra A.G., Lopez A.D.S., Ros J.J.L., Soto R.A., Sepulveda I., Diez E.P., Fernandez L.F., Gulina C.S., Arviza L.P., Fernandez L.M., Gomez A.R., Martinez C.A., Rodriguez A.B.R., Soto C.L., Aldecoa C., Garcia C., Lorenzo M., Pinilla E., Rico J., Ruperez I., Alonso E., Leira F., Maseda D.P.E., Royo C., Villagran J., Candi G.M., Esteva G.E., Folgado R.M., Fornaguera N.J., Montse P.C., Prat A.S., Sintes D., Arteta D.A., Delgado H.G., Lopez-Cuervo J.F., Lopez M.C., Ramirez A., Saldana F.J., Aliste P., Anchuelo A.H., Campos A.G., Catalan M., Gomez M.G., Gonzalaez O.G., Lopez E.L., Navacerrada I.R., de Quevedo S.A., Serrano M.G., Silvestre F.P.-C., Torrente F.M., Arocas B., Martinez E.P., Soro M., Maroto F., Algarra R.R., Aleixandre I.S., Argente G.R., Lleo A.B., Rubio A.V., Sanchez J.L.V., Valcarcel I.E., Balust C., Balust J., Borrat X., Carretero M.J., Gracia I., Matute P., Mercadal J., Pujol R., Tena B., Ubre M., Albalad D.D., Alcaide C.M., Caballero J., Cervantes A.C., de Nadal Clanchet M., Estruch N.M., Ferrer M.B., Fornells A.L., Galera E.T., Martinez I.G., Munoz S.M., Pelavski A., Perez P.T., Posada M.A.G., de Prat I.C., Rello J., Serrano L.G., Sieiro J.M.N., Silva L., Sole M.J.C., Sune A.B., Villach I.R., Herreras J.I.G., Poves R., Rafael B.M., Almeida I.M., Collates A.F., Bartolome M.J., Cimadevilla B., Gonzalez A.M.G., Llevot J.M.R., de Teran Mira J.C.D., Molina B.G., Pardo S., Sanchez C.L., Williams M., Zaldibar E., Corsini L.M., Fraile J.R.R., de la Lastra M., Sacramento M.K., Sana F.J.L., Alvarez J.T., Bulnes M.L.C., Carrasco V.G., del Rocio Miguez Crespo M., Cubillos D.N., Laza E.L., del Pino Heredia Perez M., Seisdedos A.A., Torres B.F., Ampuero M.S., Llano M.C., Mata E., Munoz M., Orts M., Planas A., Ramasco F., Roman C., Duran M.V., del Rio Fernandez S., Otero Y.S., Pineiro S.L., Pardal C.B., Alcantud J.F., Antolinos M.A., Barrios F., Casanova A.C., Castro M.R., Crespo B.I., Felipe U.L., Fuster M.L., Garcia M.S., Garrote B.H., Gonzalez R.M., Granero M.J.M., de la Guia C.L., Lopez R.C., de Frutos Lopez S., Martinez J.J.M., Mostaza A.G., Moreno A.J., Osado I.R., Perez M.R., Pina M.A., Romero C.A., Rodriguez E.R., Salvan J.H., Sampedro M.G., de la Torre P.A., Toro J.P., Unzue C.L., Vargas M.J., Bernal D.G., Echevarria M., Iglesias A.U., Loza A., Morillo A.R., Serrano P.D., Sevilla F.C.B., Cacho E., Calderon R., Dufur M., Marginet C., Monedero P., Yepes M.J., Alvarez L.R., Carballal F.F., Castineiras A.P., Garcia P.D., Lopez L.R., Maceiras P.R., Puente M.S.M., Rilo M.T.R., Alonso A.E.T., Fernandez S.R., Garcia R.O., Garcia A.P., Puentes R.B., Aguado D.N., Carballo C.L., Fernandez R.F., Presedo A.T., de Rabago R.B.D., Velasco A.R., Capel Y.J., Cortes A.F., Garcia E.M., Gimeno L.M., Klamburg J., Omedas R.C., Nunez M.G., Maristany C.L., Ruiz E.M., Artigas X., Castrillon S., Espinosa N., Gomez-Caro A.M., Illa S., India I., Martin-Huerta B., Moral V., Moreno M., Fernandez C.I., Garcia V.F., Hernandez P.P., Checa A.A.H., Diaz D.S., Noguera M.L., Varela I.P., Gonzalez Gallego M.A., Garcia O.M., Irujo J.J.A., Perrino C.G., Picazo J.R., Timoneda F.L., Arroyo M.M., Blanco I.A., Borja M.M., Burcio S.M., Castro N.M., Cerdeirina A.P., de la Torre Concostrina M., Cristina M.V., Diaz T.D., Esteruelas J.A., Ingelmo I.I., Insuga P.D., Llamas E.C., Lopez J.J.M., Martin M.B., Martin E.E., Mesa E.U., Monterde M.L., Montoiro P.A., Mostoles M.L.G., Olarte E.V., Perez A.M., Perez F.D., Romero A.S., Rous D.P., Ruiz N.M., Ruiz J.A.P., Saiz A.R., de la Vega Terol A., Toha A.C., Utrera F.A., Alberdi F., Elosegui I., Garcia J., Garde P.M., Mintegui E.I., Saez I.G., Salas E., Zabarte M., Diaz-Boladeras R.-M., Mora-Guevara E., Zamora J.F., Bonet A., Salo L., Salinas U., Zaballos J.M., Alvarez A.A., Garrido C.J., Roa J.R.H., Vidal F.G., Garcia-Egea J., Elson M.Z., Seron-Arbeloa C., Asensio M.A.M., Simeon R.G., Alameda L.E.M., Angulo G.O., Aranzubia M., Arcas J.J., Arevalo J., Belvert B.Q., Calvo C.P., Cremades M., Crespo P., Cuarental A., Del Olmo M., Fernandez P.T., Vega J.L.F.G.I.G., Herrera E., Llorente M.A.A., Rabes C.M., de Maeyer A.G., Marquez M.P., Mendoza D.L., Munoz J.M.M., Martinez N.A., Oviedo A.S., Garrigues P.B., Inigo J.A., Ferrandiz S.T., Sanchez-Morcillo S., Sanchez M.L., Parra A.M., Vidal S.G., Allue R.M., Etayo B.Z., Rodriguez R.B., Villen L.M., Jimenez C.M., de Zayas R.S., Moreno C.D., Pacheco F.S., Pascual J.L.A., Gude F.T., Riestra E.M., Delgado F.C., de la Torre Prados M.V., Barrios J., Cervera-Montes M., Garcia-Sanz M., Garcia V., Sanmiguel G., Alvaro J.L., Barrachima B.B., Bermejo F.J.R., Garcia A.G.F.P.M., Ramirez C.N., Ramos J.G., Samaniego L.A., Belenguer-Muncharaz A., Ferrandiz-Selles A., Mateu-Campos M.-L., Dominguez D., Espinosa E., Leon T., Betancor N.O., Canalechevarria A.M., Novales B.F., Pena J.M.G., Delgado T.R., Roquerio B.S., Sainz J.J.G., Soto T.T., Dahm P., Herges H.O., Lundborg C., Seeman-Lodding H., Sondergaard S., Rylander C., Sari F., Tibblin A.O., Adolfsson A., Klarin B., Schrey S., Chew M.S., Merisson E., Ryden J., Divander M.B., Hedin A., Hedlund D., Lindkvist M.A., Jawad M., Layous L., Wernerman J., Bjorne H., Brattstrom O., Olheden S., Oldner A., Sellden E., Walder B., Wickboldt N., Rossi A., Steiner L., Djurdjevic M., Lussmann R., Geisen M., Hofer C., Turina M., Everett L., Harris K., Wright M., Adams D., Alderson L., Baker J., Christie I., Ferguson C., Hill M., Holmes K., Hutton A., Porter A., Struthers R., Akotia N., Belhaj A., Chang S., Collantes E., Eigener K., Husband M., Khan A., Kong M.-L., McAlees E.J., MacDonald N., Niebrzegowska E., Parnell W., Smith A., Chhatwal A., Jhingan S., Muswell R., Poon Y., Singh N., Stephens R., Vasan R., Waife N., Weda T., Clarke A., Szakmany T., Fletcher S., Rosbergen M., Blunt M., Prince L., Wong K., Goldhill D., Kumar R., Stilwell S., Couper K., Crooks N., Gao-Smith F., Melody T., Snaith C., Patel J., Parekh D., Yeung J., Loughnan B., Moosajee V., Rope T., Edger L., Dawson J., Hadfield D., Hopkins P., McDonald L., Willars C., Craig J., Ladipo K., Lockwood G., Moreno J., Ballington R., Hamandishe S., Rogerson D., Cowman S., Hayden P., Sandhar T., Arawwawala D., Brotherston L., Mitchell-Inwang C., Walsh H., Alagarsamy F., Goon S., Karcheva S., Krepska A., McKinney B., Patil V., Batchelor N., Day C., Finch L., Gibson C., Grayling M., Hubble S., Key W., Knight T., Loosley A., Margetts P., Stewart H., Bewley J., Hurley K., Murphy R., Philpott C., Pollock K., Sweet K., Thomas M., Tucker K., Windsor D., Conway D., Gold S., Quraishi T., Cupitt J., Baddeley S., Brown J.D., Foo I., Mantle D., Carvalho P., Huddart S., Kirk-Bayley J., Smith R.-L., Milligan L., Poulose S., Sarkar S., Nolan J., Pedley E., Padkin A., Pesian S., Rajamanickam S., Ramkumar K., Crayford A., Turner A., Bottrill F., Webb S., Jhanji S., MacCallum N., Wessels K., Wigmore T., Meikle A., Wilson S., White S., Bonnett A., Rushton A., Williams C., Zuzan O., Hall A., Montgomery J., Piggot A., Read R., Stocker M., Tamm T., Agarwal B., Ward S., Brown L., Joy M., Venkatesh S., Hughes T., Zsisku L., Roy A., Hooper V., Mouland J., Nightingale J., Rose S., Chiam P., Chohan H., Dickson C., Gibb S., Higham C., Harvey C., Janarthanan C., Jones L., Kapoor A., Moll M., Roberts L., Saunders D., Arnold G., Gibbs C., Jhurgursing M., Pierro D., Pritchard F., Doyle P., Templeton M., Wilson R., Zantua K., Collyer T., Featherstone J., Worton R., Bruce J., McGuigan K., Price G., Moreton S., Pulletz M., Anderson H., Baxter I., Beckingsale A., Callaghan M., Datta A., Gollogly J., Izod C., Lobaz S., MacFie C., Patel M., Payne H., Singh R., Timms G., McLeod S., O'Brian P., Horner E., Joshi V., Stuart-Smith K., Seale T., Bolger C., Collins H., Ekins E., Golder K., Hawkins L., Jonas M., Linford K., Wadams B., Beach M., Vizcaychipi M., Jewsbury W., Davies S., Balaji P., Kangaraj M., Pissay N., Smith N., Gopalakrishnan S., MacKinnon J., Strandvik G., Francis R., Jennings A., Keating M., Kumar S., Leese S., Magee C., Pilsbury J., Ralph J., Riddington D., Sachdeva R., Snelson C., Vasanth S., Wilde J., Lavender B., Lyons R., Watters M., Adams T., Dyer S., Tindall L., Claxton A., Netke M., Akouds E., Bates D., Gallagher H., Hatton J., Holroyd W., Mitra A., Nurse T., Reed D., Desikan S., Barber R., Childs S., O'Carroll-Kuehn B., Wyldbore M., Al-Abdaly A., Amatya S., Bhaskaran S., Chandan G., Chaudhry S., Chikungwa M., Earnshaw G., Grewal M., Haque S., Hawkins J., Javaid A., Jackson C., Kamel M., Marla R., Mculloch D.-A., Parker T., Salib Y., Saravanmuthu R., Secker C., Sockalingam S., Taylor A., Austine P., Kanade V., Paal D., Mok M.U.S., Burtenshaw A., Davis L., Ellahee P., Freeman D., Pierson R., Wollaston J., Karmarkar A., Ball C., Calton E., Maxwell L., Walker R., Bland M., Bullock L., Harrison-Briggs D., Hodge P., Krige A., Dempsey G., Hammell C., Loveridge R., Parker R., Snell J., Wright C., Baker A., Barr K., Belcher A., Bonnington S., Bougeard A.-M., Fitzgerald E., Ford R., Gillard C., Griffiths L., Greenberg L., Huber J., Mathieu S., Richardson N., Tompsett L., White N., Patel S., Corner V., Thomas R., Trodd D., Wilson J., Copley E., Flutter L., Hulme J., Susarla J., Thwaites A., Jayasundera S., McAfee S., Chantler J., McKechnie S., Neely J., Mouton R., Scarth E., Soar J., Buss J., Currie V., Sange M., Kuttler A., Power F., Alexander D., Dunne K., Shinner G., Black E., Haldane G., Kerr J., Saran T., Ward G., Jefferies F., Alexander P., Royle A., Nahla F., Bowles T., Gregory M., Ahern R., Cartlidge D., Craker L., Thompson C., Bidd H., Giles J., Manser A., Parry G., Chan P., Das D., Fahmy N., Higgins D., Khader A.A., Stone A., Leonardi S., Rose O., Bright E., Ercole A., Rafi M.A., Ramasamy R., Sheshgiri B., Merrill C., Page V., Walker E., Harris S., Hughes S., Morrison A., Razouk K., Ayman M., Al-Subaie N., Arif F., Cashman J., Cecconi M., Edsell M., Fossati N., Hammond S.J., Hamilton M., Lonsdale D., Moran C., Rhodes A., Siegmueller C., Velzeboer F., Wong P., Jakeman A., Mowatt C., Kahan B.C., Wijeysundera D., Haddow J., Everingham K., Fleisher L.A., Phull M.-K., Januszewska M., Wilson M., Hewson R., Beattie S., Ahmad T., Fang X., Halliwell R., Shulman M., Myles P., Schmid W., Hiesmayr M., Wouters P., de Hert S., Lobo S., Rasmussen L., Biais M., Venara A., Slim K., Sander M., Chan M., Kulkarni A., Chandra S., Tantri A., Geddoa E., Abbas M., Sivasakthi D., Mansor M., Luna P., Bouwman A., Buhre W., Beavis V., Campbell D., Short T., Osinaike T., Grigoras I., Kirov M., Protsenko D., Biccard B., Chew M., Hubner M., Ditai J., Fleisher L., Ferguson M., MacMahon M., Cherian R., Currow H., Kanathiban K., Pathmanathan E., Phillips K., Reynolds J., Rowley J., Douglas J., Garg S., Bennett M., Jain M., Alcock D., Terblanche N., Cotter R., Leslie K., Stewart M., Zingerle N., Clyde A., Hambidge O., Rehak A., Cotterell S., Huynh W.B.Q., McCulloch T., Ben-Menachem E., Egan T., Cope J., Fellinger P., Haselberger S., Holaubek C., Lichtenegger P., Scherz F., Hoffer F., Cakova V., Eichwalder A., Fischbach N., Klug R., Schneider E., Vesely M., Wickenhauser R., Grubmueller K.G., Leitgeb M., Lang F., Toro N., Bauer M., Laengle F., Mayrhofer T., Buerkle C., Forstner K., Germann R., Rinoesl H., Schindler E., Trampitsch E., Fritsch G., Szabo C., Bidgoli J., Verdoodt H., Pregardien C., Pospiech A., Steyaert A., Veevaete L., De Kegel D., De Jongh K., Abeloos J., Bouchez S., Coppens M., De Baerdemaeker L., Deblaere I., De Bruyne A., De Hert S., Fonck K., Heyse B., Jacobs T., Lapage K., Moerman A., Neckebroek M., Parashchanka A., Roels N., Van Den Eynde N., Vandenheuvel M., Limmen J., AnnVanluchene, CarolineVanpeteghem, Wyffels P., Huygens C., PunithaVandenbempt, Van de Velde M., Dylst D., Janssen B., Schreurs E., Aleixo F.B., Candido K., Batista H.D., Guimaraes M., Guizeline J., Hoffmann J., Lobo F.R.M., Nascimento V., Nishiyama K., Pazetto L., Souza D., Rodrigues R.S., dos Santos A.M.V., Jardim J., Silva J., do Nascimento Junior P., Baio T.H., de Castro G.I.P., Oliveira H.R.W., Amendola C.P., Cardoso G., Ortega D., Brotto A.F., De Oliveira M.C., Rea-Neto A., Dias F., Azambuja P., Knibel M.F., Almeida W., Neto C.N., Tardelli M.A., Caser E., Machado M., Aguzzoli C., Baldisserotto S., Tabajara F.B., Bettega F., Junior L.H.C.R., de Gasperi J., Faina L., Nolasco M.F., da Costa Fischer B.F., de Campos Ferreira M.F., Hartmann C., Kliemann M., Ribeiro G.L.H., Fraga J.M., Netto T.M., Pozza L.V., Wendling P.R., Azevedo C., Lopes M., Maia B., Maselli P., Melo R., Mendes W., Neves M., Ney J., Piras C., Applewhaite C., Carr A., Chow L., Duttchen K., Foglia J., Greene M., Hinther A., Houston K., McCormick T.J., Mikhayel J., Montasser S., Ragan A., Suen A., Woolsey A., Yu H.C., Funk D., Kowalski S., Legaspi R., McDonald H., Siddiqui F., Pridham J., Rowe B., Sampson S., Thiessen B., Zbitnew G., Bernard A., George R., Jones P., Moor R., Siddiqui N., AlexandraWolfer, Tran D., Winch D., Dobson G., McCormick T., Montasser O., Hall R., Baghirzada L., Dai S.Y., Hare G., Lee E., Shastri U., Tsui A., Yagnik A., Alvares D., Choi S., Dwyer H., Flores K., McCartney C., Somascanthan P., Carroll J., Pazmino-Canizares J., Wolfer A., Ami N., Chan V., Perlas A., Argue R., Lavis K., Mayson K., Cao Y., Gao H., Lv J., Yang J., Yang Y., Zhong Y., Zhou J., Zou X., He M., Li X., Luo D., Wang H., Yu T., Chen L., Wang L., Cai Y., Cao Z., Li Y., Lian J., Sun H., Wang S., Wang Z., Wang K., Zhu Y., Du X., Fan H., Fu Y., Huang L., Huang Y., Hwan H., Luo H., Qu P.-S., Tao F., Wang G., Zhang Y., Zhang X., Chen C., Wang W., Liu Z., Fan L., Tang J., Chen Y., Han Y., Huang C., Liang G., Shen J., Wang J., Yang Q., Zhen J., Zhou H., Chen J., Chen Z., Meng B., Ye H., Bi Y., Cao J., Guo F., Lin H., Liu Y., Lv M., Shi P., Song X., Sun C., Sun Y., Wang Y., Zhang M., Chen R., Hou J., Leng Y., Meng Q.-T., Qian L., Shen Z.-Y., Xia Z.-Y., Xue R., Zhao B., Zhou X.-J., Chen Q., Guo H., Guo Y., Qi Y., Wei J., Zhang W., Zheng L., Bao Q., Fei Y., Hu N., Hu X., Lei M., Lv X., Miao F., Ouyang L., Shen C., Wang D., Wu C., Xu L., Yuan J., Zhang L., Zhang H., Zhao J., Zhao C., Zhao L., Zheng T., Zhou D., Zhou C., Lu K., Zhao T., He C., Chen H., Chen S., Cheng B., He J., Jin L., Li C., Li H., Pan Y., Shi Y., Wen X.H., Wu S., Xie G., Zhang K., Lu X., Chen F., Liang Q., Lin X., Ling Y., Liu G., Tao J., Yang L., Feng Y., Hou B., Lin J., Liu M., Luo F., Shi X., Xiong Y., Yang S., Zhao W., Bai Y., Dai Q., Geng W., Han K., He X., Ji B., Jia D., Jin S., Li Q., Liang D., Luo S., Lwang L., Mo Y., Qi X., Qian M., Qin J., Ren Y., Xie J., Yan Y., Yao Y., Zhuang X., Ai Y., Du F., He L., Li Z., Li L., Meng S., Yuan Y., Zhang E., Zhang J., Zhao S., Ji Z., Pei L., Dong B., Li J., Miao Z., Mu H., Qin C., Su L., Wen Z., Xie K., Yu Y., Yuan F., Xiao W., Zhu Z., Fu K., Hu R., Huang S., Liang Y., Yu S., Guo Z., Jing Y., Tang N., Wu J., Yuan D., Zhang R., Zhao X., Bai H.-P., Liu C.-X., Liu F.-F., Ren W., Wang X.-L., Xu G.-J., Li B., Ou Y., Tang Y., Yao S., Zhang S., Kong C.-C., Liu B., Wang T., Lu B., Xia Y., Cai F., Chen P., Hu S., Xu Q., Hu L., Jing L., Liu Q., Peng Z.D., Qiu X., Ren Q., Tong Y., Wen Y., Wu Q., Xia J., Xiong X., Xu S., Yang T., Yin N., Zeng Q., Zhang B., Zheng K., Cang J., Fan Y., Fu S., Ge X., Guo B., Huang W., Jiang L., Jiang X., Shan Q., Wang F., Christiansen I.C., Granum S.N., Rasmussen B.S., Daugaard M., Gambhir R., Steingrimsdottir G.E., Jensen-Gadegaard P., Olsen K.S., Siegel H., Eskildsen K.Z., Gatke M.R., Wibrandt I., Heintzelmann S.B., Lange K.H.W., Lundsgaard R.S., Amstrup-Hansen L., Hovendal C., Larsen M., Lenstrup M., Kobborg T., Larsen J.R., Pedersen A.B., Smith S.H., Oestervig R.M., Andersen C., Ekelund K., Brandsborg B., Beloeil H., Lasocki S., Ouattara A., Sineus M., Molliex S., Legouge M.L., Tesniere A., Gaudin C., Lehur P., Forsans E., de Rudnicki S., Maudet V.S., Mutter D., Sojod G., Ouaissi M., Regimbeau J.-M., Comptaer N., el Manser D., Ethgen S., Hartl C., Deja M., Legashov K., Sonnemann S., Wiegand-Loehnert C., Falk E., Angermair S., Schmidt K., Von Heymann C., Jelschen F., Pabel S., Gille J., Lueke K., Wetzel P., Weimann J., Schirmer F., Huppe M., Klotz K., Schon J., Mencke T., Bankewitz C., Baumgarten G., Fleischer A., Guttenthaler V., Hack Y., Kirchgaessner K., Manner O., Schurig-Urbaniak M., Struck R., van Zyl R., Goebel U., Veit S., Andreadaki E., Souri F., Katsiadramis I., Skoufi A., Vasileiou M., Katsourakis A., Veroniki F., Vlachogianni G., Petra K., Chlorou D., Oloktsidou E., Ourailoglou V., Papapostolou K., Tsaousi G., Daikou P., Dedemadi G., Kalaitzopoulos I., Loumpias C., Bristogiannis S., Dafnios N., Kontis E., Kozompoli D., Papailia A., Theodosopoulos T., Bizios C., Plaitakis I., Christodoulopoulou T., Theodorakopoulou M., Asimakos A., Ischaki E., Tsagkaraki A., Zakynthinos S., Antoniadou E., Koutelidakis I., Pozidou I., Voloudakis N., Dalamagka M., Elena G., Chronis C., Manolakaki D., Mosxogiannidis D., Slepova T., Lampiri C., Vachlioti A., Panagiotakis C., Tsimpoukas F., Axioti E., Filippopoulos A., Kalliafa E., Kassavetis G., Katralis P., Komnos I., Pilichos G., Ravani I., Totis A., Apagaki E., Efthymiadi A., Kampagiannis N., Paraforou T., Tsioka A., Georgiou G., Vakalos A., Bairaktari A., Charitos E., Markou G., Niforopoulou P., Papakonstantinou N., Tsigou E., Xifara A., Zoulamoglou M., Gkioni P., Mainas E., Papapanagiotou I., Fragandreas G., Georgopoulou E., Katsika E., Psarras K., Synekidou E., Verroiotou M., Vetsiou E., Zaimi D., Anagnou A., Apostolou K., Melissopoulou T., Rozenberg T., Tsigris C., Boutsikos G., Kalles V., Kotsalas N., Lavdaiou C., Paikou F., Panagou G.-L., Botis I., Drimala M., Georgakakis G., Kiourtzieva E., Ntouma P., Prionas A., Xouplidis K., Dalampini E., Giannaki C., Iasonidou C., Ioannidis O., Papageorgiou G., Kokkinoy M., Gaitanakis S., Karydakis P., Paltoglou J., Ponireas P., Chaloulis P., Provatidis A., Sousana A., Gardikou V.V., Konstantivelli M., Lataniotou O., Lisari E., Margaroni M., Stamatiou K., Nikolaidis E., Pnevmatikos I., Sertaridou E., Andreou A., Arkalaki E., Athanasakis E., Chaniotaki F., Chatzimichali C.A., Christofaki M., Dermitzaki D., Fiorentza K., Frantzeskos G., Geromarkaki E., Kafkalaki K., Kalogridaki M., Karydi K., Kokkini S., Kougentakis G., Lefaki T., Lilitsis E., Makatounaki A., Michelakis D., Neonaki M., Palikyra I., Papadakis E., Sfakianakis K., Sgouraki M., Souvatzis X., Spartinou A., Stefanidou N., Syrogianni P., Tsagkaraki G., Arnaoutoglou C., Bali C., Bouris V., Doumos R., Gkini K.-P., Kapaktsi C., Lena A., Lepida D., Michos E., Papadopoulos D., Paschopoulos M., Rompou V.A., Siouti I., Tsampalas S., Ververidou O., Zilis G., Charlalampidoy A., Christodoulidis G., Flossos A., Stamoulis K., Tsang M.S.C., Tsang M.S., Lai M.L., Yip C.P., Chan H.M.H., Law B., Li W.S., Chu H.M., Koo E.G.Y., Lam C.C.J., Cheng K.H., Lam T., Chu S., Wong K.W.K., Kwok D., Hung C.Y.J., Chan W.K.J., LamWong W., Chung C.K.E., Ma S.K., Kaushik S., Shah B., Shah D., Shah S., Ar P., Muthuchellappan R., Agarwal V., Divatia J., Mishra S., Nimje G., Pande S., Savarkar S., Shrivastava A., Yegnaram S., Hidayatullah R., Puar N., Niman S., Indra I., Hamzah Z., Yuliana A., Abidin U.N., Dursin A.N., Kurnia A., Susanti A., Handayani D., Alit M.A., Arya A., Senapathi T.G.A., Utara U.H., Wid W.M., Wima S., Wir W.M., Jehosua B., Kaunang J., Lantang E.Y., Najoan R., Waworuntu N., Awad H., Fuad A., Geddoa B., Khalaf A.R., Albaj S., Kenber M., Bettinelli A., Spadaro S., AlbertoVolta C., Sottosanti L.G.V., Alloj C., Cardellino S., Costanzo E., Fanfani L.C., Bellandi M., Beretta L., Bocchino S., Cabrini L., Corti D., Landoni G., Meroni R., Moizo E., Pintaudi M., Plumari V.P., Taddeo D., Testa V., Winterton D., Zangrillo A., Cloro L.M., Colangelo C., Colangelo A., Giuseppe R., Paludi M.A., Maria C.P., Pata A., Arrigo M., Benevento A., Bottini C., Gastaldi C., Marchesi A., Pascazio A., Pozzi E., Premoli A., Tessera G., Boschi L., D'Andrea R., Ghignone F., Poggioli G., Sibilio A., Taffurelli M., Ugolini G., Majid M.A.A., Rahman R.A., Joseph J., Pathan F., Shah M.H.S., Yap H.L., Cheah S., Chin I.I., Looi J.K., Tan S.C., Visvalingam S., Kwok F.Y., Lee C.K., Tan T.S., Wong S.M., Abdullah N.H., Liew C.F., Luxuman L., Zin N.H.M., Norddin M.F., Alias R.L.R., Wong J.Y., Yong J., Mustapha M.T.B., Chan W.K., Dzulkipli N., Kuan P.X., Lee Y.C., Alias A., Guok E.C., Jee C.C., Ramon B.R., Wong C.W., Ghafar F.N.I.A., Aziz F.Z., Hussain N., Lee H.S., Sukawi I., Woon Y.L., Hadi H.Z.A., Azam U.A.A., Alias A.H., Kesut S.A., Lee J.M., Ooi D.V., Sulaiman H.A., Lih T.A.T., Veerakumaran J., Rojas E., Flores A.A.A., Amador J.C.B., Avila E.J.D., Aquino L.P.G., Rodriguez R.L., Landa M.T., Urias E., Hollmann M., Hulst A., Preckel O.K.B., Gemert A.K.-V., Buise M., Tolenaar N., Weber E., de Fretes J., Houweling P., Van Bommel J., Lance M., Smit-Fun V., van Zundert T., Baas P., de Boer H.D., Sprakel J., Elferink-Vonk R., Noordzij P., van Zeggeren L., Brand B., Numan S., van Klei W., van Zaane B., Boer C., van Duivenvoorde Y., Hering J.P., Zonneveldt H., Hoare S., Santa S., Bell R., Choi H.-M.D., Drake M., Farrell H., Higgie K., Jenkins N., Kim C.J., Kim S., Law K.C., McAllister D., Park K., Pedersen K., Pfeifer L., Salmond T., Steynor M., Tan M., Waymouth E., Rahman A.S.A., Armstrong J., Dudson R., Nilakant J., Richard S., Virdi P., Dixon L., Donohue R., Farrow M., Kennedy R., Marissa H., McKellow M., Nicola D., Pascoe R., Roberts S.J., Rowell G., Sumner M., Templer P., Chandrasekharan S., Fulton G., Ali M., More R., Wilson L., Chang Y.H., Foley J., Fowler C., Panckhurst J., Sara R., Stapelberg F., Cherrett V., Ganter D.L., McCann L., Gilmour F., Lumsden R., Moores M., Olliff S., Sardareva E., Tai J., Wikner M., Wong C., Chaddock M., Czepanski C., McKendry P., Polakovic D., Polakovich D., Robert A., Belda M.T., Norton T., Alherz F., Barneto L., Sayeed A., Bennett C., McQuoid S., Jansen T.-L., Nico Z., Scott J., Freschini D., Freschini A., Hopkins B., Manson L., Stoltz D., Bates A., Davis S., Freeman V., McGaughran L., Sharma S.B., Burrows T., Byrne K., English D., Johnson R., Manikkam B., Naidoo S., Rumball M., Whittle N., Franks R., Gibson-Lapsley H., Salter R., Walsh D., Cooper R., Perry K., Obobolo A., Sule U.M., Ahmad A., Atiku M., Mohammed A.D., Sarki A.M., Adekola O., Akanmu O., Durodola A., Olukoju O., Raji V., Olajumoke T., Oyebamiji E., Adenekan A., Adetoye A., Faponle F., Olateju S., Owojuyigbe A., Talabi A., Adenike O., Adewale B., Collins N., Ezekiel E., Fatungase O.M., Grace A., Sola S., Stella O., Ademola A., Adeolu A.A., Adigun T., Akinwale M., Fasina O., Gbolahan O., Idowu O., Olonisakin R.P., Osinaike B.B., Asudo F., Mshelia D., Abdur-Rahman L., Agodirin O., Bello J., Bolaji B., Oyedepo O.O., Ezike H., Iloabachie I., Okonkwo I., Onuora E., Onyeka T., Ugwu I., Umeh F., Alagbe-Briggs O., Dodiyi-Manuel A., Echem R., Obasuyi B., Onajin-Obembe B., Bandeira M.E., Tome M., Costa A.C.M.M., Krystopchuk A., Branco T., Esteves S., Melo M.A., Monte J., Pinho-Oliveira V.M., Rodrigues C.M., Cabral R., Marques S., Rego S., Jesus J.S.T., Marques M.C., Romao C., Dias S., Santos A.M., Alves M.J., Salta C., Cruz S., Duarte C., Paiva A.A.F., do Nascimento Cabral T., Faria D., Maia, da Silva R.F.M.C., Resendes H.O., da Conceicao Soares M., Abrunhosa A., Miranda L., Pereira H., Mitre C., Manga G., Stefan A., Filipescu D., Paunescu M.-A., Stefan M., Stoica R., Gavril L., Patra?canu E., Rusu D., Iosep G.F., Pulbere D., Ursu I., Balanescu A., Grintescu I., Mirea L., Rentea I., Vartic M., Lupu M.-N., Stanescu D., Antal O., Patras D., Petrisor C., Tosa F., Tranca S., Copotoiu S.M., Ungureanu L.L., Harsan C.R., Cernea D.D., Dragoescu N.A., Aflori L., CarmenVaida, Ciobotaru O.R., Carp C.P., Cobzaru I., Mardare O., Purcarin B., Tutunaru V., Ionita V., Arustei M., Codita A., Busuioc M., Chilinciuc I., Ciobanu C., Sandu G., Bruma D., Dutu M., Krepil A., Copaciu E., Dumitrascu C.O., Jemna R., Mihaescu F., Petre R., Tudor C., Ursache E., Kulikov A., Lubnin A., Grigoryev E., Pugachev S., Tolmasov A., Hussain A., Ilyina Y., Roshchina A., Iurin A., Chazova E., Dunay A., Karelov A., Khvedelidze I., Voldaeva O., Belskiy V., Dzhamullaev P., Grishkowez E., Kretov V., Levin V., Molkov A., Puzanov S., Samoilenko A., Tchekulaev A., Tulupova V., Utkin I., Allorto N.L., Bishop D.G., Builu P.M., Cairns C., Dasrath A., de Wet J., den Hoedt M., Grey B., Hayes M.P., Kusel B.S., Shangase N., Wise R., Cacala S., Farina Z., Govindasamy V., Kruse C.-H., Lee C., Marais L., Naidoo T.D., Rajah C., Rodseth R.N., Ryan L., von Rhaden R., Adam S., Alphonsus C., Ameer Y., Anderson F., Basanth S., Bechan S., Bhula C., Biyase T., Buccimazza I., Cardosa J., Daya B., Drummond L., Elabib A., Goad E.H.A., Goga I.E., Goga R., Harrichandparsad R., Hodgson R.E., Jordaan J., Kalafatis N., Kampik C., Landers A.T., Loots E., Madansein R., Madaree A., Madiba T.E., Manzini V.T., Mbuyisa M., Moodley R., Msomi M., Mukama I., Naidoo D., Naidoo R., Naidu T.K., Ntloko S., Padayachee E., Padayachee L., Phaff M., Pillay B., Pillay D., Pillay L., Ramnarain A., Ramphal S.R., Ryan P., Saloojee A., Sebitloane M., Sigcu N., Taylor J.L., Torborg A., Visser L., Anderson P., Conradie A., de Swardt M., de Villiers M., Eikman J., Liebenberg R., Mouton J., Paton A., van der Merwe L., Wilscott-Davids C., Barrett W.J., Bester M., de Beer J., Geldenhuys J., Gouws H., Potgieter J.-H., Strydom M., WilberforceTurton E., Chetty R.R., Chirkut S., Cronje L., de Vasconcellos K., Dube N.Z., Gama N.S., Green G.M., Green-Thompson R., Kinoo S.M., Kistnasami P., Maharaj K., Moodley M.S., Mothae S.J., Noorbhai M.A.F., Rughubar V., Reddy J., Singh A., Skinner D.L., Smith M.J., Singh B., Misra R., Naidoo M., Ramdharee P., Selibea Y., Sewpersad S., Sham S., Wessels J.D., Africander C., Bejia T., Blakemore S.P., Botes M., Bunwarie B., Hernandez C.B., Jeeraz M.A., Legutko D.A., Lopez A.G., De Meyer J.N., Muzenda T., Naidoo N., Pentela R., Junge M., Mansoor N., Rademan L., Scislowski P., Seedat I., van den Berg B., van der Merwe D., van Wyk S., Govender K., Naicker D., Ramjee R., Saley M., Kuhn W.P., Matos-Puig R., Moolla Z., Beltran A.V., Lozano A., Navarro C.D., Duca A., Ernesto E.P.M., Ferrando C., Fuentes I., Garcia-Perez M.L., Gracia E., Palomares A.I., Katime A., Minana A., Incertis R.R., Romero E., Garcia C.S.R., Rubio C., Artiles T.S., Valls P., Laguarda G.A., Benavent P., Cuenca V.C., Cueva A., Lafuente M., Rodrigo A.R., Tormo S., Redondo F.J., De Andres J., Diago L.G., Cadiz M.J.H., Manuel G.G., Peris R., Saiz C., Tatay J., Soto M.T.T., Brunete T., Cancho D., Zamudio D., Del Valle S.G., Serrano M.L., Anillo V., Maseda E., Salgado P., Suarez L., Suarez-de-la-Rica A., Villagran M.J., Alonso J.I., Cabezuelo E., Garcia-Saiz I., del Moral O.L., Martin S., Gonzalez A.P., Doncel M.S.T., Vera M.A., Sanchez F.J.A., Castano B., Moreira B.C., Risco S.F., Martin D.P., Martin F.P., Poza P., Ruiz A., Martinez W.F.S., Vicente B.V., Dominguez S.V., Fernandez S., Munoz-Lopez A., Bernat M.J., Mas A., Planas K., Saeed Y., Levander H., Holmstrom S., Lonn D., Zoerner F., Akring I., Widmark C., Zettergren J., Liljequist V.A., Nystrom L., Odeberg-Wernerman S., Reje P., Lyckner S., Sperber J., Ogren K., Barras J.-P., Buhrer T., Despotidis V., Helmy N., Holliger S., Raptis D.A., Schmid R., Jaquet Y., Kessler U., Muradbegovic M., Nahum S.R., Rotunno T., Schiltz B., Voruz F., Worreth M., Christoforidis D., Popeskou S.G., Furrer M., Prevost G.A., Stocker A., Lang K., Breitenstein S., Ganter M.T., Soll C., Korkmaz M., Lubach I., Schmitz M., Zingg U., Hillermann T., Wildi S., Mariotti G., Slankamenac K., Namuyuga M., Kyomugisha E., Kituuka O., Shikanda A.W., Kakembo N., Tom C.O., Antonina W., Bua E., Ssettabi E.M., Epodoi J., Kabagenyi F., Kirya F., Seasman C., Khan R.B.N., Kurasz C., Butt G., Chicken D.-W., Christmas N., Allen S., Daniel G.D., Dempster A., Kemp J., Matthews L., Mcglone P., Tambellini J., Freitas K., Garg A., Karpate S., O'Hara C., Troko J., Angus K., Bradley J., Brennan E., Brooks C., Brown J., Brown G., Finch A., Gratrix K., Hesketh S., Hill G., Jeffs C., Morgan M., Pemberton C., Slawson N., Spickett H., Swarbrick G., Van Duyvenvoorde G., Brennan A., Briscoe R., Cooper S., Lawton T., Northey M., Senaratne R., Stanworth H., Burrows L., Cain H., Craven R., Davies K., Jonas A., Pachucki M., Walkden G., Davies H., Gudaca M., Hobrok M., Fergey L., Gardiner M., Gunn J., Johnson L., Lofting A., Lyle A., Neela F.M., Smolen S., Topliffe J., Williams S., Kaura V., Lanka P., Naylor C., Ahmed A., Myatt J., Shenoy R., Soon W.C., Tan J., Karadia S., Self J., Durant E., Tripathi S., Bullock C., Ghosh A., Bengeri S., Cowton A., Khalid M.S., Limb J., McAdam C., Porritt M., Shekar P., Harden C., Hollands H., King A., March L., Minto G., Patrick A., Waugh D., Kumara P., Simeson K., Yarwood J., Browning J., Julian H., Newton M., Pernu P.K., Wilson A., Commey T., Foot H., Glover L., Gupta A., Lancaster N., Levin J., Mackenzie F., Mestanza C., Nofal E., Pout L., Varden R., Wild J., Jones S., Davies C., Martin M., Thomas S., Burns K., McArthur C., Patel P., Lau G., Rich N., Davis F., Port B., Prout R., Smith C., Adelaja Y., Bennett V., Dumitrescu A., Murphy J.F., Keen A., Mguni N., Ong C., Adams G., Boshier P., Brown R., Butryn I., Chatterjee J., Freethy A., Tsakok M., Tsiligiannis S., Peat W., Stephenson L., Bradburn M., Pick S., Cunha P., Olagbaiye O., Tayeh S., Abernethy C., Balasubramaniam M., Bennett R., Bolton D., Martinson V., Bell S., Heather B., Kushakovsky V., Alcock L., Alexander H., Anderson C., Baker P., Brookes M., Cawthorn L., Cirstea E., Colling K., Coulter I., Das S., Haigh K., Hamdan A., Hugill K., Kottam L., Lisseter E., Mawdsley M., McGivern J., Padala K., Phelps V., Stewart K., Towse K., Tregonning J., Vahedi A., Walker A., Baines D., Bilolikar A., Chande S., Dunk N., Kulkarni R., Kumar P., Metodiev Y., Ncomanzi D., Raithatha B., Raymode P., Szafranski J., Twohey L., Watt P., Weatherall L., Weatherill J., Whitman Z., Wighton E., Abayasinghe C., Chan A., Darwish S., Gill J., Glasgow E., Harris C., Kochhar A., Mellis C., Pool A., Riozzi P., Selman A., Smith E.-J., Vele L., Gercek Y., Guy K., Holden D., Watson N., Whysall K., Andreou P., Hales D., Thompson J., Bowrey S., McDonald S., Gilmore J., Hills V., Kelly C., Kelly S., Lloyd G., Abbott T., Gall L., Torrance H., Vivian M., Berntsen E., Nolan T., Vohra A., Brown A., Clark R., Coughlan E., Daniel C., Patvardhan C., Pearson R., Predeep S., Saad H., Shanmugam M., Varley S., Wylie K., Cooper L., Makowski A., Misztal B., Moldovan E., Pegg C., Donovan A., Foot J., Large S., Netke B., Armstrong R., Calderwood C., Kwok A., Mohr O., Oyeniyi P., Patnaik L., Post B., Ali S., Arshad H., Baker G., Brenner L., Brincat M., Brunswicker A., Cox H., Cozar O.I., Durst A., Fengas L., Flatt J., Glister G., Narwani V., Photi E., Rankin A., Beaton C., Horn R., Hunt J., Rousseau G., Stancombe L., Absar M., Allsop J., Drinkwater Z., Hodgkiss T., Smith K., Alexander-Sefre F., Campey L., Dudgeon L., Hall K., Hitchcock R., James L., Winstone U., Ahmad N., Bauchmuller K., Harrison J., Jeffery H., Miller D., Pinder A., Pothuneedi S., Rosser J., Sanghera S., Swift D., Bester D., Cavanagh S., Cripps H., Daniel H., Lynch J., Pyke S., Scholefield J., Whitworth H., Ramalingam G., Akerman N., Antill P., Bourner L., Buckley S., Castle G., Charles R., Eggleston C., Foster R., Gill S., Lindley K., Lklouk M., Lowery T., Martin O., Milne D., O'Connor P., 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Solanki S., Spowart E., Stevens A., Waggett H., Yassaee A., Kennedy A., Scott S., Somanath S., Berg A., Hernandez M., Nanda R., Tank G., Wilson N., Wilson D., Al-Soudaine Y., Baldwin M., Cornish J., Davies Z., Davies L., Edwards M., Frewer N., Gallard S., Glasbey J., Harries R., Hopkins L., Kim T., Koompirochana V., Lawson S., Lewis M., Makzal Z., Scourfield S., Ahmad Y., Bates S., Blackwell C., Bryant H., Coulter S., Cruickshank R., Daniel S., Daubeny T., Helen B., Hinxman H., Levett D., Skinner B., Walsgrove J., Dickson J., Constantin K., Karen M., O'Brien P., O'Donohoe L., Sundayi S., Brooke J., Cardy J., Humphreys S., Kessack L., Kubitzek C., Cotterill D., Hodzovic E., Hosdurga G., Miles E., Saunders G., Campbell M., Jemmett K., Raj A., Naik A., Ramamoorthy R., Shah N., Sylvan A., Blyth K., Johnson E., Lo P., Martin T., Plunkett E., Allison J., Carroll C., Craw N., Craw S., Pitt-Kerby T., Rowland-Axe R., Spurdle K., McDonald A., Simon D., Sinha V., Banner-Goodspeed V., Boone M., Campbell K., Lu F., Scannell J., Sobol J., Balajonda N., Clemmons K., Conde C., Funk B., Hopkins T., Olaleye O., Omer O., Pender M., Porto A., Waweru P., Yeh E., Bodansky D., Evans A., Kleopoulos S., Maril R., Mathney E., Sanchez A., Tinuoye E., Bateman B., Eng K., Jiang N., Ladha K., Needleman J., Chen L.-L., Lane R., Robinowitz D., Ghushe N., Irshad M., Takemoto S., Wallace A., Mazzeffi M., Rock P., Wallace K., Zhu X., Chua P., Mattera M., Sharar R., Thilen S., Treggiari M., Morgan A., Sofjan I., Subramaniam K., Avidan M., Maybrier H., Muench M., Wildes T., Elkhogia A.M., Omigbodun A.O., Antwi-Kusi A., Samateh A.L.S., Ndonga A., Basenero A., Mbwele B., Gordon C.S., Youssouf C., Ashebir D.Z., Munlemvo D.M., Zoumenou E., Madzimbamuto F., Ndayisaba G., Sama H.D., Ndasi H., Kluyts H.-L., Tumukunde J., Fawzy M., Mehyaoui R.M., Amanor-Boadu S.D., Rakotoarison S., Esterhuizen T.M., Patel U., Gobin V., Le Manach Y., Ngumi Z., Mehyaoui R., Kanoun H., Chelbi L., Alghazali A., Metali A., Mokretar R., Ouanes F., Imessaoudene Z., Khalfallah, Guenane M., Sadat S., Gadi B., Benali D., Chikh N., Laksari M., Boufas F., Akodjenou J., Gbehade O., Mewanou S., Djessouho E., Ahossi R., Abadagan H., Guegni A., Assoum G., Zomahoun L., Oscar K., Souhe R., Dewanou H., Nascimento R., Guezo M., Adjignon S.V., Anani F., Allaye T., Tchegnonsi C., Fanou L., Hadecon R., Atomabe A., Tchaou B., Horugavye E., Habimana L., Nkesha T., Manirimbere C., Ndikumana R., Niyondiko J.C., Minani P., Bigirimana F., Uwiteyimbabazi J., Konwuoh N.D., Ekwen G., Kaggya M., Constance N., Samuel N., Akanyun S., Freeman T., Royas L., Tchoupa M., Simo W.A.G., Ngouane D., Tanjong B.N., Bouya A.P., Carlos F., Gallou P.D., Prosper A., Athombo J.S., Sanduku D.K., Mampangula Y., Nziene V.N., Odia P.K., Mbombo W.D., Wms M., Mukuna P.M., Boloko P.M., Mvwama N.M., Jjn I., Manzombi J.K., Mvwala K.R., Ilunga J.P.M., Mawisa T., Kilembe A.M., Bikuelo C.J., Mwepu I.M., Mwaluka C.N., Sarah H.N., Kukembila A.M., Diyoyo M.P., Ngalala A.M., Kabango R., Kongolo M., Mbayabu M., Namegabe E.S., Bula Bula I.M., Likongo T.B., Pengemale G.N., Bingidimi S.S., Imposo D.H., Matondo P.M., Lelo S.N., Kamanda R.J., Kady N., Ntueba B., Christian M., Badianga E.K., Clc L., Mubeya F.K., Bahta M.T., Kassa S.K., Assefa S.B., Girmaye G.T., Samateh A.L., Janneh L., Sanyang L.N., Nyassi M.T., Grey-Johnson S.V., Villarreal R., Antunez O., Jallow C.S., Roberts C.A., Clegg-Lamptey J.N., Kutor Y.Y., Adu-Aryee N.A., Domoyyeri D.P., Atito-Narh E., Anabah T.W.A., Ndonga A.K.N., Ngumi Z.W.W., Bitta C., Nyawanda H.O., Oduor O.E.O., Okelo O.S., Ogendo S.W.O., Ngari N.B.M., Nyokabi N.N., Chokwe T.M., Gacii V.M., Githae B., Gatheru A.P., Maranga O., Muriithi J.M., Mwangi C.M., Mwiti T.M., Nabulindo S.M., Ndung'u C., Mugambi J., Mtongwe V.M., Kiprop B., Mbadi R., Wambugu P.K., Hersi S., Mutahi S., Aluvale J.S., Gitau S., Kariuki K., Ngatia E., Sitima S., Obadiah S., Mwenda V., Iraya A.M., Waweru E.N., Muturi A., Miima S., Ojujo M., Mossy P., Macharia I., Gakenia A., Mitema F., Manvinder M., Kipng'etich B., Njoroge M., Ndegwa D., Karanja J.K., Muchiri K., Makori O., Kibochi W., Mathangani W., Swaleh A., Wafula A., Maina S.N., Njenga P.W., Okonu N., Maghrabi M., Saed S.S., al Shams E.S., Shkirban A.S., Alakkari E.A., Gweder M.G., Baghni R.B., Alsabri S.A., Hebli S.H., Elghandouri M., Shanin S.H., Rokhsi S., Hensheri M.E.L., Eltaguri M., Elyasir I.E., Alwahedi H.W., Almoraid F., Anjar N., Alkilani A., Ghnain A., Senusi F.S., Elsaity R., Almajbery A., Abokris A., Montenegro L., Mohammed F.A.M., Hammouda M., Elsaadi G., Makhlouf N.M., Elzoway A.Z., Abuzalout T.S., Elmehdawi H., Alhendery A.A., Tarhuni A., Feituri A., Benamour A.S.B., Alkobty F.A., Azzaidey H.M.Z., Mohammed N.M., Elghazal Z.S.E., Alhoty F.F.H., Abugassa S.O.A., Al-Zubaidy K., Ilbarasi M.N., Alalem R., Swayeb E., Zubia N.Z., Mohamed P., Teeka M.O., Sohoub A., Abushnaf A., Mohamed A., Ramadan L., Shubba A., Huwidi O., Al-Serksi M., Eshtiwi M., Hadia E., Ahmed A.-J., Mansour I., Rian J.R., Yousef G., Mohamed S., Ahmed E.-Z., Ahmed B., Jamal Z., Abujanah S.A., Amer A.-A., Yousef O., Abozaid W., Elfagieh M.A., Ali A., Zoobei N.Z., Juwid A., Wafa A., Alatresh O.A., Alashhab M., Elzufri A.M., Aldarrat A.D., Matoug F., Alsellabi B., Alkesa T., Addanfour A., Badi H.B., Elfaghi I.E., Salaheddin E., Hamadi L., Hashmi H., Abd-rouf A., Ahmed M., Karar M., Zidan A., Alraheem A.A., Attia A., Yahya A.A., Otman F., Elmadany H., Gerbel G., Saleh M., Eurayet O., Almesmary R., Mostafa H., Abdurazig S., Dahim L., Jermi K., Koraz M.Y.K., Elghallal A.M., Eshwehdi A.A., Elwerfelli A., Elharati F.T., Elrafifi D., Algbali M., Abuhdema F., Elmadani L., Algedar H.A., Shefren I., Abdulrahman A., Najat N.Z., Elkhwildi R.M., Elgelany S., Abduljalil A., Hdud A., Zentuti H.Z., Khetrish S.B., Zeiton A.Z., Altagazi A.A., Almisslati S.H.A., Gandy Y.G., Jasim I., Alghafoud I.A., Hokoma M., Abusnina S.A., Gwila M., Yahya A.I., Mohammed M., Alqawi O.A., Hasan S.H., Rakotoarison S.R., Albert F., Hery A.H., Mamy R.M., Andriamampionona A.G.B., Judicael M., Ramilson H.E., Eloi H., Athanse V., Zo A., Andrianina L., Judicael R.M., Rakotoarisoa A.H.N., Rakotoarijaona A.H.R., Ramananasoa M.L.R., Angelin R., Hanta R., Raherison R.A.R., Rija F.R., Fanjandrainy R.F., Coulibaly Y., Zie S.Z., Gangaly D., Mahamane D.D., Toure Mamadou K., Simaga Abdoul K., Ibrahim T., Abdoulaye T., Alioune B.S., Souleymane T., Oumar O., Sogoba G., Amadou M., Moussa K., Veerasamy B., Heerah H.M.S.N., Limbajee M.L., Alleesaib S.B.M., Ramchurn T.P.R., Mandarry M.T.M., Joomye S., Thakoor B., Aungraheeta M., Sookun S.S., Lumbala K.F., Ikandi K., Kabongo L.T., Garcia M., Izquirdo P., Castro A.C., Ilunga I.B.B., Imbangu N.A.V., Nakandungile F., Mmasi J.E., Tobiko O., Polishchuk O., Kashuupulwa P.N.K., Kalume S., Sihope S.E., Arrey O., Kakololo S.I., Taiwo N.A., Kairuki P.C.K., Gazmuri O.G.G., Imene A.M., Umenushkin U.A., Kibandwa A., Cisekedi J.C., Nakangombe P., Musiba V.E.M., Gama G.G.N., Mwanga H.A.M., Mgonja L., Rink B., Amisi B.T., Bangure L., Rois W., Rois I., Sabwa H.K., Barongo M.L., Tshisekedi S.M., Mbuyi T., Lyimo T.S.K., Munyika A.A., Kornilov A.A., Rwehumbiza S.S.R., Kumar M., Makopa E.K., Njuguna W., Mavesere H.P., Kabongo A.N., Mutasiigwa M.G.H., Yangazov Y.M., Masiyambiri A.T.M., Jannetjies M.J., Dibwe D.F., Manyere D.V., Gorelyk O., Kabangu J.K., Gagara M., Salaou H., Moutari M., Bori I., Ogboli-Nwasor E.O., Aghadi K., Mohammed I., Sarkin-Pawa A., Yunus A.A., Ibrahim A.I., Edaigbini S.A., Yakubu Y., Sholadoye T., Koledale A.K., Anyanwu L.J.C., Salisu-Kabara H.M., Sheshe A.A., Ekwunife N.C., Ike I.A.R., Anele A., Isiguzo M., Ihezie O., Onyegbule A., Enendu E.O., Akhideno I., Desalu I.S., Bankole O.B., Ojewola R.W., Osinowo A.O., Afolabi B.B., Menkiti I.D., Mofikoya B.O., Osazuwa M.O., Yusuf A.S., Adamu Y.B., Alatise O.I., Arowolo O.A., Adisa A.O., Etuk E.B., Eyelade O.R., Ogunbode O., Shittu O.B., Idowu O.K., Ayandipo O.O., Lawal T.A., Echem R.C., Otokwala J., Jamabo S., Gueye S., Allopi K., Singh U., Bester J.J.A., Saaiman C.R., Alli A., Bischof K.E., Hurri H., Smith O.I., Elghobashy A.M., Omoshoro-Jones J., Murray R., Basson C.H., de Wet J.B., Skinner G.C., Kransingh S., Kuhn W., Madsen A.S.M., Matubatuba J.T., Mayeza S., Naidoo L.C., Narain S.J., Nkuebe T.N., Nabela L., Nkunjana M., Mhatu S., Thomas B.P., Wynne E.E., Davids J.G., Grunewald K.K., Kruger S., Ras W.A.P., Venter P.J., Cacala S.R.C., Kruse C., Mahomva O., Marais L.C., Semenya E.M., Rayne S.R., Alphonsus C.S., Mbuyisa M.W., Torborg A.M., De Lange J.T., Drummond L.W., Dullab K.D., Enicker B.C., Gigabhoy R., Hardcastle T.C., Maharaj A., Majola N., Moopanar M., Mukama I.F., Naicker K., Ngcobo G.K., Ramnarain H., Rocher A.G.L., Singh S., Stoltenkamp H.L., Alberts A.N.J.D., Luthuli L., Lumbamba A.J.M., Anderson P.G.R., du Plessis W.M., Ellis S., Ford L.M., Rousseau F.J., Rousseau N., Steyn G., Steyn H.C., Weideman M., Church B., Holford E.B., Szpytko A.J., Brouckaert N.T., Freeman Y.B.M., Ehouni A., Jithoo S., Naidoo L., Peter A.M., Belhaj S., Tun M., Kapp P., Bwambale Y.B., Holder H., Kasongo K.J.P., Makhanya V., Morapedi M., Mahomedy N.A., Pillay V., Reddy S.R., Mgoqo N., Mrara B., Nibe Z., Ninise E., Pahlana S.M., Usenbo A.O., Malongwe S.M., Nepogodiev, D., Omar, O. M., Glasbey, J. C., Li, E., Simoes, J. F. F., Abbott, T. E. F., Ademuyiwa, A. O., Biccard, B. M., Chaudhry, D., Davidson, G. H., Di Saverio, S., Gallo, G., Ghosh, D., Harrison, E. M., Hutchinson, P. J., Kamarajah, S. K., Keller, D. S., Lawani, I., Minaya-Bravo, A., Moore, R., Morton, D. G., Ntirenganya, F., Pata, F., Pearse, R. M., la Medina, A. R. -D., Tabiri, S., Venn, M. L., Omar, A. B. O. M., Bhangu, A., Siaw-Acheampong, K., Adamina, M., Agarwal, A., Alameer, E., Alderson, D., Alakaloko, F., Alser, O., Arnaud, A. P., Augestad, K. M., Bankhead-Kendall, B. K., Barlow, E., Benson, R. A., Blanco-Colino, R., Brar, A., Breen, K. A., Buarque, I. L., Caruana, E. J., Chakrabortee, S., Cox, D., Cunha, M. F., Dawson, B. E., Desai, A., Drake, T. D., Edwards, J. G., Elhadi, M., Evans, J. P., Farik, S., Fiore, M., Fitzgerald, J. E., Ford, S., Gomes, G. M. A., Griffiths, E. A., Gujjuri, R. R., Halkias, C., Heritage, E., Isik, A., Jenkinson, M. D., Jones, C. S., Khatri, C., Keatley, J. M., Kolias, A., Lawday, S., Lederhuber, H., Leventoglu, S., Laffler, M. W., Martin, J., Mashbari, H. N., Mazingi, D., Mckay, S. C., Metallidis, S., Mohan, H. M., Moszkowicz, D., Moug, S., Ng-Kamstra, J. S., Niquen, M., Outani, O., Pellino, G., Pinkney, T. D., Pockney, P., Radenkovic, D., Roberts, K., Roslani, A. C., Santos, I., Schache, A., Schnitzbauer, A. A., Stewart, G. D., Shaw, R., Shu, S., Soreide, K., Spinelli, A., Sundar, S., Tiwari, A., Townend, P., Trout, I. M., Tsoulfas, G., van Ramshorst, G. H., Vidya, R., Vimalachandran, D., Warren, O., Wilkin, R. J. W., Wright, N., Hoste, E., Huyghens, L., Jacobs, R., Opdenacker, G., Poelaert, J., Rijckaert, D., De Decker, K., Foubert, L., De Neve, N., Biston, P., Piagnerelli, M., Collin, V., den Blauwen, N., Clauwaert, C., De Crop, L., Verbeke, A., Derumeaux, P., Gardin, C., Kindt, S., Louage, S., Verhamme, B., Druwacopyright, P., Lahaye, I., Rosseel, F., Rutsaert, R., Vanlinthout, L., De Kock, M., Forget, P., Kahn, D., Lois, F., Momeni, M., Yemnga, A. P. B., Jadoul, J. -L., Malbrain, M., Bosinceanu, D., Collard, E., Jorens, P., Reyntiens, D., Smitz, C., Vercauteren, M., Fagnoul, D., Toplice, K., Oremua¡, K., Bea¡lic, G., Duzel, V., Hauptman, A., Peremin, S., Aribar, A., Aupcic, M., Brod, S., Mirkovic, I., Bauer, Z. A., Belavic, M., Blaa¾anin, B., Katua¡in, M. L., Krijan, A. B., Mia¡kovic, P., Aimic-Korac, N., Topic, J., Ailic, A., Aunic, J., Acan, I., Adanic, M., Ivanov, N., Aaric, J. P., Tomulic, K., Viskovic, N., Boa¡njak, S., Drenjancevic, I. H., Kristek, G., Kvolik, S., Markic, S., Rakipovic, A. S., Tot, O. K., Fabris, L. K., Bacak-Kocman, I., Balenovic, I., Bandic, D., Deutsch, P. A. J., Divjak, L., Filipovic, I. G., Gua¾vinec, Z., Krznaric, Z., Loncaric, Y., Magaa¡, J. V., Mitrovic, M., Okic, M., Pavlek, M., Ramov, E., Rezek, K., Sekulic, A., Tomasevic, B., Miric, M., Tomaa¡evic, A., Mahecic, T. T., Vrbanovic, V., Bobinac, M., Boa¾ic, A., Debelic, D., Frkovic, V., Batinica, I. M., Baranovic, S., Gavranovic, A., Kikec, M., Maldini, B., Maric, S., Agnic, I., Delic, N., Dropulic, N., Gaa¡pic, T. K., Ilic, D., Ivancev, B., Karanovic, N., Kua¡cevic, D., Marovic, Z., Milic, M., Nevea¡canin, A., Petkovic, T., Smoje, M., Brozovic, G., Goranovic, T., Jelisavac, M., Matolic, M., Mazul-Sunko, B., Oberhofer, D., Pavicic, A. M., Aakic, K., Bozovic, M. D., Krecek, Z. 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M., Grigorjevs, S., Rikmane, M., Rozkalne, D., Stepanovs, J., Suba, O., Golubovska, I., Kazune, S., Miscuk, A., Nemme, J., Oss, P., Sipylaite, J., Macas, A., Ragaisis, V., Kontrimaviciute, E., Tomkute, G., Boerma, E. C., Leeuwarden, M. C., Kramer, I. F., Poeze, M., Maria, J., Pelzer, G., Nijsten, M., Schoorl, M., Spanjersberg, R., Buhre, W., Dieleman, S., van Klei, W. A., Bouw, M., Pickkers, P., Schreiner, F., Zandvliet, R., van den Berg, R., De Wit, E., Keijzer, C., Hollmann, M. W., Preckel, B., van Acker, G. J. D., Dennesen, P. J. W., Kuijpers-Visser, A. G., Inan, T., Gemert, A. W. M. M. K. -V., Ponssen, H. H., Brouwer, T., Koopmans, M., van Bommel, J., van Duijn, D., van der Hoven, B., Ormskerk, P., Beck, O., Schiere, S., Reidinga, A. C., Venema, A., Jammer, I., Dokka, V., Monsen, S. A., Ytrebo, L. M., Noursadeghi, M., Shahzad, A., Boksasp, O. D., Roiss, C., Strietzel, H. F., Berntsen, A. G. S., Haugland, H., Vingsnes, S. O., Axelsson, P., Risom Olsen, T. 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V., Konstantivelli, M., Lataniotou, O., Lisari, E., Margaroni, M., Stamatiou, K., Nikolaidis, E., Pnevmatikos, I., Sertaridou, E., Andreou, A., Arkalaki, E., Athanasakis, E., Chaniotaki, F., Chatzimichali, C. A., Christofaki, M., Dermitzaki, D., Fiorentza, K., Frantzeskos, G., Geromarkaki, E., Kafkalaki, K., Kalogridaki, M., Karydi, K., Kokkini, S., Kougentakis, G., Lefaki, T., Lilitsis, E., Makatounaki, A., Michelakis, D., Neonaki, M., Palikyra, I., Papadakis, E., Sfakianakis, K., Sgouraki, M., Souvatzis, X., Spartinou, A., Stefanidou, N., Syrogianni, P., Tsagkaraki, G., Arnaoutoglou, C., Bali, C., Bouris, V., Doumos, R., Gkini, K. -P., Kapaktsi, C., Lena, A., Lepida, D., Michos, E., Papadopoulos, D., Paschopoulos, M., Rompou, V. A., Siouti, I., Tsampalas, S., Ververidou, O., Zilis, G., Charlalampidoy, A., Christodoulidis, G., Flossos, A., Stamoulis, K., Tsang, M. S. C., Tsang, M. S., Lai, M. L., Yip, C. P., Chan, H. M. H., Law, B., Li, W. S., Chu, H. M., Koo, E. G. Y., Lam, C. C. J., Cheng, K. H., Lam, T., Chu, S., Wong, K. W. K., Kwok, D., Hung, C. Y. J., Chan, W. K. J., Lamwong, W., Chung, C. K. E., Ma, S. K., Kaushik, S., Shah, B., Shah, D., Shah, S., Ar, P., Muthuchellappan, R., Agarwal, V., Divatia, J., Mishra, S., Nimje, G., Pande, S., Savarkar, S., Shrivastava, A., Yegnaram, S., Hidayatullah, R., Puar, N., Niman, S., Indra, I., Hamzah, Z., Yuliana, A., Abidin, U. N., Dursin, A. N., Kurnia, A., Susanti, A., Handayani, D., Alit, M. A., Arya, A., Senapathi, T. G. A., Utara, U. H., Wid, W. M., Wima, S., Wir, W. M., Jehosua, B., Kaunang, J., Lantang, E. Y., Najoan, R., Waworuntu, N., Awad, H., Fuad, A., Geddoa, B., Khalaf, A. R., Albaj, S., Kenber, M., Bettinelli, A., Spadaro, S., Albertovolta, C., Sottosanti, L. G. V., Alloj, C., Cardellino, S., Costanzo, E., Fanfani, L. C., Bellandi, M., Beretta, L., Bocchino, S., Cabrini, L., Corti, D., Landoni, G., Meroni, R., Moizo, E., Pintaudi, M., Plumari, V. P., Taddeo, D., Testa, V., Winterton, D., Zangrillo, A., Cloro, L. M., Colangelo, C., Colangelo, A., Giuseppe, R., Paludi, M. A., Maria, C. P., Pata, A., Arrigo, M., Benevento, A., Bottini, C., Gastaldi, C., Marchesi, A., Pascazio, A., Pozzi, E., Premoli, A., Tessera, G., Boschi, L., D'Andrea, R., Ghignone, F., Poggioli, G., Sibilio, A., Taffurelli, M., Ugolini, G., Majid, M. A. A., Rahman, R. A., Joseph, J., Pathan, F., Shah, M. H. S., Yap, H. L., Cheah, S., Chin, I. I., Looi, J. K., Tan, S. C., Visvalingam, S., Kwok, F. Y., Lee, C. K., Tan, T. S., Wong, S. M., Abdullah, N. H., Liew, C. F., Luxuman, L., Zin, N. H. M., Norddin, M. F., Alias, R. L. R., Wong, J. Y., Yong, J., Mustapha, M. T. B., Chan, W. K., Dzulkipli, N., Kuan, P. X., Lee, Y. C., Alias, A., Guok, E. C., Jee, C. C., Ramon, B. R., Wong, C. W., Ghafar, F. N. I. A., Aziz, F. Z., Hussain, N., Lee, H. S., Sukawi, I., Woon, Y. L., Hadi, H. Z. A., Azam, U. A. A., Alias, A. H., Kesut, S. A., Lee, J. M., Ooi, D. V., Sulaiman, H. A., Lih, T. A. T., Veerakumaran, J., Rojas, E., Flores, A. A. A., Amador, J. C. B., Avila, E. J. D., Aquino, L. P. G., Rodriguez, R. L., Landa, M. T., Urias, E., Hollmann, M., Hulst, A., Preckel, O. K. B., Gemert, A. K. -V., Buise, M., Tolenaar, N., Weber, E., de Fretes, J., Houweling, P., Van Bommel, J., Lance, M., Smit-Fun, V., van Zundert, T., Baas, P., de Boer, H. D., Sprakel, J., Elferink-Vonk, R., Noordzij, P., van Zeggeren, L., Brand, B., Numan, S., van Klei, W., van Zaane, B., Boer, C., van Duivenvoorde, Y., Hering, J. P., Zonneveldt, H., Hoare, S., Santa, S., Bell, R., Choi, H. -M. D., Drake, M., Farrell, H., Higgie, K., Jenkins, N., Kim, C. J., Kim, S., Law, K. C., Mcallister, D., Park, K., Pedersen, K., Pfeifer, L., Salmond, T., Steynor, M., Tan, M., Waymouth, E., Rahman, A. S. A., Armstrong, J., Dudson, R., Nilakant, J., Richard, S., Virdi, P., Dixon, L., Donohue, R., Farrow, M., Kennedy, R., Marissa, H., Mckellow, M., Nicola, D., Pascoe, R., Roberts, S. J., Rowell, G., Sumner, M., Templer, P., Chandrasekharan, S., Fulton, G., Ali, M., More, R., Wilson, L., Chang, Y. H., Foley, J., Fowler, C., Panckhurst, J., Sara, R., Stapelberg, F., Cherrett, V., Ganter, D. L., Mccann, L., Gilmour, F., Lumsden, R., Moores, M., Olliff, S., Sardareva, E., Tai, J., Wikner, M., Wong, C., Chaddock, M., Czepanski, C., Mckendry, P., Polakovic, D., Polakovich, D., Robert, A., Belda, M. T., Norton, T., Alherz, F., Barneto, L., Ramirez, A., Sayeed, A., Bennett, C., Mcquoid, S., Jansen, T. -L., Nico, Z., Scott, J., Freschini, D., Freschini, A., Hopkins, B., Manson, L., Stoltz, D., Bates, A., Davis, S., Freeman, V., Mcgaughran, L., Sharma, S. B., Burrows, T., Byrne, K., English, D., Johnson, R., Manikkam, B., Naidoo, S., Rumball, M., Whittle, N., Franks, R., Gibson-Lapsley, H., Salter, R., Walsh, D., Cooper, R., Perry, K., Obobolo, A., Sule, U. M., Ahmad, A., Atiku, M., Mohammed, A. D., Sarki, A. 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K., Ramnarain, H., Rocher, A. G. L., Singh, S., Stoltenkamp, H. L., Alberts, A. N. J. D., Luthuli, L., Lumbamba, A. J. M., Anderson, P. G. R., du Plessis, W. M., Ellis, S., Ford, L. M., Rousseau, F. J., Rousseau, N., Steyn, G., Steyn, H. C., Weideman, M., Church, B., Holford, E. B., Szpytko, A. J., Brouckaert, N. T., Freeman, Y. B. M., Ehouni, A., Jithoo, S., Naidoo, L., Peter, A. M., Belhaj, S., Tun, M., Kapp, P., Bwambale, Y. B., Holder, H., Kasongo, K. J. P., Makhanya, V., Morapedi, M., Mahomedy, N. A., Pillay, V., Reddy, S. R., Mgoqo, N., Mrara, B., Nibe, Z., Ninise, E., Pahlana, S. M., Usenbo, A. O., Malongwe, S. M., Giles, D. G., Porrill, O. S., Reed, A. R., Visser, J., Davies, G. L., Koller, V. L., Moodie, Q. K., Spicer, J. M., Van Dyk, J. G., Diedericks, B. J. S., Esterhuizen, J. L., Mavhungu, R., Mhlari, T. M., Akhter, M., Baloyi, A. M., Bamuza, K. A., Bamuza, M. I., Bashiya, L., Blignaut, F., Machowski, A. Z., Madzivhe, L. J., Mafafo, S. C., Mashile, M. V., Masia, O. R., Masipa, J. N., Matenchi, M. W., Mathe, R. C., Mogale, J. O., Mohlala, M. P., Mongwe, K. N., Morulana, T. G., Motloutsi, S. P., Mphephu, P. E., Muroonga, M. P., Mzezewa, S. Z., Neil, M. C., Neluheni, E. V., Nesengani, D. S., Nesengani, N. T., Netshimboni, L. E., Notoane, I., Omoding, S., Orjiako, O., Perez, N., Pheeha, R. M., Pilusa, K. A., Pochana, M. P., Pupyshev, M., Rambau, M., Ramuntshi, R., Roura, H., Ryabchiy, B. B., Ryndine, V., Sebei, M. P., Moses, V. L., Mungherera, A. R. W., and Pansegrouw, J.

Subjects
Adult, Global Health, SARS‐CoV‐2, Health Services Accessibility, NO, cancellation, Models, COVID‐19, Humans, Pandemics, Bayes Theorem, COVID-19, Elective Surgical Procedures, Health Care Rationing, Health Policy, Infection Control, Models, Statistical, health care economics and organizations, Elective Surgical Procedure, Original Articles, Statistical, elective surgery, Original Article, human activities, Human
Abstract

The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19.A global expert response study was conducted to elicit projections for the proportion of elective surgery that would be cancelled or postponed during the 12 weeks of peak disruption. A Bayesian β-regression model was used to estimate 12-week cancellation rates for 190 countries. Elective surgical case-mix data, stratified by specialty and indication (surgery for cancer versus benign disease), were determined. This case mix was applied to country-level surgical volumes. The 12-week cancellation rates were then applied to these figures to calculate the total number of cancelled operations.The best estimate was that 28 404 603 operations would be cancelled or postponed during the peak 12 weeks of disruption due to COVID-19 (2 367 050 operations per week). Most would be operations for benign disease (90·2 per cent, 25 638 922 of 28 404 603). The overall 12-week cancellation rate would be 72·3 per cent. Globally, 81·7 per cent of operations for benign conditions (25 638 922 of 31 378 062), 37·7 per cent of cancer operations (2 324 070 of 6 162 311) and 25·4 per cent of elective caesarean sections (441 611 of 1 735 483) would be cancelled or postponed. If countries increased their normal surgical volume by 20 per cent after the pandemic, it would take a median of 45 weeks to clear the backlog of operations resulting from COVID-19 disruption.A very large number of operations will be cancelled or postponed owing to disruption caused by COVID-19. Governments should mitigate against this major burden on patients by developing recovery plans and implementing strategies to restore surgical activity safely.La pandemia de COVID-19 ha interrumpido los servicios hospitalarios habituales a nivel mundial. En este estudio se calculó el número total de operaciones electivas para adultos que se cancelarían en todo el mundo durante las 12 semanas de interrupción máxima debido a COVID’19. MÉTODOS: Se realizó un estudio global de respuestas de expertos para obtener proyecciones sobre la proporción de cirugía electiva que se cancelaría o pospondría durante las 12 semanas del pico máximo de disrupción. Se usó un modelo bayesiano de regresión beta para estimar las tasas de cancelación durante 12 semanas en 190 países. Se determinaron los datos de la casuística de casos quirúrgicos electivos, estratificados por especialidad e indicación (cáncer versus cirugía benigna). Esta casuística de casos se aplicó a volúmenes quirúrgicos a nivel de país. Las tasas de cancelación de las 12 semanas se aplicaron a estas cifras para calcular el total de operaciones suspendidas.La mejor estimación fue que 28.404.603 operaciones hubieran sido canceladas o pospuestas durante las 12 semanas del pico de disrupción por COVID-19 (2.367.050 operaciones por semana). La mayoría hubieran sido operaciones por enfermedad benigna (90,2%, 25.638.922/28. 404. 603). La tasa de cancelación general en 12 semanas sería del 72,3%. A nivel mundial, el 81,7% (25.638.921/31.378.062) de la cirugía benigna, el 37,7% (2. 324.069/6.162.311) de la cirugía por cáncer y el 25,4% (441.611/1.735.483) de las cesáreas electivas hubieran sido canceladas o pospuestas. Si los países aumentan su volumen quirúrgico normal en un 20% después de la pandemia, se tardaría una mediana de 45 semanas para eliminar la acumulación de operaciones resultantes de la disrupción por COVID’19. CONCLUSIÓN: Se cancelará o pospondrá un número muy grande de operaciones debido a la disrupción causada por COVID-19. Los gobiernos deberían mitigar esta importante carga para los pacientes mediante el desarrollo de planes de recuperación e implementando estrategias para reiniciar de manera segura la actividad quirúrgica.

Published
2020

49. Edoxaban for the Long‐Term Therapy of Venous Thromboembolism: Should the Criteria for Dose Reduction be Revised?

Author

Camporese, G., Simioni, P., Di Micco, P., Fernandez-Capitan, C., Rivas, A., Font, C., Sahuquillo, J. C., Villares, P., Prandoni, P., Monreal, M., Adarraga, M. D., Agud, M., Aibar, J., Aibar, M. A., Alfonso, J., Amado, C., Arcelus, J. I., Baeza, C., Ballaz, A., Barba, R., Barbagelata, C., Barron, M., Barron-Andres, B., Blanco-Molina, A., Camon, A. M., Castro, J., Caudevilla, M. A., Cerda, P., Chasco, L., Criado, J., de Ancos, C., de Miguel, J., del Toro, J., Demelo-Rodriguez, P., Diaz-Peromingo, J. A., Diez-Sierra, J., Dominguez, I. M., Encabo, M., Escribano, J. C., Falga, C., Farfan, A. I., Fernandez de Roitegui, K., Fernandez-Reyes, J. L., Fidalgo, M. A., Flores, K., Font, L., Francisco, I., Gabara, C., Galeano-Valle, F., Garcia, M. A., Garcia-Bragado, F., Garcia-Mullor, M. M., Gavin-Blanco, O., Gavin-Sebastian, O., Gil-Diaz, A., Gomez-Cuervo, C., Gonzalez-Martinez, J., Grau, E., Guirado, L., Gutierrez, J., Hernandez-Blasco, L., Jara-Palomares, L., Jaras, M. J., Jimenez, D., Joya, M. D., Jou, I., Lacruz, B., Lalueza, A., Lecumberri, R., Lima, J., Lobo, J. L., Lopez-Brull, H., Lopez-Jimenez, L., Lopez-Miguel, P., Lopez-Nunez, J. J., Lopez-Reyes, R., Lopez-Saez, J. B., Lorente, M. A., Lorenzo, A., Loring, M., Madridano, O., Maestre, A., Marchena, P. J., Martin del Pozo, M., Martin-Martos, F., Martinez-Baquerizo, C., Mella, C., Mellado, M., Mercado, M. I., Moises, J., Morales, M. V., Munoz-Blanco, A., Munoz-Guglielmetti, D., Munoz-Rivas, N., Nart, E., Nieto, J. A., Nunez, M. J., Olivares, M. C., Ortega-Recio, M. D., Osorio, J., Otalora, S., Otero, R., Paredes, D., Parra, P., Parra, V., Pedrajas, J. M., Pellejero, G., Peris, M. L., Pesantez, D., Porras, J. A., Portillo, J., Ramos, E., Reig, L., Riera-Mestre, A., Rodriguez-Cobo, A., Rodriguez-Matute, C., Rogado, J., Rosa, V., Rubio, C. M., Ruiz-Artacho, P., Ruiz-Gimenez, N., Ruiz-Ruiz, J., Ruiz-Sada, P., Salgueiro, G., Samperiz, A., Sanchez-Munoz-Torrero, J. F., Sancho, T., Siguenza, P., Sirisi, M., Soler, S., Suarez, S. Surinach J. M., Tiberio, G., Torres, M. I., Tolosa, C., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valle, R., Vela, J. R., Vidal, G., Vilar, C., Zamora, C., Gutierrez, P., Vazquez, F. J., Vanassche, T., Vandenbriele, C., Verhamme, P., Hirmerova, J., Maly, R., Salgado, E., Benzidia, I., Bertoletti, L., Bura-Riviere, A., Crichi, B., Debourdeau, P., Espitia, O., Farge-Bancel, D., Helfer, H., Mahe, I., Moustafa, F., Poenou, G., Schellong, S., Braester, A., Brenner, B., Tzoran, I., Amitrano, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., Colaizzo, D., Dentali, F., Giammarino, E., Grandone, E., Mangiacapra, S., Mastroiacovo, D., Maida, R., Mumoli, N., Pace, F., Pesavento, R., Pomero, F., Quintavalla, R., Rocci, A., Siniscalchi, C., Tufano, A., Visona, A., Vo Hong, N., Zalunardo, B., Make, K., Meilanden, K., Skride, A., Ferreira, M., Fonseca, S., Martins, F., Meireles, J., Bosevski, M., Zdraveska, M., Bounameaux, H., Mazzolai, L., Caprini, J. A., Tafur, A. J., Weinberg, I., Wilkins, H., Bui, H. M., and UAM. Departamento de Medicina

Subjects
Male, medicine.medical_specialty, Time Factors, Dose, Medicina, Pyridines, Hemorrhage, General Biochemistry, Genetics and Molecular Biology, Article, chemistry.chemical_compound, Edoxaban, Recurrence, Internal medicine, medicine, Humans, Prospective Studies, Registries, General Pharmacology, Toxicology and Pharmaceutics, Long term therapy, Aged, Aged, 80 and over, Dose-Response Relationship, Drug, Drug Tapering, business.industry, lcsh:Public aspects of medicine, General Neuroscience, Mortality rate, Research, lcsh:RM1-950, Hazard ratio, Anticoagulants, lcsh:RA1-1270, General Medicine, Articles, Venous Thromboembolism, Middle Aged, Confidence interval, Thiazoles, lcsh:Therapeutics. Pharmacology, chemistry, Practice Guidelines as Topic, Dose reduction, Female, business, Venous thromboembolism, Follow-Up Studies
Abstract

Edoxaban is used for venous thromboembolism (VTE) treatment. Real-life data are lacking about its use in long-term therapy. We aimed to assess the efficacy and the safety of edoxaban for long-term VTE treatment in a real-life setting. Patients with VTE included in the Registro Informatizado Enfermedad TromboEmbólica (RIETE) registry, receiving edoxaban 60 or 30 mg daily were prospectively followed up to validate the benefit of using different dosages. The main outcome was the composite of VTE recurrences or major bleeding in patients with or without criteria for dose reduction. Multivariable analysis to identify predictors for the composite outcome was performed. From October 2015 to November 2019, 562 patients received edoxaban for long-term therapy. Most (94%) of the 416 patients not meeting criteria for dose reduction received 60 mg daily, and 92 patients meeting criteria (63%) received 30 mg daily. During treatment, two patients developed recurrent VTE, six had major bleeding and nine died (2 from fatal bleeding). Among patients not meeting criteria for dose reduction, those receiving 30 mg daily had a higher rate of the composite event (hazard ratio (HR) 8.37; 95% confidence interval (CI) 1.12–42.4) and a significant higher mortality rate (HR 31.1; 95% CI 4.63–262) than those receiving 60 mg. Among patients meeting criteria for dose reduction, those receiving 60 mg daily had no events, and a nonsignificantly higher mortality rate (HR 5.04; 95% CI 0.54–133) than those receiving 30 mg daily. In conclusion, edoxaban seems to be effective and safe for long-term VTE treatment in real life. Criteria for dose reduction should be reformulated., No funding was received for this work

Published
2020

50. Cardiovascular End Points and Mortality Are Not Closer Associated With Central Than Peripheral Pulsatile Blood Pressure Components

Author

Qi-Fang Huang, Lucas S. Aparicio, Lutgarde Thijs, Fang-Fei Wei, Jesus D. Melgarejo, Yi-Bang Cheng, Chang-Sheng Sheng, Wen-Yi Yang, Natasza Gilis-Malinowska, José Boggia, Teemu J. Niiranen, Wiktoria Wojciechowska, Katarzyna Stolarz-Skrzypek, Jessica Barochiner, Daniel Ackermann, Valérie Tikhonoff, Belen Ponte, Menno Pruijm, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovský, Danuta Czarnecka, Kalina Kawecka-Jaszcz, Antti M. Jula, Murielle Bochud, Thomas Vanassche, Peter Verhamme, Harry A.J. Struijker-Boudier, Ji-Guang Wang, Zhen-Yu Zhang, Yan Li, Jan A. Staessen, LS Aparicio, J Barochiner, L Thijs, JA Staessen, FF Wei, WY Yang, ZY Zhang, YB Cheng, QH Guo, JF Huang, QF Huang, Y Li, CS Sheng, JG Wang, J Filipovský, J Seidlerová, EP Juhanoja, AM Jula, AS Lindroos, TJ Niiranen, SS Sivén, E Casiglia, A Pizzioli, V Tikhonoff, BS Chori, B Danladi, AN Odili, H Oshaju, W Kucharska, K Kunicka, N Gilis-Malinowska, K Narkiewicz, W Sakiewicz, E Swierblewska, K Kawecka-Jaszcz, K Stolarz-Skrzypek, AE Schutte, GR Norton, AJ Woodiwiss, D Ackermann, M Bochud, B Ponte, M Pruijm, R Álvarez-Vaz, C Américo, C Baccino, L Borgarello, L Florio, P Moliterno, A Noboa, O Noboa, A Olascoaga, P Parnizari, M Pécora, RS: Carim - H03 ECM and Wnt signaling, Farmacologie en Toxicologie, IDCARS (International Database of Central Arterial Properties for Risk Stratification) Investigators, Aparicio, L.S., Barochiner, J., Thijs, L., Staessen, J.A., Wei, F.F., Yang, W.Y., Zhang, Z.Y., Cheng, Y.B., Guo, Q.H., Huang, J.F., Huang, Q.F., Li, Y., Sheng, C.S., Wang, J.G., Filipovský, J., Seidlerová, J., Juhanoja, E.P., Jula, A.M., Lindroos, A.S., Niiranen, T.J., Sivén, S.S., Casiglia, E., Pizzioli, A., Tikhonoff, V., Chori, B.S., Danladi, B., Odili, A.N., Oshaju, H., Kucharska, W., Kunicka, K., Gilis-Malinowska, N., Narkiewicz, K., Sakiewicz, W., Swierblewska, E., Kawecka-Jaszcz, K., Stolarz-Skrzypek, K., Schutte, A.E., Norton, G.R., Woodiwiss, A.J., Ackermann, D., Bochud, M., Ponte, B., Pruijm, M., Álvarez-Vaz, R., Américo, C., Baccino, C., Borgarello, L., Florio, L., Moliterno, P., Noboa, A., Noboa, O., Olascoaga, A., Parnizari, P., and Pécora, M.

Subjects
Male, Pulsatile flow, population, morbidity, 030204 cardiovascular system & hematology, DISEASE, 0302 clinical medicine, 030212 general & internal medicine, 610 Medicine & health, risk, education.field_of_study, Hazard ratio, blood pressure, Middle Aged, LOCAL PULSE PRESSURE, Pulse pressure, Peripheral, Cardiovascular Diseases, Hypertension, Cardiology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, mortality, ARTERIAL STIFFNESS, Adult, medicine.medical_specialty, Population, ASCENDING AORTIC PRESSURE, EVENTS, 03 medical and health sciences, KIDNEY, Internal medicine, Internal Medicine, medicine, Humans, education, Sensitivity analyses, Aged, business.industry, Epidemiology/Population Science, Blood Pressure Determination, Original Articles, Total mortality, Blood pressure, Heart Disease Risk Factors, business
Abstract

Supplemental Digital Content is available in the text., Pulsatile blood pressure (BP) confers cardiovascular risk. Whether associations of cardiovascular end points are tighter for central systolic BP (cSBP) than peripheral systolic BP (pSBP) or central pulse pressure (cPP) than peripheral pulse pressure (pPP) is uncertain. Among 5608 participants (54.1% women; mean age, 54.2 years) enrolled in nine studies, median follow-up was 4.1 years. cSBP and cPP, estimated tonometrically from the radial waveform, averaged 123.7 and 42.5 mm Hg, and pSBP and pPP 134.1 and 53.9 mm Hg. The primary composite cardiovascular end point occurred in 255 participants (4.5%). Across fourths of the cPP distribution, rates increased exponentially (4.1, 5.0, 7.3, and 22.0 per 1000 person-years) with comparable estimates for cSBP, pSBP, and pPP. The multivariable-adjusted hazard ratios, expressing the risk per 1-SD increment in BP, were 1.50 (95% CI, 1.33–1.70) for cSBP, 1.36 (95% CI, 1.19–1.54) for cPP, 1.49 (95% CI, 1.33–1.67) for pSBP, and 1.34 (95% CI, 1.19–1.51) for pPP (P

Published
2020

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