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On November 23, 2015 in Protvino of the Moscow Region there was begun proton therapy using Russia's first medical therapeutic complex "Prometheus" produced by JSC "PRO- TOM" and certified to treat patients with head and neck tumors. The complex allows irradiating patients with active scanning beam. Energy of beam is 30-250MeV and maximum field size is 10 cm vertically and 40 cm horizontally. The manufacturer declared parameters were confirmed during preclinical stud- ies. By April 8, 2016 the successful proton therapy received 20 patients with complex "targets" mostly located, from the point of view of radiation tolerance, near the critical structures.

The paper presented results of photodynamic therapy for 139 patients with basal cell carcinoma. We conducted a study of the efficacy and safety of four methods of photodynamic therapy. There were used the following photosensitizers: photohem, photosens, photolon and photodithazine. Photodynamic therapy using photosensitizers of chlorine series (photolon and photoditazin) provides a better long-term results improving disease-free 3-year survival rate to 90.4% and 92.3%, respectively compared to 54.7% and 71.1% in groups, in which treatment was restricted by photohem and photosens.

A comparative analysis of the efficacy and safety of neoadjuvant chemoradiotherapy (CRT) in colorectal cancer patients older and younger than 60 years has been performed. It was determined that the risk of complications of neoadjuvant CRT, as well as the degree of its adverse effect on outcomes after surgical treatment, are not significant for the age of patients. However, the use of preoperative CRT in elderly patients is associated with a less significant increase in recurrence-free survival in comparison with younger patients. Thus, the age factor should not limit the use of neoadjuvant CRT in patients with satisfactory general status and the absence of severe complications of the pathological process.Проведен сравнительный анализ эффективности и безопасности неоадъювантной химиолучевой терапии (ХЛТ) рака прямой кишки у больных моложе и старше 60 лет. Определено, что риск развития осложнений неоадъювантной ХЛТ, так же как и степень ее неблагоприятного влияния на исходы последующего хирургического лечения, не имеет существенной зависимости от возраста пациентов. Однако применение предоперационной ХЛТ у больных гериатрического профиля сопровождается менее значимым приростом безрецидивной выживаемости по сравнению с более молодыми пациентами. Таким образом, возрастной фактор не должен ограничивать использование неоадъювантной ХЛТ у больных с удовлетворительным общесоматическим статусом и отсутствием выраженных осложнений опухолевого процесса.

In clause results of treatment of 1794 patients with a sharp pancreatitis are analyzed. The interstial form was observed at 1186 are sick, for 608 (33,9%) patients has been diagnosed pancreonecrosis. Men (73%) prevailed, the age was within the limits of from 18 till 75 years, middle age has made 46,7 years. The basic part of patients (97,3%) have acted in hospitals in a phase fermental [Cyrillic word: see text]. During till 24 o'clock from the beginning of disease 24,6% patients have acted only, at other patients terms from the beginning of disease exceeded 24 and more hours. Spent complex infusion, antifermental and antibacterial therapy. During medical-diagnostic laparoscopic spent [Cyrillic word: see text] a belly cavity, retrogastric bags and formation of holecyctostoms. At presence of purulent complications of pancreonecrosis a unconditional priority gave littletrauwm to methods of treatment (a puncture abscesses under UZ prompting, and as during retroperitoneoscopy). Duration of treatment at a simple pancreatitis has averaged 15,4 days, at pancreonecrosis 22,9, at purulent complications of a destructive pancreatitis it reached 39,8 day. Mortalyti at a sharp pancreatitis has made 2,2% (26 patients), at pancreonecrosis 9,7% (59 patients), and at purulent complications of a destructive pancreatitis 25,7% (17 patients).

The article is devoted to an analysis of 51 cases of nonepithelial formations of the small intestine. Benign tumors were diagnosed in 22 of them (leiomyomas, lipomas, fibromas). Malignant tumors were found in 29 cases (leiomyosarcomas and fibrosarcomas) The article describes the clinical picture, diagnosis and surgical treatment of nonepithelial formations of the small intestine.

Non-epithelial tumors of the gastrointestinal tract (GIT) are rare diseases, their rate is less than 2.6% of all tumors of this localization. Analysis of 271 clinical cases of non-epithelial tumors demonstrated that most of them (n = 174) belonged to smooth muscle tumors. Features of growth and localization of benign and malignant non-epithelial tumors were demonstrated. It was revealed that only morphologic study (frequently with histochemical methods) verified the diagnosis of neoplasm. The choice of the scope of surgical intervention depends on the localization, spread and morphology of tumor. Difficulties of verification before surgery lead to active surgical policy for non-epithelial GIT tumors.

The authors have analyzed their observations of 30 patients. Nonepithelial tumors were shown to be rare. Complex employment of endoscopic and X-ray methods of examination should be used for their diagnosis and differential diagnosis. Transanal interventions are thought to be palliative and can be used in patients with a high operative rick.

An analysis of results of the examination and treatment of 92 patients with nonepithelial colorectal tumors has shown that the correct diagnosis can be made in 82% of the cases on the basis of using complex X-ray, ultrasonic and endoscopic methods. Of decisive significance in determination of the tumor tissue character is the morphological investigation. Extensive surgical interventions were performed due to suspected malignization on 21 patients with benign nonepithelial tumors. In other cases (n = 49) the organ-saving operations were fulfilled. The decision between the volumes of the surgery for malignant nonepithelial tumors (n = 24) was not difficult in most cases and depended on the spread of the oncological process. The 5-year survival in this group of patients was 57%. No recurrences were noted after ablation of benign tumors.