Author: "T Kimura" / Topic: humans - Searchworks@Jio Institute Digital Library Search Results

881 results on '"T Kimura"'

1. hnRNP A1 and hnRNP C associate with miR‐17 and miR‐18 in thyroid cancer cells

Author: Maria Gabriela Pereira Santos, Guilherme Henrique Gatti da Silva, Helder Yudi Nagasse, Cesar Seigi Fuziwara, Edna T. Kimura, and Patricia Pereira Coltri
Subjects: MicroRNAs, Heterogeneous Nuclear Ribonucleoprotein A1, Humans, EXPRESSÃO GÊNICA, Thyroid Neoplasms, Heterogeneous-Nuclear Ribonucleoproteins, General Biochemistry, Genetics and Molecular Biology
Abstract: Heterogeneous nuclear ribonucleoproteins (hnRNPs) are essential players in the regulation of gene expression. The majority of the twenty different hnRNP proteins act through the modulation of pre-mRNA splicing. Most have been shown to regulate the expression of critical genes for the progression of tumorigenic processes and were also observed to be overexpressed in several types of cancer. Moreover, these proteins were described as essential components for the maturation of some microRNAs (miRNAs). In the human genome, over 70% of miRNAs are transcribed from introns; therefore, we hypothesized that regulatory proteins involved with splicing could be important for their maturation. Increased expression of the miR-17-92 cluster has already been shown to be related to the development of many cancers, such as thyroid, lung, and lymphoma. In this article, we show that overexpression of hnRNP A1 and hnRNP C in BCPAP thyroid cancer cells directly affects the expression of miR-17-92 miRNAs. Both proteins associate with the 5'-end of this cluster, strongly precipitate miRNAs miR-17 and miR-18a and upregulate the expression of miR-92a. Upon overexpression of these hnRNPs, BCPAP cells also show increased proliferation, migration, and invasion rates, suggesting upregulation of these proteins and miRNAs is related to an enhanced tumorigenic phenotype.
Published: 2022
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2. Artificial pneumothorax suppresses postoperative inflammatory reaction in mediastinal tumor surgery

Author: Toshihiko Shibata, Takuma Tsukioka, Hiroaki Komatsu, T. Kimura, Noritoshi Nishiyama, Hidetoshi Inoue, Nobuhiro Izumi, and Ryuichi Ito
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pleural effusion, Mediastinal tumor, Postoperative reaction, Mediastinal Neoplasms, 胸水, Surgical oncology, 縦隔腫瘍, medicine, Pneumothorax, Artificial, Artificial pneumothorax, Humans, Retrospective Studies, Skin incision, business.industry, Clinical course, Mediastinum, Pneumothorax, General Medicine, respiratory system, medicine.disease, respiratory tract diseases, Cardiac surgery, Surgery, surgical procedures, operative, Cardiothoracic surgery, 胸膜滲出液, Cardiology and Cardiovascular Medicine, business
Abstract: The induction of artificial pneumothorax has many intraoperative advantages. However, few reports on the postoperative effects of artificial pneumothorax induction are available. In this study, we investigated the effect of artificial pneumothorax on postoperative clinical course in patients with mediastinal tumors. We retrospectively investigated the clinical courses of 89 patients who had undergone mediastinal tumor resection between January 2010 and December 2020. Sixty-five patients had undergone resection with artificial pneumothorax. The tumor location significantly varied across patients. The proportion of patients in whom artificial pneumothorax was induced was higher among those having anterior mediastinal tumors. The number of ports and the total skin incision length were significantly higher in patients without artificial pneumothorax. The C-reactive protein level elevation on postoperative day 2 and pleural effusion at 24 h after surgery were significantly higher in patients without artificial pneumothorax. Furthermore, the albumin level reduction and hospital stay after surgery were significantly lower in patients with artificial pneumothorax. Multiple regression analysis showed that the use of artificial pneumothorax was an independent predictive factor of the C-reactive protein level elevation on postoperative day 2 and pleural effusion at 24 h after surgery. In patients without artificial pneumothorax, the operation time positively correlated with the C-reactive protein level (r = 0.646, P
Published: 2022

3. Changes in pedicle pericardial fat tissue around the anastomotic site after tracheobronchoplasty

Author: Takuma Tsukioka, Ryuichi Ito, Yumi Matsuda, Noritoshi Nishiyama, Yukio Miki, Hidetoshi Inoue, Hiroaki Komatsu, T. Kimura, and Nobuhiro Izumi
Subjects: medicine.medical_specialty, Computed tomography value, Serum albumin, Adipose tissue, Bronchi, Anastomosis, Tracheobronchoplasty, medicine, Humans, Pneumonectomy, Lung cancer, Pedicle flap, biology, business.industry, Bronchial coverage, General Medicine, Plastic Surgery Procedures, medicine.disease, Pedicle pericardial fat tissue, Surgery, Adipose Tissue, Pericardial fat, biology.protein, business, Pericardium, Body mass index
Abstract: Pericardial fat is appropriate tissue to cover the bronchial anastomotic site because its harvesting is minimally invasive. We investigated the changes in pericardial fat tissue around the anastomotic site after pulmonary resection with tracheobronchoplasty. The subjects of this study were 43 lung cancer patients who underwent pulmonary resection with tracheobronchoplasty. We measured the maximum cross-sectional area and average computed tomography (CT) values of the pedicle pericardial fat pad around the anastomotic site 1 week and then 6 months after the operation. The average volume of the residual pedicle pericardial fat pad 6 months postoperatively was 61%. A body mass index (BMI)
Published: 2021
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4. Evolocumab on top of empagliflozin improves endothelial function of individuals with diabetes: randomized active-controlled trial

Author: Andrei C, Sposito, Ikaro, Breder, Joaquim, Barreto, Jessica, Breder, Isabella, Bonilha, Marcus, Lima, Alessandra, Oliveira, Vaneza, Wolf, Beatriz, Luchiari, Helison R, do Carmo, Daniel, Munhoz, Daniela, Oliveira, Otavio R, Coelho-Filho, Otavio R, Coelho, Jose Roberto, Matos-Souza, Filipe A, Moura, Luiz Sergio F, de Carvalho, Wilson, Nadruz, Thiago, Quinaglia, and Sheila T, Kimura-Medorima
Subjects: Male, Endocrinology, Diabetes and Metabolism, PCSK9 Inhibitors, Isoprostanes, Middle Aged, Antibodies, Monoclonal, Humanized, Treatment Outcome, Diabetes Mellitus, Type 2, Glucosides, Cardiovascular Diseases, Humans, Female, Benzhydryl Compounds, Proprotein Convertase 9, Cardiology and Cardiovascular Medicine
Abstract: Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve endothelial dysfunction and reduce cardiovascular events in individuals with type 2 diabetes (T2D). Proprotein convertase subtilisin/kexin 9 (PCSK9i) inhibitors reduce cardiovascular events in high-risk patients. Whether the addition of PCSK9i to SGLT2i treatment adds benefits is not known. Objectives To assess the PCSK9-i effect on the endothelial function of T2D individuals under treatment with SGLT2-i. Methods Individuals with T2D were randomized in a 1:1 ratio to a 16-week treatment with either empagliflozin (E) or empagliflozin plus evolocumab (EE). The primary endpoint was post-treatment change from baseline in flow-mediated dilation (FMD) at 1-min. Secondary outcomes included changes in plasma levels of nitric oxide metabolites and isoprostane. Results A total of 110 patients were enrolled, the mean age was 58 years, and 71% were men. The median post-treatment change in FMD at 1-min was 2.7% (interquartile range [IQR]: 0.9%) and 0.4% (IQR: 0.9%) in the EE and E groups, respectively (p Conclusions In individuals with T2D, the addition of evolocumab on top of empagliflozin improves endothelial function.
Published: 2022
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5. Enfortumab vedotin-induced cutaneous adverse events manifesting as miliaria-like eruptions with the presence of keratinocyte apoptosis in clinically intact skin

Author: K. Oya, Y. Nakamura, K. Iwamoto, T. Kimura, H. Negoro, H. Nishiyama, and Y. Fujisawa
Subjects: Keratinocytes, Miliaria, Infectious Diseases, Humans, Antibodies, Monoclonal, Apoptosis, Dermatology
Published: 2022

6. Tumor Size and N2 Lymph Node Metastasis Are Significant Risk Factors for Early Recurrence in Completely Resected Centrally Located Primary Lung Cancer Patients

Author: Hikaru Miyamoto, Nobuhiro Izumi, Takuma Tsukioka, Ryuichi Ito, Hidetoshi Inoue, Noritoshi Nishiyama, Hiroaki Komatsu, and T. Kimura
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Time Factors, Early Recurrence, medicine.medical_treatment, Lymph node metastasis, Pneumonectomy, Risk Factors, Carcinoma, Non-Small-Cell Lung, medicine, Humans, Postoperative Period, Neoplasm Metastasis, Lung cancer, Pathological, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, Tumor size, business.industry, Sleeve Lobectomy, General Medicine, Middle Aged, Prognosis, medicine.disease, Tumor Burden, Oncology, Lymphatic Metastasis, Resection margin, Female, Lymph Nodes, Radiology, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract: In centrally-located lung cancer treatment, it is difficult to attain a sufficient resection margin. It is important to investigate recurrent styles in centrally-located lung cancer patients.Primary lung cancer located at the hilar area that requires pneumonectomy or sleeve lobectomy is defined as centrally-located lung cancer. Early recurrence was defined as that within 1 year after surgery.This study included 43 centrally-located lung cancer patients. Ten patients underwent pneumonectomy and 33 underwent sleeve lobectomy. Eleven patients experienced early recurrence. Non-squamous cell carcinoma (p=0.012), tumor size64 mm (p0.001) and pathological N2 (p=0.012) were significant predictors for early recurrence by univariate analysis. Also, tumor size64 mm (p=0.006) and pathological N2 (p=0.019) were independent predictors by multivariate analysis.Non-squamous cell carcinoma, tumor size and pathological N2 were significant predictors of early recurrence in centrally-located lung cancer. The type of surgical procedure did not affect recurrence development.
Published: 2021
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7. Surgical Outcomes in Patients With Centrally Located Non-small Cell Lung Cancer

Author: Hiroaki Komatsu, T. Kimura, Nobuhiro Izumi, Hidetoshi Inoue, Ryuichi Ito, Noritoshi Nishiyama, Takuma Tsukioka, and Yumi Matsuda
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, General Biochemistry, Genetics and Molecular Biology, Pneumonectomy, Carcinoma, Non-Small-Cell Lung, Internal medicine, medicine, Humans, In patient, Stage (cooking), Lung cancer, Pathological, Neoplasm Staging, Retrospective Studies, Pharmacology, business.industry, Sleeve Lobectomy, medicine.disease, Treatment Outcome, T-stage, Non small cell, business, Research Article
Abstract: Background/aim Identification of prognostic factors is helpful in selecting optimal treatment for centrally-located non-small cell lung cancer (NSCLC). This study aimed to detect prognostic factors in patients with centrally-located NSCLC. Patients and methods NSCLCs in the hilar area requiring pneumonectomy or sleeve lobectomy for complete removal are defined as centrally-located NSCLCs. We retrospectively investigated the clinical courses of 45 patients with such lesions. Results Sleeve lobectomies were performed on 33 patients and pneumonectomies on 12. Three and five-year survival rates were 72% and 62%, respectively. Presence of comorbidities (p=0.013), severe symptoms (p=0.001), high white cell count (p=0.001), and pathological T3-4 stage (p=0.004) were identified as independent predictors of poor prognosis. Operative procedures did not correlate with outcomes (p=0.722). Conclusion Presence of comorbidities, severe symptoms, high white cell counts, and pathological T stage are independent predictors of poor prognosis. These data can contribute in selecting appropriate treatments for such lesions.
Published: 2021
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8. Epidemiological Correlations Between Head and Neck Cancer and Hepatitis B Core Antibody Positivity

Author: Mai Fukushima Komori, Tomoo Onoda, Yoshihiro Kimata, Seiji Iida, Seiko Takeda, Kazunori Nishizaki, Shin Kariya, T. Kimura, and Nobuyoshi Mizukawa
Subjects: Male, Hepatitis B virus, Cancer Research, medicine.medical_specialty, Multivariate analysis, Comorbidity, medicine.disease_cause, Gastroenterology, Japan, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, Hepatitis B Antibodies, Aged, Retrospective Studies, Hepatitis B Surface Antigens, biology, business.industry, Head and neck cancer, Cancer, General Medicine, Odds ratio, Middle Aged, Hepatitis B, medicine.disease, Hepatitis B Core Antigens, Confidence interval, Oncology, Head and Neck Neoplasms, Case-Control Studies, biology.protein, Female, Antibody, business
Abstract: Background/aim Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. Patients and methods We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008-2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. Results Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. Conclusion HBc antibody positivity and HNC are epidemiologically correlated.
Published: 2020
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9. Outcomes of robot-assisted versus conventional laparoscopic low anterior resection in patients with rectal cancer: propensity-matched analysis of the National Clinical Database in Japan

Author: K Uehara, Hideki Endo, Tsunekazu Hanai, Masahumi Inomata, Yoshihiro Kakeji, Yusuke Kinugasa, Hiroyuki Yamamoto, Ichiro Takemasa, H Hasegawa, T Matsuyama, T Kimura, Hiroaki Miyata, and Yuukou Kitagawa
Subjects: Laparoscopic surgery, AcademicSubjects/MED00910, medicine.medical_treatment, Population, computer.software_genre, Japan, medicine, Humans, education, Laparoscopy, Retrospective Studies, education.field_of_study, medicine.diagnostic_test, Database, Rectal Neoplasms, business.industry, Mortality rate, Retrospective cohort study, Robotics, General Medicine, Perioperative, Anus, Treatment Outcome, medicine.anatomical_structure, Propensity score matching, Original Article, AcademicSubjects/MED00010, business, computer
Abstract: Background Robot-assisted laparoscopic surgery has several advantages over conventional laparoscopy. However, population-based comparative studies for low anterior resection are limited. This article aimed to compare peri-operative results of robot-assisted low anterior resection (RALAR) and laparoscopy Methods This retrospective cohort study used data from patients treated with RALAR or conventional laparoscopic low anterior resection (CLLAR) between October 2018 and December 2019, as recorded in the Japanese National Clinical Database, a data set registering clinical information, perioperative outcomes, and mortality. Of note, the registry does not include information on the tumour location (centimetres from the anal verge) and diverting stoma creation. Perioperative outcomes, including rate of conversion to open surgery, were compared between RALAR and CLLAR groups. Confounding factors were adjusted for using propensity score matching. Results Of 21 415 patients treated during the study interval, 20 220 were reviewed. Two homogeneous groups of 2843 patients were created by propensity score matching. The conversion rate to open surgery was significantly lower in the RALAR group than in the CLLAR group (0.7 versus 2.0 per cent; P < 0.001). The RALAR group had a longer operating time (median: 352 versus 283 min; P < 0.001), less intraoperative blood loss (15 versus 20 ml; P < 0.001), a lower in-hospital mortality rate (0.1 versus 0.5 per cent; P = 0.007), and a shorter postoperative hospital stay (median: 13 versus 14 days; P < 0.001) compared with the CLLAR group. The CLLAR group had a lower rate of readmission within 30 days (2.4 versus 3.3 per cent; P = 0.045). Conclusion These data highlight the reduced conversion rate, in-hospital mortality rate, intraoperative blood loss, and length of postoperative hospital stay for rectal cancer surgery in patients treated using robot-assisted laparoscopic surgery compared with laparoscopic low anterior resection., A retrospective cohort study was undertaken using data from 20 220 patients who underwent robot-assisted low anterior resection (RALAR) or conventional laparoscopic low anterior resection as recorded in the National Clinical Database in Japan. The data highlight the potential benefit of RALAR in improving the conversion rate to open surgery, in-hospital mortality rate, intraoperative blood loss, and length of postoperative hospital stay for rectal cancer surgery.
Published: 2021
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10. Dapagliflozin increases the lean-to total mass ratio in type 2 diabetes mellitus

Author: Joaquim Barreto, Elza Muscelli, Ikaro Breder, Andrei C. Sposito, Riobaldo M. R. Cintra, Daniel B. Munhoz, Vaneza Lira Waldow Wolf, Alexandre A.S. Soares, Luiz F. Carvalho, Sheila T. Kimura-Medorima, Wilson Nadruz, Thiago Quinaglia, Addenda-Bhs trial investigators, and Gil Guerra-Júnior
Subjects: 0301 basic medicine, Adult, Blood Glucose, Carotid Artery Diseases, Male, medicine.medical_specialty, Randomization, Waist, RC620-627, Endocrinology, Diabetes and Metabolism, Urology, 030209 endocrinology & metabolism, Brief Communication, Glibenclamide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Absorptiometry, Photon, Diabetes complications, Glucosides, Glyburide, Internal Medicine, Medicine, Humans, Hypoglycemic Agents, Dapagliflozin, Benzhydryl Compounds, Nutritional diseases. Deficiency diseases, Glycemic, Aged, Glycated Hemoglobin, Hand Strength, business.industry, Body Weight, Type 2 Diabetes Mellitus, Middle Aged, Metformin, 030104 developmental biology, Treatment Outcome, chemistry, Diabetes Mellitus, Type 2, Lean body mass, Randomized controlled trials, Body Composition, Female, business, medicine.drug
Abstract: We compared the effect of dapagliflozin versus glibenclamide on the ratio of lean-to total mass in patients with type 2 diabetes mellitus, carotid subclinical atherosclerosis, HbA1c 7.0–9.0% and 40–70 years-old. Ninety-eight patients (61% male; mean age 57 ± 7 years) were randomized into dapagliflozin 10 mg/day or glibenclamide 5 mg/day on top of metformin. Body composition was measured by Dual Energy X-Ray at randomization and after 12 weeks of treatment. Glycemic control was equivalent in both groups. Dapagliflozin decreased total body mass (−2741 g [95% CI: −3360 to 1945]; p p p p p p p
Published: 2021

11. Collaboration between the National Association of Cardiologists of Mexico, the Mexican Society of Cardiology, and the University of Guanajuato. COVID-19 and Cardiac Imaging Personnel: Review of Sanitary Practices in Early 2021

Author: Andrés, Preciado-Anaya, Isabel, Carvajal-Juárez, Sara, Llanos-Osuna, Gabriela, Meléndez-Ramírez, Rafael, Paz-Gómez, Erik T, Kimura-Hayama, Nelsy C, González-Ramírez, Sergio G, Olmos-Temois, Erasmo, de la Peña-Almaguer, Alejandro E, Macías-Hernández, Óscar U, Preciado-Gutiérrez, Sandra X, Bolaños-Hurtado, Áyax N, Sobrino-Saavedra, Alejandra, de la Torre-Gascón, Moisés, Jiménez-Santos, Adriana, Puente-Barragán, Luiz, Ruiz-Monterrubio, and José E, Jaramillo-Almaguer
Subjects: Infection Control, Cardiology, COVID-19, Humans, Cardiovascular System, Mexico, Societies, Medical
Abstract: The authors of the image chapters of the National Association of Cardiologists of Mexico (ANCAM) and the Mexican Society of Cardiology (SMC), as well as personnel from the Department of Medicine and Nutrition of the University of Guanajuato, together with prominent experts in cardiovascular imaging from Mexico, have collaborated in the review, analysis and expansion of the various health strategies published in the first year of the coronavirus disease 2019 (COVID-19) pandemic, to safely perform cardiac imaging studies. This update aims to reduce the risk of COVID-19 transmission among patients and health-care personnel in the CT, MRI, and nuclear cardiology services. This work was expanded with supplementary information available free of charge on the website www.ancam-imagen.com.Los capítulos de imagen de la Asociación Nacional de Cardiólogos de México (ANCAM) y de la Sociedad Mexicana de Cardiología (SMC), así como personal del Departamento de Medicina y Nutrición de la Universidad de Guanajuato, en conjunto con destacados expertos de la imagen cardiovascular en México, han colaborado en la revisión, análisis y ampliación de las diversas estrategias sanitarias publicadas en los primeros 15 meses de la pandemia de enfermedad por coronavirus 2019 (COVID-19) para realizar con seguridad los estudios de imagen cardiaca; esta actualización tiene como objetivo principal disminuir el riesgo de transmisión de la COVID-19 entre los pacientes y el personal de salud en los servicios de tomografía, resonancia y cardiología nuclear. Este trabajo se amplió con información suplementaria disponible sin costo en el sitio www.ancam-imagen.com.
Published: 2021

12. Influence of caliber mismatch on patients' clinical course after sleeve lobectomy

Author: Takuma Tsukioka, Nobuhiro Izumi, Hidetoshi Inoue, Hiroaki Komatsu, Ryuichi Ito, T. Kimura, Noritoshi Nishiyama, and Hikaru Miyamoto
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Lung Neoplasms, Primary lung cancer, Pleural effusion, Respiratory complication, Bronchopleural fistula, Bronchi, 030204 cardiovascular system & hematology, Anastomosis, 03 medical and health sciences, 0302 clinical medicine, Main Bronchus, Carcinoma, Non-Small-Cell Lung, Medicine, Bronchoplasty, Humans, 気管支形成術, Pneumonectomy, Bronchus, business.industry, Anastomosis, Surgical, Sleeve Lobectomy, General Medicine, medicine.disease, Surgery, Cardiac surgery, Caliber mismatch, medicine.anatomical_structure, Cardiothoracic surgery, 030220 oncology & carcinogenesis, Cardiology and Cardiovascular Medicine, business
Abstract: Respiratory complications are critical events after sleeve lobectomy. A caliber mismatch is an important factor in wound healing at the anastomotic site. This study aimed to determine the influence of caliber mismatches on patients’ clinical courses after sleeve lobectomy. We investigated the clinical courses of 56 patients with primary lung cancer who underwent pulmonary resection with end-to-end bronchoplasty. Anastomoses between the main bronchus and the segmental, right upper or middle bronchus, and between the trunks intermedius and the segmental or middle bronchus are categorized as an “anastomosis with caliber mismatch”. Among the 56 patients, 22 underwent bronchoplasty with caliber mismatch. There were no in-hospital deaths, and the mortality rates at the 30- and 90-day evaluations were zero. Respiratory complications (n = 10, 52%, p = 0.005), such as pneumonia (n = 7, 32%, p = 0.029), retention of pleural effusion (n = 6, 27%, p = 0.026) and bronchopleural fistula (n = 3, 14%, p = 0.027), were significantly increased after bronchoplasty with caliber mismatch. Lower body mass index (BMI) is a significant risk factor for respiratory complications after sleeve lobectomy with caliber mismatch (median value; 23.2 vs 21.2, p = 0.036). Significant respiratory complications are apparent after bronchoplasty with caliber mismatch, especially patients with low BMI have a high risk of respiratory complications. Appropriate patient selection and cautious perioperative management are mandatory for this type of lung-preserving surgery.
Published: 2020

13. Surgical outcomes of primary lung cancers following esophagectomy for primary esophageal carcinoma

Author: Hidetoshi Inoue, Hiroaki Komatsu, T. Kimura, Noritoshi Nishiyama, Takuma Tsukioka, Nobuhiro Izumi, Hikaru Miyamoto, and Ryuichi Ito
Subjects: Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Esophageal Neoplasms, medicine.medical_treatment, 03 medical and health sciences, 0302 clinical medicine, medicine, Carcinoma, Humans, Radiology, Nuclear Medicine and imaging, Thoracotomy, Lung cancer, Aged, Retrospective Studies, business.industry, Retrospective cohort study, General Medicine, Perioperative, medicine.disease, Prognosis, Surgery, Esophagectomy, Treatment Outcome, 030228 respiratory system, Oncology, 030220 oncology & carcinogenesis, Video-assisted thoracoscopic surgery, Female, business, Wedge resection (lung)
Abstract: Background The aim of this retrospective study is to evaluate the perioperative complications and prognosis of patients with a history of resected esophageal carcinoma who subsequently underwent pulmonary resection of a primary lung cancer. Methods The study cohort comprised 23 patients who had undergone curative resection of a primary lung cancer following esophagectomy for a primary esophageal carcinoma. Clinical characteristics and surgical outcomes were analyzed. Results The initial treatment for esophageal carcinoma was esophagectomy by thoracotomy in 10 patients and video assisted thoracoscopic surgery in 13. The treatments for lung cancer comprised wedge resection in three patients, segmentectomy in seven and lobectomy in 13. The pulmonary resections were performed by thoracotomy in six and video assisted thoracoscopic surgery in 17. The average operating time for the lung cancer surgeries was 202 min and average blood loss 122 ml. There were no perioperative deaths or severe complications. Three- and Five-year overall survival rates were 78.0% and 68.2%. According to univariate survival analysis, age, restrictive ventilatory impairment and histology of lung cancer were significant predictors of poor prognosis (all P Conclusions Pulmonary resection for primary lung cancers following esophagectomy for esophageal carcinoma is acceptable in selected patients. Such surgery requires caution concerning intrathoracic adhesions and postoperative prolonged air leakage. Patients with restrictive ventilatory impairment had a poorer prognosis, and the indication for surgery in these patients should be carefully considered.
Published: 2020

14. Dapagliflozin reduces adiposity and increases adiponectin in patients with type 2 diabetes and atherosclerotic disease at short-term: An active-controlled randomised trial

Author: Alexandre A.S. Soares, Isabella Bonilha, Thiago Quinaglia, Ikaro Breder, Wilson Nadruz, Daniel B. Munhoz, Jessica S. Cunha, Riobaldo M. R. Cintra, Joaquim Barreto, Otavio R. Coelho-Filho, Elza Muscelli, Luiz F. Carvalho, Gil Guerra-Júnior, Vaneza Lira Waldow Wolf, Andrei C. Sposito, and Sheila T. Kimura-Medorima
Subjects: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Adipokine, Inflammation, Type 2 diabetes, chemistry.chemical_compound, Endocrinology, Glucosides, Internal medicine, Internal Medicine, medicine, Humans, In patient, Obesity, Benzhydryl Compounds, Dapagliflozin, Adiposity, Adiponectin, business.industry, Atherosclerotic disease, General Medicine, medicine.disease, Diabetes Mellitus, Type 2, chemistry, medicine.symptom, business
Published: 2022
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15. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author: Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. 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A., Andersson, A., Malmqvist, L., Martinsson, B., Bernsten, F., Engdahl, J., Thulin, J., Hot-Bjelac, A., Stalby, P., Aaröe, H., Ahbeck, E., Ahlmark, H., Al-Khalili, F., Bonkowski, G., Dzeletovic, S., Ekstrand, A. -B., Eriksson, G. -B., Floren, K., Grässjö, C., Hahn, S., Jaensson, P., Jansson, B., Jansson, J. -H., Kangert, R. -M., Koch, A., Kusiak, D., Lettenström, A., Lindberg, A., Lindholm, C. -J., Mannermyr, A., Mansson, K., Millborg, M., Nilsson, C., Ohlin, A. -M., Olofsson, A., Osberg, A., Pedersen, A., Risbecker, K., Rosenberg, K., Samuelsson, J., Shayesteh, M., Skoglund, K., Stjernberg, M., Thorsen, C., Steffel, J., Beer, J. H., Debrunner, J., Amstutz, D., Bruegger, J., Elise, G., Grau, A., Guinand, A., Henriette, I., Saga, E., Winnik, S., Parkhomenko, A., Rudyk, I., Tseluyko, V., Karpenko, O., Zhurba, S., Kraiz, I., Kupnovytska, I., Serediuk, N., Mostovoy, Y., Ushakov, O., Koval, O., Kovalskyi, I., Svyshchenko, Y., Sychov, O., Stanislavchuk, M., Kraydashenko, O., Yagensky, A., Tykhonova, S., Fushtey, I., Belegai, R., Berko, G., Burdeuna, L., Chabanna, O., Daniuk, I., Ivanov, A., Kamenska, E., Kaplan, P., Khyzhnyak, O., Kizim, S., Matova, O., Medentseva, O., Mochonyi, V., Mospan, M., Nemtsova, V., Ovdiienko, T., Palamarchuk, O., Pavelko, M., Petrovskyy, R., Plevak, D., Proshak, O., Pyvovar, S., Rasputina, L., Romanenko, O., Romanova, O., Sapatyi, A., Shumakov, O., Stets, R., Todoriuk, L., Varenov, V., Fitzmaurice, D., Chauhan, N., Goodwin, D., Saunders, P., Evans, R., Leese, J., Jhittay, P. S., Ross, A., Kainth, M. S., Pickavance, G., Mcdonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J. A., Ainsworth, P., Jones, C. P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R. P., Wong, S. W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D. F., Bradshaw, C., Van Zon, G., Jones, K. P., Thomas, M. J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Gibbs, H., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M. H., Hayes, K., Hegde, M. P., Hesketh, L., Hoffmann, B., Jacobson, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., Mackenzie, M., Mccarthy, C., Mcintosh, C., Mckeon, L., Morrison, H., Mussap, C., Myers, J. -D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thompson, S., Tsay, I. M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Connolly, S. J., Spyropoulos, A., Eikelboom, J., Luton, R., Gupta, M., Pandey, A. S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., Macdonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M. -C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A. M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., Ragy, H., Abd El-Aziz, A., Abou Seif, S. K., El Din, M. G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Al Mahmeed, W., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E. M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Goldhaber, S. Z., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
Subjects: Registrie, Male, Time Factors, Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF, 030204 cardiovascular system & hematology, Electrocardiography, 0302 clinical medicine, Risk Factors, Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF, Aged, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Incidence, India, Prevalence, Prognosis, Prospective Studies, Survival Rate, Thromboembolism, Registries, Risk Assessment, Medicine, 030212 general & internal medicine, Prospective cohort study, Incidence (epidemiology), cardiovascular system, medicine.symptom, Cardiology and Cardiovascular Medicine, Risk assessment, Human, medicine.medical_specialty, Time Factor, RD1-811, Prognosi, Follow-Up Studie, 03 medical and health sciences, Internal medicine, Diseases of the circulatory (Cardiovascular) system, cardiovascular diseases, Risk factor, Survival rate, Fibrillation, business.industry, Risk Factor, ta3121, medicine.disease, Clinical trial, Prospective Studie, RC666-701, Surgery, Clinical and Preventive Cardiology, business
Abstract: Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
Published: 2018
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16. Dapagliflozin increases retinal thickness in type 2 diabetic patients as compared with glibenclamide: A randomized controlled trial

Author: Daniel B. Munhoz, Andrei C. Sposito, Luiz F. Carvalho, Fernando Rodrigo Pedreira Chaves, Thiago Quinaglia, Alexandre A.S. Soares, Carlos Eduardo Leite Arieta, Addenda-Bhs trial investigators, Joaquim Barreto, Jéssica da Silva Cunha Breder, Riobaldo M. R. Cintra, Ikaro Breder, Wilson Nadruz, Vicente Hidalgo Rodrigues Fernandes, and Sheila T. Kimura-Medorima
Subjects: Blood Glucose, medicine.medical_specialty, Randomization, genetic structures, Endocrinology, Diabetes and Metabolism, Urology, Retina, law.invention, Glibenclamide, chemistry.chemical_compound, Endocrinology, Glucosides, Randomized controlled trial, law, Glyburide, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Benzhydryl Compounds, Dapagliflozin, Glycemic, Glycated Hemoglobin, business.industry, General Medicine, Diabetic retinopathy, Middle Aged, medicine.disease, Metformin, Treatment Outcome, Diabetes Mellitus, Type 2, chemistry, sense organs, Glycated hemoglobin, business, medicine.drug
Abstract: Aim In patients with type 2 diabetes mellitus (T2DM) a progressive thinning in the central retinal thickness (CRT) is mainly related to neuroretinal degeneration and occurs before the decline in visual acuity or capillary density. We investigated the change in CRT by optical coherence tomography (OCT) in T2DM patients after 12 weeks of treatment with dapagliflozin or glibenclamide. Methods Ninety-seven patients (57 ± 7 years) with T2DM and clinical or subclinical atherosclerosis were randomized 1:1 to dapagliflozin (10 mg/day) or glibenclamide (5 mg/day) on top of metformin XR 1.5 g/day. OCT was obtained in all patients enrolled in the study, both at the time of randomization and at the end of the study. Results Baseline and post-treatment values of fasting glucose and glycated hemoglobin were equivalent in the two arms. There was no difference in change in diabetic retinopathy status after therapy. The center subfield thickness changed by +2(6)μm in the dapagliflozin group and by -1(7) μm in the glibenclamide group (P = 0.001). Conclusion A short-term treatment with dapagliflozin may increase CRT as compared with equivalent glycemic control with glibenclamide.
Published: 2021
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17. Combined sleeve lobectomy for centrally located primary lung cancer and lung cancer with hilar lymph node metastasis

Author: Hikaru Miyamoto, Takuma Tsukioka, Hiroaki Komatsu, Ryuichi Ito, Hidetoshi Inoue, T. Kimura, Nobuhiro Izumi, and Noritoshi Nishiyama
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, 030204 cardiovascular system & hematology, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Superior vena cava, medicine.artery, Angioplasty, medicine, Pericardium, Humans, Radiology, Nuclear Medicine and imaging, Lung cancer, Pneumonectomy, Phrenic nerve, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Sleeve Lobectomy, General Medicine, Middle Aged, medicine.disease, Surgery, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Pulmonary artery, Female, Lymph Nodes, Airway, business
Abstract: Background Centrally located lung cancer or metastatic hilar lymph nodes can invade the airway and other hilar structures, and they must be removed to achieve complete resection. Methods We retrospectively assessed the clinical course of 47 patients with centrally located lung cancer or metastatic hilar lymph nodes who underwent sleeve lobectomy from January 2010 to December 2017. Results The invaded structure other than the airway was the pulmonary artery in 21 patients, chest wall in 3, esophageal muscular wall in 2, vagus nerve in 2, pericardium in 2, left atrium in 1, phrenic nerve in 1 and superior vena cava in 1. Twenty-four patients were treated with sleeve lobectomy alone (simple sleeve lobectomy), and 23 patients were treated with sleeve lobectomy with additional methods (combined sleeve lobectomy). Adverse events occurred in 10 patients (48%) in the simple sleeve lobectomy group and 7 patients (30%) in the combined sleeve lobectomy group. During the follow-up period, 15 patients developed recurrent disease and 12 patients died. Patients in the combined sleeve lobectomy group had significantly shorter overall survival (P = 0.004) and disease-free survival periods (P = 0.013). Combined sleeve lobectomy was a significantly poor prognostic factor in the univariate and multivariate analyses. Patients who underwent sleeve lobectomy with an additional method other than angioplasty had a significantly poorer prognosis. However, no patient developed recurrent disease in the hilar area. Conclusions Combined sleeve lobectomy has acceptable adverse events and good local controllability. However, combined sleeve lobectomy is associated with a significantly poorer prognosis than simple sleeve lobectomy in terms of overall survival and disease-free survival.
Published: 2019

18. Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study

Author: S, Ikehara, T, Kimura, A, Kakigano, T, Sato, H, Iso, and Takahiko, Katoh
Subjects: Adult, medicine.medical_specialty, Alcohol Drinking, Maternal-Child Health Services, Epidemiology, Pregnancy Trimester, Third, Population, Gestational Age, Lower risk, Logistic regression, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Japan, Pregnancy, Risk Factors, Surveys and Questionnaires, the Japan Environment and Children's Study (JECS), medicine, Humans, Alcohol consumption, Prospective Studies, Child, education, Prospective cohort study, Consumption (economics), education.field_of_study, 030219 obstetrics & reproductive medicine, Ethanol, business.industry, Obstetrics, Medical record, Infant, Newborn, Obstetrics and Gynecology, Odds ratio, medicine.disease, Pregnancy Trimester, Second, Premature Birth, Female, preterm delivery, business, pregnant women, prospective study
Abstract: Objective To examine the association between maternal alcohol consumption during pregnancy and the risk of preterm delivery. Design Prospective cohort study. Setting The Japan Environment and Children's Study (JECS). Population A total of 94 349 singleton pregnancies. Methods Participants completed questionnaires detailing alcohol consumption during the first trimester and during the second and third trimesters. Participants were divided into four categories according to alcohol consumption (non‐drinkers, consumers of 1–149 g, 150–299 g and ≥300 g ethanol/week). We examined the effect of alcohol consumption during different stages of pregnancy on the risk of preterm delivery. Odds ratios (OR) and 95% CI were calculated relative to non‐drinkers using logistic regression. Main outcome measures Medical record‐based preterm delivery. Results Alcohol consumption during the second and third trimesters, but not during the first trimester, was associated with increased risk of preterm delivery. Heavy alcohol consumption (≥300 g ethanol/week) during the second and third trimesters was associated with a four‐fold higher risk compared with non‐drinkers (multivariable OR 4.52; 95% CI 1.68–12.2). Light alcohol consumption (1–149 g ethanol/week) tended to be associated with lower risk of preterm delivery (multivariable OR 0.78; 95% CI 0.60–1.00). Conclusions Heavy alcohol consumption during the second and third trimesters was associated with increased risk of preterm delivery among pregnant women. Tweetable abstract Heavy drinking during pregnancy may increase the risk of preterm delivery., Tweetable abstract Heavy drinking during pregnancy may increase the risk of preterm delivery.
Published: 2019

19. Placenta accreta following laparoscopic adenomyomectomy: a case report

Author: S, Matsuzaki, K, Yoshino, T, Tomimatsu, T, Takiuchi, K, Kumasawa, and T, Kimura
Subjects: Adult, Pregnancy, Humans, Female, Laparoscopy, Placenta Accreta, Adenomyoma
Abstract: The influence of adenomyomectomy on subsequent pregnancy is unknown. Placenta accreta is most often associated with placenta previa in women with multiple previous cesarean sections.A 41-year-old woman became pregnant six years after a laparoscopic uterine posterior adenomyomectomy. She was diagnosed with complete placenta previa and considered at a low risk for placenta accreta by ultrasonography. Cesarean section and subsequent hysterectomy were required, and histopathological analysis revealed a posterior placenta accreta.The authors discuss the association of adenomyomectomy and placenta accreta on subsequent pregnancy and conclude that previous adenomyomectomy may increase the risk of abnormal placentation. Therefore, careful treatment is required during the pregnancies of patients with previous adenomyomectomy.
Published: 2018

20. Identification of a novel E‐box binding pyrrole‐imidazole polyamide inhibiting <scp>MYC</scp> ‐driven cell proliferation

Author: Carla Grandori, Masayoshi Soma, Narendra Kumar Verma, Tsugumichi Koshinaga, Jin Takeuchi, Rajeev Mishra, Hiroki Nagase, Xiaofei Wang, Jun Igarashi, Shota Uekusa, Norimichi Nemoto, Nobuko Koshikawa, Takeshi Kusafuka, Yujin Kobayashi, Christopher J. Kemp, Takayoshi Watanabe, Diptiman Choudhury, Noboru Fukuda, Miki Ohira, Maki Ikeda, Kyoko Fujiwara, Makoto T. Kimura, and Hiroyuki Kawashima
Subjects: Cancer Research, Apoptosis, MYC, Mice, SCID, Cell cycle, Biology, transcription therapy, E-Box Elements, Proto-Oncogene Proteins c-myc, Mice, pyrrole-imidazole polyamide, Cyclin D1, Cell Line, Tumor, Gene expression, Consensus sequence, Animals, Humans, Pyrroles, E-box binding, Promoter Regions, Genetic, Gene, Cell Proliferation, Binding Sites, Cell growth, Imidazoles, Cyclin-Dependent Kinase 4, Promoter, Original Articles, General Medicine, Burkitt Lymphoma, Xenograft Model Antitumor Assays, 3. Good health, DNA-Binding Proteins, Nylons, Oncology, E-Box, Cancer research, Eukaryotic Initiation Factor-4G, Protein Binding, K562 cells
Abstract: The MYC transcription factor plays a crucial role in the regulation of cell cycle progression, apoptosis, angiogenesis, and cellular transformation. Due to its oncogenic activities and overexpression in a majority of human cancers, it is an interesting target for novel drug therapies. MYC binding to the E-box (5'-CACGTGT-3') sequence at gene promoters contributes to more than 4000 MYC-dependent transcripts. Owing to its importance in MYC regulation, we designed a novel sequence-specific DNA-binding pyrrole-imidazole (PI) polyamide, Myc-5, that recognizes the E-box consensus sequence. Bioinformatics analysis revealed that the Myc-5 binding sequence appeared in 5'- MYC binding E-box sequences at the eIF4G1, CCND1, and CDK4 gene promoters. Furthermore, ChIP coupled with detection by quantitative PCR indicated that Myc-5 has the ability to inhibit MYC binding at the target gene promoters and thus cause downregulation at the mRNA level and protein expression of its target genes in human Burkitt's lymphoma model cell line, P493.6, carrying an inducible MYC repression system and the K562 (human chronic myelogenous leukemia) cell line. Single i.v. injection of Myc-5 at 7.5 mg/kg dose caused significant tumor growth inhibition in a MYC-dependent tumor xenograft model without evidence of toxicity. We report here a compelling rationale for the identification of a PI polyamide that inhibits a part of E-box-mediated MYC downstream gene expression and is a model for showing that phenotype-associated MYC downstream gene targets consequently inhibit MYC-dependent tumor growth.
Published: 2015
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21. Genotyping of the ABCG2 gene using Matrix-Associated Laser Desorption/Ionisation, Time-of-Flight Mass Spectrometry

Author: M, Tanaka, I, Kamada, J, Takahashi, T, Kimura, and Y, Tani
Subjects: Male, Asian People, Genotyping Techniques, Japan, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, ATP Binding Cassette Transporter, Subfamily G, Member 2, Humans, Female, Polymorphism, Single Nucleotide, Neoplasm Proteins
Abstract: The aim of this study was to evaluate the applicability of genotyping of the ABCG2 gene using MALDI-TOF MS and to estimate the allele frequency in the Japanese population.Jr (a-) phenotype has a prevalence of approximately 0·05% among Japanese blood donors; DNA-based genotyping was conducted to investigate the molecular basis of the Jr (a-) phenotype along with serological typing. To detect all SNPs of the ABCG2 gene, a high-throughput SNP genotyping platform is needed.Overall, 1004 Jr (a-) blood samples were collected from blood donors in Japan and pre-genotyped. To detect the SNPs of the ABCG2 gene using MALDI-TOF MS, polymerase chain reaction and unextend primer were designed. In total, 205 Jr (a-) samples were genotyped using MALDI-TOF MS analysis.The SNPs of 1004 Jr (a-) samples were identified using the HRM analysis and DNA sequencing, and 799 of 1004 (80%) Jr (a-) samples had the homozygous for c.376 T. The designed primers for MALDI-TOF MS perfectly detected the SNPs of the ABCG2 gene. A total of 205 Jr (a-) samples were genotyped using MALDI-TOF MS. Calling failures occurred in only two samples with the mutations c.736CT to c.376C and c.421C to c.421CA. The concordance rate between the pre-genotyped and MALDI-TOF MS-based genotyping results was very high (99·02%) for all ABCG2 alleles.Jr (a-) Japanese donors had almost the homozygous for c.376 T. However, detections of more than 20 SNPs of the ABCG2 gene for the JR blood group genotyping are needed. MALDI-TOF MS-based genotyping was highly concordant with the pre-genotyped results for all ABCG2 alleles.
Published: 2017

22. Multicentred surgical site infection surveillance using partitioning analysis

Author: T. Kimura, H. Matsukawa, Yukihiro Ohno, Munenori Takaoka, T. Onoda, Masashi Kimura, Yasuhiro Shirakawa, Y. Otawa, Shunsuke Tanabe, H. Sasaki, Yasuhiro Fujiwara, Toshiyoshi Fujiwara, Kazuhiro Noma, Takuya Fukazawa, Tomoki Yamatsuji, Y. Nonaka, Takako Yamada, Hideki Aoki, and Yoshio Naomoto
Subjects: Adult, Male, Microbiology (medical), medicine.medical_specialty, Hospital practice, Active surveillance, Japan, Health care, Prevalence, Humans, Surgical Wound Infection, Medicine, Partitioning analysis, Aged, Infection Control, business.industry, Incidence (epidemiology), Public health, General Medicine, Middle Aged, Intervention studies, Surgery, Clinical Practice, Infectious Diseases, Epidemiological Monitoring, Actual practice, Emergency medicine, Female, business, Surgical site infection
Abstract: Background: Surgical site infection (SSI) is an ongoing major public health problem throughout the world that increases healthcare costs. Utilizing a methodology that can help clinicians to continuously collect data about SSIs, analyse it and implement the feedback into routine hospital practice has been identified as a top national priority in Japan. Aim: To conduct an intervention study through 'operations research' using partitioning at multiple facilities, and to reduce the incidence and consequences of SSI. Methods: The Setouchi SSI Surveillance Group, which consists of seven institutes, started SSI surveillance in 2006. Until May of 2008, there were four surveillance periods (A-D). In all, 3089 patients underwent gastrointestinal surgery and were followed up for 30 days after their operations. Twenty-six factors that have been reported to be related to SSI were evaluated for all patients. The top three factors from each surveillance period were determined and then actual practice improvements were planned for each subsequent period. Findings: The total SSI occurrence was 6.9% for period A, 6.3% for period B, 6.4% for period C and 3.9% for period D. Comparing periods A and D, there was a statistical significance in the decrease of SSI occurrence (P = 0.012). Conclusion: Using the results and partitioning analysis of active SSI surveillance to contribute to action plans for improving clinical practice was effective in significantly reducing SSIs.
Published: 2013

23. Gender difference in tooth autotransplantation with complete root formation: a retrospective survey

Author: I Kikukawa, O Hokkedo, Y Takahashi, Takashi Matsukubo, T Hayashi, Koichi Yoshino, M Kimura, S Okudaira, S Shioji, H Nishihara, Masatsugu Fujiseki, Yoichi Ishizuka, M Nojima, T Toake, Kenneth K. Tanabe, A Fukuda, K Ito, Masahiko Kuroda, H Kimura, Atsushi Saito, N Hattori, A Fukuyama, D Namura, H Fukuda, K Tsukiyama, K Mitsuhashi, Naoki Sugihara, J Shinoda, R Matsushima, K Fukai, N Kariya, Masakazu Nishibori, Mieko Toyoda, M Nakano, D Hidaka, Y Shimakura, Yasushi Miyata, N Yamazaki, F Kamei, Kazuhiro Umehara, I Noji, H Mibu, T Kimura, S Ikumi, and K Yamamoto
Subjects: Adult, Male, Molar, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Dentistry, Transplantation, Autologous, Tooth Loss, Sex Factors, Risk Factors, Periodontal Attachment Loss, Tooth loss, medicine, Humans, Bicuspid, Tooth Root, General Dentistry, Survival rate, Aged, Retrospective Studies, Root formation, business.industry, Graft Survival, Retrospective cohort study, Middle Aged, Prognosis, Autotransplantation, Surgery, Transplantation, stomatognathic diseases, Treatment Outcome, Clinical attachment loss, Odontogenesis, Female, medicine.symptom, business, Tooth, Follow-Up Studies
Abstract: Gender-related risk factors in the survival of transplanted teeth with complete root formation have not yet been identified. The purpose of this study was to investigate gender differences in tooth autotransplantation at dental clinics. We asked participating dentists to provide information on transplantations they had undertaken from 1 January 1990 to 1931 December 2010. The data were screened to exclude patients who underwent more than one transplantation, smokers or those whose smoking habits were unknown, patients under 30 or who were 70 years old and over, cases where the transplanted teeth had incomplete root formation or multiple roots and those with fewer than 20 present teeth post-operation. We analysed 73 teeth of 73 males (mean age, 47.2 years) and 106 teeth of 106 females (mean age, 45.3 years) in this study. The cumulative survival rate and mean survival time were calculated using the Kaplan-Meier method. The cumulative survival rate for males was 88.3% at the 5-year mark, 64.8% at 10 years and 48.6% at 15 years; for females, it was 97.2% at the 5-year mark, 85.9% at 10 years and 85.9% at 15 years. A log-rank test indicated the difference between males and females to be significant (P = 0.011). There was also a significant difference in the main causes for the loss of transplanted teeth: males lost more transplanted teeth due to attachment loss than females (P < 0.05). These results indicate that males require more attention during the autotransplantation process, particularly at the stage of pre-operation evaluation and that of follow-up maintenance.
Published: 2013
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24. Cesarean delivery via a transverse uterine fundal incision for the successful management of a low-lying placenta and aplastic anemia

Author: S, Matsuzaki, K, Yoshino, K, Mimura, T, Kanagawa, and T, Kimura
Subjects: Adult, Sutures, Cesarean Section, Pregnancy, Pregnancy Complications, Hematologic, Uterus, Blood Loss, Surgical, Placenta Previa, Anemia, Aplastic, Disease Management, Humans, Female, Placentation
Abstract: To present a case report on the successful management of a low-lying placenta and aplastic anemia. Aplastic anemia is a rare but serious disorder that is often characterized by severe pancytopenia. Because of the rarity of aplastic anemia, a pregnancy complicated by it is rarely encountered by obstetricians. Moreover, placenta previa (low-lying placenta) complicated by aplastic anemia has not been previously reported.The authors present the first reported case of placenta previa with aplastic anemia in a patient who had undergone a previous cesarean delivery.They successfully managed this case by making a transverse uterine fundal incision during an elective cesarean delivery. This incision minimized blood loss and enabled good visualization of the source of bleeding in the lower uterine segment. Bleeding was stemmed by suturing the source of bleeding.The authors propose that this procedure should be considered for patients with low platelet counts and abnormal placentation.
Published: 2016

25. Estimation of the kinetic-optimized stimulus intensity envelope for drop foot gait rehabilitation

Author: Yoshikiyo Kanada, T. Kimura, Norihide Itoh, Shinji Kubota, Shigeo Tanabe, Yoshihiro Muraoka, and A. Shimizu
Subjects: Adult, Male, Biomedical Engineering, Electric Stimulation Therapy, Electromyography, Stimulus (physiology), Kinetic energy, symbols.namesake, medicine, Humans, Torque, Functional electrical stimulation, Muscle, Skeletal, Gait, Gait Disorders, Neurologic, Mathematics, Leg, medicine.diagnostic_test, General Medicine, Sigmoid function, Anatomy, Pearson product-moment correlation coefficient, Biomechanical Phenomena, medicine.anatomical_structure, symbols, Female, Ankle, Ankle Joint, Biomedical engineering
Abstract: The purpose of present study is to estimate the optimal stimulus intensity envelope for drop foot rehabilitation based on a kinetic perspective. The voluntary and electric-stimulated elicited dorsiflexion torque responses of 11 healthy subjects were measured. During dorsiflexion, we recorded the tibialis anterior (TA) electromyography (EMG) or the stimulation intensity at four angles of the ankle joint. From these measurements, we derived two approximate equations that estimate dorsiflexion produced by either voluntary contraction or by electrical stimulation using a sigmoid function and a stepwise-regression analysis. We then tested the predictive capability of the model using Pearson correlation. Both equations indicated high correlation coefficients. Finally, we derived a relation between the TA EMG amplitude and stimulation intensity. From the obtained equation, we determined the optimal stimulus amplitude. We assume that the derived stimulus intensity envelope, calculated from EMG amplitude and angle of ankle joint, satisfies kinetic demand.
Published: 2012
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26. A retrospective survey of autotransplantation of teeth in dental clinics

Author: K, Yoshino, N, Kariya, D, Namura, I, Noji, K, Mitsuhashi, H, Kimura, A, Fukuda, I, Kikukawa, T, Hayashi, N, Yamazaki, M, Kimura, K, Tsukiyama, K, Yamamoto, A, Fukuyama, D, Hidaka, J, Shinoda, H, Mibu, Y, Shimakura, A, Saito, S, Ikumi, K, Umehara, F, Kamei, H, Fukuda, T, Toake, Y, Takahashi, Y, Miyata, S, Shioji, M, Toyoda, N, Hattori, H, Nishihara, R, Matsushima, M, Nishibori, O, Hokkedo, M, Nojima, T, Kimura, M, Fujiseki, S, Okudaira, K, Tanabe, M, Nakano, K, Ito, M, Kuroda, and T, Matsukubo
Subjects: Adult, Male, Adolescent, Dental Clinics, Oral Surgical Procedures, Middle Aged, Transplantation, Autologous, Young Adult, Treatment Outcome, Humans, Female, Tooth, Aged, Follow-Up Studies, Retrospective Studies
Abstract: The aim of this study was to investigate the usage of tooth autotransplantation in dental clinics which offer the treatment and evaluate its practicality. Participating dentists were requested to provide information on transplantations they had undertaken from 1 January 1990 to 31 December 2010. A total of 614 teeth from 552 patients (37 dentists) ranging in age from 17 to 79 (mean age: 44·1) were examined. Cumulative survival rate and mean survival time were calculated using the Kaplan-Meier method, and log rank test was used for analysis of factors. The mean number of autotransplantation patients per clinic per year was 1·4. Upper third molars constituted 36·8% of donor teeth, while 37·1% were lower third molars. The lower first molar region was the most common recipient site at 32·6%, followed by the lower second molar region (28·0%). Prosthodontic treatment of transplanted teeth involved coverage with a single crown (72·5%) and abutment of bridge (18·9%). A total of 102 transplanted teeth were lost owing to complications such as attachment loss (54·9%) and root resorption (25·7%). The cumulative survival rate in cases where donor teeth had complete root formation was 90·1% at 5 years, 70·5% at 10 years and 55·6% at 15 years. The mean survival time was 165·6 months. Older age was a significant risk factor (P0·05) for survival. In cases where suitable donor teeth are available, autotransplantation of teeth may be a plausible treatment option for dealing with missing teeth in dental clinics.
Published: 2012

27. Pretranscriptional Regulation of Tgf-β1 by PI Polyamide Prevents Scarring and Accelerates Wound Healing of the Cornea After Exposure to Alkali

Author: Noboru Fukuda, Xiaofei Wang, Hiroki Nagase, Linghua Wang, Hiroyuki Matsuda, Jun Igarashi, Min Chen, Takayoshi Watanabe, Tohru Sakimoto, Mitsuru Sawa, and Makoto T. Kimura
Subjects: Stromal cell, Pharmacology, Cornea, Transforming Growth Factor beta1, Cicatrix, Downregulation and upregulation, Drug Discovery, Genetics, medicine, Animals, Humans, Pyrroles, RNA, Messenger, Promoter Regions, Genetic, Molecular Biology, Wound Healing, Binding Sites, Corneal Haze, Dose-Response Relationship, Drug, Activator (genetics), Chemistry, HEK 293 cells, Imidazoles, Original Articles, Anatomy, eye diseases, Rats, Nylons, medicine.anatomical_structure, Gene Expression Regulation, Molecular Medicine, sense organs, Wound healing, Transforming growth factor
Abstract: Corneal alkali burns are a serious clinical problem that often leads to permanent visual impairment. In this process, transforming growth factor (Tgf)-beta1 is upregulated and involved in the response to corneal injury and the process of corneal stromal scarring. To develop an efficient compound to inhibit Tgf-beta1 in the cornea, we designed GB1201, a pyrrole-imidazole (PI) polyamide targeting rat Tgf-beta1 gene promoter to the activator protein-1 (AP-1) binding site. GB1201 showed a high binding affinity to the target DNA sequence in the gel mobility shift and Biacore assays. GB1201 significantly inhibited the rat Tgf-beta1 gene promoter activity in HEK (human embryonic kidney) 293 cells in a concentration-dependent manner. Topically administrated GB1201 was distributed immediately to the nuclei of all cell layers of the cornea and remained for 24 hours. A corneal alkali burn model in rats was used to evaluate the therapeutic efficacy of GB1201. GB1201 suppressed the upregulation of Tgf-beta1 in the burned cornea, both in the mRNA and protein levels. Moreover, daily treatment with GB1201 for a week significantly improved the corneal tissue wound healing, reduced corneal stromal scarring, and prevented corneal haze formation. Our data suggest that PI polyamide may open new opportunities for therapeutic intervention in the treatment of chemically burned corneas.
Published: 2010
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28. In vivo dynamics of human cord blood-derived CD34− SCID-repopulating cells using intra-bone marrow injection

Author: T Kimura, Y Matsuoka, M Murakami, M Takahashi, T Nakamoto, K Yasuda, K Matsui, K Kobayashi, S Imai, H Asano, R Nakatsuka, Y Uemura, Y Sasaki, and Y Sonoda
Subjects: Cancer Research, Cell Separation, Mice, SCID, CD38, Biology, Mice, Cell Movement, Mice, Inbred NOD, immune system diseases, hemic and lymphatic diseases, medicine, Animals, Humans, Bone Marrow Transplantation, Severe combined immunodeficiency, Leukosialin, Hematopoietic stem cell, hemic and immune systems, Hematology, Fetal Blood, Hematopoietic Stem Cells, medicine.disease, ADP-ribosyl Cyclase 1, Cell biology, Transplantation, medicine.anatomical_structure, Oncology, Cord blood, Immunology, SCID-Repopulating Cell, Female, Bone marrow, Stem cell
Abstract: The identification of human CD34-negative (CD34(-)) hematopoietic stem cells (HSCs) provides a new concept for the hierarchy in the human HSC compartment. This study investigated the long-term repopulating capacity and redistribution kinetics of human cord blood-derived CD34(-) severe combined immunodeficiency (SCID)-repopulating cells (SRCs) and compared them with those of CD34(+)CD38(+) and CD34(+)CD38(-) SRCs using the intra-bone marrow injection (IBMI) to clarify the characteristics of CD34(-) SRCs. On the basis of the limiting dilution analyses data, estimated numbers of CD34(+)CD38(+), CD34(+)CD38(-), and CD34(-) SRCs were transplanted to NOD/SCID mice by IBMI. The human cell repopulation at the site of injection and the other bones were serially investigated. Interestingly, CD34(+)CD38(+), CD34(+)CD38(-), and CD34(-) SRCs began to migrate to other bones 2 and 5 weeks after the transplantation, respectively. Accordingly, the initiation of migration seemed to differ between the CD34(+) and CD34(-) SRCs. In addition, CD34(+)CD38(+) SRCs only sustained a short-term repopulation. However, both CD34(+)CD38(-) and CD34(-) SRCs had longer-term repopulation capacity. Taken together, these findings showed that CD34(-) SRCs show different in vivo kinetics, thus suggesting that the identified CD34(-) SRCs are a distinct class of primitive HSCs in comparison to the CD34(+)CD38(+) and CD34(+)CD38(-) SRCs.
Published: 2009
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29. Effect of dobutamine on the arterial ketone body ratio and portal blood flow velocity in cirrhosis

Author: K Kajimura, Fuminori Moriyasu, T Kimura, K. Mori, Minoru Okuma, and Kazue Ozawa
Subjects: Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, Cardiac index, Hemodynamics, Ketone Bodies, Chronic liver disease, Hepatitis, Dobutamine, Internal medicine, Humans, Medicine, Ultrasonography, Hepatology, business.industry, Blood flow, Middle Aged, medicine.disease, Surgery, Portal System, Liver, Flow velocity, Chronic Disease, Cardiology, Ketone bodies, Female, business, Blood Flow Velocity, medicine.drug
Abstract: We studied the relationship between the portal blood flow velocity and the arterial ketone body ratio in patients with chronic liver disease receiving a dobutamine infusion. We used an ultrasonic Doppler duplex system to evaluate the portal blood flow velocity. Dobutamine was given intravenously at 5 micrograms/kg/min for 20 min. Dobutamine infusion induced smaller changes in the portal blood flow velocity and ketone body ratio in liver cirrhosis than in chronic hepatitis. The existence of shunts and the poor increase of the cardiac index in response to dobutamine explained the limited improvement of portal blood flow velocity in cirrhosis patients. The ketone body ratio was improved by dobutamine in cirrhosis patients whose portal blood flow velocity was increased by more than 10%, while this ratio decreased when the increase of it was less than 10%. There was no change in portal oxygen extraction in the cirrhosis group, and portal oxygen uptake only increased when the portal blood flow velocity rose by more than 10%. Dobutamine should only be used to treat liver failure if the portal blood flow velocity is increased by more than 10% or the arterial ketone body ratio is improved by a test infusion.
Published: 2008
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30. Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer

Author: Graham Steers, Leticia Campo, S Kameoka, K C Gatter, Takao Kato, Francesco Pezzella, Helen Turley, R Leek, T Nishikawa, Adrian L. Harris, T Kimura, Helen Roberts, and M Kobayashi
Subjects: Adult, Cancer Research, medicine.medical_specialty, Aging, medicine.medical_treatment, international differences, Breast Neoplasms, Gastroenterology, Metastasis, angiogenesis, Breast cancer, breast cancer, microvessel density, Japan, Internal medicine, medicine, Humans, Neoplasm Invasiveness, Stage (cooking), Pathological, Survival rate, Molecular Diagnostics, Aged, Neoplasm Staging, Aged, 80 and over, Chemotherapy, Neovascularization, Pathologic, business.industry, Hazard ratio, Cancer, Middle Aged, medicine.disease, Prognosis, Combined Modality Therapy, United Kingdom, Surgery, Survival Rate, Treatment Outcome, Oncology, Receptors, Estrogen, Chemotherapy, Adjuvant, Female, Neoplasm Recurrence, Local, business, Receptors, Progesterone
Abstract: The purpose of this study is to investigate the associations of microvessel density (MVD) and other pathological variables with survival, and whether they accounted for survival differences between Japanese and British patients. One hundred seventy-three Japanese and 184 British patients were included in the study. British patients were significantly older (56.3+/-11.4 years vs 52.5+/-12.9 years; P
Published: 2007

31. Excessive oxygen Uptake during Exercise and Recovery in Heavy Exercise

Author: Takahiro Yunoki, T. Arimitsu, Ryouta Matsuura, T. Kimura, and Tokuo Yano
Subjects: Adult, Male, medicine.medical_specialty, Physiology, Heavy exercise, Oxygen Consumption, Moderate exercise, Internal medicine, medicine, Humans, Power output, Exercise, Chemistry, musculoskeletal, neural, and ocular physiology, Time constant, General Medicine, Oxygen uptake, Aerobiosis, Kinetics, Exercise Test, Cardiology, High ratio, human activities, Algorithms, Excessive oxygen uptake, circulatory and respiratory physiology
Abstract: The aim of this study was to determine whether excessive oxygen uptake (Vo2) occurs not only during exercise but also during recovery after heavy exercise. After previous exercise at zero watts for 4 min, the main exercise was performed for 10 min. Then recovery exercise at zero watts was performed for 10 min. The main exercises were moderate and heavy exercises at exercise intensities of 40 % and 70 % of peak Vo2, respectively. Vo2 kinetics above zero watts was obtained by subtracting Vo2 at zero watts of previous exercise (DeltaVo2). Delta Vo2 in moderate exercise was multiplied by the ratio of power output performed in moderate and heavy exercises so as to estimate the Delta Vo2 applicable to heavy exercise. The difference between Delta Vo2 in heavy exercise and Delta Vo2 estimated from the value of moderate exercise was obtained. The obtained Vo2 was defined as excessive Vo2. The time constant of excessive Vo2 during exercise (1.88+/-0.70 min) was significantly shorter than that during recovery (9.61+/-6.92 min). Thus, there was excessive Vo2 during recovery from heavy exercise, suggesting that O2/ATP ratio becomes high after a time delay in heavy exercise and the high ratio continues until recovery.
Published: 2007

32. Parietal white matter abnormalities in obsessive-compulsive disorder: a magnetic resonance spectroscopy study at 3-Tesla

Author: Masaki Ohkubo, Toshiki Shioiri, Hideaki Kitamura, Toshiyuki Someya, T. Kimura, and Tsutomu Nakada
Subjects: Adult, Male, Obsessive-Compulsive Disorder, medicine.medical_specialty, Magnetic Resonance Spectroscopy, Adolescent, Thalamus, Central nervous system, Creatine, Choline, Phosphocreatine, White matter, chemistry.chemical_compound, Neurochemical, Parietal Lobe, Internal medicine, mental disorders, Basal ganglia, medicine, Humans, Aspartic Acid, Parietal lobe, Anatomy, Radiography, Psychiatry and Mental health, medicine.anatomical_structure, Endocrinology, nervous system, chemistry, Female, Nerve Net, Psychology
Abstract: Objective: To identify a neurochemical basis for the hypothesis that an aberrant cortico-subcortical circuit underlies obsessive–compulsive disorder (OCD). The white matter was also investigated because of recent research which suggests the altered connectivity of axons. Method: Using 3-Tesla magnetic resonance spectroscopy, the relative concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) to creatine/phosphocreatine (Cr) were measured in the anterior cingulate, basal ganglia, thalamus, frontal and parietal white matter of 12 OCD patients, and 32 control subjects. Results: The mean concentration of Cho/Cr was significantly higher in the patients than in the controls, but only in the parietal white matter, while no significant group differences in NAA/Cr were observed in any of the brain regions. Parietal Cho/Cr correlated positively with the severity of OCD symptoms. Conclusion: This finding provides indirect evidence for the parietal white matter involvement in OCD, thus suggesting a change in the phospholipids of myelinated axons and/or glia cells.
Published: 2006
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33. Two Functional Coding Single Nucleotide Polymorphisms in STK15 (Aurora-A) Coordinately Increase Esophageal Cancer Risk

Author: Makoto T. Kimura, Norma J. Nowak, Takahiro Mori, Susumu Satomi, Jeffrey M. Conroy, Hiroki Nagase, and Katsuyuki Tamai
Subjects: Cancer Research, Esophageal Neoplasms, Gene Dosage, Single-nucleotide polymorphism, Protein Serine-Threonine Kinases, Biology, Polymorphism, Single Nucleotide, Article, Aurora Kinases, Polymorphism (computer science), Chromosome instability, medicine, Humans, Genetic Predisposition to Disease, Kinase activity, Aurora Kinase A, Cell Nucleus, Chromosome Aberrations, Genetics, Haplotype, Case-control study, Cancer, DNA, Neoplasm, Odds ratio, medicine.disease, Molecular biology, Isoenzymes, Haplotypes, Oncology, Case-Control Studies, Carcinoma, Squamous Cell, Subcellular Fractions
Abstract: STK15/Aurora-A is a serine/threonine kinase essential for chromosome segregation and cytokinesis, and is considered to be a cancer susceptibility gene in mice and humans. Two coding single nucleotide polymorphisms in Aurora-A, 91T>A [phenylalanine/isoleucine (F/I)] and 169G>A [valine/isoleucine (V/I)], create four haplotypes, 91T-169G, 91A-169G, 91T-169A, and 91A-169A. We evaluated the association between these coding single nucleotide polymorphisms and esophageal cancer risk by genotyping 197 esophageal cancer cases and 146 controls. Haplotype 91A-169A (I31/I57) was observed to be statistically more frequent in cancer cases (odds ratio, 3.1452; 95% confidence interval, 1.0258-9.6435). Functional differences among the four isoforms were then analyzed to reveal the source of the cancer risk. Kinase activity levels of I31/I57 and F31/I57 were reduced to 15% and 40% compared with I31/V57 in vivo and in vitro. We considered the differences between the kinase activities and divided individuals into four categories of Aurora-A haplotype combination. Category I had 57.5% or less kinase activity compared with the most common category, category III, and had a significantly higher estimated cancer risk (odds ratio, 5.5328; 95% confidence interval, 1.8149-16.8671). Abnormal nuclear morphology, a characteristic of genomic instability, was observed to be 30 to 40 times more frequent in human immortalized fibroblast cells overexpressing I31/I57 or F31/I57 compared with the others. Furthermore, significantly higher levels of chromosomal instability were observed in cancers in category I (homozygote 91T-169A) than those in category III (homozygous 91A-169G). These results indicate that the less kinase active Aurora-A haplotype combinations might induce genomic instability and increase esophageal cancer risk either in a recessive or a dominant manner.
Published: 2005
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34. Operative Treatment of Hip Fracture in Haemodialysed Patients

Author: A Kou, A Imakiire, T Ueno, K Ito, T Kimura, Y Inahata, and K Sano
Subjects: Male, musculoskeletal diseases, 0301 basic medicine, medicine.medical_specialty, Activities of daily living, Arthroplasty, Replacement, Hip, medicine.medical_treatment, 030209 endocrinology & metabolism, Diabetic nephropathy, Sepsis, Fracture Fixation, Internal, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, lcsh:Orthopedic surgery, Renal Dialysis, Fracture fixation, medicine, Humans, Myocardial infarction, Dialysis, Aged, Aged, 80 and over, Hip fracture, Hip Fractures, business.industry, Middle Aged, medicine.disease, Arthroplasty, Surgery, lcsh:RD701-811, Treatment Outcome, Female, 030101 anatomy & morphology, business, Follow-Up Studies
Abstract: Purpose. To study operative treatment and postoperative clinical outcomes of hip fracture in haemodialysed patients. Methods. In 12 patients (8 men and 4 women) undergoing haemodialysis, 14 hip fractures were treated. Of these, 8 hips were treated with bipolar hip arthroplasty, one hip with total hip arthroplasty, 4 hips with a compression hip screw, and one hip with a gamma nail. The mean duration of dialysis treatment until fracture was 7 years. During a mean postoperative follow-up period of 17 months (range, 1–44 months), the patients' renal condition, type of fracture, and level of activities of daily living before and after surgery were assessed. Results. Of the 7 patients who died during a mean follow-up period of 17 months, 2 died from myocardial infarction, 2 from sepsis, and one each from gastric cancer, pulmonary oedema, and liver failure. Five of the 8 patients with diabetic nephropathy died, whereas 6 of the 8 patients who underwent bipolar hip arthroplasty or total hip arthroplasty died. Most of the patients had declined level of activities of daily living postoperatively. Conclusion. For haemodialysed patients with fractures, it is essential to select the most suitable operating method and to conduct vigilant management before and after the operation.
Published: 2004
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35. STK15 polymorphism and breast cancer risk in a population-based study

Author: Christine B. Ambrosone, Hiroki Nagase, Kathleen M. Egan, Linda Titus-Ernstoff, Makoto T. Kimura, Amy Trentham-Dietz, Polly A. Newcomb, and John M. Hampton
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Genotype, Population, Mitosis, Breast Neoplasms, Protein Serine-Threonine Kinases, Biology, Breast cancer, Aurora Kinases, Risk Factors, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Genetic variability, education, Aurora Kinase A, Genetics, education.field_of_study, Polymorphism, Genetic, Ubiquitin, Incidence, Estrogen Replacement Therapy, Cancer, General Medicine, Odds ratio, medicine.disease, Penetrance, United States, Confidence interval, Amino Acid Substitution, Female, Half-Life, Maternal Age
Abstract: STK15 is considered a potential cancer susceptibility gene owing to its functions in normal cell mitosis. Two common coding region polymorphisms in the gene (F31I and V57I) may affect ubiquitin-dependent degradation and thus the half-life of the encoded protein. There are limited data on the relevance of these polymorphisms to population cancer rates. To examine whether functional variation in STK15 may affect breast cancer risk, we genotyped a large series of incident breast cancer cases (n = 941) and age-matched population controls (n = 830) for the F31I and V57I polymorphisms. Individually, neither the F31I polymorphism [odds ratio (OR) 1.54; 95% confidence interval (CI) 0.96-2.47, comparing 31I with 31F homozygotes] nor the V57I polymorphism (OR 0.92; 95% CI 0.50-1.71, comparing 57I with 57V homozygotes) was significantly associated with breast cancer risk. A relatively common genotype, combining the two polymorphisms (31I-57V/31I-57V, 3% of controls) was related to a significant 2-fold increase in the risk of post-menopausal breast cancer (OR 1.96; 95% CI 1.01-3.79). No interaction was detected between STK15 variants and estrogenic risk factors, although the power of these analyses was limited. These results suggest that STK15 may represent a low penetrance type breast cancer susceptibility gene.
Published: 2004
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36. Treatment of a plunging ranula with fenestration and continuous pressure

Author: T. Kimura, J. L. Asaumi, Nobuyoshi Mizukawa, and Shin Takagi
Subjects: Adult, medicine.medical_specialty, Adolescent, Female patient, Pressure, medicine, Humans, Minimally Invasive Surgical Procedures, Effective treatment, Ranula, Child, Mouth Floor, Wound Healing, medicine.diagnostic_test, business.industry, Plunging ranula, Conventional treatment, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Surgery, Otorhinolaryngology, Drainage, Female, Oral Surgery, Mouth Diseases, business, Fenestration, After treatment, Follow-Up Studies
Abstract: We present a new method of fenestration and continuous pressure as a simple, effective and uninvasive procedure for the treatment of plunging ranulas. We have recently used in four female patients, aged 10-29 years old. After treatment, the patients remained symptom-free and assessment by magnetic resonance imaging (MRI) showed regression of the ranula in all cases. The procedure resulted in satisfactory healing and we advocate it as a simple and effective treatment that is better for patients than conventional treatment.
Published: 2003
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37. The combination of angiogenesis and blood vessel invasion as a prognostic indicator in primary breast cancer

Author: T Nishikawa, Takao Kato, T Kimura, M Kobayashi, and S Kameoka
Subjects: Adult, musculoskeletal diseases, Oncology, Cancer Research, Pathology, medicine.medical_specialty, Mitotic index, Adolescent, Angiogenesis, Breast Neoplasms, Disease-Free Survival, Metastasis, Neovascularization, angiogenesis, breast cancer, Breast cancer, microvessel density, blood vessel invasion, Internal medicine, medicine, Humans, Neoplasm Metastasis, Microvessel, haematogenous dissemination, Univariate analysis, Neovascularization, Pathologic, business.industry, Molecular and Cellular Pathology, Middle Aged, Neoplastic Cells, Circulating, Prognosis, medicine.disease, medicine.anatomical_structure, Lymphatic Metastasis, Blood Vessels, Female, medicine.symptom, business, long-term survival, Blood vessel
Abstract: This study was undertaken to examine the interaction between the combination of angiogenesis and blood vessel invasion (BVI) and haematogenous metastasis, and to determine the prognostic significance of that combination in predicting 20-year relapse-free survival (RFS) and overall survival (OS) rates in primary breast cancer. Five hundred and nine patients were studied. We investigated 11 factors, including average microvessel count (AMC)/BVI, lymph-node status (n), clinical tumour size (T), histological grade (HG), lymphatic vessel invasion (LVI), p53, proliferating cell nuclear antigen (PCNA), c-erbB-2, mitotic index (MI), apoptotic index, and tumour necrosis (TN). Blood vessel invasion was detected by both factor VIII-related antigen and elastica van Gieson staining. To evaluate the best objective method to quantify microvessel density in angiogenesis, AMC was employed. The rate of AMC-high and BVI-positive tumours was 32.6 and 29.3%, respectively. That of both AMC-high and BVI-positive tumours was 10.1%. Univariate analysis showed that AMC/BVI, n, T, HG, LVI, p53, PCNA, MI, and TN were significantly predictive of RFS and OS. By multivariate analysis, AMC/BVI was the strongest independent prognostic factor for 20-year RFS (relative risk (RR)=5.5; P
Published: 2003
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38. Measurement of serum total bile acid levels in long-term postoperative follow-up of patients with congenital bile-duct dilatation

Author: A. Okada, Toshimichi Hasegawa, T. Sasaki, N. Shukri, and T. Kimura
Subjects: Male, medicine.medical_specialty, Time Factors, Adolescent, medicine.drug_class, Bilirubin, Gastroenterology, Bile Acids and Salts, chemistry.chemical_compound, Cholestasis, Internal medicine, medicine, Humans, Choledochal cysts, Child, Postoperative Care, Bile acid, medicine.diagnostic_test, business.industry, Infant, General Medicine, medicine.disease, Fibrosis, Surgery, Liver, chemistry, Biliary tract, Child, Preschool, Choledochal Cyst, Liver biopsy, Pediatrics, Perinatology and Child Health, Alkaline phosphatase, Female, Complication, business, Follow-Up Studies
Abstract: Serum total bile acid levels (STBA), a sensitive indicator of cholestasis, were measured during the long-term postoperative period in patients with congenital bile-duct dilatation (CBDD) (choledochal cyst) and the factors contributing to elevation of STBA were analyzed in 44 patients. Their ages at operation ranged from 1 month to 16 years. A STBA level over 12 nmol/ml on two or more measurements during outpatient follow-up was considered abnormal. Patients were classified into three groups: group 1, STBA, 12-50 nmol/ml; group 2, STBAor = 50 nmol/ml; group N, STBA normal. In 19 patients (43.2%) STBA was normal. Of the 25 patients (56.8%) with elevated STBA, groups 1 and 2 comprised 12 (27.3%) and 13 patients (29.5%), respectively. The mean age in group N was 5.1 +/- 4.2 years, which was higher than in groups 1 (2.6 +/- 2.3) and 2 (2.3 +/- 2.5 years) ( P0.05). Preoperative STBA and total bilirubin were higher in group 2 (79.2 +/- 75.1 nmol/ml resp. 5.2 +/- 4.2 mg/dl) than in groups N (20.1 +/- 32.6, 1.3 +/- 1.4) and 1 (22.8 +/- 37.2, 1.4 +/- 1.0) ( P0.05). Preoperative alkaline phosphatase and gamma-glutamyl transpeptidase were higher in group 2 (1,006 +/- 872 IU/l, 452 +/- 326 IU/l) than in group N (573 +/- 371, 205 +/- 238) ( P0.05). Histologic findings on liver biopsy showed fibrosis in 38.5% of group 2 patients, which was significantly higher than in groups N (15.8%) and 1 (16.7%) ( P0.05). Cholestasis was detected in 41.7% of group 1 and 61.5% of group 2 patients, compared to 10.5% of group N patients ( P0.05). Postoperative elevation of STBA may thus persist in more than one-half of patients with CBDD, and is likely to occur in patients of young age who have severe cholestasis or liver fibrosis preoperatively. Further investigations may be required in regard to the development of postoperative complications.
Published: 2002
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39. Expression of cytokeratins (CKs) 8, 13 and 18 and their mRNA in epithelial linings of radicular cysts: implication for the same CK profiles as nasal columnar epithelium in squamous epithelial lining

Author: D P Lu, T Kimura, T Osaki, and Y Tatemoto
Subjects: Adult, Male, Pathology, medicine.medical_specialty, In situ hybridization, Biology, Immunoenzyme Techniques, Cytokeratin, medicine, Humans, Cyst, RNA, Messenger, General Dentistry, In Situ Hybridization, Radicular Cyst, Reverse Transcriptase Polymerase Chain Reaction, Epithelial Cells, RNA Probes, Anatomy, Middle Aged, medicine.disease, Epithelium, Staining, Reverse transcription polymerase chain reaction, Nasal Mucosa, stomatognathic diseases, Phenotype, medicine.anatomical_structure, Otorhinolaryngology, Keratins, Immunohistochemistry, Female
Abstract: OBJECTIVE: Our objective was to specify cytokeratin (CK) patterns in lining epithelia of radicular cysts which are sometime lined with ciliated columnar epithelia as seen in the nasal epithelia. MATERIALS AND METHODS: We examined the CK expression in 52 radicular cysts obtained from 32 maxillary and 20 mandibular lesions and investigated CK-mRNA expression using in situ hybridization in 24 maxillary and 13 mandibular cysts and reverse transcription-polymerase chain reaction (RT–PCR) in 24 maxillary cysts. RESULTS: Of the maxillary cysts, 20, 29 and 19 squamous epithelial linings were positive for CK8, CK13 and CK18, respectively; of the mandibular cysts, 10, 20 and 11 linings were positive for these CKs, respectively. The expression patterns of CK18(+)-CK13(−), CK18(+)-CK13(+) and CK18(−)-CK13(+) were observed in 3, 16 and 13 linings of the maxillary cysts and 0, 11 and 9 linings of the mandibular cysts, respectively. In situ hybridization revealed the expression of CK18-mRNA in 9 and 4 linings of 24 maxillary and 13 mandibular cysts examined, respectively. With RT-PCR, we explored that both CK18- and CK13-mRNA were expressed not only in the normal nasal and gingival epithelia but also in the examined maxillary cyst linings although their expression levels differed correlating with the difference in CK staining. CONCLUSION: It is concluded that CK13- and CK18-mRNA are constitutively expressed in columnar and squamous epithelial cells, respectively, and that the variant CK expression patterns with CK18-mRNA expression in maxillary radicular cysts are indicative of the possibility of phenotypic transformation in the cyst linings.
Published: 2002
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40. Practice adaptive reserve and colorectal cancer screening best practices at community health center clinics in 7 states

Author: Shin-Ping, Tu, Vicki M, Young, Letoynia J, Coombs, Rebecca S, Williams, Michelle C, Kegler, Amanda T, Kimura, Betsy C, Risendal, Daniela B, Friedman, Beth A, Glenn, Debbie J, Pfeiffer, and Maria E, Fernandez
Subjects: Adult, Young Adult, Data Collection, Practice Guidelines as Topic, Humans, Community Health Centers, Healthcare Disparities, Middle Aged, Colorectal Neoplasms, Early Detection of Cancer, United States, Article, Aged
Abstract: Enhancing the capability of community health centers to implement best practices (BPs) may mitigate health disparities. This study investigated the association of practice adaptive reserve (PAR) with the implementation of patient-centered medical home (PCMH) colorectal cancer (CRC) screening BPs at community health center clinics in 7 states.A convenience sample of clinic staff participated in a self-administered, online survey. Eight PCMH CRC screening BPs were scored as a composite ranging from 0 to 32. The PAR composite score was scaled from 0 to 1 and then categorized into 3 levels. Multilevel analyses examined the relation between PAR and self-reported implementation of PCMH BPs.There were 296 respondents, and 59% reported 6 or more PCMH BPs at their clinics. The mean PAR score was 0.66 (standard deviation, 0.18), and the PCMH BP mean scores were significantly higher for respondents who reported higher clinic PAR categories. In comparison with the lowest PAR level, adjusted PCMH BP means were 25.0% higher at the middle PAR level (difference, 3.2; standard error, 1.3; t = 2.44; P = .015) and 63.2% higher at the highest PAR level (difference, 8.0; standard error, 1.9; t = 4.86; P .0001).A higher adaptive reserve, as measured by the PAR score, was positively associated with self-reported implementation of PCMH CRC screening BPs by clinic staff. Future research is needed to determine the PAR levels most conducive to implementing CRC screening and to develop interventions that enhance PAR in primary care settings.
Published: 2014

41. Early skin toxicity predicts better outcomes, and early tumor shrinkage predicts better response after cetuximab treatment in advanced colorectal cancer

Author: H. Ihara, T. Mizushima, A. Doi, T. Sumiyoshi, Tamer M. Fouad, T. Kukitsu, S. Okushiba, Takahiro Kogawa, H. Kondo, N. Yoshizaki, Y. Tsuji, F. Tamura, Syuji Kitashiro, T. Sasaki, M. Shimokawa, M. Hirayama, S. Abe, Y. Kawarada, T. Osuga, and T. Kimura
Subjects: Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Colorectal cancer, Cetuximab, Antineoplastic Agents, Kaplan-Meier Estimate, Adenocarcinoma, Disease-Free Survival, Advanced colorectal cancer, Internal medicine, medicine, Humans, Pharmacology (medical), neoplasms, Aged, Proportional Hazards Models, Retrospective Studies, Skin, Aged, 80 and over, Proportional hazards model, business.industry, Tumor shrinkage, Retrospective cohort study, Middle Aged, medicine.disease, digestive system diseases, Treatment efficacy, Skin toxicity, Treatment Outcome, Female, business, Colorectal Neoplasms, medicine.drug
Abstract: Cetuximab-containing treatments for metastatic colorectal cancer have been shown to have higher overall response rates and longer progression-free and overall survival than other systemic therapies. Cetuximab-related manifestations, including severe skin toxicity and early tumor shrinkage, have been shown to be predictors of response to cetuximab. We hypothesized that early skin toxicity is a predictor of response and better outcomes in patients with advanced colorectal carcinoma. We retrospectively evaluated 62 patients with colorectal adenocarcinoma who had unresectable tumors and were treated with cetuximab in our institution. Skin toxicity grade was evaluated on each treatment day. Tumor size was evaluated using computed tomography prior to treatment and 4–8 weeks after the start of treatment with cetuximab.Patients with early tumor shrinkage after starting treatment with cetuximab had a significantly higher overall response rate (P = 0.0001). Patients with early skin toxicity showed significantly longer overall survival (P = 0.0305), and patients with higher skin toxicity grades had longer progression-free survival (P = 0.0168).We have shown that early tumor shrinkage, early onset of skin toxicity, and high skin toxicity grade are predictors of treatment efficacy and/or outcome in patients with advanced colorectal carcinoma treated with cetuximab.
Published: 2014

42. Pulmonary infiltration with eosinophilia (PIE) syndrome induced by antibiotics, PIPC and TFLX during cancer treatment

Author: Tokio Osaki, Tetsuya Yamamoto, Sayoko Doi, T. Tanida, Eisaku Ueta, and T Kimura
Subjects: Male, Cancer Research, medicine.medical_specialty, Pathology, medicine.medical_treatment, Penicillins, Gastroenterology, Fatal Outcome, Anti-Infective Agents, Internal medicine, medicine, Eosinophilic pneumonia, Humans, Eosinophilia, Naphthyridines, Pulmonary Eosinophilia, Aged, Aged, 80 and over, Piperacillin, Mouth neoplasm, 4-Quinolones, business.industry, Respiratory disease, Neck dissection, medicine.disease, Oncology, Epidermoid carcinoma, Lymphatic Metastasis, Carcinoma, Squamous Cell, Prednisolone, Lymph Node Excision, Mouth Neoplasms, Interleukin-5, Oral Surgery, medicine.symptom, business, Neck, Fluoroquinolones, medicine.drug
Abstract: Drugs induce a variety of pulmonary diseases including pulmonary infiltration with eosinophilia (PIE) syndrome. We report a case of PIE syndrome which was observed after neck dissection. An 83-year-old male patient attended our clinic complaining of upper neck swelling and was diagnosed as advanced lymph node metastasis related to previously resected oral carcinoma and underwent neck dissection. Despite administration of antibiotics (piperacillin sodium, PIPC; and tosufloxacin tosilate, TFLX), fever and an elevation of the c-reactive protein (CRP) level with neutrophilia appeared, and an infiltration shadow was observed in the right lower pulmonary field. With the suspicion of pneumonia, the antibiotics were exchanged for panipenem/betamipron. However, the pulmonary infiltration spread widely, CRP increased to 12.9 mg/dl and severe eosinophilia (23%) was observed a few days after changing the antibiotics. PIE syndrome was suspected, and the patient underwent steroid mini-pulse therapy consisting of methylprednisolone sodium succinate (500 mg) and prednisolone (60 mg). After steroid therapy, the pulmonary condition largely improved. However, about 2 weeks after the start of steroid administration, a fever and a further elevation of CRP were observed with an increase of beta-D-glucan in serum. Roentgenography revealed diffuse infiltration shadows throughout the lungs, and the patient died about 3 weeks after the onset from respiratory distress. In vitro, blastogenesis of patient's peripheral blood lymphocytes was strongly enhanced by PIPC and TFLX, and they generated a large amount of interleukin-5 in the presence of PIPC or TFLX. The clinical course and laboratory examination results revealed that PIE syndrome may have been induced by PIPC and TFLX and that PIE syndrome should be suspected in treatment of carcinomas when dyspnea and pulmonary infiltration are complicated with eosinophilia.
Published: 2001
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43. Acceptable Residual Renal Function after Retroperitoneoscopic Kidney Donation in Elderly Donors

Author: M. Yashi, T. Iwabuchi, Yasunaru Sakuma, Takashi Yagisawa, T. Kimura, Akinori Nukui, Osamu Muraishi, T. Fujiwara, and Nobuo Ishikawa
Subjects: Male, medicine.medical_specialty, Population, Urology, Renal function, Kidney, Kidney Function Tests, chemistry.chemical_compound, medicine, Humans, education, Kidney transplantation, Aged, Transplantation, Creatinine, education.field_of_study, business.industry, Age Factors, Kidney donation, Perioperative, medicine.disease, Kidney Transplantation, Tissue Donors, Surgery, chemistry, Donation, Female, business, Body mass index, Glomerular Filtration Rate
Abstract: Recent studies suggest that the overall survival and risk of end-stage renal disease among renal transplant donors are similar to those of the general population, but few studies focused on elderly donors. Among 88 donors who underwent retroperitoneoscopic live donor nephrectomies; 20 (22.7%) were elderly, namely, older than 65 years. Perioperative characteristics, such as sex, donor kidney side (left or right), body mass index, operative time, blood loss, and complication rate were not significantly different among groups classified by age: young (50), middle (50-65), or elderly (65). One month after kidney donation, the serum, creatinine values in the young, middle, and elderly groups increased to 1.05 ± 0.25, 0.96 ± 0.24, and 1.06 ± 0.15 mg/dL (P = .103) and the estimated glomerular filtration rate (eGFR) decrease to 63 ± 10, 63 ± 14, 56 ± 8 mL/min/1.73 m(2), respectively (P = .037). At three months and at three years after donation these parameters showed the same degree of improvement in all groups. Percentage of eGFR (% eGFR) of its pre-donation value in the young and middle groups improved up to 21% and up to 9%, respectively, until four years after donation, whereas that of the elderly group remained unchanged below 1%. In conclusion residual renal function after retroperitoneoscopic kidney donation in elderly donors was stable and acceptable during mid-term observation. Our retroperitoneoscopic approach was safe.
Published: 2010
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44. Congenital extrahepatic portocaval shunt associated with hepatic hyperplastic nodules in a patient with Dubin–Johnson syndrome

Author: Hiromu Mori, S. Matsumoto, T. Tsuda, H. Kiyosue, H. Yonemitsu, T. Kimura, Y. Yamada, and K. Kagawa
Subjects: medicine.medical_specialty, Pathology, Adolescent, Urology, Portal venous system, Vena Cava, Inferior, Gastroenterology, Inferior vena cava, Mesenteric Veins, Internal medicine, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Radiological and Ultrasound Technology, Jaundice, Chronic Idiopathic, Portal Vein, business.industry, Vascular disease, Focal nodular hyperplasia, General Medicine, medicine.disease, Hypoplasia, Shunt (medical), medicine.vein, Focal Nodular Hyperplasia, Splenic Vein, cardiovascular system, Female, Tomography, X-Ray Computed, business, Splanchnic, Venous return curve, Liver Circulation
Abstract: We report a rare case of congenital extrahepatic portocaval shunt diagnosed during evaluation of hyperplastic nodules in the liver. Diagnostic imagings showed hypoplasia of the intrahepatic portal venous system and splanchnic portal venous return to the inferior vena cava through aberrant vessels. Altered hepatic blood flow dynamics due to this shunt may have been implicated in the etiology of the hepatic hyperplastic nodules. RID="" ID="" Correspondence to: H. Yonemitsu
Published: 2000
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45. Laparoscopic cholecystectomy performed by a single surgeon using a visual field tracking camera

Author: Sumio Matsumoto, Y. Umehara, and T. Kimura
Subjects: Male, Laparoscopic surgery, Zoom lens, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Forceps, Middle Aged, Tracking (particle physics), Laparoscopes, Single surgeon, Visual field, Surgery, Cholecystectomy, Laparoscopic, Humans, Medicine, Female, Cholecystectomy, business, Laparoscopy
Abstract: Background: This report describes a visual field tracking camera for laparoscopic surgery that allows the visual field to be changed without moving the laparoscope. We also report on our early experience with this camera for single-surgeon laparoscopic cholecystectomy. Methods: The visual field tracking camera has a tracking mechanism (composed of a zoom lens and a charge-coupled device [CCD] slide mechanism) built into the camera head. The 80° visual field observed with the laparoscope can be expanded using the zoom lens, and the field can be shifted by changing the size of the area being viewed by the CCD. This is accomplished by pushing a switch on the forceps or by verbal command. Cholecystectomy was carried out on 12 patients with gallstones using this camera. The operations were performed by either a single surgeon or two surgeons. Forceps held with a forceps holder were inserted through the right port to lift the fundus of the gallbladder. The single surgeon used the other two ports to resect the gallbladder by the two-handed technique. Results: In all cases, cholecystectomy was completed without any need to move the laparoscope at any point during the operation. Seven operations were performed by a single surgeon. Mainly for education purposes, five other operations were performed by a pair of surgeons. The mean time required for surgery was 76 ± 17 min. This time did not differ from that of laparoscopic cholecystectomy performed during the same period on 22 patients by teams of three surgeons using conventional cameras. Conclusions: Using the visual field tracking camera, laparoscopic cholecystectomy can be performed without any need to touch the laparoscope. This camera allowed laparoscopic cholecystectomy to be performed by a single surgeon.
Published: 2000
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46. Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

Author: Isao Hozumi, Ichiro Kanazawa, Yasuteru Sano, Mitsunori Yamada, Takayoshi Shimohata, Yasuyuki Aoyagi, Osamu Onodera, Kumi Sakoe, Toshiya Sato, Hiroshi Ishiguro, Naoko Tanese, Chiharu Uchida, Takeshi Ikeuchi, Kenkichi Nozaki, Irwin Davidson, Reiji Koide, Mutsuo Oyake, Masatoyo Nishizawa, Takayuki Ooshima, Toshihiro Nakajima, Yoshihisa Takiyama, Shoji Tsuji, Toshiharu Nagatsu, Satoshi Naruse, Hitoshi Takahashi, Jun Goto, T. Kimura, and Aki Sato
Subjects: Transcription, Genetic, Transcription (biology), Cloning, Molecular, Cyclic AMP Response Element-Binding Protein, Aged, 80 and over, Genetics, Cell Death, biology, Neurodegeneration, Brain, Neurodegenerative Diseases, Middle Aged, Cell biology, DNA-Binding Proteins, COS Cells, Electrophoresis, Polyacrylamide Gel, Female, Cell Nucleolus, Plasmids, Protein Binding, Transcriptional Activation, Programmed cell death, Recombinant Fusion Proteins, Blotting, Western, Green Fluorescent Proteins, Molecular Sequence Data, Globus Pallidus, Transfection, CREB, Cell Line, Two-Hybrid System Techniques, Coactivator, medicine, Animals, Humans, Aged, Cell Nucleus, TATA-Binding Protein Associated Factors, beta-Galactosidase, medicine.disease, Element binding protein, Precipitin Tests, Luminescent Proteins, Dentate Gyrus, biology.protein, Transcription Factor TFIID, Atrophy, Peptides, Trinucleotide Repeat Expansion, Transcription Factors
Abstract: At least eight inherited neurodegenerative diseases are caused by expanded CAG repeats encoding polyglutamine (polyQ) stretches. Although cytotoxicities of expanded polyQ stretches are implicated, the molecular mechanisms of neurodegeneration remain unclear. We found that expanded polyQ stretches preferentially bind to TAFII130, a coactivator involved in cAMP-responsive element binding protein (CREB)-dependent transcriptional activation, and strongly suppress CREB-dependent transcriptional activation. The suppression of CREB-dependent transcription and the cell death induced by polyQ stretches were restored by the co-expression of TAFII130. Our results indicate that interference of transcription by the binding of TAFII130 with expanded polyQ stretches is involved in the pathogenetic mechanisms underlying neurodegeneration.
Published: 2000
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47. Pulmonary lymphangitic carcinomatosis from an oropharyngeal squamous cell carcinoma: a case report

Author: T. Kimura, Tomoko Nakane, Tetsuya Yamamoto, and Tokio Osaki
Subjects: Male, Cancer Research, Pathology, medicine.medical_specialty, Lung Neoplasms, Metastasis, medicine, Carcinoma, Humans, Aged, Lung, medicine.diagnostic_test, business.industry, medicine.disease, respiratory tract diseases, Oropharyngeal Neoplasms, medicine.anatomical_structure, Oncology, Epidermoid carcinoma, Lymphangitic Carcinomatosis, Cervical lymph nodes, Lymphatic Metastasis, Carcinoma, Squamous Cell, Lymph, Oral Surgery, Chest radiograph, business
Abstract: Pulmonary lymphangitic carcinomatosis (PLC), a form of lymphatic spread of cancer cells, from head and neck cancers is extremely rare. We report here a case of PLC from an oropharyngeal squamous cell carcinoma in a 68-year-old man. The patient underwent inductive chemoradioimmunotherapy which resulted in complete tumor remission. The tumor, however, recurred 6 months later and was resected. Late metastasis occurred in the ipsilateral cervical lymph nodes 13 months post surgery and these lymph nodes were dissected. Three months later, the patient suffered from a fever, cough and dyspnea and a chest radiograph revealed an interstitial linear pattern from the right hilum to the right upper lung field. Without diagnosis of the pulmonary lesion, swelling of the bilateral lymph nodes followed after a few months and dyspnea worsened with spread of the reticular shadow and appearance of Kerley's B line on the roentgenogram, suggesting PLC. The patient gradually became more distressed and finally died 6 months after the onset of dyspnea. The microscopy of the autopsied pulmonary tissue revealed tumor cell nests in the lymph vessels in the septa and the pulmonary lesion was histopathologically diagnosed as PLC. The present case indicates that we should consider PLC when cough and dyspnea with reticular shadows and Kerley's B line are observed in patients with head and neck carcinoma.
Published: 2000
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48. Allele frequencies of eight STRs in Japanese and Chinese

Author: X. Li, Masaki Hashiyada, P. He, Masato Funayama, Kaoru Sagisaka, Masayuki Nata, Wei Yan, and T. Kimura
Subjects: Genetics, China, Chinese population, Genotype, Chromosome Mapping, Biology, Japanese population, Pathology and Forensic Medicine, Genetics, Population, Asian People, Gene Frequency, Japan, Tandem Repeat Sequences, Population data, Str loci, Humans, Allele, Allele frequency, Alleles
Abstract: Allele frequencies for the eight STR loci Hum-CSF1P0, F13A01, F13B, FES/FPS, LPL, TH01, TPOX and VWA were investigated in Japanese and Chinese populations. No significant deviations from Hardy-Weinberg equilibrium could be found for all loci. In the Japanese population VWA, CSF1PO, TH01, FES/FPS and TPOX were found to be useful for forensic applications and in the Chinese population, VWA, CSF1PO, TH01 and TPOX were found to be useful. Allele distributions were similar between both populations except for FES/FPS.
Published: 1999
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49. Laparoscopic Ultrasonography and Operative Cholangiography Prevent Residual Common Bile Duct Stones in Laparoscopic Cholecystectomy

Author: T, Kimura, Y, Umehara, M, Yoshida, S, Sakuramachi, A, Kawabe, and K, Suzuki
Subjects: Adult, Male, Gallstones, Middle Aged, Sensitivity and Specificity, Endosonography, Primary Prevention, Treatment Outcome, Cholecystectomy, Laparoscopic, Monitoring, Intraoperative, Preoperative Care, Secondary Prevention, Humans, Female, Surgery, Cholangiography, Aged, Follow-Up Studies, Retrospective Studies
Abstract: We retrospectively evaluated the role of intraoperative cholangiography (IOC) combined with laparoscopic intraoperative ultrasonography (LIOU) for detection of common bile duct (CBD) stones in patients undergoing laparoscopic cholecystectomy. We reviewed 184 patients with biliary stones. Preoperatively, all patients underwent ultrasonography (US); 183 of the patients were investigated by cholangiography (oral and intravenous cholangiography in 145 and endoscopic retrograde cholangiography in 44). LIOU was carried out in all patients and IOC was done in 183. LIOU visualized the bile duct in 94.6% of the patients and IOC was successful in 95.6%. CBD stones were detected in a total of 17 patients, 9 (52.9%) of whom were positive on preoperative investigations. The sensitivity for detecting CBD stones was 29.4% with US, 22.2% with oral and intravenous cholangiography, 50.0% with endoscopic retrograde cholangiography, 82.4% with LIOU, and 93.3% with IOC. The diameter of the stones visualized intraoperatively (4.4 +/- 1.2 mm) was smaller than that of the stones detected preoperatively (6.9 +/- 2.6 mm). The stones were removed during laparoscopy in 15 patients and after conversion to laparotomy in 2. None of the patients had residual CBD stones after follow-up for 6 to 50 months. Intraoperative examination using both LIOU and IOC was useful for prevention of residual CBD stones.
Published: 1999
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50. Pharmacokinetics of [125I]-recombinant human interleukin-11

Author: T. Watanabe, M. Tateishi, S. Higuchi, K. Aoyama, Y. Takariki, T. Uchida, T. Usui, M. Hirose, T. Kimura, K. Mori, and N. Asahara
Subjects: medicine.medical_specialty, Amniotic fluid, Metabolic Clearance Rate, Injections, Subcutaneous, Placenta, Uterus, Ovary, Biology, Iodine Radioisotopes, Rats, Sprague-Dawley, Excretion, Pharmacokinetics, Pregnancy, Internal medicine, Lactation, medicine, Animals, Humans, Tissue Distribution, Pharmacology (medical), Maternal-Fetal Exchange, Pharmacology, Fetus, Interleukin-11, Recombinant Proteins, Rats, medicine.anatomical_structure, Endocrinology, Animals, Newborn, Female
Abstract: Placental transfer and excretion into milk of [125I]-rhIL-11 (recombinant human interleukin-11) after subcutaneous administration in female rats were investigated. After administration of [125I]-rhIL-11 to rats on the 14th day of gestation, radioactivity in the kidney was the highest among excised tissues, being 3 times higher than that in the plasma at 1.5 h. Radioactivity in other tissues, including the mammary gland, ovary, uterus, placenta and amniotic fluid, was lower than that in the plasma. Although radioactivity in fetuses was detected 6 h after administration, the level was only 2% of the plasma concentration in dams, and the radioactivity was not found in fetal-derived TCA precipitates. These results indicate that rhIL-11 does not readily pass through the placenta into the fetus. After subcutaneous administration of [125I]-rhIL-11 to lactating rats 14 days after delivery, radioactivity in milk was 1.1-1.6 times that in the plasma of dams. Radioactivity in clotted milk in the stomachs of suckling infants was almost equal to that in the dam's milk; however, only a small amount of radioactivity was detected in infant kidneys.
Published: 1998
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