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The complex and specific surgical instruments (SI) acquired from loaner companies are provided non-sterile and must be reprocessed before each use. We evaluated the management practices of SI in loaner companies in a high (Australia) and a middle-income (Brazil) country.Seven company managers in Australia and eight in Brazil replied to the self-administrated survey.Failures to meet recommended practices were detected, including standard operating procedure (SOP) provision, minimum delivery time, transport container and decontamination in loaner companies in both countries. Six of seven loaner companies in each country provided SOP for instrument reprocessing (one company in Brazil did not reply). Solicitation of the SI may occur 12 h before need in Brazil, and delivery of the set could be accepted 4 h before surgery in both countries. Transport of SI on stainless steel/aluminium trays was reported by 42.85% and 28.6% of companies in Brazil and Australia, respectively. In Australia, 57.1% of the loaner companies affirmed they performed cleaning only if the SI were visibly dirty. In Brazil, 62.5% of the companies reported they use alcohol to wipe SI.There is a need for standardisation of requirements and process verification improvement in loaner SI reprocessing and management.

We previously reported a novel polymeric surface coating, namely, HaloFilm™ that can immobilize and extend the antimicrobial activity of chlorine on surfaces. In this study, we demonstrated the continuous antiviral efficacy of HaloFilm when applied on stainless steel and cotton gauze as two representative models for non-porous and porous surfaces against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Forty-eight hours post HaloFilm application and chlorination and 2 h post the viral challenge, the inoculum titre was reduced by 2.25 ± 0.33 and ≥4.36 ± 0.23 log10 TCID50 on non-porous and porous surfaces, respectively. The half-life of the virus was shorter (13.86 min) on a HaloFilm-coated surface than what has been reported on copper (46.44 min).

Staphylococcus aureus is one of the main aetiological agents causing food-borne diseases. Some strains produce enterotoxins responsible for food poisoning. In addition, they can form biofilms on several surfaces such as plastics, glass and stainless steel making it difficult to eliminate them. The present study evaluated, for the first time, the antibacterial and antibiofilm activities of the synthetic compound LMM6 against S. aureus. The minimum inhibitory concentration was 0·97, 1·95 and 1·95 μg ml−1 against S. aureus ATCC 25923, S. aureus 629/94 and S. aureus FRI S-6, respectively. The time-kill curves showed that 96 h treatment with LMM6 reduced approximately 4 log CFU per ml at all tested concentrations. Furthermore, LMM6 reduced S. aureus preformed biofilm by approximately 1 log CFU per cm2. During biofilm formation, a reduction of approximately 4 log CFU per cm2 was observed. LMM6 also reduced biofilm biomass during (~60%) and after biofilm formation (~25 to 45%), as shown by the crystal violet assay. Based on these results, we conclude that LMM6 exhibits antibacterial and antibiofilm activity and may be an innovative synthetic molecule for controlling S. aureus.

Purpose The aim of this study is to evaluate the levels of chromium (Cr), cobalt (Co), and titanium (Ti) after instrumented fusion for scoliosis. Methods Serum samples were collected at median 2.24 (range 0.1–38.8) years after fusion surgery for scoliosis in 91 individuals, of which 71 had been treated with steel implants and 20 with titanium implants. 91 sex and age-matched non-surgically treated individuals with scoliosis were used as controls. Levels of Cr, Co, and Ti were measured. Results In the 91 surgically treated individuals median levels of Cr were 0.54 µg/l vs 0 µg/l in the 91 controls, p p = 0.19, and for Ti were 0 µg/l vs. 0 µg/l, p In the individuals with steel implants and their corresponding controls median Cr levels were 0.63 µg/l vs. 0.00 µg/l, p p = 0.36. No Ti was detected. In the individuals with titanium implants, median Cr levels were 0 µg/l vs. 0 µg/l in their corresponding controls, p = 0.38. Corresponding results for Co was 0.39 µg/l vs. 0.31 µg/l, p = 0.27 and for Ti 4.31 µg/l vs. 0 µg/l, p In the individuals with steel implants a negative correlation between implant time in situ and levels of Cr was found ($$\rho$$ ρ = − 0.52, p $$\rho$$ ρ = − 0.14, p = 0.23). Ti was not detected. In the individuals with titanium implants, there was no correlation between implant time in situ and levels of Cr ($$\rho$$ ρ = 0.36, p = 0.12), Co ($$\rho$$ ρ = − 0.12, p = 0.60) or Ti ($$\rho$$ ρ = 0.22, p = 0.35). Conclusion The use of stainless steel and titanium implants in spinal fusion surgery is associated with elevated metal ion concentrations several years after surgery.

Objectives To compare between 3 archwires (AWs) for leveling curve of Spee (COS) in terms of efficacy of reduction, external apical root resorption (EARR), pain experienced, and the lower arch dimensional changes during COS leveling. Trial design Randomized clinical trial. Setting Jordan University of Science and Technology Postgraduate dental clinics. Material and methods Fifty-three subjects with COS > 5 mm were included in this study. The subjects were randomly divided into three groups based on the AW used: group 1, 0.017 × 0.025-inch stainless-steel (SS) AW; group 2, 0.019 × 0.025-inch SS AW; and group 3, 0.021 × 0.025-inch β-titanium (TMA) AW. The intervention was randomly allocated using the permuted random block size of 3 with a 1:1:1 allocation ratio. In the three groups, a 5-mm depth reverse COS was placed in the AWs. The following time points were defined for COS assessment: T1, before interventional leveling AW placement; and T2–T7, 1–6 months after interventional leveling AW placement. Records consisted of dental study models and periapical (PA) radiographs. Pain scores were recorded using visual analogue scale. Patients were followed up on a monthly basis until COS Main outcome measures COS depth reduction, lower incisors’ EARR, pain scores, and arch dimensional changes. Results An overall reduction of 3.82 mm, 4.47 mm, and 3.85 mm of the depth of COS was achieved in groups 1, 2, and 3, respectively. The mean differences of 0.65 mm between groups 1 and 2 and 0.62 mm between groups 2 and 3 were significant at P P > 0.05). Higher pain scores were reported by group 2 subjects during the first 24 h. Arch length and width increased significantly in groups 2 and 3 (P Conclusions All investigated AWs were effective in leveling COS with minimal lower incisors’ EARR ( Clinical relevance The 3 investigated leveling AWs were effective for the leveling COS and at the same time safe on the roots of the lower anterior teeth.

Purpose To assess clinical and safety outcomes associated with different rod materials and diameters in adult spinal deformity (ASD) surgery. Methods A systematic literature review and meta-analysis evaluated ASD surgery using pedicle screw fixation systems with rods of different materials and sizes. Postoperative outcomes (i.e., Cobb, sagittal vertical axis, and pelvic tilt angle) and complications (i.e., pseudarthrosis and rod breakage) were assessed. Random effects models (REMs) pooled data for outcomes reported in ≥ 2 studies. Results Among 50 studies evaluating ASD surgery using pedicle screw fixation systems, 17 described rod material/diameter. Postoperative outcomes did not statistically differ between cobalt–chromium (CoCr) vs. titanium (Ti) rods (n = 2 studies; mean [95% confidence interval (CI)] sagittal vertical axis angle: CoCr 37.00° [18.58°–55.42°] and Ti 32.58° [24.62°–40.54°]; mean [95% CI] pelvic tilt angle: CoCr 26.20° [22.87°–29.53°] and Ti 20.15° [18.0°–22.31°]). The pooled proportion (95% CI) of pseudarthrosis was 15% (7–22%) for CoCr and 12% (− 8–32%) for stainless steel (SS) (n = 2 studies each; Chi2 = 0.07, p = 0.79). The pooled proportion (95% CI) of broken rods was 12% (1–22%) for Ti (n = 3 studies) and 10% (2–19) for CoCr (n = 1 study). Among 6.0–6.35 mm rods, the pooled (95% CI) postoperative Cobb angle (n = 2) was 12.01° (9.75°–14.28°), sagittal vertical axis angle (n = 4) was 35.32° (30.02°–40.62°), and pelvic tilt angle was 21.11° (18.35°–23.86°). Conclusions For ASD patients undergoing posterior fixation and fusion, there are no statistically significant differences in postoperative outcomes or complications among rods of varying materials and diameters. Benchmark postsurgical outcomes and complication rates by rod material and diameter are provided. Level of Evidence III

Objectives To investigate canine retraction (CR) and anchorage loss (AL) among average facial height (AFH) and high facial height subjects (HFH) with or without piezocision surgery (PS). Materials and Methods This was a split-mouth, randomized clinical trial. Twenty-three females (aged 19.05 ± 2.95 years) who presented with Class II division I malocclusion requiring bilateral maxillary extraction and who fulfilled eligibility criteria were included and categorized into two groups: AFH (12 participants) and HFH (11 participants). Atraumatic extractions were performed 10 weeks following bonding. Before space closure, impressions were taken to fabricate models, which were scanned to generate digital models. Each participant had PS on the randomly assigned side. Space closure was undertaken using 100-g nickel-titanium coil closing springs on 0.019 × 0.025-inch stainless steel archwire. Digital models were collected 6 and 12 weeks post-PS. They were superimposed using reliable reference points and a region of interest on the palate, and crown movements were analyzed in three dimensions. Results Three months post-PS, intergroup comparisons showed that rates of CR for control sides (mean = 1.88 ± 0.83 mm for AFH, mean = 1.76 ± 0.62 mm for HFH) and intervention sides (mean = 1.48 ± 0.74 mm for AFH, mean = 1.40 ± 0.85 mm for HFH) were not significantly different. AL was not significantly different (P > .05) between groups. Conclusion Regardless of whether the patient underwent PS, CR and AL rates for AFH and HFH patients were not significantly different.

This overview analyzed the quality of the systematic reviews (SRs) available on treatments for molar-incisor hypomineralization (MIH).Six electronic databases were searched (PubMed/MEDLINE, Scopus, Web of Science, LILACS, Brazilian Bibliography of Dentistry and Cochrane Library) until March 2022. Two reviewers independently performed the selection, the quality assessment (Assessment of Multiple Systematic Reviews 2 - AMSTAR-2), and the risk of bias assessment of the SR (Risk of Bias in Systematic Reviews - ROBIS).Two hundred nine records were retrieved; after removing duplicates and applying the inclusion/exclusion criteria, 5 SRs remained. Three SRs were rated as showing critically low methodological quality and high risk of bias, and two were rated as moderate methodological quality and low risk of bias. The identified treatments that may be suitable for MIH were classified as (1) non-invasive - casein incorporated into toothpaste and sugar-free chewing gum, toothpaste containing arginine, 0.4% stannous fluoride gel; fluoride varnish; (2) micro-invasive - resin sealants for pits and fissures, microabrasion, dental whitening, resin infiltration; (3) invasive - ART restorations, indirect restorations (metal, composite, or ceramic); and (4) mixed intervention - stainless steel crowns.Despite the considerable number of published papers included in this set of systematic reviews, the evidence supporting the effectiveness of treatments for treating MIH is limited due to the methodological quality and risk of bias of the systematic reviews, as well as the quality of the primary studies (PROSPERO: CRD42020144831).Different treatments have been purposed for MIH treatment, but there is still not enough scientific evidence of good quality for the establishment of a definitive clinical protocol for the treatment of MIH.

The aim was to compare the glide path and final preparation times of WaveOne Gold and TruNatomy in conjunction with two different endodontic access cavity designs in extracted human molar teeth.60 extracted human mandibular molars with mesiobuccal canals were selected and randomly divided into two different access cavity design preparation groups (n = 30). Traditional access cavities (TAC) and conservative access cavities (CAC). Within each cavity design group, the 30 teeth were divided in to two instrumentation groups (WaveOne Gold Primary (n = 15) and TruNatomy Prime (n = 15)). Group 1: TAC, #10 stainless steel manual K-file followed by WaveOne Gold Glider and WaveOne Gold Primary. Group 2: CAC, #10 stainless steel manual K-file followed by WaveOne Gold Glider and WaveOne Gold Primary. Group 3: TAC, #10 stainless steel manual K-file followed by TruNatomy Orifice Modifier and Glider and TruNatomy Prime. Group 4: CAC, #10 stainless steel manual K-file followed by TruNatomy Glider and TruNatomy Prime. Glide path and final preparation times were recorded.Shaping time with TruNatomy Glider in combination with TruNatomy Prime instruments were faster compared to the WaveOne Gold Glider/ WaveOne Gold Primary instruments regardless of the type of access cavity preparation. TAC design yielded faster preparation time (38.2 ± 4.57 seconds) compared to the CAC (55.6 ± 6.91 seconds) in the WaveOne Gold Glider/ WaveOne Gold Primary instrumentation group. No difference was found between the different access cavity design groups in combination with TruNatomy Glider/TruNatomy Prime preparation.Preparation time with TruNatomy Glider and Prime instruments was significantly faster than WaveOne Gold Glider/WaveOne Gold Primary, regardless of the access cavity design. TAC design in combination with WaveOne Gold Glider/ WaveOne Gold Primary instrumentation resulted in faster preparation time compared to WaveOne Gold Glider/WaveOne Gold in combination with the CAC design.

The Essure® permanent contraceptive implant, comprised of four alloys (nickel-titanium, 316L stainless steel, platinum-iridium, and tin-silver solder) and Dacron (PET) fibers, has been approved for use in the US for about two decades. However, little has been published on this implant's biomaterials performance, and as this implant gains interest in terms of in vivo performance, methods of implant post-retrieval storage also need to be assessed. This study investigated the electrochemical properties and ion release profile of Essure® during storage in phosphate buffered saline (PBS), 10 mM H

With the awakening of environmental awareness, the importance of air quality to human health and the proper functioning of social mechanisms is becoming increasingly prominent. The low cost and high efficiency of catalytic technique makes it a natural choice for achieving deep air purification. Stainless steel alloys have demonstrated their full potential for application in a variety of catalytic fields. The diversity of 3D networks or fibrous structures increases the turbulence within the heterogeneous catalysis, balance the temperature distribution in the reaction bed and, in combination with a highly thermally conductive skeleton, avoid agglomeration and deactivation of the active components; corrosion resistance and thermal stability are adapted to highly endothermic/exothermic or corrosive reaction environments; oxide layers formed by bulk transition metals activated by thermal treatment or etching can significantly alter the physico-chemical properties between the substrate and active species, further improving the stability of stainless steel catalysts; suitable electronic conductivity can be applied to the electrothermal catalysis, which is expected to provide guidance for the reduction of intermittent emission exhausts and the storage of renewable energy. The current applications of stainless steel as catalyst or support in the air purification have covered soot particle capture and combustion, catalytic oxidation of VOCs, SCR, and air sterilization. This paper summarizes several preparation methods and presents the relationships between the preparation process and the activity, and reviews its application and the current status of research in atmospheric environmental management, proposing the advantages and challenges of the stainless steel-based catalysts.

Objectives. To evaluate the efficacy of computer-aided design/computer-aided manufacturing (CAD/CAM) technology in interventions implemented in orthodontics. Methods. A scoping review of scientific evidence was accomplished, involving different databases. MesH terms and keywords were provided to examine clinical trials (CTs) in all languages. Exclusively CTs that fulfilled the eligibility criteria were admitted. Results. Eight CTs were chosen. These experiments evaluated 542 patients. Four CTs compared the computer-aided indirect bonding method versus the traditional direct bonding of orthodontic brackets. Three CTs compared CAD/CAM retainers with other types of retainers, and one CT compared the CAD/CAM group with multistranded stainless steel wires versus stainless steel wires. Regarding the efficacy of the interventions with CAD/CAM technology used in orthodontics, variable results were found. The indirect bonded customized CAD/CAM brackets presented just a slight effect on the treatment efficacy and therapy results. Two CTs showed that an indirect bonding self-ligating standard system had a similar quality of therapy in comparison with the CAD/CAM customized bracket system. Concerning the clinical failure rate, no differences were presented between the CAD/CAM retainer and other retainers. A CAD/CAM system had more loose brackets than a noncustomized system and was observed also a greater amount of immediate debonding with CAD/CAM indirect bonding than with direct bonding. CAD/CAM fixed retainers revealed inferior relapse and fewer failures than lab-based and conventional chairside retainers. No changes between treatment groups were observed regarding the total therapy time, amount of appointments, and quantity of archwire bends. Conclusions. In general terms, no greater efficacy of CAD/CAM technology was observed over traditional therapies used in orthodontics. However, it was found that gingival inflammation and the accumulation of bacterial plaque and dental calculus were lower when CAD/CAM retainers were used. When comparing interventions that include CAD/CAM systems with conventional therapies, no significant reduction in care times was found.

Even with the exponential popularity of the contemporary clear aligners, the main stream of orthodontic practice still remains to be metal braces especially in adolescent age-group.

Although stainless steel crowns (SSCs) on permanent molars are a common interim full-coverage restoration, there are few clinical studies on longevity.To evaluate the longevity of SSCs as restorations on young permanent first molars (PFMs) that have undergone vital pulp therapy (VPT) treatment and to identify factors associated with SSC treatment failure.This study conducted a retrospective chart review of children who had PFMs that have undergone VPT treatment and been restored with SSCs. Data from treatment and follow-up visits were collected. The Kaplan-Meier survival analysis was used to analyse the longevity of SSCs. A multivariate Cox proportional hazards regression model was used to identify factors associated with SSC treatment failure.Data from 140 SSCs were included, with an average follow-up period of 33.5 ± 21.6 (range, 6-104) months. Although none of the teeth had pulpal failure, 35.7% had SSC treatment failure. The survival probabilities of SSCs declined over time, reaching 39.6% (95% CI 27.0-51.9) after 60 months. The immediate post-operative condition of SSCs and the loss of proximal wall on the abutment tooth were significant factors associated with SSC treatment failure.Stainless steel crowns are suitable for use as interim restorations in PFMs that have undergone VPT treatment in children, but their longevity is limited, necessitating replacement over time.

Background Afghan refugee children resettled in Washington State have the highest prevalence of elevated blood lead levels (BLLs) of any other refugee or immigrant population. Resettled families brought several lead-containing items with them from Afghanistan, including aluminum cookpots. Objectives To evaluate the potential contribution of lead-containing cookpots to elevated BLLs in Afghan children and determine whether safer alternative cookware is available. Methods We screened 40 aluminum cookpots for lead content using an X-ray fluorescence (XRF) analyzer and used a leachate method to estimate the amount of lead that migrates into food. We also tested five stainless steel cookpots to determine whether they would be safer alternatives. Results Many aluminum cookpots contained lead in excess of 100 parts per million (ppm), with a highest detected concentration of 66,374 ppm. Many also leached sufficient lead under simulated cooking and storage conditions to exceed recommended dietary limits. One pressure cooker leached sufficient lead to exceed the childhood limit by 650-fold. In contrast, stainless steel cookpots leached much lower levels of lead. Significance Aluminum cookpots used by refugee families are likely associated with elevated BLLs in local Afghan children. However, this investigation revealed that other U.S. residents, including adults and children, are also at risk of poisoning by lead and other toxic metals from some imported aluminum cookpots. Impact Statement Some aluminum cookware brought from Afghanistan by resettled families as well as cookpots available for purchase in the United States represent a previously unrecognized source of lead exposure.

Finite element models that simulate the effects of class II elastics on the mandibular arch in six different scenarios, using various immobilization methods of the posterior dentition, were studied. Per-element distribution of linear elastic stress-strain and total displacement was computed. Maximum strain on the PDL and maximum stress on alveolar bone increased with posterior tip-back and with the use of archwires vs. aligners. The configuration of the dentition affects the performance of aligners. They perform best on an unlevelled mandibular arch. Applying class II elastics results in vertical side effects that can be modulated by various mandibular stabilization methods. This is likely to be clinically relevant for high-angle patients and may explain the differing effects on the facial profile observed using various treatment modalities. 1-Increasing mandibular molar tip-back generally resulted in less eruption tendencies, with mandibular anchorage preparation resulting in the least amount of calculated vertical displacement. 2-Unexpectedly, with class II forces the use of aligner technology on an unlevelled curve of Spee resulted in improved vertical control when compared to aligner use on a levelled dentition. 3-Generally, using an archwire results in better transmission of stresses to adjacent teeth than the use of aligners. 4-Simulating interarch elastics requires implementing a medial component/orientation of the forces to better emulate clinical situations. 5-A hypothetical configuration: 15

Objectives To evaluate the effect of nitrogen (N)-doped titanium dioxide (TiO2) coated stainless steel brackets activated with natural visible light and dental operating lights on Streptococcus mutans concentration in the plaque of orthodontic patients at 30 and 60 days. Materials and Methods A total of 30 patients were recruited for this split-mouth study; 60 upper lateral incisor brackets constituted the study sample. A total of 30 brackets (15 right and 15 left) were coated with N-doped TiO2 using the (radio frequency) magnetron sputtering method. Plaque samples were collected at 30 days and 60 days after appliance placement. S mutans concentration was evaluated using real-time polymerase chain reaction. Results At both time intervals, the concentration of S mutans in the control group was greater than that in the study group (P = .005). In both the study and the control groups, the S mutans concentrations significantly increased from 30 to 60 days (P = .005). Conclusions N-doped TiO2, on exposure to natural visible light and dental operating light, was effective in reducing the plaque concentration of S mutans in orthodontic patients. The efficacy was better at 30 days than at 60 days after placing the orthodontic appliances.

A laser-induced periodic surface structure (LIPSS) was shown to have antibacterial adhesion properties in previous research. In this study, the antibacterial performance of LIPSS on traditional biometals (stainless steel and titanium alloy) and a potential biometal (zirconium-based bulk metallic glass, Zr-BMG) was investigated. A femtosecond laser was used to fabricate LIPSS on the specimens. Gram-negative

Orthodontic treatment with fixed mechanotherapy using appliances and permanent retainers bonded after treatment is a routine procedure performed in clinical dentistry. Patients with braces or retainers sometimes need to undergo magnetic resonance imaging (MRI) for various reasons. Radiologists do not know the exact impact of the materials used in orthodontics on the diagnostic image quality of MRI scans.The aim of the study was to evaluate the influence of different types of orthodontic brackets and permanent retainers on the diagnostic image quality of MRI scans.Twenty patients with bonded brackets (stainless steel buccal/labial, stainless steel lingual, ceramic self-ligating with metal slots, ceramic, and polycarbonate) and 18 patients with bonded fixed retainers (titanium, fiber-reinforced composite, multi-stranded stainless steel, and different combinations of permanent retainers) participated in the study. The same adhesive was used for bonding. Cranial MRI scans of 6 regions were acquired for each subject, using a 1.5T MAGNETOM machine. Six radiologists evaluated the images and provided scores based on the modified receiver operating characteristic (ROC) analysis of distortion. The paired Wilcoxon signed-rank test was used to assess differences between the materials and the anatomic sites with regard to the distortion rating scale. Cohen's kappa coefficient (κ) was applied to establish the interrater reliability.A statistically significant difference was found between stainless steel brackets (both buccal/ labial and lingual) and all other experimental materials in terms of mean distortion scores (p = 0.020 or p = 0.024). The interrater reliability proved to be high.Stainless steel buccal/labial and lingual brackets caused maximum distortion of the images, which became non-diagnostic; hence, such brackets should be removed before MRI. Ceramic and polycarbonate brackets as well as fiber-reinforced composite retainers did not distort the images; thus, they need not be removed. Ceramic self-ligating brackets with metal slots, titanium retainers, multi-stranded stainless steel retainers, and combinations of fixed retainers caused minimal distortion; however, the images were still diagnostic. Hence, patients using these materials may not need to have them removed before MRI.

Background/Purpose (s): Nosocomial pathogens can develop biofilms on hospital surfaces and medical devices; however, few studies have focused on the evaluation of mono-and dual-species biofilms developed by nosocomial pathogens under different growth conditions. Methods: This study investigated biofilm development by nosocomial pathogens (Acinetobacter baumannii, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa) on biomaterials in different culture media and their components of the extracellular matrix biofilm. Results: The mono-species biofilms showed cell densities from 7.50 to 9.27 Log10 CFU/cm2 on natural rubber latex type I (NLTI) and from 7.58 to 8.79 Log10 CFU/cm2 on stainless steel (SS). Dual-species biofilms consisted of S. aureus + P. aeruginosa (7.87–8.27 Log10 CFU/cm2 in TSBP and TSBME onto SS; p

While acupuncture has been used for thousands of years, modern technology to develop new needle materials has rarely been discussed. We aim to explore a new acupuncture needle material and compare the differences in the needling sensations between the acupuncture needle surface treated with nitrogen applied supercritical fluid (SCF-N) and conventional stainless steel needles.This was a double-blind cohort study. The acupuncture needles were randomly used in this experiment, including the SCF-N-treated needles and the control stainless steel needles. LI 4 (Hegu) and LI 11 (Quchi) acupuncture points in the Yangming Large Intestine Meridian of Hand were treated. Physical electrical resistance, scanning electron microscopy, energy dispersive spectrometry, and visual analog scale (VAS) score including the sensations of soreness, numbness, distention, and heaviness were assessed.The proportion of nitrogen (N) was significantly higher in the SCF-N-treated needles than in the stainless steel needles group (2.3 ± 0.2% vs 0.0 ± 0.0%, P 0.01). The cumulative de-qi sensation score at the LI 4 Hegu acupoint (1.87 ± 1.88 vs 1.54 ± 1.62, P = 0.014), especially the sensation of soreness score (2.76 ± 2.06 vs 2.13 ± 1.85, P = 0.045), revealed statistically significant differences between both groups. SCF-N surface treatment of acupuncture needles may lower the electrical resistance more than the control stainless steel needles (24.67 ± 0.88 kW vs 26.45 ± 0.75 kW, p 0.01).Acupuncture needles modified with SCF-N surface treatment can enhance de-qi sensations to improve electrical conductivity of the meridian and therapeutic effects on the Yangming Large Intestine Meridian of Hand. SCF-N surface treated needles can be as a new acupuncture needle material in the future.

Summary Aim To test the null hypothesis that there was no difference in treatment efficiency between therapies undertaken with conventional (CBs), passive self-ligating (PSLBs) or active self-ligating (ASLBs) brackets. Materials and methods An electronic search was performed in 3 data bases (Pubmed, Web of Science, Cochrane Library) from their origin up to January 2019. Additional references were hand searched. Search was strictly restricted to randomized controlled trials (RCTs) and split-mouth design studies (SMDs). RCTs and SMDs were initially processed separately and subsequently combined in a network meta-analysis. The following variables were evaluated: treatment duration, number of visits, occlusal outcomes, alignment rate, transverse arch dimensional changes, incisor position modification, rate of space closure, anchorage loss, bond failure, root resorption, perception of discomfort during the initial phase of alignment, time to ligate in or to untie an archwire, periodontal variables, quality of life. Results On 229 papers, 30 RCTs and 9 SMDs were finally included in this study. Out of 85 comparisons, 16 only revealed statistically significant differences. It was quicker to untie and ligate an 0.014 NiTi arch from/in 6 ASLBs anterior ceramic brackets compared to 6 ceramic CBs. It was also more painful to insert and remove an 0.019 × 0.025 SS wire in/from PSLB's brackets compared to CB's attachments. Compared to conventional brackets, there was less maxillary incisor proclination with PSLBs in non-extraction cases. Moreover, there was less bleeding on probing 4-5 weeks after bonding with PSLBs compared to CBs brackets. The only significant difference between ASLBs and PSLBs was that alignment was 10 days faster with active self-ligating braces compared with passive self-ligating braces even if treatment duration between ASLBs and PSLBs was not significantly different. The network meta-analysis revealed that IMPA was greater in extractions cases with CBs compared with both ASLBs (+2,5°) and PSLBs (+1,6°). Conclusions The vast majority of the studied variables did not show any significant differences between the three types of brackets. The most significant findings were that it was quicker to insert and remove archwires from ASLBs compared to CBs, and it was more painful to insert and remove an 0.019 × 0.025” stainless steel wire in/from PSLBs compared to CBs. The major difference between ASLBs and PSLBs was that alignment was 10 days faster with active self-ligating braces compared with passive self-ligating braces even if treatment duration between ASLBs and PSLBs was not significantly different. Most of the claims put forward by the suppliers were not substantiated by our network meta-analysis.

Objectives: The aims of this study were to investigate the effect of the working archwire intra-aging on the rate of upper first premolar space closure and to measure frictional resistance during space closure. Methods: A total of 28 subjects participated in this study. All patients were treated by upper first premolar extraction. Subjects were subdivided into 2 groups: non-replacement side: consisted of the right or left sides of the upper arch where space closure was done using the same 0.019 × 0.025-inch SS; replacement side: comprised the other side of the subjects where the working archwire was replaced with a new one each visit. The working archwire in the upper arch was split into 2 halves (new archwire on one side and old one on the other side); each one-half was connected to the other in the midline by a joining shim. Elastomeric chain was used to close extraction spaces. The amount of space closure (mm) was recorded each visit for 3 months. Results: In the non-replacement side, the rate of upper space closure was 0.80 mm/month coronally and 0.75 mm/month gingivally. In the replacement side, it was 0.69 mm/month coronally and 0.67 mm/month gingivally (p > 0.05). Mean frictional force for the non-replacement side was 3.58 ± 1.20 N, and it was 2.43 ± 1.21 N for the replacement side (p < 0.01). Conclusions: Intraoral archwire aging has no effect on the rate of upper premolar space closure/month although frictional resistance of the aged archwire was higher than of the new one. Clinical relevance No need to replace 0.019 × 0.025-inch SS every visit during space closure to overcome corrosion and frictional resistance. The study was supported by the Deanship of Research at Jordan University of Science and Technology (research grant number 53/2019).

Introduction Torque in orthodontics is the activation of the archwire for the third-order movement of teeth. During this force transfer mechanism from the twisted archwire, the bracket is prone to deformation. This study aimed to compare the deformation in tie wings and the slot region of the bracket during torque using finite element analysis. Methods Three-dimensionally modeled 0.017 × 0.025-in and 0.019 × 0.025-in stainless steel (SS) and titanium molybdenum alloy archwires were assembled in 0.018-in and 0.022-in solid modeled SS edgewise brackets, respectively. The finite element model of the bracket-archwire combinations was developed with contact boundary conditions. The deformation between tie wings and the slot was analyzed for various angles of twist. Results For SS archwires at 30° angle of twist, the tie wings deformation in 0.018-in and 0.022-in brackets were 48.67 μm and 34.87 μm, respectively. The slot deformations of 0.018-in and 0.022-in brackets were 66.33 μm and 45.69 μm, respectively. Similarly, the amount of deformation in the bracket—titanium molybdenum alloy archwire combinations were also presented. Conclusions The slot deformation was more than the tie wings deformation as the slot walls bear the immediate torque force. Thus, orthodontic researchers should know that the torque-relevant bracket deformation should ideally be evaluated in the slot region rather than the tie wings.

The purpose was to determine the effect of different environments (artificial saliva, human saliva, distilled water, dry storage) on frictional forces between various tribological systems made from self-ligating brackets in combination with stainless-steel wires (dimensions: 0.016″×0.022″, 0.018″×0.025″ and 0.019″×0.025″). An universal testing-machine applied a normal force of 1 N. Two-way ANOVA and Tukey post-hoc tests (α=5%) were used. Saliva had significantly higher frictional forces (p

Summary Introduction The mechanical properties of orthodontic archwires can be defined using experimental setups incorporating brackets that provide conditions closer to those encountered in vivo. We aimed to compare a methodology based on computer-aided design with the gold standard protocol, performed when brackets are engaged to a full-size archwire to test the behaviour of wires in this condition. Methods Three models simulating a dental arch with an orthodontic fixed appliance (0.018-inch aesthetic conventional brackets) were designed. The brackets were positioned with a stainless-steel full-size wire on the first two models, with different interbracket distances. The setup 3, based on a computer-assisted design, allowed individualized placement of each bracket. Mean forces recorded and standard deviation were compared for a 0.016 × 0.022–inch copper-nickel-titanium wire deflected until 2 mm. Results The inter-bracelet distances do not cause a statistical difference in the average maximum force recorded (12.6 N and 11.4 N; P = 0.081) whereas the behaviour of the wires is affected. With setup 3, the recorded efforts (mean value: 8 N) are statistically lower than with setup 1 and 2 respectively (P = 0.018; P = 0.012). Conclusion An individualization of the housings by CAD-CAM dedicated to each bracket optimizes their placement. In our test conditions, the mechanical behaviour of the wires is more influenced by the positioning methods of the brackets than by the value of the interbracket distance. In perspective, our innovative methodology can be extended to other types of brackets.

Quaternary ammonium salts (QAS) commonly occur as active substances in disinfectants. QAS have the important property of coating abiotic surfaces, which prevents adhesion of microorganisms, thus inhibiting biofilm formation. In this study, a group of nine monomeric QAS, differing in the structure and length of the aliphatic chain (C12, C14, C16) and the counterion (methylcarbonate, acetate, bromide), were investigated. The study included an analysis of their action against planktonic forms as well as bacterial biofilms. The compounds were tested for their anti-adhesion properties on stainless steel, polystyrene, silicone and glass surfaces. Moreover, mutagenicity analysis and evaluation of hemolytic properties were performed. It was found that compounds with 16-carbon hydrophobic chains were the most promising against both planktonic forms and biofilms. Tested surfactants (C12, C14, C16) showed anti-adhesion activity but it was dependent on the type of the surface and strain used. The tested compounds at MIC concentrations did not cause hemolysis of sheep blood cells. The type of counterion was not as significant for the activity of the compound as the length of the hydrophobic aliphatic chain.

Welders are daily exposed to various levels of welding fumes containing several metals. This exposure can lead to an increased risk for different health effects which serves as a driving force to develop new methods that generate less toxic fumes. The aim of this study was to explore the role of released metals for welding particle-induced toxicity and to test the hypothesis that a reduction of Cr(VI) in welding fumes results in less toxicity by comparing the welding fume particles of optimized Cr(VI)-reduced flux-cored wires (FCWs) to standard FCWs. The welding particles were thoroughly characterized, and toxicity (cell viability, DNA damage and inflammation) was assessed following exposure to welding particles as well as their released metal fraction using cultured human bronchial epithelial cells (HBEC-3kt, 5–100 µg/mL) and human monocyte-derived macrophages (THP-1, 10–50 µg/mL). The results showed that all Cr was released as Cr(VI) for welding particles generated using standard FCWs whereas only minor levels (

Minimally invasive dentistry is being used increasingly often, especially in paediatric dentistry. It involves replacing traditional 'drilling and filling' with treatment modalities that are tissue-saving and minimally burdensome to the patient. One of these techniques for treating carious dentine lesions is the Hall technique. A stainless-steel crown is cemented onto the primary molar without the use of anaesthesia or any form of preparation. The molar is 'sealed' under the crown and this stops the carious process in the cavity. Usually, the procedure requires 2 sessions. The Hall technique is well tolerated by children and provides the primary molar with a durable restoration. Together with this technique, the patient is also guided in an individual prevention process. The survival rates of Hall crowns are very high.Minimaal invasieve tandheelkunde wordt steeds meer toegepast, vooral in de kindertandheelkunde. Het traditionele ‘boren en vullen’ wordt hierbij vervangen door behandelmethodes die weefselbesparend zijn en minimaal belastend voor de patiënt. Eén van deze technieken om carieuze dentinecaviteiten te behandelen is de Hall-techniek. Een roestvrij-stalen kroon wordt zonder gebruik van verdoving of enige vorm van preparatie op de tijdelijke molaar gecementeerd. De molaar wordt als het ware ‘gesealed’ onder de kroon en daardoor stopt het cariësproces in de caviteit. Meestal zijn 2 afspraken nodig. De Hall-techniek wordt goed geaccepteerd door kinderen en voorziet de tijdelijke molaar van een duurzame restauratie. Uiteraard wordt bij deze techniek ook de patiënt begeleid in een individueel preventietraject. De overlevingspercentages van Hall-kronen zijn erg hoog.

Summary Introduction This study investigated the effect of the timing of second molar bonding on the time required for the levelling of the mandibular dental arch. Trial design Single-centre two-arm parallel randomized clinical trial using random permuted blocks. Allocation concealment was achieved through sealed envelopes. There was blinding in outcome assessment, but not of patient or operator. Methods Thirty-six patients (12–18 years old) with mild to moderate crowding and fully erupted mandibular second molars were assigned randomly (1:1 ratio) in two groups. Group A started fixed orthodontic treatment by bracket bonding in both jaws. Initial wire was 0.014” NiTi. Lower second molar tubes were bonded at the time of 0.016” x 0.022” NiTi wire placement. Group B was same as Group A, but second lower molars were bonded at the first appointment. Placement of the 0.017” x 0.025” stainless steel wire in the mandibular arch was considered the primary endpoint of the trial, indicating the completion of the levelling phase. The days required from bonding to the endpoint comprised the main outcome. Non-parametric statistics were applied. Results There were two dropouts in each group. The compared groups had similar baseline characteristics regarding age, sex, overjet, overbite, space in the dental arch, average Curve of Spee (CoS), and maximum CoS. Group A tended to require more days for levelling (median: 203 days) than Group B (median: 168 days). However, this difference was not statistically significant (P = 0.128). From the tested occlusal factors, only initial overjet was found to be moderately associated with the days required to complete levelling of the mandibular arch (r = 0.45, P = 0.009). Conclusions In the frame of the current study, the duration of the levelling phase of orthodontic treatment with fixed appliances was not affected by the timing of second molar inclusion in the appliance. Future research could aim in cases with deep CoS to generalize the present findings and in larger sample sizes.

Background: Determine the exact slot dimension of a sample of a MBT prescription stainless steel conventional brackets from different manufacturers to compare the actual values with the nominal ones declared by the manufacturers and to verify the compliance with tolerance limits given by the ISO 27020:2019. Different batches from each manufacturer were evaluated to determine whether or not they are different in size. In addition, the geometry of the slot walls was assessed. Methods: 360 stainless steel preadjusted orthodontic brackets of 12 different manufacturers were assessed. All brackets had a nominal slot size of 0.022 by 0.028 inches, belonged to the right upper central incisor, and were fabricated with the metal injection molding technique (MIM). For each manufacturer, three different manufacturing batches were evaluated. Brackets were coded using a single-blind design. Results: All bracket systems in the study group except one displayed a statistically significant difference with the nominal declared value, although only four of the systems did not comply with the tolerance limits established by the ISO 27020:2019. In most of the systems, the slot height was oversized when compared to the nominal one. A significant interbatch variability was found in most of the evaluated systems. Most of the brackets walls were divergent. Conclusions: The dimensional accuracy of commercially available metal brackets is not guaranteed. The respect for the norm should be enforced as well as the quality controls along the manufacturing process since orthodontic brackets are a precision medical device. Objetivos: Determinar la dimensión exacta del slot de una muestra de brackets convencionales de acero inoxidable recetados MBT de diferentes fabricantes para comparar los valores reales con los nominales declarados por los fabricantes y verificar el cumplimiento de los límites de tolerancia dados por la norma ISO 27020:2019. Se evaluaron diferentes lotes de cada fabricante para determinar si eran o no de tamaño diferente. Además, se evaluó la geometría de las paredes de las ranuras. Métodos: Se evaluaron 360 brackets de ortodoncia preajustados de acero inoxidable de 12 fabricantes diferentes. Todos los brackets tenían un tamaño de ranura nominal de 0.022 por 0.028 pulgadas, pertenecían al incisivo central superior derecho y fueron fabricados con la técnica de moldeo por inyección de metal (MIM). Para cada fabricante se evaluaron tres lotes de fabricación diferentes. Los corchetes se codificaron utilizando un diseño simple ciego. Resultados: Todos los sistemas de brackets del grupo de estudio excepto uno presentaron una diferencia estadísticamente significativa con el valor nominal declarado, aunque solo cuatro de los sistemas no cumplieron con los límites de tolerancia establecidos por la norma ISO 27020:2019. En la mayoría de los sistemas, la altura de la ranura estaba sobredimensionada en comparación con la nominal. Se encontró una importante variabilidad entre lotes en la mayoría de los sistemas evaluados. La mayoría de las paredes de los soportes eran divergentes. Conclusiones: No se garantiza la precisión dimensional de los brackets metálicos disponibles en comercio. Se debe hacer cumplir el respeto a la norma y los controles de calidad a lo largo del proceso de fabricación ya que los brackets de ortodoncia son un dispositivo médico de precisión. Sin financiación 2.151 JCR (2020) Q3, 58/92, Dentistry, Oral Surgery & Medicine 0.620 SJR (2020) Q2, 47/141 Dentistry (miscellaneous) No data IDR (2020) UEV

A 3D printed flexible tactile sensor with graphene-polydimethylsiloxane (PDMS) microspheres for microstructure perception is presented. The structure of the tactile sensor is inspired by the texture of the human finger and is designed to enable the detection of various levels of surface roughness via the processing of tactile signals. The tactile sensor with a unique graphene-PDMS microsphere structure shows excellent comprehensive mechanical properties, including a robust stretching ability (elongation at break of the sensing layer is 70%), excellent sensing ability (short response time of 60 ms), high sensitivity (sensitivity up to 2.4 kPa-1), and cycle stability (over 2000 loading cycles). In addition, such versatility and sensitivity allow the electronic skin not only to accurately monitor pressure but also to distinguish various surface topographies with microscale differences, and to detect the action of an air fluid.

Summary Objective The present study was performed to affirm surface characterization, as well as to compare the effect of coating of stainless-steel (SS) orthodontic brackets and wires by nanoparticles Chitosan (CTS) or Zinc oxide (ZnO) during friction. Material and methods Seventy SS brackets for the upper right central incisors with a 0.022–inch system and seventy 0.019 × 0.025-inch SS rectangular wires, with and without ZnO and CTS nanoparticle coating, were used. Coating was analysed by SEM. A universal testing machine was used to calculate the friction between the wires and brackets. Statistical analysis was performed using one-way ANOVA and Tukey's tests. Results Significant differences were detected between coated and uncoated wires and brackets for friction with either ZnO or CTS nanoparticles. The mean values of the wires and brackets coated with ZnO and CTS nanoparticles were 0.64 ± 0.24 N and 0.85 ± 0.23 N, respectively, while they were 1.79 ± 0.61 N for the uncoated group. In addition, there was a significant decrease of about 64% and 53% found after coating with ZnO and CTS nanoparticles, respectively. The results of CTS nanoparticle coating were consistent with those of ZnO nanoparticles. Conclusions Friction force decreased significantly after coating of CTS or ZnO nanoparticles. These nanoparticles provide an opportunity to reduce friction during tooth movement, resulting in better anchorage control, reduced treatment time and risk of root resorption.

This study aimed to evaluate the performance of accelerated hydrogen peroxide® wipes (HPW) for decontamination of the chimpanzee adenovirus AZD1222 vaccine strain used in the production of recombinant COVID-19 vaccine in a pharmaceutical industry. Two matrices were tested on stainless-steel (SS) and low-density-polyethylene (LDP) surfaces: formulated recombinant COVID-19 vaccine (FCV) and active pharmaceutical ingredient (API). The samples were spiked, dried and the initial inoculum, possible residue effect (RE) and titre reduction after disinfection with HPW were determined. No RE was observed. The disinfection procedure with HPW resulted in complete decontamination the of AZD1222 adenovirus strain in FCV (≥7·46 and ≥7·49 log10 infectious unit [IFU] ml−1 for SS and LDP carriers respectively) and API (≥8·79 and ≥8·78 log10 IFU ml−1 for SS and LDP carriers respectively). In conclusion, virucidal activity of HPW was satisfactory against the AZD1222 adenovirus strain and can be a good option for disinfection processes of SS and LPD surfaces in pharmaceutical industry facilities during recombinant COVID-19 vaccine production. This procedure is simple and can be also applied on safety unit cabins and sampling bags made of LDP as well.

Background The influence of thread profile on the fixation stability of bone screws remains unclear. This study aimed to compare the fixation stability of screws with different thread profiles under several loading conditions. Methods Bone screws that differed in thread profile (buttress, triangle, and square thread) only were made of stainless steel. Their fixation stabilities were evaluated individually by the axial pullout test and lateral migration test, besides, they were also evaluated in pairs together with a dynamic compression plate and a locking plate in polyurethane foam blocks under cyclic craniocaudal and torsional loadings. Results The triangle-threaded and square-threaded screws had the highest pullout forces and lateral migration resistance. When being applied to a dynamic compression plate, higher forces and more cycles were required for both triangle- and square-threaded screws to reach the same displacement under cyclic craniocaudal loading. On the other hand, the triangle-threaded screws required a higher torque and more cycles to reach the same angular displacement under cyclic torsional loading. When being applied to a locking plate, the square-threaded screws needed higher load, torque, and more cycles to reach the same displacement under both cyclic craniocaudal and torsion loadings. Conclusions The triangle-threaded screws had superior pullout strength, while square-threaded screws demonstrated the highest lateral migration resistance. Moreover, dynamic compression plate fixation with triangle- and square-threaded screws achieved more favorable fixation stability under craniocaudal loading, while triangle-threaded screws demonstrated superior fixation stability under torsional loading. Locking plate fixation with a square-threaded screw achieved better fixation stability under both loading types.

Aims This study aimed to determine the extent of Phi6 (Φ6) transfer between skin and surfaces relevant to consumer-facing environments based on inoculum matrix, surface type and contact time. Methods and Results Φ6 transfer rates were determined from skin-to-fomite and fomite-to-skin influenced by inoculum matrix (artificial saliva and tripartite), surface type (aluminium, plastic, stainless steel, touchscreen, vinyl and wood) and contact time (5 and 10 s). Significant differences in estimated means were observed based on surface type (both transfer directions), inoculum matrix (skin-to-fomite) and contact time (both transfer directions). During a sequential transfer experiment from fomite-to-skin, the maximum number of consecutive transfer events observed was 3.33 ± 1.19, 2.33 ± 1.20 and 1.67 ± 1.21 for plastic, touchscreen and vinyl, respectively. Conclusions Contact time significantly impacted Φ6 transfer rates, which may be attributed to skin absorption dynamics. Surface type should be considered for assessing Φ6 transfer rates. Significance and Impact of the Study Although the persistence of Φ6 on fomites has been characterized, limited data are available regarding the transfer of Φ6 among skin and fomites. Determining Φ6 transfer rates for surfaces in consumer-facing environments based on these factors is needed to better inform future virus transmission mitigation strategies.

To analyze the effects of various fluoride agents on metallic orthodontic materials.PubMed, Google Scholar, and Embase were searched using keyword combinations such as fluoride mouthwash and orthodontic appliance and corrosion, fluoride and fixed appliance, and metal degradation.Of 315 articles, 20 were selected for inclusion in the review. All types of fluoride agents, especially the acidulated form of fluoride, seemed to influence the corrosion of orthodontic metallic appliances.Since most of the studies reported suggest that fluoride ions are capable of causing corrosion of metallic orthodontic appliances, attention should be paid while prescribing fluoride agents for orthodontic patients. The degree of corrosion seems to be directly correlated with the acidity of the medium and the concentration of fluoride ions. Co-Cr brackets are resistant to corrosion by fluoride while stainless steel and Ti brackets are susceptible.It allows making the right choice while choosing the orthodontic brackets in relation to their susceptibility to corrosion by fluoride ions.

Determination of difference between conventional and passive self-ligating brackets (SLBs) in respect of extraction space closure, patient perception and root resorption.Eighty patients were divided into four groups of 20 each with age-sex-matched control using a simple randomisation technique and allocation concealment with a closed opaque envelope method. Group 1 consisted of conventional brackets with Connecticut New Archwire (CNA) wire mushroom loop, group 2 consisted of conventional brackets with TAD (AbsoAnchor, Korea) supported retraction, group 3 consisted of passive SLB with CNA archwires (Libral Traders, India) mushroom loop and group 4 consisted of passive SLB brackets with TAD (AbsoAnchor, Korea) supported retraction. The rate of retraction, root resorption and patient satisfaction were assessed. All conventional brackets (Orthox, USA) and passive SLBs (CaptainOrtho, India) had 0.018 Roth prescriptions with a slot size of 0.018 × 0.025.Retraction was the fastest in group 2 with a mean of 1.266 ± 0.14 mm/4 week and a duration of 23.40 weeks. Similarly, group 4 showed the most sluggish movement with a mean of 1.182 ± 0.80 mm/4 weeks with a total duration of 25 weeks; howeverdifferencesce among groups were not statistically significant (P = 0.470).SLBs have advantage of better patient comfort, less pain and reduced chairside time. Though the present study found increased treatment duration with SLB along with friction mechanics, refuting the previous claims of reduced friction with SLBs, however, the difference was not statistically significant and results have to be extrapolated with caution and experience considering other advantages of SLBs.

Most studies on surface persistence of SARS-CoV-2 have been conducted at temperatures between 20°C and 30°C. There is limited data on the survival of SARS-CoV-2 at low temperatures. In this study, the stability of SARS-CoV-2 Alpha and Delta variants on stainless steel was investigated at two temperatures (4°C and 24°C). The results show that both variants decayed more rapidly at 24°C compared with 4°C. At 24°C, Alpha and Delta variants showed reductions of 0.33 log

Background Before the magnetic resonance imaging (MRI) examination fixed orthodontic devices, such as brackets and wires, cause challenges not only for the orthodontist but also for the radiologist. Essentially, the MRI-safe scan of the fixed orthodontic tools requires a proper guideline in clinical practice. Therefore, this systematic review aimed to examine all aspects of MRI-safe scan, including artifact, thermal, and debonding effects, to identify any existing gaps in knowledge in this regard and develop an evidence-based protocol. Methods The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement was used in this study. The clinical question in “PIO” format was: “Does MRI examination influence the temperature of the orthodontic devices, the size of artifacts, and the debonding force in patients who have fixed orthodontic bracket and/or wire?” The search process was carried out in PubMed, PubMed Central, Scopus, and Google Scholar databases. The search resulted in 1310 articles. After selection according to the eligibility criteria, 18 studies were analyzed by two reviewers. The risk of bias was determined using the Quality In Prognosis Studies tool. Results Out of the eligible 18 studies, 10 articles examined the heating effect, 6 were about the debonding effect, and 11 measured the size of artifact regarding brackets and wires. Considering the quality assessment, the overall levels of evidence were high and medium. The published studies showed that heating and debonding effects during MRI exposure were not hazardous for patients. As some wires revealed higher temperature changes, it is suggested to remove the wire or insert a spacer between the appliances and the oral mucosa. Based on the material, ceramic and plastic brackets caused no relevant artifact and were MRI-safe. Stainless steel brackets and wires resulted in susceptibility artifacts in the orofacial region and could cause distortion in the frontal lobe, orbits, and pituitary gland. The retainer wires showed no relevant artifact. Conclusions In conclusion, the thermal and debonding effects of the fixed orthodontic brackets and wires were irrelevant or resoluble; however, the size of the artifacts was clinically relevant and determined most significantly the feasibility of fixed brackets and wires in MRI examination.

Additive manufacturing (AM) is an emerging method for the fabrication of stents, which is cost-saving and capable of producing personalised stent designs. However, poor surface finish and dimension discrepancy in the manufactured stents can significantly affect not only their own mechanical behavior but also mechanical response of arteries. This study investigates the effects of surface irregularities and dimension discrepancy of a 316L stainless steel stent, manufactured using laser powder bed fusion (LPBF), on its biomechanical performance, in comparison with the original design and a commercial stent. In silico simulations of stent deployment in a patient-specific coronary artery, based on intravital optical coherency tomography imaging, are conducted to assess the stent deformation as well as arterial stress and damage. Severe plastic strain concentrations (with a maximum value of 1.93) occur in the LPBF stent after deployment due to surface irregularities, suggesting a high risk of stent fracture. The LPBF stent is harder to expand due to its thicker struts and closed-cell design (diameter of 4.14 mm at the peak inflating pressure during deployment, compared to 4.58 mm and 4.65 mm for the designed and MULTI-LINK RX ULTRA stents, respectively). Also, the LPBF stent induces a higher level of stress concentration (with a maximum value of 23.04 MPa) to the arterial layers, suggesting a higher risk of tissue damage and in-stent restenosis. This study demonstrates a clear need for further development of the AM process for manufacturing medical implants, especially the surface finish and dimension accuracy.

Objective: The purpose of this study was to evaluate the effect of different crown materials on the interleukinone beta (IL-1β) content of the gingival crevicular fluid and to study which crown material causes the highest inflammation on the marginal gingiva on a biochemical basis in pediatric patients. Study design: Twenty patients in the age group of 4-8 years with endodontically treated primary molars indicated for crown placement were selected for the study which was further divided into 3 groups for sample consideration: group 1-stainless steel crown, group 2-preformed zirconia crown, and group 3- control group (primary second molar). All assay procedures were carried out and the results of the collected samples were calculated using the ELISA-AID TM technique. Results: On mean comparison among the groups using ANOVA oneway test, P-value turns out to be highly significant, on mean comparison using Tukey’s HSD post–hoc test, The p-value was 0.000 ,0.000 ,0.193 on comparing group 1 with group 2, group 1 with group 3, group 2 with group 3 respectively. Conclusion: Preformed zirconia crown can be a relative replacement of SSC in primary molars as it causes comparatively less inflammation and with an advantage of esthetics.