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5 results on '"Raffaldi I"'

1. Complications and risk factors for severe outcome in children with measles

Author

Lo Vecchio, A, Krzysztofiak, A, Montagnani, C, Valentini, Piero, Rossi, N, Garazzino, S, Raffaldi, I, Di Gangi, M, Esposito, S, Vecchi, B, Melzi, Ml, Lanari, M, Zavarise, G, Bosis, S, Valenzise, M, Cazzato, S, Sacco, Monica, Govoni, Mr, Mozzo, E, Cambriglia, Md, Bruzzese, E, Di Camillo, C, Pata, Davide, Graziosi, A, Sala, D, Magurano, F, Villani, A, Guarino, A, Galli, L, SITIP Measles Study, Group., Lo Vecchio, A, Krzysztofiak, A, Montagnani, C, Valentini, P, Rossi, N, Garazzino, S, Raffaldi, I, Di Gangi, M, Esposito, S, Vecchi, B, Melzi, Ml, Lanari, M, Zavarise, G, Bosis, S, Valenzise, M, Cazzato, S, Sacco, M, Govoni, Mr, Mozzo, E, Cambriglia, Md, Bruzzese, E, Di Camillo, C, Pata, D, Graziosi, A, Sala, D, Magurano, F, Villani, A, Guarino, A, Galli, L, Lo Vecchio, Andrea, Krzysztofiak, Andrzej, Montagnani, Carlotta, Valentini, Piero, Rossi, Nadia, Garazzino, Silvia, Raffaldi, Irene, Di Gangi, Maria, Esposito, Susanna, Vecchi, Barbara, Melzi, Maria Luisa, Lanari, Marcello, Zavarise, Giorgio, Bosis, Samantha, Valenzise, Mariella, Cazzato, Salvatore, Sacco, Michele, Govoni, Maria Rita, Mozzo, Elena, Cambriglia, Maria Donata, Bruzzese, Eugenia, Di Camillo, Chiara, Pata, Davide, Graziosi, Alessandro, Sala, Debora, Magurano, Fabio, Villani, Alberto, Guarino, Alfredo, and Galli, Luisa

Subjects
Male, Pediatrics, medicine.medical_specialty, Neutropenia, genotype, severe outcome, complication, Intensive Care Units, Pediatric, Measles, Severity of Illness Index, children, measles, Risk Factors, Intensive care, medicine, measle, Humans, Viral, Encephalitis, Viral, Preschool, Child, Pediatric, biology, Receiver operating characteristic, business.industry, C-reactive protein, Child, Preschool, Female, Infant, Italy, Measles virus, Pancreatitis, ROC Curve, Retrospective cohort study, medicine.disease, Settore MED/38, Intensive Care Units, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Pediatrics, Perinatology and Child Health, biology.protein, Encephalitis, Complication, business
Abstract

Objective and designRisk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.ResultsNineteen hospitals enrolled 249 children (median age 14.5 months): 207 (83%) children developed a complication and 3 (1%) died. Neutropaenia was more commonly reported in children with B3-genotype compared with other genotypes (29.5% vs 7.7%, p=0.01). Pancreatitis (adjusted OR [aOR] 9.19, p=0.01) and encephalitis (aOR 7.02, p=0.04) were related to severe outcome in multivariable analysis, as well as C reactive protein (CRP) (aOR 1.1, p=0.028), the increase of which predicted severe outcome (area under the receiver operating characteristic curve 0.67, 95% CI 0.52 to 0.82). CRP values >2 mg/dL were related to higher risk of complications (OR 2.0, 95% CI 1.15 to 3.7, p=0.01) or severe outcome (OR 4.13, 95% CI 1.43 to 11.8, pConclusionThe risk of severe outcome in measles is independent of age and underlying conditions, but is related to the development of organ complications and may be predicted by CRP value.

Published
2018

2. Recommendations for pediatric tuberculosis vaccination in Italy

Author

Montagnani, C, Esposito, S, Galli, L, Chiappini, E, Principi, N, de Martino, M, Bosis, S, Tagliabue, C, Senatore, L, Ascolese, B, Villani, A, Lancella, L, Cursi, L, Grandin, A, Marabotto, C, Ciofi, D, Festini, F, Anziati, M, Becciani, S, Remaschi, G, Sollai, S, Tersigni, C, Venturini, E, Guarino, A, Lo Vecchio, A, Scotto, R, Gabiano, C, Garazzino, S, Le Serre, D, Raffaldi, I, Bernardi, F, Bertazzoni, E, Blasi, F, Bocchino, M, Assante, L, Castagnola, E, Losurdo, G, Codecasa, L, Di Mauro, G, Faccini, M, Marseglia, G, Mascolo, A, Di Comite, A, Stronati, M, Matteelli, A, Migliori, Gb, D’Ambrosio, L, Centis, R, Pasinato, Cirillo, Tortoli, Russo, Scaglione, F, Scala, E, and Tomà, P

Subjects
Pediatrics, medicine.medical_specialty, Tuberculosis, Immunology, Breastfeeding, Tuberculin, Reviews, Disease, Tuberculous meningitis, 03 medical and health sciences, 0302 clinical medicine, children, prevention, BCG, tuberculosis, vaccination, vaccine, 030225 pediatrics, medicine, Immunology and Allergy, Humans, 030212 general & internal medicine, Immunization Schedule, Pharmacology, business.industry, medicine.disease, Settore MED/38, Pediatric tuberculosis, Vaccination, Italy, BCG Vaccine, business, BCG vaccine
Abstract

Bacillus Calmette-Guerin (BCG) vaccine is still the only vaccine approved for the prevention of tuberculosis (TB), and is widely used in highly endemic countries, where all newborns receive a single intradermal dose immediately after birth; however, the recommendations concerning its use in Europe vary widely from country to country. This document describes the recommendations of a group of Italian scientific societies concerning its pediatric use in Italy, the persistence of the protection it provides, its safety, its interference with tuberculin skin test (TST) responses, and the children who should be vaccinated. The experts conclude that BCG vaccination provides a good level of protection against tuberculous meningitis and disseminated forms, and a fair level of protection against pulmonary disease; the protective effective lasts at least 10 years, and revaccination offers no advantages over a single administration. The vaccine is safe in immunocompetent subjects, and affects the response to a TST for at least 6 y On the basis of these observations, we recommend its use in Italy in all TST-negative immunocompetent newborns and breastfeeding infants aged

Published
2015

3. Drug use and upper gastrointestinal complications in children: A case-control study

Author

Bianciotto, M, Chiappini, E, Raffaldi, I, Gabiano, C, Tovo, P, Sollai, S, De Martino, M, Mannelli, F, Tipo, V, Da Cas, R, Traversa, G, Mores, Nadia, Romagnoli, Costantino, Chiaretti, Antonio, Bersani, Giulia, De Nisco, Alessia, Riccardi, Riccardo, Italian, Multicenter Study Group For Drug And Vaccine Safety In Children, Bianciotto, M, Chiappini, E, Raffaldi, I, Gabiano, C, Tovo, Pa, Sollai, S, de Martino, M, Mannelli, F, Tipo, V, Da Cas, R, Traversa, G, Menniti Ippolito, F, Capuano, Annalisa, and Rafaniello, Concetta

Subjects
Male, Pediatrics, Gastrointestinal Diseases, Anti-Inflammatory Agents, Logistic regression, THERAPY, Upper Gastrointestinal Tract, Adrenal Cortex Hormones, PEPTIC-ULCER DISEASE, gastrointestinal complications, drug use, adverse events, case-control study, Medicine, Prospective Studies, Prospective cohort study, Child, media_common, RISK, Anti-Inflammatory Agents, Non-Steroidal, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, ASSOCIATION, Anti-Bacterial Agents, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Italy, Child, Preschool, ANTIBIOTIC-ASSOCIATED HYPOPROTHROMBINEMIA, SAFETY, Population study, Female, medicine.symptom, Non-Steroidal, Drug, medicine.medical_specialty, Settore BIO/14 - FARMACOLOGIA, media_common.quotation_subject, TOLERABILITY, IBUPROFEN, Drug Therapy, Melena, Humans, Adverse effect, Preschool, Acetaminophen, business.industry, Case-control study, Infant, Logistic Models, Concomitant, Case-Control Studies, Pediatrics, Perinatology and Child Health, business
Abstract

Objective: To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population. Methods: This study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emergency departments of eight clinical centres. Patients admitted for UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis or melena) comprised the case series; children hospitalised for neurological disorders formed the control group. Information on drug and vaccine exposure was collected through parental interview during the children's hospitalisation. Logistic regression was used to estimate ORs for the occurrence of UGIC associated with drug use adjusted for age, clinical centre and concomitant use of any drug. Results: 486 children hospitalised for UGIC and 1930 for neurological disorders were enrolled between November 1999 and November 2010. Drug use was higher in cases than in controls (73% vs 54%; p

Published
2013

4. Medical care related laboratory-confirmed bloodstream infections in paediatrics

Author

Virano, S, Scolfaro, C, Garazzino, S, De Intinis, C, Ghisetti, V, Raffaldi, I, Calitri, C, Tovo, Pa, Regina Margherita Children’s Hospital Bloodstream Infections Study Group including Plazzotta, C, Zotti, Cm, Neve, V, Conio, A, Vitale, P, Giacchino, M, Bertin, D, Carraro, F, Le Serre, D, Iannandrea, S, Grassitelli, Sm, Luccoli, L, Esposito, I, Ragazzi, P, Carlino, C, Porcellini, Mg, Bonaudo, R, Calvo, Pl, Baldi, M, Laudati, R, Ferraris, S, Aidala, E, Valori, A, Banaudi, E, Riggi, C, Bertino, E, Coscia, A, Di Nicola, P, Cavecchia, I, Cerchio, R, Bosetti, Fm, Bianciotto, M, Farina, D, and Manzoni, P

Subjects
Male, Methicillin-Resistant Staphylococcus aureus, Staphylococcus aureus, Drug Resistance, Anti-Bacterial Agents, Bacteremia, Child, Child, Preschool, Cross Infection, Drug Resistance, Multiple, Bacterial, Female, Hospitals, Pediatric, Hospitals, Teaching, Humans, Incidence, Infant, Infant, Newborn, Intensive Care Units, Pediatric, Italy, Prospective Studies, Risk Factors, Staphylococcal Infections, Pediatrics, Preschool, Pediatric, Teaching, Bacterial, Newborn, Hospitals, Intensive Care Units, Multiple
Abstract

The aim of this survey was to describe the incidence, epidemiology, microbiology, risk factors and outcome of medical care related laboratory-confirmed bloodstream infections (LCBIs) observed during a twelve-month prospective study in a Paediatric Teaching Hospital in Turin, Italy. Inclusion criteria were clinical signs of sepsis and positivity of one or more of the following tests: blood culture, polymerase chain reaction for bacterial and fungal DNA on blood, and culture on intravascular device tips. In all, 140 episodes of sepsis were documented in 131 children: 37 (26.4%) were healthcare outpatient-associated, 91 (65.0%) healthcare-associated and 12 (8.6%) community-acquired. The overall incidence of healthcare-associated LCBIs was 13.6/1,000 hospitalized patients and incidence density 1.4/1,000 inpatient days. The overall mortality was 3.9%. Forty-seven (36.7%) episodes involved newborns and 107 (83.6%) episodes were observed in children with an indwelling central venous catheter. Coagulase-negative staphylococci (26.8%), Staphylococcus aureus (15.2%), Escherichia coli (8.7%) and Candida spp. (7.2%) were responsible for the majority of cases. 9.5% of S. aureus isolates were methicillin-resistant and 6.5% of Gram negatives were extended-spectrum beta-lactamase-producing. Incidence and epidemiology of medical care related LCBIs were similar to the existing literature data. LCBIs caused by antibiotic-resistant microorganisms were fewer and mortality rate was lower. Most of the LCBIs recorded involved newborns and oncological children.

Published
2015

5. Indications to Hospital Admission and Isolation of Children With Possible or Defined Tuberculosis: Systematic Review and Proposed Recommendations for Pediatric Patients Living in Developed Countries. [Corrected]

Author

Susanna Esposito, Silvia Garazzino, Marialuisa Bocchino, Alfredo Guarino, Clara Gabiano, L.R. Assante, Laura Lancella, Andrea Lo Vecchio, Alberto Villani, Irene Raffaldi, Riccardo Scotto, Lo Vecchio, A., Bocchino, M., Lancella, L., Gabiano, C., Garazzino, S., Scotto, R., Raffaldi, I., Assante, L. R., Villani, A., Esposito, S., and Guarino, A.

Subjects
Developed Countrie, Male, medicine.medical_specialty, Pediatrics, Tuberculosis, Isolation (health care), Tuberculosi, MEDLINE, HIV Infections, Child Nutrition Disorders, Patient Isolation, Immunocompromised Host, Child Nutrition Disorder, Risk Factors, Epidemiology, Drug Resistance, Bacterial, medicine, Humans, Age Factor, HIV Infection, Glasgow Coma Scale, Intensive care medicine, Infection Control, business.industry, Medicine (all), Risk Factor, Developed Countries, Age Factors, Infant, Newborn, Infant, General Medicine, medicine.disease, Settore MED/38, Hospitalization, Malnutrition, Systematic review, Meta-analysis, Child, Preschool, Practice Guidelines as Topic, Observational study, Female, business, Systematic Review and Meta-Analysis, Research Article, Human
Abstract

Tuberculosis (TB) is a re-emerging health problem in developed countries. This paper is part of large guidelines on the global management of TB in children, by a group of scientific societies. It describes the indications to hospitalization of children with suspected or diagnosed TB, the isolation measures, hospital discharge, and re-admission into the community. Using the Consensus Conference method, relevant publications in English were identified by means of a systematic review of MEDLINE and the Cochrane Database of Systematic Reviews from their inception until 31 December 2014. Available data on indications to hospitalization were mainly indirect and largely derived from observational studies. They include: (1) host-related risk factors, the main being age

Published
2015

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