1. Lower limb strength training (LLST) modulates serum and urinary levels of renin angiotensin system molecules in healthy young males.
- Author
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Salviano de Faria, Marcelo Henrique, Nunes-Silva, Albená, Marcucci-Barbosa, Lucas Soares, Barroso, Lucélia Scarabeli Silva, de Barros, João Luís Vieira Monteiro, Kakehasi, Adriana Maria, Vieira, Erica Leandro Marciano, and Simões e Silva, Ana Cristina
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RENIN-angiotensin system , *STRENGTH training , *ANGIOTENSIN converting enzyme , *ANGIOTENSIN II , *MOLECULES , *LEAN body mass - Abstract
Purpose: We investigated lower limb strength training (LLST)'s effect on the levels of renin angiotensin system (RAS) molecules in urine and serum. Methods: Twelve male volunteers with 23.4 ± 2.7 years old performed our LLST protocol for 10 weeks. The effect of LLST was evaluated based on urine and serum levels of RAS molecules, including Angiotensin II, Ang-(1–7), angiotensin converting enzyme ACE 1 and ACE 2, before and immediately after the first (S1) and the last (S30) training sessions. Results: The training protocol significantly reduced the percentage of fat and increased the total lean mass. Serum and urinary levels of Ang II were higher after the last session in comparison to levels before this session as well as if compared to values after the first exercise session. Levels of Ang-(1–7) significantly increased in serum and urine after first and last sessions and in the comparison to values before and after last session to those before and after first session, respectively. Levels of ACE1 and ACE2 did not modify in any condition. In addition, LLST seems to chronically shift the balance between both RAS axes toward the alternative axis based on the analysis of Ang-(1–7)/Ang II ratio. Conclusion: LLST acutely and chronically modified serum and urinary concentrations of Ang II and Ang-(1–7). [ABSTRACT FROM AUTHOR]
- Published
- 2022
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