Search

卡瑞利珠单抗是一种免疫检查点抑制剂，可造成严重的心脏损害。该文报道1例乳腺癌骨转移患者在应用卡瑞利珠单抗的基础上联合应用红豆杉后发生三度房室传导阻滞、心肌炎及左心室收缩功能下降。通过追踪患者的临床症状、肌钙蛋白、B型利钠肽、心电图及超声心动图的变化，诊断、评价病情变化。最终该患者接受了永久心脏起搏器植入及糖皮质激素治疗，随访3个月左心功能未见明显改善。免疫抑制剂的应用越来越广泛，我们应对其相关的心血管不良反应给予重视，此类患者的治疗方案有待进一步探索。.

肺乳头状腺瘤是肺部罕见的良性肿瘤，该文报道1例。患者女，56岁。镜下观察肿瘤细胞由具有血管轴心的真性乳头构成，细胞大小一致，核圆形或卵圆形，染色质细腻，可见核仁，细胞异型性不明显，未见核分裂象及坏死。免疫组织化学表达细胞角蛋白（CK）7、甲状腺转录因子1（TTF1）、Napsin A，不表达CK20、CK5/6、p63、p40和p53，Ki-67阳性指数很低。肺乳头状腺瘤的诊断依赖病理组织学，其形态学特点极易误诊，需与肺乳头状腺癌及转移性甲状腺乳头状癌等肿瘤鉴别，临床予局部手术切除治疗。.

The incidence and mortality rate of leukemia in the cancer registration areas of Zhejiang Province from 2010 to 2014 were analyzed to depict their epidemiological characteristics. From 2010 to 2014, 3789 new cases were diagnosed as leukemia in Zhejiang cancer registration areas, with a crude incidence rate of 6.47 per 100 000. The age-standardized incidence rate of males (standardized by China census data 2000) was 1.35 times that of females. The age-standardized incidence rate of urban areas was similar to that in rural areas (1.04∶1). From 2010 to 2014, 2 568 cases died due to leukemia, with a crude mortality rate of 4.38 per 100 000. The age-standardized mortality rate of males was 1.44 times that of females. The age-standardized mortality rate of urban areas was 0.99 times that of rural areas. The age-standardized incidence and mortality rate did not show any significant change from 2010 to 2014. The annual percent change of these two metrics was -2.36% (分析2010—2014年浙江省肿瘤登记地区的白血病发病和死亡数据，描述其流行特征。2010—2014年浙江省肿瘤登记地区共报告白血病新发病例数为3 789例，发病率为6.47/10万，采用2000年中国标准人口标化（中标率）后，男性中标率为女性的1.35倍，城市中标率为农村的1.04倍；共报告白血病死亡病例数为2 568例，死亡率为4.38/10万，男性中标率为女性的1.44倍，城市中标率为农村的0.99倍。2010—2014年白血病发病率、死亡率变化趋势均较为平稳[APC（95

From 2010 to 2014, a total of 17 150 new cases of thyroid cancer (TC) reported in cancer registration areas of Zhejiang province, the crude incidence rate of TC was 29.28/100 000. Using the Chinese Census in 2000 and the World Segi's population as the standard population, the age-standardized incidence rate by Chinese standard population (ASIRC) and by world standard population (ASIRW) were 24.11/100 000 and 20.65/100 000 respectively. 256 TC death cases reported in all, the crude mortality rate was 0.44/100 000, the age-standardized mortality rate by Chinese standard population (ASMRC) and by World standard population (ASMRW) were 0.23/100 000 and 0.23/100 000 respectively. The ASIRC had a upward trend [annual percent change (APC)=28.62%, 952010—2014年浙江省肿瘤登记地区共报告甲状腺癌发病病例17 150例，发病率为29.28/10万，采用2000年中国标准人口和Segi′s世界标准人口的标化率（中标率和世标率）分别为24.11/10万和20.65/10万；共报告甲状腺癌死亡病例256例，死亡率为0.44/10万，中标率为0.23/10万，世标率为0.23/10万。中标发病率呈逐年上升趋势（APC=28.62%，95