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1. Prevalence and Outcomes of Congenital Heart Disease in Very Low Birth Weight Preterm Infants: An Observational Study From the Brazilian Neonatal Network Database

Author

Fernanda P. G. Melo, Daniela Anderson, Carolina Boschi Gimenes, Rita de Cássia dos Santos Silveira, Manoel A. S. Ribeiro, João H. C. L. Almeida, Daniela Testoni, Vera Lúcia Jornada Krebs, José M. S. Alves, Márcia Gomes Penido, Patrícia Franco Marques, Jamil Pedro de Siqueira Caldas, Nathalia Moura de Mello e Silva, Ligia Maria Suppo de Souza Rugolo, Walusa Assad Gonçalves-Ferri, José L. M. B. Duarte, Gabriela Nunes Leal, Daniela Marques de Lima Mota Ferreira, Fabio Carmona, Paulyne Stadler Venzon, Juliana Paula Ferraz dos Santos, Jucille do Amaral Meneses, Paulo Henrique Manso, Davi Casale Aragon, Karen M. K. Sakano, Universidade de São Paulo (USP), Universidade Estadual de Campinas (UNICAMP), Fundacao Oswaldo Cruz, Pontificia Univ Catolica Rio Grande do Sul, Univ Fed Rio Grande do Sul, Universidade do Estado do Rio de Janeiro (UERJ), Universidade Federal de Minas Gerais (UFMG), Universidade Federal de Uberlândia (UFU), Maternidade Escola Hilda Brandao, Hosp Estadual Sumare, Hosp Geral Pirajussara, Hosp Estadual Diadema, Universidade Estadual de Londrina (UEL), Univ Fed Parana, Inst Med Integral Prof Fernando Figueira, Univ Fed Maranhao, Universidade Estadual Paulista (Unesp), and Universidade Federal de São Paulo (UNIFESP)

Subjects
Adult, Heart Defects, Congenital, Pediatrics, medicine.medical_specialty, Heart disease, MEDLINE, very low birth weight, Gestational Age, Critical Care and Intensive Care Medicine, outcomes, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, 030225 pediatrics, Infant Mortality, Prevalence, Birth Weight, Humans, Infant, Very Low Birth Weight, Medicine, Retrospective Studies, business.industry, Infant, Newborn, Infant, preterm birth, 030208 emergency & critical care medicine, ESTUDOS TRANSVERSAIS, medicine.disease, congenital heart disease, mortality, Low birth weight, Cross-Sectional Studies, Pediatrics, Perinatology and Child Health, Female, Christian ministry, Observational study, medicine.symptom, business, Brazil, Infant, Premature
Abstract

Made available in DSpace on 2021-06-25T15:01:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Brazilian Ministry of Health (Ministerio da Saude do Brasil, Fiocruz) Objectives: To evaluate the prevalence of congenital heart disease and their outcomes in a Brazilian cohort of very low birth weight preterm infants. Design: Post hoc analysis of data from the Brazilian Neonatal Network database, complemented by retrospective data from medical charts and a cross-sectional survey. Setting: Twenty public tertiary-care university hospitals. Patients: A total of 13,955 newborns weighing from 401 to 1,499 g and between 22 and 36 weeks of gestational age, born from 2010 to 2017. Interventions: None. Measurements and Main Results: The prevalence of congenital heart disease was 2.45% (95% CI, 2.20-2.72%). In a multivariate regression analysis, risk factors associated with congenital heart disease were maternal diabetes (relative risk, 1.55; 95% CI, 1.11-2.20) and maternal age above 35 years (relative risk, 2.09; 95% CI, 1.73-2.51), whereas the protection factors were maternal hypertension (relative risk, 0.54; 95% CI, 0.43-0.69), congenital infection (relative risk, 0.45; 95% CI, 0.21-0.94), and multiple gestation (relative risk, 0.73; 95% CI, 0.55-0.97). The pooled standardized mortality ratio in patients with congenital heart disease was 2.48 (95% CI, 2.22-2.80), which was significantly higher than in patients without congenital heart disease (2.08; 95% CI, 2.03-2.13). However, in multiple log-binomial regression analyses, only the presence of major congenital anomaly, gestational age (< 29 wk; relative risk, 2.32; 95% CI, 2.13-2.52), and Score for Neonatal Acute Physiology and Perinatal Extension II (> 20; relative risk, 3.76; 95% CI, 3.41-4.14) were independently associated with death, whereas the effect of congenital heart disease was spotted only when a conditional inference tree approach was used. Conclusions: The overall prevalence of congenital heart disease in this cohort of very low birth weight infants was higher and with higher mortality than in the general population of live births. The occurrence of a major congenital anomaly, gestational age (< 29 wk), and Score for Neonatal Acute Physiology and Perinatal Extension II (> 20) were significantly and independently associated with death, whereas the association of congenital heart disease and death was only evident when a major congenital anomaly was present. Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Puericultura & Pediat, Sao Paulo, Brazil Univ Sao Paulo, Hosp Clin, Fac Med, Dept Pediat, Sao Paulo, Brazil Univ Estadual Campinas, Fac Ciencias Med, Dept Pediat, Sao Paulo, Brazil Fundacao Oswaldo Cruz, Inst Nacl Saude Mulher Crianca & Adolescente Fern, Rio De Janeiro, Brazil Pontificia Univ Catolica Rio Grande do Sul, Hosp Sao Lucas, Porto Alegre, RS, Brazil Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil Univ Estado Rio de Janeiro, Hosp Univ Pedro Ernesto, Rio De Janeiro, Brazil Univ Fed Minas Gerais, Hosp Clin, Pampulha, MG, Brazil Univ Fed Uberlandia, Hosp Clin, Fac Med, Uberlandia, MG, Brazil Maternidade Escola Hilda Brandao, Fac Ciencias Med Minas Gerais, Belo Horizonte, MG, Brazil Univ Sao Paulo, Hosp Univ, Fac Med, Sao Paulo, Brazil Hosp Estadual Sumare, Sumare, SP, Brazil Hosp Geral Pirajussara, Sao Paulo, Brazil Hosp Estadual Diadema, Sao Paulo, Brazil Univ Estadual Londrina, Dept Pediat & Cirurgia Pediat, Londrina, Parana, Brazil Univ Fed Parana, Dept Pediat, Curitiba, Parana, Brazil Inst Med Integral Prof Fernando Figueira, Recife, PE, Brazil Univ Fed Maranhao, Hosp Univ, Sao Luis, Maranhao, Brazil Univ Estadual Paulista, Fac Med Botucatu, Dept Pediat, Sao Paulo, Brazil Univ Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Sao Paulo, Brazil Univ Estadual Paulista, Fac Med Botucatu, Dept Pediat, Sao Paulo, Brazil Brazilian Ministry of Health (Ministerio da Saude do Brasil, Fiocruz): IFF 45/2010 Brazilian Ministry of Health (Ministerio da Saude do Brasil, Fiocruz): 80/2012 e 203/2013

Published
2021

2. Pré-eclâmpsia: Rastreamento universal ou prevenção universal para países de baixa e média-renda?

Author

Leandro Gustavo De Oliveira, Angélica Lemos Debs Diniz, Caio Antônio de Campos Prado, Edson Vieira Da Cunha Filho, Francisco Lázaro Pereira De Souza, Henri Augusto Korkes, José Geraldo Ramos, Maria Laura Costa, Mário Dias Corrêa Junior, Nelson Sass, Ricardo De Carvalho Cavalli, Sérgio Hofmeister De Almeida Martins-Costa, José Carlos Peraçoli, Universidade Estadual Paulista (Unesp), Universidade Federal de Uberlândia (UFU), Universidade de São Paulo (USP), Pontificia Univ Catolica Rio Grande do Sul, Ctr Univ Lusiada, Pontificia Univ Catolica Sao Paulo, Univ Fed Rio Grande do Sul, Universidade Estadual de Campinas (UNICAMP), Universidade Federal de Minas Gerais (UFMG), and Universidade Federal de São Paulo (UNIFESP)

Subjects
aspirin, Programas de rastreamento, preeclampsia, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, prevention, Pregnancy, Prenatal Diagnosis, Humans, 030212 general & internal medicine, Aspirina, Developing Countries, 030219 obstetrics & reproductive medicine, calcium, Prevenção de doenças, Cálcio, screening, ácido acetilsalicílico, Obstetrics and Gynecology, Pré-eclâmpsia, Gynecology and obstetrics, prevenção, Practice Guidelines as Topic, RG1-991, Female, rastreamento, PAÍSES EM DESENVOLVIMENTO, Brazil
Abstract

Made available in DSpace on 2021-06-25T12:40:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01. Added 1 bitstream(s) on 2021-07-15T14:36:35Z : No. of bitstreams: 1 S0100-72032021000100061.pdf: 351132 bytes, checksum: ec2e22a997ed83c899edfdc67368253f (MD5) Brazilian Federation of Gynecology and Obstetrics (FEBRASGO) Pre-eclampsia (PE) is a severe disorder that affects up to 8% of all pregnancies and represents an important cause of maternal and perinatal morbidity and mortality. The screening of the disease is a subject of studies, but the complexity and uncertainties regarding its etiology make this objective a difficult task. In addition, the costs related to screening protocols, the heterogeneity of the most affected populations and the lack of highly effective prevention methods reduce the potential of current available algorithms for screening. Thus, the National Specialized Commission of Hypertension in Pregnancy of the Brazilian Association of Gynecology and Obstetrics Federation (Febrasgo, in the Portuguese acronym) (NSC Hypertension in Pregnancy of the Febrasgo) considers that there are no screening algorithms to be implemented in the country to date and advocates that Aspirin and calcium should be widely used. Univ Estadual Paulista, Botucatu Med Sch, Dept Gynecol & Obstet, Botucatu, SP, Brazil Univ Fed Uberlandia, Fac Med, Dept Obstet & Gynecol, Uberlandia, MG, Brazil Univ Sao Paulo, Fac Med, Dept Gynecol & Obstet, Ribeirao Preto, SP, Brazil Pontificia Univ Catolica Rio Grande do Sul, Gynecol & Obstet Training Ctr, Sch Med, Porto Alegre, RS, Brazil Ctr Univ Lusiada, Dept Tocoginecol, Santos, SP, Brazil Pontificia Univ Catolica Sao Paulo, Fac Med, Dept Obstet & Gynecol, Sorocaba, SP, Brazil Univ Fed Rio Grande do Sul, Fac Med, Dept Gynecol & Obstet, Porto Alegre, RS, Brazil Univ Estadual Campinas, Fac Med Sci, Dept Gynecol & Obstet, Campinas, SP, Brazil Univ Fed Minas Gerais, Fac Med, Dept Gynecol & Obstet, Belo Horizonte, MG, Brazil Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil Univ Estadual Paulista, Botucatu Med Sch, Dept Gynecol & Obstet, Botucatu, SP, Brazil

Published
2021

3. Sleep Disorders in Patients with Temporomandibular Disorders (TMD) in an Adult Population-Based Cross-Sectional Survey in Southern Brazil

Author

Márcio Lima Grossi, Patricia Saram Progiante, Patrícia Krieger Grossi, Marcos Pascoal Pattussi, Daniela Ds Rehm, Eduardo Piza Pellizzer, Brazilian Dent Assoc, Pontificia Univ Catolica Rio Grande do Sul, Vale Rio Sinos Univ UNISINOS, and Universidade Estadual Paulista (Unesp)

Subjects
Adult, Sleep Wake Disorders, medicine.medical_specialty, Cross-sectional study, Joint Dislocations, Research Diagnostic Criteria, Osteoarthritis, 03 medical and health sciences, 0302 clinical medicine, Facial Pain, Surveys and Questionnaires, medicine, Humans, business.industry, Chronic pain, 030206 dentistry, General Medicine, Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome, medicine.disease, Sleep in non-human animals, stomatognathic diseases, Cross-Sectional Studies, Physical therapy, Oral Surgery, business, human activities, Student's t-test, Brazil
Abstract

Made available in DSpace on 2020-12-10T19:44:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Purpose: To verify the prevalence of sleep disorders in temporomandibular disorders (TMD) subjects in a Brazilian population-based, cross-sectional survey (N = 1,643). Materials and Methods: Patients were assessed with the Research Diagnostic Criteria for TMD (RDC/TMD) Axes I and II and the Sleep Assessment Questionnaire. Student t test and Pearson chi-square test were used for continuous and categorical data analyses, respectively. Results: TMD subjects had significantly worse sleep disorders than controls (Graded Chronic Pain Severity categories I through IV vs 0, respectively) in RDC/TMD Axis II variables. Sleep disorders were also worse in the Axis I TMD groups (myofascial pain and arthralgia/osteoarthritis/osteoarthrosis), with the exception of disc displacements. Conclusion: TMD subjects had worse sleep disorders, mainly in Axis I TMD groups, with higher pain/disability levels. Brazilian Dent Assoc, Specialty Program Temporomandibular Disorders & O, Porto Alegre, RS, Brazil Pontificia Univ Catolica Rio Grande do Sul, Sch Hlth Sci, Postgrad Program Dent Prosthodont, Porto Alegre, RS, Brazil Vale Rio Sinos Univ UNISINOS, Postgrad Program Publ Hlth, Sao Leopoldo, Brazil State Univ Sao Paulo, Aracatuba Fac Dent, Dept Dent Mat & Prosthodont, Sao Paulo, SP, Brazil Pontificia Univ Catolica Rio Grande do Sul, Sch Humanities, Postgrad Program Social Work, Porto Alegre, RS, Brazil State Univ Sao Paulo, Aracatuba Fac Dent, Dept Dent Mat & Prosthodont, Sao Paulo, SP, Brazil CAPES: 001

Published
2020

4. Admission hypothermia, neonatal morbidity, and mortality: evaluation of a multicenter cohort of very low birth weight preterm infants according to relative performance of the center

Author

Rita C S Silveira, Nathalia Moura de Mello e Silva, Daniela Marques de Lima Mota Ferreira, Sérgio Tadeu Martins Marba, Jamil Pedro de Siqueira Caldas, Silvia Cwajg, Lígia S L Ferrari, Regina Paula Guimarães Vieira Cavalcante da Silva, Juliana Paula Ferraz dos Santos, Edna Maria de Albuquerque Diniz, Lêni Márcia Anchieta, Walusa Assad Gonçalves Ferri, Marco B Pavanelli, Mandira Daripa Kawakami, Marynéa Silva do Vale, José Mariano Sales Alves Júnior, Maria Regina Bentlin, Maria Fernanda Branco de Almeida, Werther Brunow de Carvalho, Humberto Holmer Fiori, Jucille do Amaral Meneses, Ruth Guinsburg, José L. M. B. Duarte, Davi Casale Aragon, Universidade Estadual de Campinas (UNICAMP), Universidade de São Paulo (USP), Universidade Federal de São Paulo (UNIFESP), Inst Crianca, Univ Fed Rio Grande do Sul, Maternidade Hilda Brandao, Hosp Geral Pirajussara, Universidade Estadual Paulista (Unesp), Universidade Federal de Uberlândia (UFU), Univ Fed Maranhao, Pontificia Univ Catolica Rio Grande do Sul, Universidade do Estado do Rio de Janeiro (UERJ), Inst Med Integral Prof Fernando Figueira, Fundacao Oswaldo Cruz, Universidade Estadual de Londrina (UEL), Hosp Estadual Diadema, Univ Fed Parana, Universidade Federal de Minas Gerais (UFMG), and Hosp Estadual Sumare

Subjects
Pediatrics, medicine.medical_specialty, Infant, Premature, Diseases, Hypothermia, Severity of Illness Index, Premature newborns, 03 medical and health sciences, 0302 clinical medicine, Enterocolitis, Necrotizing, Intensive Care Units, Neonatal, 030225 pediatrics, Infant Mortality, Humans, Infant, Very Low Birth Weight, Medicine, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Retrospective Studies, business.industry, Mortality rate, Infant, Newborn, Infant, Protective Factors, medicine.disease, Confidence interval, Death, Low birth weight, Relative risk, Pediatrics, Perinatology and Child Health, Necrotizing enterocolitis, Cohort, medicine.symptom, Morbidity, business, Brazil, Infant, Premature
Abstract

Made available in DSpace on 2019-10-04T12:14:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-01 This prospective cohort study aimed to assess the association of admission hypothermia (AH) with death and/or major neonatal morbidities among very low birth weight (VLBW) preterm infants based on the relative performance of 20 centers of the Brazilian Network of Neonatal Research. This is a retrospective analysis of prospectively collected data using the database registry of the Brazilian Network on Neonatal Research. Center performance was defined by the relative mortality rate using conditional inference trees. A total of 4356 inborn singleton VLBW preterm infants born between January 2013 and December 2016 without malformations were included in this study. The centers were divided into two groups: G1 (with lower mortality rate) and G2 (with higher mortality rate). Crude and adjusted relative risks (RR) and 95% confidence intervals (95%CI) were estimated by simple and multiple log-binomial regression models. An AH rate of 53.7% (19.8-93.3%) was significantly associated with early neonatal death in G1 (adjusted RR 1.41, 95% CI 1.09-1.84) and G2 (adjusted RR 1.29, 95%CI 1.01-1.65) and with in-hospital death in G1 (adjusted RR 1.29, 95%CI 1.07-1.58). AH was significantly associated with a lower frequency of necrotizing enterocolitis (adjusted RR 0.58, 95%CI 38-0.88) in G2.Conclusion: AH significantly associated with early neonatal death regardless of the hospital performance. In G2, an unexpected protective association between AH and necrotizing enterocolitis was found, whereas the other morbidities assessed were not significantly associated with AH. Univ Estadual Campinas, Fac Ciencias Med, Dept Pediat, Campinas, SP, Brazil Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pediat, Ave Bandeirantes 3900, BR-14049900 Sao Paulo, Brazil Univ Fed Sao Paulo, Div Neonatal Med, Sao Paulo, Brazil Univ Sao Paulo, Dept Pediat, Sch Med, Sao Paulo, Brazil Inst Crianca, Ave Dr Eneas de Carvalho Aguiar,647 Pinheiros, BR-05403000 Sao Paulo, Brazil Univ Fed Rio Grande do Sul, HCPA, Div Neonatol, Rua Silva Jardim 1155-701, BR-90450071 Porto Alegre, RS, Brazil Maternidade Hilda Brandao, Fac Ciencias Med Minas Gerais, Dept Pediat, Belo Horizonte, MG, Brazil Hosp Geral Pirajussara, Neonatal Unit, Taboao Da Serra, Brazil Univ Estadual Paulista, Fac Med Botucatu, Div Neonatol, Botucatu, SP, Brazil Univ Fed Uberlandia, Dept Pediat, Uberlandia, MG, Brazil Univ Fed Maranhao, Dept Pediat, Sao Luis, Brazil Pontificia Univ Catolica Rio Grande do Sul, Fac Med, Hosp Sao Lucas, Dept Pediat, Porto Alegre, RS, Brazil Univ Estado Rio de Janeiro, Hosp Univ Pedro Ernesto, Dept Pediat, Rio De Janeiro, Brazil Inst Med Integral Prof Fernando Figueira, Dept Pediat, Recife, PE, Brazil Fundacao Oswaldo Cruz, Div Neonatol, Rio De Janeiro, Brazil Univ Estadual Londrina, Dept Pediat, Univ Hosp, Curitiba, Parana, Brazil Hosp Estadual Diadema, Neonatal Unit, Diadema, Brazil Univ Fed Parana, Hosp Clin, Dept Pediat, Curitiba, Parana, Brazil Univ Fed Minas Gerais, Div Neonatol, Belo Horizonte, MG, Brazil Hosp Estadual Sumare, Neonatal Div, Sumare, Brazil Univ Estadual Paulista, Fac Med Botucatu, Div Neonatol, Botucatu, SP, Brazil

Published
2019

5. Consenso brasileiro para o tratamento da esclerose múltipla : Academia Brasileira de Neurologia e Comitê Brasileiro de Tratamento e Pesquisa em Esclerose Múltipla

Author

Fernando Coronetti, Carlos Bernardo Tauil, Samira Luiza dos Apóstolos-Pereira, Douglas Kazutoshi Sato, Jefferson Becker, Alfredo Damasceno, Giordani Rodrigues dos Passos, Mônica Koncke Fiuza Parolin, Andre Muniz, Maria Fernanda Mendes, Maria Lucia Brito Ferreira, André Palma da Cunha Matta, Frederico Jorge, Renan Barros Domingues, Rogerio Rizo Morales, Claudia Cristina Ferreira Vasconcelos, Rodrigo Barbosa Thomaz, Marcus Goncalves, Elizabeth Regina Comini-Frota, Suzana C. Nunes Machado, Bianca Etelvina Santos de Oliveira, Marco Aurélio Lana-Peixoto, Ronaldo Maciel Dias, Vanessa Daccach Marques, Damacio Ramón Kaimen Maciel, Anderson Kuntz Grzesiuk, Renata Simm, T. Junqueira, Henry Koiti Sato, Osvaldo J. M. Nascimento, Denise Sisteroli Diniz, Paulo Diniz da Gama, Dagoberto Callegaro, Eber Castro Correa, Nise Alessandra de Carvalho Sousa, Universidade de São Paulo (USP), Pontificia Univ Catolica Rio Grande do Sul, Universidade Federal de Minas Gerais (UFMG), Univ Jose Rosario Vellano, Univ Fed Estado Rio de Janeiro, Hosp Restauracao, Clin Goncalves Dias, Universidade Estadual de Campinas (UNICAMP), Clin Privada, Hosp Sao Rafael, Universidade Federal Fluminense (UFF), Fundacac Ctr Integrado Apoio Portador Deficiencia, Universidade de Brasília (UnB), Univ Catolica Brasilia, Santa Casa Misericordia Londrina, Universidade Federal de Goiás (UFG), Clin Neurol & Endocrinol, Universidade Estadual Paulista (Unesp), Inst Neurol Curitiba, Univ Regiao Joinville, Univ Fed Amazonas, Pontificia Univ Catolica Sao Paulo, Senne Liquor Diagnost, Hosp Cruz Azul, Fac Sao Leopoldo Mandic, Hosp Israelita Albert Einstein, Universidade Federal de Uberlândia (UFU), Hosp Base Dist Fed, Imperial Hosp Caridade, and Escola Bahiana Med & Saude Publ

Subjects
medicine.medical_specialty, Multiple Sclerosis, Neurology, Personalized treatment, MEDLINE, Context (language use), multiple sclerosis, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, Recurrence, medicine, Humans, Immunologic Factors, 030212 general & internal medicine, Vitamin D, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, business.industry, Multiple sclerosis, Academies and Institutes, medicine.disease, drug therapy, Esclerose múltipla, consensus, Family medicine, Neurology (clinical), business, Brazil, Immunosuppressive Agents, 030217 neurology & neurosurgery, Medicamentos - administração, Consenso (Ciências sociais)
Abstract

Made available in DSpace on 2018-11-26T22:40:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-01. Added 1 bitstream(s) on 2019-10-09T18:27:56Z : No. of bitstreams: 1 S0004-282X2018000800539.pdf: 336862 bytes, checksum: 861f2018734ed5dc938f69878cf50b6e (MD5) Biogen Idec Genzyme Merck Novartis Rocha Teva Roche Sanofi-Genzyme World Federation of Neurology European Committee on Treatment and Research in Multiple Sclerosis Biogen Schering Biogen Indec Merck-Serono Teva (EMOCEMP Study-NCT) Euroimmun AG Shire Quest/Athena Diagnostics Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Bayer Partners MS Center, Harvard Medical School Distrito Federal Research Foundation (FAP-DF) Libbs Sanofi Serono Teva Pharmaceuticals Sonofi-Genzyme Novartis-PPD Merck Serono Bayer Health Care Ipsen Sanofi Genzyme The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Research in Multiple Sclerosis and the Neuroimmunology Scientific Department of the Brazilian Academy of Neurology have convened to establish this Brazilian Consensus for the Treatment of MS, based on their understanding that neurologists should be able to prescribe MS DMTs according to what is better for each patient, based on up-to-date evidence and practice. We herein propose practical recommendations for the treatment of MS, with the main focus on the choice and management of DMTs, as well as present a review of the scientific rationale supporting therapeutic strategies in MS. Univ Sao Paulo, Fac Med Ribeirao Preto, Hosp Clin Ribeirao Preto, Ribeirao Preto, SP, Brazil Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil Univ Sao Paulo, Fac Med, Hosp Clin, Sao Paulo, SP, Brazil Univ Fed Minas Gerais, Ctr Invest Esclerose Multipla Minas Gerais, Belo Horizonte, MG, Brazil Univ Jose Rosario Vellano, Belo Horizonte, MG, Brazil Univ Fed Estado Rio de Janeiro, Rio De Janeiro, RJ, Brazil Hosp Restauracao, Recife, PE, Brazil Clin Goncalves Dias, Curitiba, Parana, Brazil Univ Estadual Campinas, Campinas, SP, Brazil Clin Privada, Cuiaba, MT, Brazil Hosp Sao Rafael, Salvador, BA, Brazil Univ Fed Fluminense, Niteroi, RJ, Brazil Fundacac Ctr Integrado Apoio Portador Deficiencia, Joao Pessoa, Paraiba, Brazil Univ Brasilia, Brasilia, DF, Brazil Univ Catolica Brasilia, Brasilia, DF, Brazil Santa Casa Misericordia Londrina, Londrina, PR, Brazil Univ Fed Goias, Fac Med, Goiania, Go, Brazil Clin Neurol & Endocrinol, Brasilia, DF, Brazil Univ Estadual Paulista, Sao Paulo, SP, Brazil Inst Neurol Curitiba, Curitiba, Parana, Brazil Univ Regiao Joinville, Joinville, SC, Brazil Univ Fed Amazonas, Hosp Univ Getulio Vargas, Manaus, Amazonas, Brazil Pontificia Univ Catolica Sao Paulo, Sorocaba, SP, Brazil Senne Liquor Diagnost, Sao Paulo, SP, Brazil Hosp Cruz Azul, Sao Paulo, SP, Brazil Fac Sao Leopoldo Mandic, Campinas, SP, Brazil Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil Univ Fed Uberlandia, Uberlandia, MG, Brazil Hosp Base Dist Fed, Brasilia, DF, Brazil Imperial Hosp Caridade, Florianopolis, SC, Brazil Escola Bahiana Med & Saude Publ, Salvador, BA, Brazil Univ Estadual Paulista, Sao Paulo, SP, Brazil Teva (EMOCEMP Study-NCT): 61080516.4.1001.5336

Published
2018

6. T-piece versus self-inflating bag ventilation in preterm neonates at birth

Author

Jucile Meneses, Ruth Guinsburg, Vera Lúcia Jornada Krebs, Maria Rafaela Conde González, Juliana P. Santos, Ana Lucia Acquesta, Edna Maria de Albuquerque Diniz, Regina P. G. Vieira Cavalcanti da Silva, João Henrique de Almeida, José Maria de Andrade Lopes, Junia Sampel de Castro, Jamil Pedro de Siqueira Caldas, Renato S. Procianoy, Márcia Gomes Penido, Navantino Alves Filho, Cristina Nunes dos Santos, Ligia Maria Suppo de Souza Rugolo, Walusa Assad Gonçalves-Ferri, Patrícia Franco Marques, Maria Fernanda Branco de Almeida, José Luiz Muniz Bandeira Duarte, Francisco Eulógio Martinez, Daniela Marques de Lima Mota Ferreira, Jorge Hecker Luz, Universidade Federal de São Paulo (UNIFESP), Universidade de São Paulo (USP), Univ Fed Maranhao, Universidade Estadual de Campinas (UNICAMP), Universidade Estadual Paulista (Unesp), Fundacao Oswaldo Cruz, Pontificia Univ Catolica Rio Grande do Sul, Univ Fed Rio Grande do Sul, Universidade do Estado do Rio de Janeiro (UERJ), Universidade Federal de Minas Gerais (UFMG), Universidade Federal de Uberlândia (UFU), Maternidade Hilda Brandao, Hosp Estadual Sumare, Hosp Geral Pirajussara, Hosp Estadual Diadema, Universidade Estadual de Londrina (UEL), Univ Fed Parana, Inst Med Integral Prof Fernando Figueira, and Inst Fernandes Figueira FIOCRUZ

Subjects
Male, Resuscitator, Pediatrics, medicine.medical_specialty, Birth weight, RESSURREIÇÃO, Gestational Age, Infant, Premature, Diseases, Cohort Studies, Positive-Pressure Respiration, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, 030225 pediatrics, Humans, Medicine, 030212 general & internal medicine, Neonatology, Prospective cohort study, Positive end-expiratory pressure, Ventilators, Mechanical, business.industry, Infant, Newborn, Pregnancy Outcome, Obstetrics and Gynecology, Gestational age, Insufflation, Equipment Design, General Medicine, medicine.disease, Respiration, Artificial, Survival Analysis, Patient Discharge, Bronchopulmonary dysplasia, Pediatrics, Perinatology and Child Health, Premature Birth, Female, business, Brazil, Infant, Premature, Neonatal resuscitation
Abstract

Made available in DSpace on 2018-11-26T15:46:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-01 Objective To verify whether the use of the T-piece resuscitator compared with the self-inflating bag in preterm infants ventilated at birth modifies survival to hospital discharge without major morbidities. Design Pragmatic prospective cohort study. Setting 20 Brazilian university hospitals of Brazilian Network on Neonatal Research. Patients were 1962 inborn infants in 2014-2015 ventilated at birth with 23-33' weeks gestation and birth weight 400-1499 g without malformations. Patients transferred until the 27th day after birth were excluded. Interventions Positive pressure ventilation at birth with T-piece resuscitator or self-inflating bag without positive end expiratory pressure valve. Intervention with ventilation followed the Brazilian Society of Pediatrics guidelines. The choice of the equipment was at the neonatologist's discretion in each delivery. The main outcome measures were survival to hospital discharge without bronchopulmonary dysplasia, severe peri-intraventricular haemorrhage and periventricular leucomalada. Logistic regression adjusted for confounding variables was applied for main outcome. Results 1456 (74%) were only ventilated with T-piece resuscitator and 506 (26%) with the self-inflating bag. The characteristics of those ventilated with T-Piece resuscitator versus self-inflating bag were birth weight 969 +/- 277 vs 941 +/- 279 g, gestational age 28.2 +/- 2.5 vs 27.8 +/- 2.7 weeks and survival to hospital discharge without major morbidities 47% vs 35%, Logistic regression adjusted for maternal characteristics, obstetric and neonatal morbidities showed that the T-piece resuscitator increased the chance of survival to hospital discharge without major morbidities (OR=1.38; 95% Cl 1.06 to 1.80; Hosmer-Lemeshow goodness of fit: 0.695). Conclusion This study is the first that highlights the effectiveness of T-piece resuscitator ventilation in improving relevant outcomes in preterm neonates. Univ Fed Sao Paulo, Div Neonatal Med, Sao Paulo, Brazil Univ Sao Paulo, Dept Pediat, Fac Med Ribeirao Preto, Ribeirao Preto, Brazil Univ Fed Maranhao, Dept Pediat, Sao Luis, Brazil Univ Estadual Campinas, Dept Pediat, Fac Ciencias Med, Campinas, SP, Brazil Univ Sao Paulo, Dept Pediat, Fac Med, Sao Paulo, Brazil Univ Estadual Paulista, Div Neonatol, Fac Med Botucatu, Botucatu, SP, Brazil Fundacao Oswaldo Cruz, Div Neonatol, Rio De Janeiro, Brazil Pontificia Univ Catolica Rio Grande do Sul, Dept Pediat, Hosp Sao Lucas, Fac Med, Porto Alegre, RS, Brazil Univ Fed Rio Grande do Sul, Div Neonatol, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil Univ Estado Rio de Janeiro, Dept Pediat, Hosp Univ Pedro Ernesto, Rio De Janeiro, Brazil Univ Fed Minas Gerais, Div Neonatol, Belo Horizonte, MG, Brazil Univ Fed Uberlandia, Pediat, Uberlandia, MG, Brazil Maternidade Hilda Brandao, Dept Pediat, Fac Ciencias Med Minas Gerais, Belo Horizonte, MG, Brazil Univ Sao Paulo, Sch Med, Dept Pediat, Sao Paulo, SP, Brazil Hosp Estadual Sumare, Neonatal Div, Sumare, Brazil Hosp Geral Pirajussara, Neonatal Unit, Taboao Da Serra, Brazil Hosp Estadual Diadema, Neonatal Unit, Diadema, Brazil Univ Estadual Londrina, Dept Pediat, Hosp Univ, Curitiba, Parana, Brazil Univ Fed Parana, Dept Pediat, Hosp Clin, Curitiba, Parana, Brazil Inst Med Integral Prof Fernando Figueira, Dept Pediat, Recife, PE, Brazil Inst Fernandes Figueira FIOCRUZ, Dept Pediat, Rio De Janeiro, Brazil Univ Estadual Paulista, Div Neonatol, Fac Med Botucatu, Botucatu, SP, Brazil

Published
2018

7. Death or survival with major morbidity in VLBW infants born at Brazilian neonatal research network centers

Author

Marynéa Silva do Vale, Jamil Pedro de Siqueira Caldas, Lígia S L Ferrari, Maria Fernanda Branco de Almeida, Ana Lucia Acquesta, Maria Elisabeth Lopes Moreira, Junia Sampel de Castro, Rita de Cássia dos Santos Silveira, Paulyne Stadler Venzon, Dulce Maria Toledo Zanardi, Maria Albertina Santiago Rego, Cristina Nunes dos Santos, Jucille do Amaral Meneses, Ruth Guinsburg, Walusa Assad Gonçalves Ferri, Maria Regina Bentlin, José Luiz Muniz Bandeira Duarte, Vânia Olivetti Steffen Abdallah, Humberto Holmer Fiori, Navantino Alves Filho, Laura Emilia Monteiro Bigélli Cardoso, Edna Maria de Albuquerque Diniz, Universidade Federal de São Paulo (UNIFESP), Univ Fed Rio Grande do Sul, Universidade Estadual de Campinas (UNICAMP), Pontificia Univ Catolica Rio Grande do Sul, Univ Fed Maranhao, Universidade Federal de Uberlândia (UFU), Universidade de São Paulo (USP), Fac Ciencias Med Minas Gerais, Fundacao Oswaldo Cruz, Hosp Geral Pirajussara, Universidade Estadual de Londrina (UEL), Universidade Estadual Paulista (Unesp), Univ Fed Parana, Inst Med Integral Prof Fernando Figueira, Hosp Estadual Sumare, Hosp Estadual Diadema, Universidade do Estado do Rio de Janeiro (UERJ), and Universidade Federal de Minas Gerais (UFMG)

Subjects
Male, Pediatrics, medicine.medical_specialty, neonatal mortality, Birth weight, Logistic regression, intraventricular hemorrhage, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Infant Mortality, preterm newborn infant, medicine, Humans, Infant, Very Low Birth Weight, retinopathy of prematurity, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Academic Medical Centers, Periventricular leukomalacia, Obstetrics, business.industry, Infant, Newborn, Infant, Obstetrics and Gynecology, Gestational age, Retinopathy of prematurity, medicine.disease, Bronchopulmonary dysplasia, Intraventricular hemorrhage, periventricular leukomalacia, very low birth weight newborn infant, Pediatrics, Perinatology and Child Health, Female, business, Brazil
Abstract

Made available in DSpace on 2018-11-26T17:55:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-03-18 Health Ministry of Brazil (Ministerio da Saude do Brasil) Objective: To analyze unfavorable outcomes at hospital discharge of preterm infants born at Brazilian public university centers.Methods: Prospective cohort of 2646 inborn infants with gestational age 23-33 weeks and birth weight 400-1499g, without malformations, born at 20 centers in 2012-2013. Unfavorable outcome was defined as in-hospital death or survival at hospital discharge with 1 major morbidities: bronchopulmonary dysplasia (BPD) at 36 corrected weeks, intraventricular hemorrhage (IVH) grades 3-4, periventricular leukomalacia (PVL) or surgically treated retinopathy of prematurity (ROP).Results: Among 2646 infants, 1390 (53%) either died or survived with major morbidities: 793 (30%) died; 497 (19%) had BPD; 358 (13%) had IVH 3-4 or PVL; and 84 (3%) had ROP. Logistic regression adjusted by center showed association of unfavorable outcome with: antenatal steroids (OR 0.70; 95%CI 0.55-0.88), C-section (0.72; 0.58-0.90), gestational age

Published
2015

8. Effectiveness of photodynamic therapy associated with irrigants over two biofilm models

Author

Fernanda Visioli, José Antônio Poli de Figueiredo, Manuela Favarin Santini, Francisco Montagner, Rodrigo Ricci Vivan, Marcus Vinícius Reis Só, Jefferson Ricardo Pereira, Ricardo Abreu da Rosa, Univ Fed Rio Grande do Sul, Ctr Univ Franciscano, Pontificia Univ Catolica Rio Grande do Sul, Univ Southern Santa Catarina, and Universidade Estadual Paulista (Unesp)

Subjects
0301 basic medicine, 030103 biophysics, Sodium Hypochlorite, medicine.medical_treatment, Biophysics, Dentistry, Photodynamic therapy, Dermatology, Antibacterial effect, Enterococcus faecalis, Microbiology, Colony-Forming Units Assay, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Confocal laser scanning microscopy, medicine, Animals, Humans, Pharmacology (medical), Bicuspid, Saline, Microscopy, Confocal, biology, Root Canal Irrigants, Chemistry, business.industry, Biofilm, Chlorhexidine, MICROSCOPIA ELETRÔNICA DE VARREDURA, 030206 dentistry, Root canal irrigants, biology.organism_classification, Antimicrobial, Oncology, Photochemotherapy, Sodium hypochlorite, Biofilms, Dentin, Cattle, business
Abstract

Made available in DSpace on 2018-11-26T15:46:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-12-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Federal University of Rio Grande do Sul Background: This study aimed to evaluate the antibacterial effect and the biofilm disruption promoted by antimicrobial photodynamic therapy (aPDT) associated with sodium hypochlorite (NaOCl) and chiorexidine (CHX) over monospecies and multispecies biofilms. Methods: In monospecies model, forty-six premolars were inoculated with Enterococcus faecalis for 21 days and divided into three groups: saline, CHX and NaOCl. After irrigation, aPDT was performed. Samples were collected at baseline (S1) and after irrigation (S2) and aPDT (S3). Colony-forming unit (CFU) counts were performed. In multispecies model, sixty bovine dentin blocks were infected intraorally for 72 h and divided into six groups: saline, saline/aPDT, CHX, CHX/aPDT, NaOCl and NaOCl/aPDT. The percentage and the biovolume of live cells and the total biovolume were assessed using confocal laser scanning microscopy. Results: CHX and NaOCl showed the lowest CFU counts (P < 0.05). aPDT reduced the bacterial counts in saline (S2-S3; P < 0.05). The lowest amount of live cells was observed in CHX, CHX/aPDT, NaOCl and NaOCl/aPDT. aPDT did not reduce the total biovolume (P > 0.05). Conclusion: aPDT associated with saline reduced the bacterial load in root canals infected with E. faecalis. aPDT did not reduce the total biovolume in situ; however, the irrigant was decisive to disrupt multispecies biofilms. Univ Fed Rio Grande do Sul, Dept Conservat Dent, Porto Alegre, RS, Brazil Ctr Univ Franciscano, Dept Endodont, Santa Maria, RS, Brazil Pontificia Univ Catolica Rio Grande do Sul, Dept Endodont, Porto Alegre, RS, Brazil Univ Fed Rio Grande do Sul, Dept Oral Pathol, Porto Alegre, RS, Brazil Univ Southern Santa Catarina, Dept Prosthodont, Tubarao, SC, Brazil Sao Paulo State Univ, Dept Endodont, Bauru, SP, Brazil Sao Paulo State Univ, Dept Endodont, Bauru, SP, Brazil

Published
2017

9. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author

Sartelli, M., Kluger, Y., Ansaloni, L., Carlet, J., Brink, A., Hardcastle, T. C., Khanna, A., Chicom-Mefire, A., Rodríguez-Baño, J., Nathwani, D., Mendelson, M., Watkins, R. R., Pulcini, C., Beović, B., May, A. K., Itani, K. M. F., Mazuski, J. E., Fry, D. E., Coccolini, F., Rasxa, K., Montravers, P., Eckmann, C., Abbo, L. M., Abubakar, S., Abu-Zidan, F. M., Adesunkanmi, A. K., Al-Hasan, M. N., Althani, A. A., Ticas, J. E. A., Ansari, S., Ansumana, R., Da Silva, A. R. A. , Augustin, G. , Bala, M. , Balogh, Z. J. , Baraket, O. , Bassetti, M. , Bellanova, G. , Beltran, M. A. , Ben-Ishay, O. , Boermeester, M. A. , Brecher, S. M. , Bueno, J. , Cainzos, M. A. , Cairns, K. , Camacho-Ortiz, A. , Ceresoli, M. , Chandy, S. J. , Cherry-Bukowiec, J. R. , Cirocchi, R. , Colak, E. , Corcione, A. , Cornely, O. A. , Cortese, F. , Cui, Y. , Curcio, D. , Damaskos, D. , Dasx, K. , Delibegovic, S. , Demetrashvili, Z. be, De Simone, B. bf, De Souza, H. P. bg, De Waele, J. bh, Dhingra, S. bi, Diaz, J. J. bj, Di Carlo, I. bk, Di Marzo, F. bl, DI TOMASO, SAVERIO, S. , Dogjani, A. , Dorj, G. , Dortet, L. , Duane, T. M. , Dupont, H. , Egiev, V. N. , Eid, H. O. , Elmangory, El-Sayed Marei, H. , Enani, M. A. , Escandón-Vargas, K. , Faro, M. P. , J.r., Ferrada, P., Foghetti, D., Foianini, E., Fraga, G. P., Frattima, S., Gandhi, C., Gattuso, G., Giamarellou, E., Ghnnam, W., Gkiokas, G., Girardis, M., Goff, D. A., Gomes, C. A., Gomi, H., Gronerth, R. I. G., Guirao, X., Guzman-Blanco, M., Haque, M., Hecker, A., Hell, M., Herzog, T., Hicks, L., Kafka-Ritsch, R., Kao, L. S., Kanj, S. S., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kashuk, J., Kenig, J., Khamis, F., Khokha, V., Kiguba, R., Kirkpatrick, A. W., Kørner, H., Koike, K., Kok, K. Y. Y., Kon, K., Kong, V., Inaba, K., Ioannidis, O., Isik, A., Iskandar, K., Labbate, M., Labricciosa, F. M., Lagrou, K., Lagunes, L., Latifi, R., Lasithiotakis, K., Laxminarayan, R., Lee, J. G., Leone, M., Leppäniemi, A., Li, Y., Liang, S. Y., Liau, K. -.H., Litvin, A., Loho, T., Lowman, W., Machain, G. Mf, Maier, R. V., Manzano-Nunez, R., Marinis, A., Marmorale, C., Martin-Loeches, I., Marwah, S., Maseda, E., McFarlane, M., BEZERRA DE MELO PEREIRA NUNES, CINTIA, R. , Melotti, R. , Memish, Z. , Mertz, D. , Mesina, C. , Menichetti, F. , Mishra, S. K. , Montori, G. , Moore, E. E. , Moore, F. A. , Naidoo, NAPOLITANO, NELLO, L. , Negoi, I. , Nicolau, D. P. , Nikolopoulos, I. , Nord, C. E. , Ofori-Asenso, R. , Olaoye, I. , Omari, A. H. , Ordoñez, C. A. , Ouadii, M. , Ouedraogo, A. , Pagani, L. , Paiva, J. A. , Parreira, J. G. , Pata, F. fm, Pereira, J., Pereira, N. R., Petrosillo, N., Picetti, E., Pintar, T., Ponce-De-Leon, A., Popovski, Z., Poulakou, G., Preller, J., Guerrero, A. P., Pupelis, G., Quiodettis, M., Rawson, T. M., Reichert, M., Reinhart, K., Rems, M., Rello, J., Rizoli, S., ROBERTS, HENRI JOHAN EDUARD, Rubio-Perez, I., Ruppé, E., Sakakushev, B., Sall, I., Kafil, H. S. j, Sanders, J., Sato, N., Sawyer, R. G., T. , Scibé, R. , Scudeller, L. , Lohse, H. S. , Sganga, G. , Shafiq, N. , Shah, J. N. , Spigaglia, P. , Suroowan, S. , Tsioutis, C. , Sifri, C. D. , Siribumrungwong, B. , Sugrue, M. , Talving, P. , Tan, B. K. , Tarasconi, A. , Tascini, C. , Tilsed, J. , Timsit, J. -.F. , Tumbarello, M. , Trung, N. T. , Ulrych, J. , Uranues, S. , Velmahos, G. , Vereczkei, A. G. , Viale, P. , Estape, J. V. , Viscoli, C. , Wagenlehner, F. , Wright, B. J. , Xiao, Y. , Yuan, K. -.C. , Zachariah, S. K. , Zahar, J. R. , Mergulhão, P. , Catena, Réanimation Médico-Chirurgicale, Groupe Hospitalier Paris Saint-Joseph, University Hospital Virgen Macarena, Internal Medicine Department, Universidad de Sevilla, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Service d'anesthésie - réanimation chirurgicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Klinik I für Innere Medizin und Zentrum für Klinische Studien (ZKS) 01KN0706, Universitätsklinikum Köln (Uniklinik Köln), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Amiens-Picardie, Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU), Université Catholique de Louvain = Catholic University of Louvain (UCL), Center for Disease Dynamics, Economics & Policy (CDDEP), Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Hartford Hospital, Department of Laboratory Medicine, Karolinska Institutet [Stockholm], Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Instituto Nacional de Matemática Pura e Aplicada (IMPA), Instituto Nacional de matematica pura e aplicada, 4th Department of Internal Medicine, ATTIKON University General Hospital, Department of Anesthesiology and Intensive Care, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Critical Care Department, Joan XXIII University Hospital, Departmet of Infectious, Parasitic and Immune-Mediated Disease, Istituto Superiore di Sanita [Rome], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, S.Orsola-Malpighi Hospital, Alma Mater Studiorum University of Bologna (UNIBO), Infectious Diseases, University of Genoa (UNIGE), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Groupe Hospitalier Paris Saint-Joseph (hpsj), Universidad de Sevilla / University of Sevilla, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Istituto Superiore di Sanità (ISS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Genova = University of Genoa (UniGe), Sartelli, Massimo, Kluger, Yoram, Ansaloni, Luca, Carlet, Jean, Dorj, Gereltuya, Catena, Fausto, [Sartelli, Massimo] Macerata Hosp, Dept Surg, Macerata, Italy, [Scibe, Rodolfo] Macerata Hosp, Dept Surg, Macerata, Italy, [Kluger, Yoram] Rambam Hlth Care Campus, Dept Gen Surg, Div Surg, Haifa, Israel, [Ben-Ishay, Ofir] Rambam Hlth Care Campus, Dept Gen Surg, Div Surg, Haifa, Israel, [Ansaloni, Luca] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Coccolini, Federico] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Ceresoli, Marco] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Montori, Giulia] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Carlet, Jean] World Alliance Antibiot Resistance, Paris, France, [Brink, Adrian] Milpark Hosp, Ampath Natl Lab Serv, Dept Clin Microbiol, Johannesburg, South Africa, [Brink, Adrian] Univ Cape Town, Dept Med, Div Infect Dis & HIV Med, Cape Town, South Africa, [Hardcastle, Timothy C.] Inkosi Albert Luthuli Cent Hosp, Trauma Serv, Durban, South Africa, [Hardcastle, Timothy C.] Nelson R Mandela Sch Clin Med, Dept Surg, Durban, South Africa, [Khanna, Ashish] Ctr Crit Care, Anaesthesiol Inst, Cleveland, OH USA, [Khanna, Ashish] Cleveland Clin, Dept Outcomes Res, Cleveland, OH 44106 USA, [Chicom-Mefire, Alain] Univ Buea, Dept Surg & Obstet Gynaecol, Buea, Cameroon, [Foianini, Esteban] Univ Buea, Dept Surg & Obstet Gynaecol, Buea, Cameroon, [Rodriguez-Bano, Jesus] Hosp Univ Virgen Macarena & Virge del Rocio IbiS, Unidad Clin Interctr Enfermedades Infecciosas Mic, Seville, Spain, [Rodriguez-Bano, Jesus] Univ Seville, Dept Med, Seville, Spain, [Nathwani, Dilip] Ninewells Hosp & Med Sch, Dundee, Scotland, [Mendelson, Marc] Univ Cape Town, Groote Schuur Hosp, Dept Med, Div Infect Dis & HIV Med, Cape Town, South Africa, [Watkins, Richard R.] Cleveland Clin Akron Gen, Div Infect Dis, Akron, OH USA, [Watkins, Richard R.] Northeast Ohio Med Univ, Rootstown, OH USA, [Pulcini, Celine] Lorraine Univ, EA APEMAC 4360, Nancy, France, [Pulcini, Celine] Nancy Univ Hosp, Infect Dis Dept, Nancy, France, [Beovic, Bojana] Univ Med Ctr Ljubljana, Ljubljana, Slovenia, [Beovic, Bojana] Univ Ljubljana, Fac Med, Ljubljana, Slovenia, [May, Addison K.] Vanderbilt Univ, Med Ctr, Div Trauma & Surg Crit Care, Nashville, TN USA, [Itani, Kamal M. F.] Boston Univ, Dept Surg, VA Boston Hlth Care Syst, Boston, MA 02215 USA, [Itani, Kamal M. F.] Harvard Med Sch, Boston, MA USA, [Mazuski, John E.] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA, [Fry, Donald E.] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60611 USA, [Fry, Donald E.] Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA, [Rasa, Kemal] Anadolu Med Ctr, Dept Surg, Kocaali, Turkey, [Montravers, Philippe] Bichat Claude Bernard Univ Hosp, Paris Diderot Sorbonne Cite Univ, Anesthesiol & Crit Care Med, HUPNSV, Paris, France, [Eckmann, Christian] Hannover Med Sch, Acad Hosp, Dept Gen Visceral & Thorac Surg, Peine, Germany, [Abbo, Lilian M.] Univ Miami, Miller Sch Med, Jackson Hlth Syst, Div Infect Dis, Miami, FL 33136 USA, [Abbo, Lilian M.] Bayero Univ, Dept Nursing Sci, Kano, Nigeria, [Abubakar, Salisu] UAE Univ, Coll Med & Hlth Sci, Dept Surg, Al Ain, U Arab Emirates, [Abu-Zidan, Fikri M.] Obafemi Awolowo Univ, Coll Hlth Sci, Dept Surg, Ife, Nigeria, [Al-Hasan, Majdi N.] Univ South Carolina, Sch Med, Dept Med, Div Infect Dis, Columbia, SC USA, [Althani, Asma A.] Qatar Univ, Biomed Res Ctr, Doha, Qatar, [Marei, Hany El-Sayed] Qatar Univ, Biomed Res Ctr, Doha, Qatar, [Ticas, Jorge Eduardo Alvarenga] Hosp Nacl Ros, Emergency Unit, San Salvador, El Salvador, [Ansari, Shamshul] Oita Univ, Dept Environm & Prevent Med, Fac Med, Oita, Japan, [Ansari, Shamshul] Chitwan Med Coll, Dept Microbiol, Bharatpur, Nepal, [Ansumana, Rashid] Univ Liverpool, Liverpool Sch Trop Med, Ctr Neglected Trop Dis, Bo, Sierra Leone, [Ansumana, Rashid] Njala Univ, Mercy Hosp, Res Lab, Bo, Sierra Leone, [Araujo da Silva, Andre Ricardo] Prontobaby Hosp Crianca, Infect Control Comm, Rio De Janeiro, Brazil, [Augustin, Goran] Univ Hosp Ctr, Dept Surg, Zagreb, Croatia, [Bala, Miklosh] Hadassah Hebrew Univ Med Ctr, Trauma & Acute Care Surg Unit, Jerusalem, Israel, [Balogh, Zsolt J.] John Hunter Hosp, Dept Traumatol, Newcastle, NSW, Australia, [Balogh, Zsolt J.] Univ Newcastle, Newcastle, NSW, Australia, [Baraket, Oussema] Bizerte Hosp, Dept Surg, Bizerte, Tunisia, [Bassett, Matteo] Santa Maria Misericordia Univ Hosp, Infect Dis Div, Udine, Italy, [Bellanova, Giovanni] SS Annunziata Hosp, Dept Surg, Taranto, Italy, [Beltran, Marcelo A.] Hosp San Juan Dios, Dept Gen Surg, La Serena, Chile, [Biffl, Walter L.] Queens Med Ctr, Acute Care Surg, Honolulu, HI USA, [Boermeester, Marja A.] Acad Med Ctr, Dept Surg, Amsterdam, Netherlands, [Brecher, Stephen M.] Boston Univ, Sch Med, VA Boston HealthCare Syst, Dept Pathol & Lab Med, Boston, MA 02118 USA, [Brecher, Stephen M.] Boston Univ, Sch Med, Dept Pathol & Lab Med, Boston, MA 02118 USA, [Bueno, Juan] Fdn Ctr Invest Bioprospecc & Biotecnol Biodivers, Barranquilla, Colombia, [Cainzos, Miguel A.] Hosp Clin Univ, Dept Surg, Santiago De Compostela, Spain, [Cairns, Kelly] Alfred Hlth, Pharm Dept, Melbourne, Vic, Australia, [Camacho-Ortiz, Adrian] Hosp Univ Dr Jose Eleuterio Gonzalez, Hosp Epidemiol & Infect Dis, Monterrey, Mexico, [Chandy, Sujith J.] Christian Med Coll & Hosp, Dept Pharmacol & Clin Pharmacol, Vellore, Tamil Nadu, India, [Cherry-Bukowiec, Jill R.] Univ Michigan, Dept Surg, Div Acute Care Surg, Ann Arbor, MI 48109 USA, [Cirocchi, Roberto] Univ Perugia, Dept Gen & Oncol Surg, Terni, Italy, [Colak, Elif] Hlth Sci Univ, Samsun Training & Res Hosp, Dept Gen Surg, Samsun, Turkey, [Corcione, Antonio] AORN Colli Vincenzo Monaldi Hosp, Anesthesia & Intens Care Unit, Naples, Italy, [Cornely, Oliver A.] Univ Cologne, German Ctr Infect Res DZIF, Dept Internal Med 1, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany, [Cortese, Francesco] San Filippo Neris Hosp, Emergency Surg Unit, Rome, Italy, [Cui, Yunfeng] Tianjin Med Univ, Tianjin Nankai Hosp, Dept Surg, Nankai Clin Sch Med, Tianjin, Peoples R China, [Curcio, Daniel] Buenos Aires Univ, Infectol Inst SRL, Buenos Aires, DF, Argentina, [Damaskos, Dimitris] Royal Infirm Edinburgh NHS Trust, Dept Surg, Edinburgh, Midlothian, Scotland, [Das, Koray] Ankara Numune Training & Res Hosp, Dept Surg, Adana, Turkey, [Delibegovic, Samir] Univ Clin Ctr Tuzla, Dept Surg, Tuzla, Bosnia & Herceg, [Deme-Trashvili, Zaza] Kipshidze Cent Univ Hosp, Dept Gen Surg, Tbilisi, Georgia, [De Simone, Belinda] Cannes Hosp, Dept Digest Surg, Cannes, France, [de Souza, Hamilton Petry] Pontificia Univ Catolica Rio Grande do Sul PUCRS, Sch Med, Dept Surg, Porto Alegre, RS, Brazil, [De Waele, Jan] Ghent Univ Hosp, Dept Crit Care Med, Ghent, Belgium, [Dhingra, Sameer] Univ West Indies, Eric Williams Med Sci Complex, Sch Pharm, Fac Med Sci, Uriah Butler Highway, Champ Fleurs, Trinidad Tobago, [Diaz, Jose J.] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Div Acute Care Surg, Program Trauma, Baltimore, MD 21201 USA, [Di Carlo, Isidoro] Univ Catania, Cannizzaro Hosp, Dept Surg Sci, Catania, Italy, [Di Marzo, Francesco] Versilia Hosp, Gen Surg, Usl Nordovest, Tuscany, Italy, [Di Saverio, Salomone] Maggiore Hosp, Dept Surg, Bologna, Italy, [Dogjani, Agron] Univ Hosp Trauma, Dept Surg, Tirana, Albania, [Dorj, Gereltuya] Mongolian Natl Univ Med Sci, Sch Pharm, Ulaanbaatar, Mongolia, [Dortet, Laurent] Paris Sud Univ, Bicetre Hosp, Dept Microbiol, La Kremlin Bicetre, France, [Duane, Therese M.] John Peter Smith Hlth Network, Dept Surg, Ft Worth, TX USA, [Dupont, Herve] Univ Picardie Jules Verne, CHU Amiens Picardie, Dept Anesthesie Reanimat, Amiens, France, [Dupont, Herve] Univ Picardie Jules Verne, INSERM, U1088, Amiens, France, [Egiev, Valery N.] Pirogov Russian Natl Res Med Univ, Dept Surg, Moscow, Russia, [Eid, Hani O.] Al Ain Hosp, Mediclin Middle East, Dept Emergency Med, Al Ain, U Arab Emirates, [Elmangory, Mutasim] Fed Minist Hlth, Sudan Natl Publ Hlth Lab, Khartoum, Sudan, [Enani, Mushira Abdulaziz] King Fahad Med City, Div Infect Dis, Dept Med, Riyadh, Saudi Arabia, [Escandon-Vargas, Kevin] Univ Valle, Escuela Med, Fac Salud, Cali, Colombia, [Faro Junior, Mario P.] ABC Med Sch, Dept Gen Surg Trauma, Santo Andre, SP, Brazil, [Faro Junior, Mario P.] ABC Med Sch, Emergency Surg Div, Santo Andre, SP, Brazil, [Ferrada, Paula] Virginia Commonwealth Univ, Dept Surg, Richmond, VA USA, [Foghetti, Domitilla] Pesaro Hosp, Dept Surg, Pesaro, Italy, Clin Foianini, Dept Surg, Santa Cruz, Bolivia, [Fraga, Gustavo P.] Univ Campinas Unicamp, Sch Med Sci, Dept Surg, Div Trauma Surg, Campinas, SP, Brazil, [Frattima, Sabrina] Ist Clin San Rocco Franciacorta, Brescia, Italy, [Gandhi, Chinmay] Bharati Vidyapeeth Deemed Univ Med Coll & Hosp, Dept Surg, Sangli, Maharashtra, India, [Gattuso, Gianni] C Poma Hosp, Infect Dis Dept, Mantua, Italy, [Giamarellou, Eleni] Hygeia Gen Hosp, Dept Internal Med 6, Athens, Greece, [Ghnnam, Wagih] Mansoura Univ, Mansoura Fac Med, Dept Gen Surg, Mansoura, Egypt, [Gkiokas, George] Natl & Kapodistrian Univ Athens, Aretaieion Univ Hosp, Dept Surg 2, Athens, Greece, [Girardis, Massimo] Modena Univ Hosp, Intens Care Unit, Modena, Italy, [Goff, Debbie A.] Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA, [Gomes, Carlos Augusto] Hosp Univ Terezinha Jesus, Dept Surg, Fac Ciencias Med & Saude Juiz de Fora, Juiz De Fora, Brazil, [Gomi, Harumi] Univ Tsukuba, Mito Kyodo Gen Hosp, Ctr Global Hlth, Mito, Ibaraki, Japan, [Guerra Gronerth, Rosio Isabel] Peruvian Navy Med Ctr, Lima, Peru, [Guirao, Xavier] Parc Tauli Univ Hosp, Dept Gen Surg, Unit Endocrine Head & Neck Surg, Sabadell, Spain, [Guirao, Xavier] Parc Tauli Univ Hosp, Dept Gen Surg, Unit Surg Infect Support, Sabadell, Spain, [Guzman-Blanco, Manuel] Hosp Privado Ctr Med Caracas, Caracas, Venezuela, [Guzman-Blanco, Manuel] Hosp Vargas Caracas, Caracas, Venezuela, [Haque, Mainul] Univ Pertahanan Nasional Malaysia, Natl Def Univ Malaysia, Unit Pharmacol, Fac Med & Def Hlth, Kuala Lumpur, Malaysia, [Reichert, Martin] Univ Pertahanan Nasional Malaysia, Natl Def Univ Malaysia, Unit Pharmacol, Fac Med & Def Hlth, Kuala Lumpur, Malaysia, [Hecker, Andreas] Univ Hosp Giessen, Dept Gen & Thorac Surg, Giessen, Germany, [Hell, Markus] Paracelsus Med Univ, Acad Teaching Lab, Clin Microbiol & Infect Control, MEDILAB Dr Mustafa Dr Richter OG, Salzburg, Austria, [Herzog, Torsten] Ruhr Univ Bochum, St Josef Hosp, Dept Surg, Bochum, Germany, [Hicks, Lauri] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA, [Kafka-Ritsch, Reinhold] Innsbruck Med Univ, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria, [Kao, Lillian S.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA, [Kanj, Souha S.] Amer Univ Beirut, Dept Internal Med, Div Infect Dis, Beirut, Lebanon, [Kaplan, Lewis J.] Univ Penn, Perelman Sch Med, Philadelphia VA Med Ctr, Dept Surg, Philadelphia, PA 19104 USA, [Kapoor, Garima] Gandhi Med Coll, Dept Microbiol, Bhopal, India, [Karamarkovic, Aleksandar] Univ Belgrade, Clin Emergency Surg, Med Fac, Belgrade, Serbia, [Kashuk, Jeffry] Tel Aviv Univ, Dept Surg, Assia Med Grp, Sackler Sch Med, Tel Aviv, Israel, [Kenig, Jakub] Jagiellonian Univ, Med Coll, Dept Gen Surg 3, Krakow, Poland, [Khamis, Faryal] Royal Hosp, Dept Internal Med, Muscat, Oman, [Khokha, Vladimir] City Hosp, Dept Emergency Surg, Mozyr, BELARUS, [Kiguba, Ronald] Makerere Univ, Dept Pharmacol & Therapeut, Coll Hlth Sci, Kampala, Uganda, [Kirkpatrick, Andrew W.] Foothills Med Ctr, Gen Acute Care Abdominal Wall Reconstruct & Traum, Calgary, AB, Canada, [Korner, Hartwig] Stavanger Univ Hosp, Dept Gastrointestinal Surg, Stavanger, Norway, [Koike, Kaoru] Kyoto Univ, Grad Sch Med, Dept Primary Care & Emergency Med, Kyoto, Japan, [Kok, Kenneth Y. Y.] Brunei Canc Ctr, Dept Surg, Jerudong Pk, Jerudong, Brunei, [Kon, Kateryna] Kharkiv Natl Med Univ, Dept Microbiol Virol & Immunol, Kharkov, Ukraine, [Kong, Victor] Edendale Hosp, Dept Surg, Pietermaritzburg, South Africa, [Inaba, Kenji] Univ Southern Calif, Los Angeles Cty & Univ So Cali fornia Med Ctr, Div Acute Care Surg & Surg Crit Care, Dept Surg, Los Angeles, CA USA, [Ioannidis, Orestis] Aristotle Univ Thessaloniki, Gen Hosp G Papanikolaou, Surg Dept 4, Med Sch, Thessaloniki, Greece, [Isik, Arda] Erzincan Univ, Dept Gen Surg, Fac Med, Erzincan, Turkey, [Iskandar, Katia] Lebanese Int Univ, Dept Pharm, Beirut, Lebanon, [Labbate, Maurizio] Univ Technol Sydney, Sch Life Sci, Sydney, NSW, Australia, [Labbate, Maurizio] Univ Technol Sydney, Inst I3, Sydney, NSW, Australia, [Labricciosa, Francesco M.] UNIVPM, Dept Biomed Sci & Publ Hlth, Unit Hyg Prevent Med & Publ Hlth, Ancona, Italy, [Lagrou, Katrien] Univ Hosp Leuven, Clin Dept Lab Med, Leuven, Belgium, [Lagrou, Katrien] Katholieke Univ Leuven, Dept Microbiol & Immunol, Leuven, Belgium, [Lagunes, Leonel] Hosp Cent Dr Ignacio Morones Prieto, San Luis Potosi, Mexico, [Latifi, Rifat] Univ Arizona, Dept Surg, Div Trauma, Tucson, AZ USA, [Lasithiotakis, Kostas] York Teaching Hosp NHS Fdn Trust, Dept Surg, York, N Yorkshire, England, [Laxminarayan, Ramanan] Ctr Dis Dynam Econ & Policy, Washington, DC USA, [Lee, Jae Gil] Yonsei Univ, Coll Med, Dept Surg, Seoul, South Korea, [Leone, Marc] Aix Marseille Univ, Hop Nord, AP HM, Dept Anaesthesiol & Crit Care, Marseille, France, [Leppaniemi, Ari] Univ Hosp Meilahti, Abdominal Ctr, Helsinki, Finland, [Li, Yousheng] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Surg, Shanghai, Peoples R China, [Liang, Stephen Y.] Washington Univ, Sch Med, Div Infect Dis, Div Emergency Med, St Louis, MO USA, [Liau, Kui-Hin] Natl Univ Singapore, Mt Elizabeth Novena Hosp, Singapore & Yong Loo Lin Sch Med, Dept Surg,Liau KH Consulting, Singapore, Singapore, [Litvin, Andrey] Immanuel Kant Balt Fed Univ, Surg Disciplines, Reg Clin Hosp, Kaliningrad, Russia, [Loho, Tonny] Univ Indonesia, Cipto Mangunkusumo Gen Hosp, Dept Clin Pathol, Div Infect Dis,Fac Med, Jakarta, Indonesia, [Lowman, Warren] Univ Witwatersrand, Sch Pathol, Vermaak Partners Pathcare Pathologists, Clin Microbiol & Infect Dis,Fac Hlth Sci, Johannesburg, South Africa, [Lowman, Warren] Wits Donald Gordon Med Ctr, Johannesburg, South Africa, [Machain, Gustavo M.] Univ Nacl Asuncion, Dept Surg, Asuncion, Paraguay, [Segovia Lohse, Helmut] Univ Nacl Asuncion, Dept Surg, Asuncion, Paraguay, [Maier, Ronald V.] Univ Washington, Dept Surg, Seattle, WA 98195 USA, [Manzano-Nunez, Ramiro] Fdn Valle Lili, Clin Res Ctr, Cali, Colombia, [Marinis, Athanasios] Tzane Gen Hosp, Dept Surg 1, Piraeus, Greece, [Marmorale, Cristina] Univ Politecn Marche, Dept Surg, Ancona, Italy, [Martin-Loeches, Ignacio] St James Univ Hosp, Trin Ctr Hlth Sci, Dept Clin Med, Wellcome Trust HRB Clin Res,MICRO, Dublin, Ireland, [Marwah, Sanjay] Postgrad Inst Med Sci, Dept Surg, Rohtak, Haryana, India, [Maseda, Emilio] Hosp Univ La Paz Madrid, Serv Anestesia & Reanimac, Madrid, Spain, [McFarlane, Michael] Univ Hosp West Indies, Dept Surg Radiol, Kingston, Jamaica, [de Melo, Renato Bessa] Ctr Hosp Sao Joao, Gen Surg Dept, Porto, Portugal, [Melotti, Maria Rita] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Anesthesiol & Intens Care, Bologna, Italy, [Memish, Ziad] Minist Hlth, Prince Mohamed Bin Abdulaziz Hosp, Dept Med, Infect Dis Div, Riyadh, Saudi Arabia, [Mertz, Dominik] McMaster Univ, Dept Med, Hamilton, ON, Canada, [Mertz, Dominik] McMaster Univ, Dept Clin Epidemiol & Biostat, Dept Pathol & Mol Med, Hamilton, ON, Canada, [Mesina, Cristian] Emergency Hosp Craiova, Surg Clin 2, Craiova, Romania, [Menichetti, Francesco] Univ Hosp Pisa, Infect Dis Unit, Pisa, Italy, [Mishra, Shyam Kumar] Tribhuvan Univ, Teaching Hosp, Inst Med, Dept Microbiol, Kathmandu, Nepal, [Moore, Ernest E.] Univ Colorado, Denver Hlth Med Ctr, Dept Surg, Denver, CO 80202 USA, [Moore, Frederick A.] Univ Florida, Coll Med, Dept Surg, Div Acute Care Surg, Gainesville, FL USA, [Moore, Frederick A.] Univ Florida, Coll Med, Ctr Sepsis & Crit Illness Res, Gainesville, FL USA, [Naidoo, Noel] Univ KwaZulu Natal, Dept Surg, Durban, South Africa, [Napolitano, Lena] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA, [Negoi, Ionut] Emergency Hosp Bucharest, Dept Surg, Bucharest, Romania, [Nicolau, David P.] Ctr Anti Infect Res & Dev, Hartford, CT USA, [Nikolopoulos, Ioannis] Lewisham & Greenwich NHS Trust, Dept Gen Surg, London, England, [Nord, Carl Erik] Karolinska Univ, Huddinge Hosp, Dept Lab Med, Div Clin Microbiol, Stockholm, Sweden, [Ofori-Asenso, Richard] Hlth Policy Consult, Res Unit, Weija, Accra, Ghana, [Olaoye, Iyiade] Univ Ilorin, Teaching Hosp, Dept Surg, Ilorin, Nigeria, [Omari, Abdelkarim H.] King Abdullah Univ Hosp, Dept Surg, Irbid, Jordan, [Ordonez, Carlos A.] Univ Valle, Fdn Valle Lili, Dept Surg & Crit Care, Cali, Colombia, [Ouadii, Mouaqit] Sidi Mohamed Benabdellah Univ, Hassan Univ Hosp 2, Dept Surg, Med Sch Fez, Fes, Morocco, [Ouedraogo, Abdoul-Salam] CHU Souro Sanou, Bacteriol & Virol Dept, Bobo Dioulasso, Burkina Faso, [Pagani, Leonardo] Bolzano Cent Hosp, Infect Dis Unit, Bolzano, Italy, [Paiva, Jose Artur] Univ Porto, Ctr Hosp Sao Joao, Intens Care Med Dept, Porto, Portugal, [Mergulhao, Paulo] Univ Porto, Ctr Hosp Sao Joao, Intens Care Med Dept, Porto, Portugal, [Parreira, Jose Gustavo] Santa Casa Sao Paulo Sch Med Sci, Dept Surg, Sao Paulo, Brazil, [Pata, Francesco] St Antonio Abate Hosp, Dept Surg, Gallarate, Italy, [Pereira, Jorge] Ctr Hosp Tondela Viseu, Surg Unit 1, Viseu, Portugal, [Pereira, Nuno R.] Sao Joao Hosp Ctr, Ctr Hosp Epidemiol, Unit Prevent & Infect Control, Porto, Portugal, [Petrosillo, Nicola] INMI Lazzaro Spallanzani IRCCS, Natl Inst Infect Dis, Rome, Italy, [Picetti, Edoardo] Univ Parma, Azienda Osped, Dept Anesthesia & Intens Care, Parma, Italy, [Pintar, Tadeja] UMC Ljubljana, Dept Surg, Ljubljana, Slovenia, [Ponce-de-Leon, Alfredo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Infect Dis, Lab Clin Microbiol, Mexico City, DF, Mexico, [Popovski, Zagorka] Hamilton Hlth Sci, Hamilton, ON, Canada, [Popovski, Zagorka] London Hlth Sci, London, ON, Canada, [Poulakou, Garyphallia] Attikon Univ Gen Hosp, Med Sch, Natl & Kapodistrian Univ Athens, Dept Internal Med 4, Athens, Greece, [Poulakou, Garyphallia] Attikon Univ Gen Hosp, Med Sch, Natl & Kapodistrian Univ Athens, Infect Dis Unit, Athens, Greece, [Preller, Jacobus] Univ Hosp NHS Fdn Trust, John Farman Intens Care Unit, Cambridge, England, [Guerrero, Adrian Puello] Univ Autonoma Santo Domingo, Inst Nacl Canc Rosa Tavares INCART, Santo Domingo, Dominican Rep, [Pupelis, Guntars] Riga East Univ Hosp Gailezers, Dept Gen & Emergency Surg, Riga, Latvia, [Quiodettis, Martha] Hosp Santo Tomas, Dept Trauma, Panama City, Panama, [Rawson, Timothy M.] Natl Inst Hlth Res, Imperial Coll London, Hlth Protect Res Unit Healthcare Associated Infec, Hammersmith Campus, London, England, [Reinhart, Konrad] Jena Univ Hosp, Dept Anesthesiol & Intens Care Med, Jena, Thuringen, Germany, [Rems, Miran] Jesenice Gen Hosp, Dept Gen Surg, Jesenice, Slovenia, [Rello, Jordi] VHIR, Dept Clin Res & Innovat Pneumonia & Sepsis, Barcelona, Spain, [Rizoli, Sandro] Univ Toronto, St Michaels Hosp, Trauma & Acute Care Serv, Toronto, ON, Canada, [Roberts, Jason] Univ Queensland, Fac Med, Brisbane, Qld, Australia, [Rubio-Perez, Ines] La Paz Univ Hosp, Gen Surg Dept, Colorectal Surg Unit, Madrid, Spain, [Ruppc, Etienne] Bichat Claude Bernard Univ Hosp, Paris Diderot Sorbonne Univ, Serv Bacteriol, HUPNSV, Paris, France, [Sakakushev, Boris] Univ Hosp St George, Med Univ, Gen Surg Dept, Plovdiv, Bulgaria, [Sall, Ibrahima] Mil Teaching Hosp, Gen Surg Dept, Dakar, Senegal, [Kafil, Hossein Samadi] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran, [Sanders, James] JPS Hlth Network, Ft Worth, TX USA, [Sato, Norio] Ehime Univ, Grad Sch Med, Dept Aeromed Serv Emergency & Trauma Care, Matsuyama, Ehime, Japan, [Sawyer, Robert G.] Western Michigan Univ, Sch Med, Dept Surg, Kalamazoo, MI 49008 USA, [Scalea, Thomas] Univ Maryland, Sch Med, Dept Trauma Surg, Baltimore, MD 21201 USA, [Scudeller, Luigia] IRCCS Policlin San Matteo Fdn, Clin Epidemiol Unit, Pavia, Italy, [Sganga, Gabriele] Univ Cattolica Sacro Cuore, Policlin A Gemelli, Dept Surg, Rome, Italy, [Shafiq, Nusrat] Postgrad Inst Med Educ & Res, Dept Pharmacol, Chandigarh, India, [Shah, Jay N.] Patan Acad Hlth Sci, Dept Surg Patan Hosp, Kathmandu, Nepal, [Spigaglia, Patrizia] Ist Super Sanita, Dept Infect Dis, Rome, Italy, [Suroowan, Shanoo] Univ Mauritius, Dept Hlth Sci, Fac Sci, Reduit, Mauritius, [Tsioutis, Constantinos] European Univ Cyprus, Sch Med, Nicosia, Cyprus, [Sifri, Costi D.] Univ Virginia Hlth Syst, Off Hosp Epidemiol Infect Prevent & Control, Charlottesville, VA USA, [Siribumrungwong, Boonying] Thammasat Univ Hosp, Thammasat Univ, Dept Surg, Fac Med, Pathum Thani, Thailand, [Sugrue, Michael] Letterkenny Hosp, Gen Surg Dept, Letterkenny, Ireland, [Talving, Peep] North Estonia Med Ctr, Dept Surg, Tallinn, Estonia, [Tan, Boun Kim] Ctr Hosp St Joseph St Luc, Intens Care Unit, Lyon, France, [Tarasconi, Antonio] Parma Maggiore Hosp, Dept Emergency Surg, Parma, Italy, [Catena, Fausto] Parma Maggiore Hosp, Dept Emergency Surg, Parma, Italy, [Tascini, Carlo] Cotugno Hosp, Azienda Osped Colli, Div Infect Dis 1, Naples, Italy, [Tilsed, Jonathan] Hull & East Yorkshire Hosp NHS Trust, Surg Hlth Care Grp, Kingston Upon Hull, N Humberside, England, [Timsit, Jean-Francois] Hop Xavier Bichat, PHP Med & Infect Dis ICU, Paris, France, [Tumbarello, Mario] Catholic Univ, Inst Infect Dis, Rome, Italy, [Ngo Tat Trung] Tran Hung Dao Hosp, Dept Mol Biol, Hanoi, Vietnam, [Ulrych, Jan] Charles Univ Prague, Fac Med 1, Dept Surg 1, Prague, Czech Republic, [Ulrych, Jan] Gen Univ Hosp Prague, Prague, Czech Republic, [Uranues, Selman] Med Univ Graz, Dept Surg, Graz, Austria, [Velmahos, George] Massachusetts Gen Hosp, Trauma Emergency Surg & Surg Crit Care, Boston, MA 02114 USA, [Vereczkei, Andras G.] Med Sch Univ Pecs, Dept Surg, Pecs, Hungary, [Viale, Pierluigi] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Infect Dis Unit, Bologna, Italy, [Vila Estape, Jordi] Univ Barcelona, ISGlobal Hosp Clin, Inst Salud Global, Barcelona, Spain, [Viscoli, Claudio] Univ Genoa DISSAL, Osped Policlin San Martino IRCCS Oncol, Infect Dis Unit, Genoa, Italy, [Wagenlehner, Florian] Univ Giessen, Dept Urol Pediat Urol & Androl, Med Fac Justus Liebig, Giessen, Germany, [Wright, Brian J.] SUNY Stony Brook, Sch Med, Dept Emergency Med & Neurosurg, Stony Brook, NY 11794 USA, [Xiao, Yonghong] Zhejiang Univ, Affilliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou, Zhejiang, Peoples R China, [Yuan, Kuo-Ching] Chang Gung Mem Hosp, Trauma & Emergency Surg Dept, Taoyuan, Taiwan, [Zachariah, Sanoop K.] MOSC Med Coll Kolenchery, Dept Surg, Cochin, Kerala, India, [Zahar, Jean Ralph] Angers Univ, CHU Angers, Infect Control Unit, Angers, France, COMBE, Isabelle, Sartelli, M, Kluger, Y, Ansaloni, L, Carlet, J, Brink, A, Hardcastle, T, Khanna, A, Chicom-Mefire, A, Rodriguez-Bano, J, Nathwani, D, Mendelson, M, Watkins, R, Pulcini, C, Beovic, B, May, A, Itani, K, Mazuski, J, Fry, D, Coccolini, F, Rasxa, K, Montravers, P, Eckmann, C, Abbo, L, Abubakar, S, Abu-Zidan, F, Adesunkanmi, A, Al-Hasan, M, Althani, A, Ticas, J, Ansari, S, Ansumana, R, Da Silva, A, Augustin, G, Bala, M, Balogh, Z, Baraket, O, Bassetti, M, Bellanova, G, Beltran, M, Ben-Ishay, O, Biffl, W, Boermeester, M, Brecher, S, Bueno, J, Cainzos, M, Cairns, K, Camacho-Ortiz, A, Ceresoli, M, Chandy, S, Cherry-Bukowiec, J, Cirocchi, R, Colak, E, Corcione, A, Cornely, O, Cortese, F, Cui, Y, Curcio, D, Damaskos, D, Dasx, K, Delibegovic, S, Demetrashvili, Z, De Simone, B, De Souza, H, De Waele, J, Dhingra, S, Diaz, J, Di Carlo, I, Di Marzo, F, Di Saverio, S, Dogjani, A, Dorj, G, Dortet, L, Duane, T, Dupont, H, Egiev, V, Eid, H, Elmangory, M, El-Sayed Marei, H, Enani, M, Escandon-Vargas, K, Faro, M, Ferrada, P, Foghetti, D, Foianini, E, Fraga, G, Frattima, S, Gandhi, C, Gattuso, G, Giamarellou, E, Ghnnam, W, Gkiokas, G, Girardis, M, Goff, D, Gomes, C, Gomi, H, Gronerth, R, Guirao, X, Guzman-Blanco, M, Haque, M, Hecker, A, Hell, M, Herzog, T, Hicks, L, Kafka-Ritsch, R, Kao, L, Kanj, S, Kaplan, L, Kapoor, G, Karamarkovic, A, Kashuk, J, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kirkpatrick, A, Korner, H, Koike, K, Kok, K, Kon, K, Kong, V, Inaba, K, Ioannidis, O, Isik, A, Iskandar, K, Labbate, M, Labricciosa, F, Lagrou, K, Lagunes, L, Latifi, R, Lasithiotakis, K, Laxminarayan, R, Lee, J, Leone, M, Leppaniemi, A, Li, Y, Liang, S, Liau, K, Litvin, A, Loho, T, Lowman, W, Machain, G, Maier, R, Manzano-Nunez, R, Marinis, A, Marmorale, C, Martin-Loeches, I, Marwah, S, Maseda, E, Mcfarlane, M, De Melo, R, Melotti, M, Memish, Z, Mertz, D, Mesina, C, Menichetti, F, Mishra, S, Montori, G, Moore, E, Moore, F, Naidoo, N, Napolitano, L, Negoi, I, Nicolau, D, Nikolopoulos, I, Nord, C, Ofori-Asenso, R, Olaoye, I, Omari, A, Ordonez, C, Ouadii, M, Ouedraogo, A, Pagani, L, Paiva, J, Parreira, J, Pata, F, Pereira, J, Pereira, N, Petrosillo, N, Picetti, E, Pintar, T, Ponce-De-Leon, A, Popovski, Z, Poulakou, G, Preller, J, Guerrero, A, Pupelis, G, Quiodettis, M, Rawson, T, Reichert, M, Reinhart, K, Rems, M, Rello, J, Rizoli, S, Roberts, J, Rubio-Perez, I, Ruppe, E, Sakakushev, B, Sall, I, Kafil, H, Sanders, J, Sato, N, Sawyer, R, Scalea, T, Scibe, R, Scudeller, L, Lohse, H, Sganga, G, Shafiq, N, Shah, J, Spigaglia, P, Suroowan, S, Tsioutis, C, Sifri, C, Siribumrungwong, B, Sugrue, M, Talving, P, Tan, B, Tarasconi, A, Tascini, C, Tilsed, J, Timsit, J, Tumbarello, M, Trung, N, Ulrych, J, Uranues, S, Velmahos, G, Vereczkei, A, Viale, P, Estape, J, Viscoli, C, Wagenlehner, F, Wright, B, Xiao, Y, Yuan, K, Zachariah, S, Zahar, J, Mergulhao, P, Catena, F, Sartelli, M., Kluger, Y., Ansaloni, L., Carlet, J., Brink, A., Hardcastle, T. C., Khanna, A., Chicom-Mefire, A., Rodríguez-Baño, J., Nathwani, D., Mendelson, M., Watkins, R. R., Pulcini, C., Beović, B., May, A. K., Itani, K. M. F., Mazuski, J. E., Fry, D. E., Coccolini, F., Rasxa, K., Montravers, P., Eckmann, C., Abbo, L. M., Abubakar, S., Abu-Zidan, F. M., Adesunkanmi, A. K., Al-Hasan, M. N., Althani, A. A., Ticas, J. E. A., Ansari, S., Ansumana, R., Da, Silva, Augustin, A. R. A., Bala, G., Balogh, M., Baraket, Z. J., Bassetti, O., Bellanova, M., Beltran, G., Ben-Ishay, M. A., Boermeester, O., Brecher, M. A., Bueno, S. M., Cainzos, J., Cairns, M. A., Camacho-Ortiz, K., Ceresoli, A., Chandy, M., Cherry-Bukowiec, S. J., Cirocchi, J. R., Colak, R., Corcione, E., Cornely, A., Cortese, O. A., Cui, F., Curcio, Y., Damaskos, D., Dasx, D., Delibegovic, K., Demetrashvili, S., Be, Z., Simone, De, Bf, B., De, Souza, Bg, H. P., De, Waele, Bh, J., Dhingra, Bi, S., Diaz, Bj, J. J., Carlo, Di, Bk, I., Di, Marzo, Bl, F., Saverio, Di, Dogjani, S., Dorj, A., Dortet, G., Duane, L., Dupont, T. M., Egiev, H., Eid, V. N., Elmangory, H. O., El-Sayed, Marei, Enani, H., Escandón-Vargas, M. A., Faro, K., M. P., J. r., Ferrada, P., Foghetti, D., Foianini, E., Fraga, G. P., Frattima, S., Gandhi, C., Gattuso, G., Giamarellou, E., Ghnnam, W., Gkiokas, G., M., Girardi, Goff, D. A., Gomes, C. A., Gomi, H., Gronerth, R. I. G., Guirao, X., Guzman-Blanco, M., Haque, M., Hecker, A., Hell, M., Herzog, T., Hicks, L., Kafka-Ritsch, R., Kao, L. S., Kanj, S. S., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kashuk, J., Kenig, J., Khamis, F., Khokha, V., Kiguba, R., Kirkpatrick, A. W., Kørner, H., Koike, K., Kok, K. Y. Y., Kon, K., Kong, V., Inaba, K., Ioannidis, O., Isik, A., Iskandar, K., Labbate, M., Labricciosa, F. M., Lagrou, K., Lagunes, L., Latifi, R., Lasithiotakis, K., Laxminarayan, R., Lee, J. G., Leone, M., Leppäniemi, A., Li, Y., Liang, S. Y., Liau, K. -. H., Litvin, A., Loho, T., Lowman, W., Machain, Mf, G., Maier, R. V., Manzano-Nunez, R., Marinis, A., Marmorale, C., Martin-Loeches, I., Marwah, S., Maseda, E., Mcfarlane, M., De, Melo, Melotti, R., Memish, R., Mertz, Z., Mesina, D., Menichetti, C., Mishra, F., Montori, S. K., Moore, G., Moore, E. E., Naidoo, F. A., Napolitano, N., Negoi, L., Nicolau, I., Nikolopoulos, D. P., Nord, I., Ofori-Asenso, C. E., Olaoye, R., Omari, I., Ordoñez, A. H., Ouadii, C. A., Ouedraogo, M., Pagani, A., Paiva, L., Parreira, J. A., Pata, J. G., F., Fm, Pereira, J., Pereira, N. R., Petrosillo, N., Picetti, E., Pintar, T., Ponce-De-Leon, A., Popovski, Z., Poulakou, G., Preller, J., Guerrero, A. P., Pupelis, G., Quiodettis, M., Rawson, T. M., Reichert, M., Reinhart, K., Rems, M., Rello, J., Rizoli, S., Roberts, J., Rubio-Perez, I., Ruppé, E., Sakakushev, B., Sall, I., Kafil, H. S. j, Sanders, J., Sato, N., Sawyer, R. G., Scibé, T., Scudeller, R., Lohse, L., Sganga, H. S., Shafiq, G., Shah, N., Spigaglia, J. N., Suroowan, P., Tsioutis, S., Sifri, C., Siribumrungwong, C. D., Sugrue, B., Talving, M., Tan, P., Tarasconi, B. K., Tascini, A., Tilsed, C., Timsit, J., Tumbarello, J. -. F., Trung, M., Ulrych, N. T., Uranues, J., Velmahos, S., Vereczkei, G., Viale, A. G., Estape, P., Viscoli, J. V., Wagenlehner, C., Wright, F., Xiao, B. J., Yuan, Y., Zachariah, K. -. C., Zahar, S. K., Mergulhão, J. R., and Catena, P.

Subjects
0301 basic medicine, antibiotic agent, antifungal agent antiinfective agent, Antifungal Agents, Drug Resistance, Declaration, Inappropriate Prescribing, 030230 surgery, Global Health, Antimicrobial Stewardship, Microbial, 0302 clinical medicine, Anti-Infective Agents, Health care, Global health, Antimicrobial stewardship, Antibiotic prophylaxis, Antibiotic stewardship, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Drug Resistance, Microbial, Public relations, Antimicrobial, Operative, Anti-Bacterial Agents, Antibiotic Prophylaxis, Humans, Surgical Procedures, Operative, Surgical Wound Infection, Surgery, Microbiology (medical), Infectious Diseases, 3. Good health, surgical infections, medicine.medical_specialty, 030106 microbiology, Guidelines, 03 medical and health sciences, Antibiotic resistance, medicine, Ventilator-associated pneumonia, Adults, Surgical Procedures, business.industry, Carbapenems, Therapy, business, hospitals, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages.

Published
2017

10. Naproxen as Prophylaxis against Atrial Fibrillation after Cardiac Surgery: The NAFARM Randomized Trial

Author

Claudio Cirenza, Felipe Martini, Adauto Castelo Filho, João Batista Petracco, João Carlos Vieira da Costa Guaragna, Luiz Carlos Bodanese, Angelo Amato Vicenzo de Paola, Stevie Jorge Horbach, Renato D. Lopes, Rajendra H. Mehta, Nafarm Investigators, Duke Univ, Universidade Federal de São Paulo (UNIFESP), Pontificia Univ Catolica Rio Grande do Sul, and Brazilian Clin Res Inst

Subjects
Male, medicine.medical_specialty, Naproxen, Coronary artery bypass graft surgery, Placebo, law.invention, Postoperative Complications, Double-Blind Method, Randomized controlled trial, law, Atrial Fibrillation, medicine, Humans, Data monitoring committee, Prospective Studies, Prospective cohort study, Aged, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Atrial fibrillation, General Medicine, Acute Kidney Injury, Length of Stay, Middle Aged, medicine.disease, Intensive care unit, Surgery, Cardiac surgery, Intensive Care Units, Anesthesia, Early Termination of Clinical Trials, Nonsteroidal anti-inflammatory, Female, business, Brazil, medicine.drug
Abstract

PURPOSE: We sought to assess the effect of naproxen versus placebo on prevention of atrial fibrillation after coronary artery bypass graft (CABG) surgery.METHODS: in this randomized, double-blind, placebo-controlled, single-center trial of 161 consecutive patients undergoing CABG surgery, patients received naproxen 275 mg every 12 hours or placebo at the same dosage and interval over 120 hours immediately after CABG surgery. the primary outcome was the occurrence of atrial fibrillation in the first 5 postoperative days.RESULTS: the incidence of postoperative atrial fibrillation was 15.2% (12/79) in the placebo versus 7.3% (6/82) in the naproxen group (P = .11). the duration of atrial fibrillation episodes was significantly lower in the naproxen (0.35 hours) versus placebo group (3.74 hours; P = .04). There was no difference in the overall days of hospitalization between placebo (17.23 +/- 7.39) and naproxen (18.33 +/- 9.59) groups (P = .44). Intensive care unit length of stay was 4.0 +/- 4.57 days in the placebo and 3.23 +/- 1.25 days in the naproxen group (P = .16). the trial was stopped by the data monitoring committee before reaching the initial target number of 200 patients because of an increase in renal failure in the naproxen group (7.3% vs 1.3%; P = .06).CONCLUSIONS: Postoperative use of naproxen did not reduce the incidence of atrial fibrillation but decreased its duration, in a limited sample of patients after CABG surgery. There was a significant increase in acute renal failure in patients receiving naproxen 275 mg twice daily. Our study does not support the routine use of naproxen after CABG surgery for the prevention of atrial fibrillation. (C) 2011 Elsevier Inc. All rights reserved. . the American Journal of Medicine (2011) 124, 1036-1042 Duke Univ, Duke Clin Res Inst, Med Ctr, Durham, NC 27705 USA Universidade Federal de São Paulo, Div Invas Clin Electrophysiol, Dept Cardiol, São Paulo, Brazil Pontificia Univ Catolica Rio Grande do Sul, Div Cardiol, Porto Alegre, RS, Brazil Brazilian Clin Res Inst, São Paulo, Brazil Universidade Federal de São Paulo, Div Invas Clin Electrophysiol, Dept Cardiol, São Paulo, Brazil Web of Science

Published
2011

11. Microbial leakage of MTA, Portland cement, Sealapex and zinc oxide-eugenol as root-end filling materials

Author

Carlos Estrela, Julio Almeida-Silva, Daniel de Almeida-Decurcio, José-Antonio Poli-Figueiredo, Pedro-Felício Estrada-Bernabé, Cyntia Rodrigues-Araújo-Estrela, Universidade Federal de Goiás (UFG), Universidade Estadual Paulista (Unesp), and Pontificia Univ Catolica Rio Grande do Sul

Subjects
Mineral trioxide aggregate, bacterial leakage, Portland cement, Smear layer, Dental Cements, Dentistry, chemistry.chemical_element, Zinc, Bacterial Physiological Phenomena, law.invention, Calcium Hydroxide, Root Canal Filling Materials, chemistry.chemical_compound, Mineral trioxide aggregate (MTA), Dental cement, law, Candida albicans, Humans, Agar diffusion test, Food science, Zinc Oxide-Eugenol Cement, Aluminum Compounds, General Dentistry, Calcium hydroxide, business.industry, Silicates, Sealapex, Oxides, Calcium Compounds, Salicylates, root-end filling, Drug Combinations, Otorhinolaryngology, chemistry, Zinc oxide eugenol, Surgery, business
Abstract

Made available in DSpace on 2013-08-12T19:03:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-05-01 Made available in DSpace on 2013-09-30T19:19:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-05-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:33:00Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T15:33:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-05-01 Objective: The aim of this study was to compare the microbial leakage of mineral trioxide aggregate (MTA), Portland cement (PC), Sealapex and zinc oxide-eugenol (ZOE) as root-end filling materials.Study design: An in vitro microbial leakage test (MLT) with a split chamber was used in this study. A mixture of facultative bacteria and one yeast (S. aureus + E. faecalis + P. aeruginosa + B. subtilis + C. albicans) was placed in the upper chamber and it could only reach the lower chamber containing Brain Heart Infusion broth by way of leakage through the root-end filling. Microbial leakage was observed daily for 60 days. Sixty maxillary anterior human teeth were randomly assigned to different groups - MTA and PC (gray and white), Sealapex + zinc oxide and ZOE, control groups and subgroups to evaluate the influence of EDTA for smear layer removal. These materials were further evaluated by an agar diffusion test (ADT) to verify their antimicrobial efficacy. Data were analyzed statistically by Kruskal-Wallis and Mann-Whitney test.Results: In the MLT, Sealapex + zinc oxide and ZOE did not show evidence of microbial leakage over the 60-day experimental period. The other materials showed leakage from the 15th day. The presence of smear layer influenced microbial leakage. Microbial inhibition zones were not observed in all samples tested by ADT.Conclusion: Sealapex + zinc oxide and ZOE did not show microbial leakage over the experimental period, whereas it was verified within 15 to 45 days in MTA and Portland cement. Universidade Federal de Goiás (UFG), Dept Oral Sci, Goiania, Go, Brazil UNESP, Dept Endodont, Fac Dent Aracatuba, Aracatuba, SP, Brazil Universidade Federal de Goiás (UFG), Inst Biol Sci, Goiania, Go, Brazil Pontificia Univ Catolica Rio Grande do Sul, Postgrad Program Dent, Porto Alegre, RS, Brazil UNESP, Dept Endodont, Fac Dent Aracatuba, Aracatuba, SP, Brazil

Published
2011

12. Childhood Trauma Questionnaire (CTQ) in Brazilian Samples of Different Age Groups: Findings from Confirmatory Factor Analysis

Author

Adriane Xavier Arteche, Hugo Cogo-Moreira, Elisa Brietzke, Rodrigo Grassi-Oliveira, Christian Haag Kristensen, Thiago Wendt Viola, Gisele Gus Manfro, Giovanni Abrahão Salum, Pontifical Catholic Univ Rio Grande Sul PUCRS, Universidade Federal de São Paulo (UNIFESP), Univ Fed Rio Grande do Sul, and Pontificia Univ Catolica Rio Grande do Sul

Subjects
Child abuse, Psychometrics, Non-Clinical Medicine, Validity, Social and Behavioral Sciences, Pediatrics, Goodness of fit, Adolescent Psychiatry, Surveys and Questionnaires, Questionários, Psychology, Child Abuse, Child, media_common, Psychiatry, Multidisciplinary, Child and Adolescent Health Policy, Age Factors, Child Health, Middle Aged, Confirmatory factor analysis, Mental Health, Medicine, Public Health, Psicometria, Brazil, Clinical psychology, Research Article, Adult, medicine.medical_specialty, Adolescent, media_common.quotation_subject, Science, Psychological Stress, Criança, Biology, Neglect, Sex Factors, medicine, Humans, Measurement invariance, Health Care Policy, CTQ tree, Developmental Psychology, Wounds and Injuries, Factor Analysis, Statistical
Abstract

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) The Childhood Trauma Questionnaire (CTQ) is internationally accepted as a key tool for the assessment of childhood abuse and neglect experiences. However, there are relative few psychometric studies available and some authors have proposed two different factor solutions. We examined the dimensional structure and internal consistency of the Brazilian version of the CTQ. A total of 1,925 participants from eight different clinical and non-clinical samples including adolescents, adults and elders were considered in this study. First, we performed Confirmatory Factor Analysis to investigate the goodness of fit of the two proposed competitive factor structure models for the CTQ. We also investigated the internal consistency of all factors. Second, multi-group analyses were used to investigate measurement invariance and population heterogeneity across age groups and sex. Our findings revealed that the alternative factor structure as opposed to the original factor structure was the most appropriate model within adolescents and adults Brazilian samples. We provide further evidence for the validity and reliability of the CTQ within the Brazilian samples and report that the alternative model showed an improvement in fit indexes and may be a better alternative over the original model. Pontifical Catholic Univ Rio Grande Sul PUCRS, Postgrad Program Psychol, Ctr Studies & Res Traumat Stress, Porto Alegre, RS, Brazil Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil Pontificia Univ Catolica Rio Grande do Sul, Ctr Studies & Res Traumat Stress, Porto Alegre, RS, Brazil Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil Web of Science

Published
2014

13. Perinatal factors associated with early deaths of preterm infants born in Brazilian Network on Neonatal Research centers

Author

Francisco Martínez, Sérgio Tadeu Martins Marba, Renato S. Procianoy, Ligia Maria Suppo de Souza Rugolo, Ruth Guinsburg, José Maria de Andrade Lopes, Cléa Rodrigues Leone, Maria Fernanda Branco de Almeida, Jorge Hecker Luz, Universidade Federal de São Paulo (UNIFESP), Universidade de São Paulo (USP), Universidade Federal do Rio Grande do Sul (UFRGS), Universidade Estadual de Campinas (UNICAMP), Universidade Estadual Paulista (Unesp), Pontificia Univ Catolica Rio Grande do Sul, and Fiocruz MS

Subjects
medicine.medical_specialty, Pediatrics, neonatal mortality, Birth weight, very low birth weight, Gestational Age, Prenatal care, Regional Medical Programs, Hospitals, University, newborn, Intensive Care Units, Neonatal, Infant Mortality, medicine, Birth Weight, Humans, Infant, Very Low Birth Weight, Hospital Mortality, Quality Indicators, Health Care, Respiratory Distress Syndrome, Newborn, Respiratory distress, business.industry, Obstetrics, Hospitals, Public, Infant, Newborn, Gestational age, Prenatal Care, medicine.disease, infant, Low birth weight, Perinatal Care, Premature birth, Pediatrics, Perinatology and Child Health, Apgar Score, Intensive Care, Neonatal, Apgar score, medicine.symptom, preterm, business, Epidemiologic Methods, Brazil, Infant, Premature, Cohort study
Abstract

Made available in DSpace on 2013-08-12T19:02:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-07-01 Made available in DSpace on 2013-09-30T18:23:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-07-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:38:02Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T13:38:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-07-01 Objective: To evaluate perinatal factors associated with early neonatal death in preterm infants with birth weights (BW) of 400-1,500 g.Methods: A multicenter prospective cohort study of all infants with BW of 400-1,500 g and 23-33 weeks of gestational age (GA), without malformations, who were born alive at eight public university tertiary hospitals in Brazil between June of 2004 and May of 2005. Infants who died within their first 6 days of life were compared with those who did not regarding maternal and neonatal characteristics and morbidity during the first 72 hours of life. Variables associated with the early deaths were identified by stepwise logistic regression.Results: A total of 579 live births met the inclusion criteria. Early deaths occurred in 92 (16%) cases, varying between centers from 5 to 31%, and these differences persisted after controlling for newborn illness severity and mortality risk score (SNAPPE-II). According to the multivariate analysis, the following factors were associated with early intrahospital neonatal deaths: gestational age of 23-27 weeks (odds ratio - OR = 5.0; 95%CI 2.7-9.4), absence of maternal hypertension (OR = 1.9; 95%CI 1.0-3.7), 5th minute Apgar 0-6 (OR = 2.8; 95%CI 1.4-5.4), presence of respiratory distress syndrome (OR = 3.1; 95%CI 1.4-6.6), and network center of birth.Conclusion: Important perinatal factors that are associated with early neonatal deaths in very low birth weight preterm infants can be modified by interventions such as improving fetal vitality at birth and reducing the incidence and severity of respiratory distress syndrome. The heterogeneity of early neonatal rates across the different centers studied indicates that best clinical practices should be identified and disseminated throughout the country. Univ Fed São Paulo, Escola Paulista Med, Disciplina Pediat Neonatal, São Paulo, Brazil Univ São Paulo, Fac Med Ribeirao Preto, Dept Pediat, Ribeirao Preto, Brazil Universidade Federal do Rio Grande do Sul (UFRGS), Fac Med, Dept Pediat, Porto Alegre, RS, Brazil Univ São Paulo, Fac Med, Dept Pediat, BR-09500900 São Paulo, Brazil Univ Estadual Campinas, Fac Ciencias Med, Dept Pediat, Campinas, SP, Brazil Univ Estadual Paulista, Fac Med, Dept Pediat, Botucatu, SP, Brazil Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil Fiocruz MS, Inst Fernandes Figueira, BR-21045900 Rio de Janeiro, Brazil Univ Estadual Paulista, Fac Med, Dept Pediat, Botucatu, SP, Brazil

Published
2008

14. Fluticasone/formoterol dry powder versus budesonide/formoterol in adults and adolescents with uncontrolled or partly controlled asthma

Author

Cukier, Alberto, Jacob, Cristina Miuki Abe [UNIFESP], Rosario Filho, Nelson Augusto, Fiterman, Jussara, Vianna, Elcio Oliveira, Hetzel, Jorge Lima, Neis, Marcio Abreu, Fiss, Elie, Castro, Fábio Fernandes Morato, Fernandes, Ana Luisa Godoy [UNIFESP], Stirbulov, Roberto, Pizzichini, Emilio, AIR Brazilian Study Grp, Universidade de São Paulo (USP), Univ Fed Parana, Pontificia Univ Catolica Rio Grande do Sul, Univ S Paulo, Santa Casa Misericordia Porto Alegre, Ctr Paulista Invest Clin, Fac Med ABC, Inst Pesquisa Clin Med Avancada, Universidade Federal de São Paulo (UNIFESP), Santa Casa Sch Med Sci São Paulo, Universidade Federal de Santa Catarina (UFSC), Universidade Estadual Paulista (Unesp), Universidade Federal do Paraná (UFPR), and Santa Casa Sch Med Sci Sao Paulo

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Budesonide, Asthma control questionnaire, Pediatrics, medicine.medical_specialty, Adolescent, Forced expiratory volume in 1 s, Treatment outcome, Peak Expiratory Flow Rate, Morning peak expiratory flow, Non-inferiority, Young Adult, Non inferiority, Forced Expiratory Volume, Formoterol Fumarate, Administration, Inhalation, Humans, Medicine, Anti-Asthmatic Agents, Child, Aged, Asthma, business.industry, Dry Powder Inhalers, Middle Aged, medicine.disease, respiratory tract diseases, Androstadienes, Clinical trial, Single inhaler, Drug Combinations, Treatment Outcome, Budesonide/formoterol, Ethanolamines, Dry powder, Asthma Control Questionnaire, Anesthesia, Fluticasone, Female, Fluticasone-formoterol, business, medicine.drug
Abstract

Made available in DSpace on 2014-12-03T13:08:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-09-01Bitstream added on 2014-12-03T13:23:26Z : No. of bitstreams: 1 WOS000330271600006.pdf: 653705 bytes, checksum: 7169480c3bce90ef10850a2c11b21d68 (MD5) This 12-week study compared the efficacy and safety of a fixed combination of fluticasone propionate plus formoterol (FL/F) 250/12 mu g b.i.d. administered via a dry powder inhaler (DPI) (Libbs Farmaceutica, Brazil) to a combination of budesonide plus formoterol (BD/F) 400/12 mu g b.i.d. After a 2-week run-in period (in which all patients were treated exclusively with budesonide plus formoterol), patients aged 12-65 years of age (N = 196) with uncontrolled asthma were randomized into an actively-controlled, open-labeled, parallel-group, multicentre, phase III study. The primary objective was to demonstrate non-inferiority, measured by morning peak expiratory flow (mPEF).The non-inferiority was demonstrated. A statistically significant improvement from baseline was observed in both groups in terms of lung function, asthma control, and the use of rescue medication. FL/F demonstrated a statistical superiority to BD/F in terms of lung function (FEV1) (p = 0.01) and for asthma control (p = 0.02). Non-significant between-group differences were observed with regards to exacerbation rates and adverse events.In uncontrolled or partly controlled asthma patients, the use of a combination of fluticasone propionate plus formoterol via DPI for 12-weeks was non-inferior and showed improvements in FEV1 and asthma control when compared to a combination of budesonide plus formoterol. (Clinical Trial number: ISRCTN60408425). (C) 2013 Elsevier Ltd. All rights reserved. Univ Sao Paulo, Fac Med, Hosp Clin, Pulm Div,Heart Inst InCor, BR-05403000 Sao Paulo, Brazil State Univ Sao Paulo, Dept Pediat, BR-05403000 Sao Paulo, Brazil Univ Fed Parana, Dept Pediat, BR-80060240 Curitiba, Parana, Brazil Pontificia Univ Catolica Rio Grande do Sul, Sao Lucas Hosp, Ctr Pesquisa Clin, BR-90610000 Porto Alegre, RS, Brazil Univ S Paulo, Med Sch Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil Santa Casa Misericordia Porto Alegre, BR-90035074 Porto Alegre, RS, Brazil Ctr Paulista Invest Clin, BR-04266010 Sao Paulo, Brazil Fac Med ABC, BR-09061650 Santo Andre, SP, Brazil Inst Pesquisa Clin Med Avancada, BR-05437000 Sao Paulo, Brazil Univ Fed Sao Paulo, BR-04062023 Sao Paulo, Brazil Santa Casa Sch Med Sci Sao Paulo, BR-01221900 Sao Paulo, Brazil Univ Fed Santa Catarina, BR-88040970 Florianopolis, SC, Brazil State Univ Sao Paulo, Dept Pediat, BR-05403000 Sao Paulo, Brazil

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