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4 results on '"Policicchio, D"'

1. The Prevalence of Diarrhea and Its Association With Drug Use in Elderly Outpatients: A Multicenter Study

Author

Pilotto, A, Franceschi, M, Vitale, D, Zaninelli, A, Di Mario, F, Seripa, D, Rengo, F, FIRI e. SOFIA Project Investigators, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Masotti, G, Maugeri, D, Mazzei, B, Nicìta, MV, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, Tardi, S, Abbiati, C, Alpa, A, Antiga, I, Antonina, MR, Arnaboldi, L, Ballotti, E, Bargellini, N, Barisone, G, Battelli, M, Beccari, G, Bitetti, E, Bologni, A, Bongera, P, Bortot, M, Bracalenti, L, Buonono, G, Busolo, M, Campanini, MC, Caputo, L, Cartei, A, Cascavilla, P, Casciaro, L, Casula, E, Cesarone, L, Chiesa, D, Chiumeo, F, Ciciarello, A, Cincotta, G, Corò, G, Corona, S, Corsini, M, Cosola, C, Dainese, A, Danza, M, De Bastiani, R, De Cesare, P, De Facci, G, De Lorenzo, R, De Vuono, AD, Della Piccola, P, D'Errico, G, Di Benedetto, G, Dodaro, M, Ercolino, M, Fatarella, P, Fazzari, F, Fiorese, G, Foco, G, Formicola, G, Franchi, F, Fronges, D, Gaetano, MA, Giordano, G, Guarino, M, Guasti, D, Kuel, AM, Kusanovic, M, Lanzavecchia, D, Lofiego, MC, Lorenzano, E, Losi, C, Magrini, F, Mancini, NM, Mander, A, Manneschi, M, Marchi, R, Maronato, G, Marsala, V, Mascia, R, Matuonto, V, Mauceri, ML, Mazzi, PA, Mezzapica, A, Mochi, F, Molenda, G, Morelli, F, Morsia, D, Mosna, MC, Muglia, A, Murgia, P, Muscetta, M, Muscetta, S, Nucci, P, Olimpi, G, Orro, W, Poletto, C, Palmieri, IP, Pastacaldi, G, Pastori, C, Pieresca, G, Pietragalla, M, Pilo, S, Poggesi, S, Poli, L, Ricciardi, A, Riggi, V, Romano, V, Rossi, T, Saccarello, A, Salatino, A, Salvati, R, Sannino, A, Santelli, M, Santucci, A, Saponaro, GM, Schergna, A, Schiavone, C, Sammarco, R, Scornavacca, G, Serena, D, Silvino, G, Sistilli, L, Soldan, S, Soro, A, Tatti, R, Tempestini, L, Testini, D, Tibeloli Carnevali, A, Toniolo, B, Torselli, R, Tremul, L, Trevisan, F, Trifilò, P, Cimenti, T, Valente, S, Vannucchi, CE, Vencato, PG, Vigotti, G, Virdis, G, Zaccaro, F, Zanzot, S, Zingone, FM, Zirillo, AM, ANNONI, GIORGIO, Pilotto, A, Franceschi, M, Vitale, D, Zaninelli, A, Di Mario, F, Seripa, D, Rengo, F, FIRI e., S, Annoni, G, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Masotti, G, Maugeri, D, Mazzei, B, Nicìta, M, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, Tardi, S, Abbiati, C, Alpa, A, Antiga, I, Antonina, M, Arnaboldi, L, Ballotti, E, Bargellini, N, Barisone, G, Battelli, M, Beccari, G, Bitetti, E, Bologni, A, Bongera, P, Bortot, M, Bracalenti, L, Buonono, G, Busolo, M, Campanini, M, Caputo, L, Cartei, A, Cascavilla, P, Casciaro, L, Casula, E, Cesarone, L, Chiesa, D, Chiumeo, F, Ciciarello, A, Cincotta, G, Corò, G, Corona, S, Corsini, M, Cosola, C, Dainese, A, Danza, M, De Bastiani, R, De Cesare, P, De Facci, G, De Lorenzo, R, De Vuono, A, Della Piccola, P, D'Errico, G, Di Benedetto, G, Dodaro, M, Ercolino, M, Fatarella, P, Fazzari, F, Fiorese, G, Foco, G, Formicola, G, Franchi, F, Fronges, D, Gaetano, M, Giordano, G, Guarino, M, Guasti, D, Kuel, A, Kusanovic, M, Lanzavecchia, D, Lofiego, M, Lorenzano, E, Losi, C, Magrini, F, Mancini, N, Mander, A, Manneschi, M, Marchi, R, Maronato, G, Marsala, V, Mascia, R, Matuonto, V, Mauceri, M, Mazzi, P, Mezzapica, A, Mochi, F, Molenda, G, Morelli, F, Morsia, D, Mosna, M, Muglia, A, Murgia, P, Muscetta, M, Muscetta, S, Nucci, P, Olimpi, G, Orro, W, Poletto, C, Palmieri, I, Pastacaldi, G, Pastori, C, Pieresca, G, Pietragalla, M, Pilo, S, Poggesi, S, Poli, L, Ricciardi, A, Riggi, V, Romano, V, Rossi, T, Saccarello, A, Salatino, A, Salvati, R, Sannino, A, Santelli, M, Santucci, A, Saponaro, G, Schergna, A, Schiavone, C, Sammarco, R, Scornavacca, G, Serena, D, Silvino, G, Sistilli, L, Soldan, S, Soro, A, Tatti, R, Tempestini, L, Testini, D, Tibeloli Carnevali, A, Toniolo, B, Torselli, R, Tremul, L, Trevisan, F, Trifilò, P, Cimenti, T, Valente, S, Vannucchi, C, Vencato, P, Vigotti, G, Virdis, G, Zaccaro, F, Zanzot, S, Zingone, F, and Zirillo, A

Subjects
Diarrhea, Drug, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, health care facilities, manpower, and services, media_common.quotation_subject, MEDLINE, Internal medicine, Outpatients, Prevalence, medicine, Humans, Psychiatry, Aged, media_common, Polypharmacy, Hepatology, business.industry, Gastroenterology, social sciences, humanities, Multicenter study, elderly outpatients, drug use, Diarrhea, MED/09 - MEDICINA INTERNA, medicine.symptom, business
Abstract

OBJECTIVES: To evaluate the prevalence of diarrhea and its association with drug use in elderly outpatients. METHODS: The study was carried out by 133 general practitioners (GPs) who referred to 24 geriatric units in Italy. The demographic data, disability, gastrointestinal symptoms, and current medications were evaluated using a structured interview, including the evaluation of the activities of daily living (ADL), the instrumental activities of daily living (IADL), and the gastrointestinal symptoms rating scale (GSRS). RESULTS: The study included 5,387 elderly subjects who regularly completed the structured interview. In total, 488 patients (9.1% of the whole population, 210 men and 278 women, mean age 75.6 6.2 yr, range 65–100 yr) reported diarrhea, that is, items 11 and 12 of the GSRS, during the 7-day period before the interview. The prevalence of diarrhea significantly increased with older age (P= 0.025), the severity of ADL (P < 0.0001) and IADL disability (P < 0.0001), and the number of drugs taken (P= 0.0002). A multivariate analysis demonstrated that the presence of diarrhea was significantly associated with the use of antibiotics (odds ratio [OR] 4.58, 95% confidence interval [CI] 1.95–10.73), proton pump inhibitors (OR 2.97, 95% CI 2.03–4.35), allopurinol (OR 2.19, 95% CI 1.26–3.81), psycholeptics (OR 1.82, 95% CI 1.26–2.61), selective serotonin reuptake inhibitors (OR 1.71, 95% CI 1.01–2.89), and angiotensin II receptor blockers (OR 1.46, 95% CI 1.08–1.99), also accounting for sex, age, and the use of antidiarrheal agents and drugs for functional gastrointestinal disorders. CONCLUSION: Diarrhea is a common problem in elderly outpatients. Its prevalence increases with old age, the severity of disability, and the number of drugs. Monitoring the presence of diarrhea and its complications in elderly patients who need treatments with drugs significantly associated with diarrhea may be clinically useful.

Published
2008
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2. Drug use by the elderly in general practice: effects on upper gastrointestinal symptoms

Author

Pilotto, A, Franceschi, M, Vitale, D, Zaninelli, A, Masotti, G, Rengo, F, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Maugeri, D, Mazzei, B, Nicita, MV, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, Tardi, S., ANNONI, GIORGIO, Pilotto, A, Franceschi, M, Vitale, D, Zaninelli, A, Masotti, G, Rengo, F, Annoni, G, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Maugeri, D, Mazzei, B, Nicita, M, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, and Tardi, S

Subjects
Male, Drug Utilization, Drug, medicine.medical_specialty, Drug use, Elderly, Gastrointestinal symptoms, Pharmacoepidemiology, Activities of daily living, Drug-Related Side Effects and Adverse Reactions, Gastrointestinal Diseases, media_common.quotation_subject, Upper Gastrointestinal Tract, Sex Factors, Internal medicine, Activities of Daily Living, Epidemiology, Humans, Medicine, Upper gastrointestinal, Pharmacology (medical), Aged, media_common, Aged, 80 and over, Pharmacology, Polypharmacy, business.industry, Age Factors, social sciences, General Medicine, Pharmacoepidemiology, humanities, Surgery, Italy, General practice, Female, Family Practice, business
Abstract

Objective To evaluate the prevalence of drug use by elderly outpatients in Italy and to identify the association between drug use and gastrointestinal symptoms. Study design and setting The study was carried out by 133 general practitioners (GPs) who referred to 24 geriatric units in Italy. All consenting elderly patients seen at the GPs’ offices were evaluated for gender, age, disability, current medications, and upper gastrointestinal symptoms. Results The study included 5,515 elderly subjects. The prevalence of drug use was 91.6%, and the mean number of drugs taken was 2.86 per person. Both the prevalence and the mean number of drugs significantly increased with advancing age. Regarding gastrointestinal symptoms, 32.7% of patients reported at least one upper gastrointestinal symptom: 25% with indigestion syndrome, 16.2% with abdominal pain, and 14.2% with reflux symptoms. A significantly higher prevalence of symptoms was observed in females, patients who were taking a higher number of drugs, and those who had higher disability. Adjusted multivariate analysis demonstrated that the use of nonsteroidal antiinflammatory drugs, steroids, psycholeptics, diuretics, selective β2 adrenoreceptor agonists or adrenergics, and antiplatelet drugs was significantly associated with upper gastrointestinal symptoms. Conclusion The prevalence of drug use is very high in this elderly outpatient population. The number of drugs and the use of some specific drug classes are significantly associated with the presence of upper gastrointestinal symptoms.

Published
2005
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3. Upper gastrointestinal symptoms and therapies in elderly out-patients, users of non-selective NSAIDs or coxibs

Author

Pilotto, A, Franceschi, M, Vitale, DF, Zaninelli, A, Masotti, G, Rengo, F, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Maugeri, D, Mazzei, B, Nicita, MV, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, Tardi, S., ANNONI, GIORGIO, Pilotto, A, Franceschi, M, Vitale, D, Zaninelli, A, Masotti, G, Rengo, F, Annoni, G, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Maugeri, D, Mazzei, B, Nicita, M, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, and Tardi, S

Subjects
Male, Drug, medicine.medical_specialty, Gastrointestinal bleeding, Gastrointestinal Diseases, media_common.quotation_subject, Drug Prescriptions, Gastroenterology, Random Allocation, Gastrointestinal Agents, Ambulatory care, Internal medicine, Ambulatory Care, Humans, Medicine, Upper gastrointestinal, Cyclooxygenase Inhibitors, Pharmacology (medical), Medical prescription, Aged, media_common, Gastrointestinal agent, Hepatology, business.industry, Stomach, Anti-Inflammatory Agents, Non-Steroidal, medicine.disease, ADR, Elderly Patients, NSAID, medicine.anatomical_structure, Ambulatory, Female, Family Practice, business
Abstract

Summary Background: The association between coxib or non-steroidal anti-inflammatory drug use with gastrointestinal symptoms and drug prescriptions in ambulatory elderly patients is not well defined. Aim: To evaluate the association between non-steroidal anti-inflammatory drug NSAID and coxib use with gastrointestinal symptoms and therapies in elderly subjects managed by their general practitioner. Materials: The study was carried out by 133 general practitioners in Italy. By using a structured interview, sex, age, physical function, current medications, new drug prescriptions and upper gastrointestinal symptoms were registered from all elderly subjects who were referred to their general practitioners during a 2-week period. The numbers of hospitalizations, gastrointestinal bleeding events and gastrointestinal diagnostic procedures occurring during the last 6-month period were recorded. Results: Included in this study were 5515 elderly subjects. The overall prevalence of drug use was 92%. Musculo-skeletal drugs were taken by 15% of patients; NSAIDs were taken by 6%, and coxibs by 3% of patients. A significantly higher prevalence of upper gastrointestinal symptoms was observed in elderly NSAID users compared with coxib users and non-users of musculo-skeletal drugs (44% vs. 33% vs. 32% respectively, P = 0.001). The prescriptions of drugs for acid-related disorders were significantly higher in patients who were concomitantly taking NSAID rather than coxibs (13% vs. 6%, P

Published
2005
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4. Quantitative ultrasound criteria for risk stratification in clinical practice: a comparative assessment

Author

Noale M, Maggi S, Gonnelli S, Limongi F, Zanoni S, Zambon S, Rozzini R, Crepaldi G, Accardi A, Angeli A, Baglio S, Baldoncini A, Ballardini P, Bancheri C, Beghe F, Bernini L, Bevilacqua M, Bianchi G, Bonomi G, Bottai M, Brogi G, Candioto G, Candiotto S, Cecchetti R, Serqua R, Cervelli S, Coaccioli S, Coin F, Colella C, Costi D, Cravero M, D'Auria S, D'Avola G, De Gennaro N, Del Forno L, D'Elia A, Di Munno O, Di Virgilio R, Favazzi F, Ferraris M, FILIPPINI, Pietro, Francucci CM, Frediani B, Gandolini G, Gasparini R, Gatti R, Gatto S, Gemini E, Gismondi T, Grassi S, Isaia GC, Izzo T, La Montagna G, La forgia R, Lapadula G, Martina GL, Lombardi P, Lovato R, Maglitto R, Magnani F, Malavolta N, Mancini G, Masellis G, Maugeri D, Micale C, Mora R, Muratore M, Occhipinti R, Oliva G, Palummeri E, Panzavecchia D, Parello S, Pellerito R, Pisanu G, Policicchio D, Pozone M, Pucci G, Respizzi S, Roberti G, Rossini M, Rossitto S, Sabadini L, Salvarani C, Salvini S, Santeufemia G, Santi I, Sartori L, Sfrappini M, Silveri F, Sinigaglia L, Vibo MS, Spinazzè R, Stancati G, Tartarelli G, Topini D, Trotta F, Varcasia G, Zanatta A., IOLASCON, Giovanni, Noale, M, Maggi, S, Gonnelli, S, Limongi, F, Zanoni, S, Zambon, S, Rozzini, R, Crepaldi, G, Accardi, A, Angeli, A, Baglio, S, Baldoncini, A, Ballardini, P, Bancheri, C, Beghe, F, Bernini, L, Bevilacqua, M, Bianchi, G, Bonomi, G, Bottai, M, Brogi, G, Candioto, G, Candiotto, S, Cecchetti, R, Serqua, R, Cervelli, S, Coaccioli, S, Coin, F, Colella, C, Costi, D, Cravero, M, D'Auria, S, D'Avola, G, De Gennaro, N, Del Forno, L, D'Elia, A, Di Munno, O, Di Virgilio, R, Favazzi, F, Ferraris, M, Filippini, Pietro, Francucci, Cm, Frediani, B, Gandolini, G, Gasparini, R, Gatti, R, Gatto, S, Gemini, E, Gismondi, T, Grassi, S, Iolascon, Giovanni, Isaia, Gc, Izzo, T, La Montagna, G, La forgia, R, Lapadula, G, Martina, Gl, Lombardi, P, Lovato, R, Maglitto, R, Magnani, F, Malavolta, N, Mancini, G, Masellis, G, Maugeri, D, Micale, C, Mora, R, Muratore, M, Occhipinti, R, Oliva, G, Palummeri, E, Panzavecchia, D, Parello, S, Pellerito, R, Pisanu, G, Policicchio, D, Pozone, M, Pucci, G, Respizzi, S, Roberti, G, Rossini, M, Rossitto, S, Sabadini, L, Salvarani, C, Salvini, S, Santeufemia, G, Santi, I, Sartori, L, Sfrappini, M, Silveri, F, Sinigaglia, L, Vibo, M, Spinazzè, R, Stancati, G, Tartarelli, G, Topini, D, Trotta, F, Varcasia, G, and Zanatta, A.

Subjects
Male, Fracture risk, medicine.medical_specialty, Acoustics and Ultrasonics, Osteoporosis, Biophysics, Logistic regression, Risk Assessment, Sensitivity and Specificity, Quantitative heel ultrasound, Environmental health, Epidemiology, Prevalence, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Ultrasonography, Radiological and Ultrasound Technology, business.industry, Reproducibility of Results, medicine.disease, Surgery, Clinical Practice, Quantitative ultrasound, Italy, Risk factors, Osteoporosis risk, Risk stratification, Female, Osteoporotic Fractures, ESOPO study, Quantitative heel ultrasound, Osteoporosis risk, Fracture risk, Risk factors, ESOPO study, Risk assessment, business
Abstract

This study aimed to compare two different classifications of the risk of fracture/osteoporosis (OP) based on quantitative ultrasound (QUS). Analyses were based on data from the Epidemiological Study on the Prevalence of Osteoporosis, a cross-sectional study conducted in 2000 aimed at assessing the risk of OP in a representative sample of the Italian population. Subjects were classified into 5 groups considering the cross-classification found in previous studies; logistic regression models were defined separately for women and men to study the fracture risk attributable to groups defined by the cross-classification, adjusting for traditional risk factors. Eight-thousand six-hundred eighty-one subjects were considered in the analyses. Logistic regression models revealed that the two classifications seem to be able to identify a common core of individuals at low and at high risk of fractures, and the importance of a multidimensional assessment in older patients to evaluate clinical risk factors together with a simple, inexpensive, radiation-free device such as QUS.

Published
2012

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