1. MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer
- Author
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Michael Hsiao, Luo Ping Ger, Hui Chuan Cheng, Yun Chin Yao, Cheng-Han Lin, Yao Lung Kuo, Jhih Kai Pan, and Pei Jung Lu
- Subjects
0301 basic medicine ,Cancer Research ,Tumor cells ,Nerve Tissue Proteins ,Triple Negative Breast Neoplasms ,Biology ,Article ,Metastasis ,SOXC Transcription Factors ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,In vivo ,Cell Movement ,microRNA ,Genetics ,medicine ,Basic Helix-Loop-Helix Transcription Factors ,Humans ,Neoplasm Invasiveness ,Neoplasm Metastasis ,Molecular Biology ,Triple-negative breast cancer ,Cell Proliferation ,Brain Neoplasms ,medicine.disease ,In vitro ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Female ,Brain metastasis - Abstract
Brian metastasis, which is diagnosed in 30% of triple-negative breast cancer (TNBC) patients with metastasis, causes poor survival outcomes. Growing evidence has characterized miRNAs involving in breast cancer brain metastasis; however, currently, there is a lack of prognostic plasma-based indicator for brain metastasis. In this study, high level of miR-211 can act as brain metastatic prognostic marker in vivo. High miR-211 drives early and specific brain colonization through enhancing trans-blood–brain barrier (BBB) migration, BBB adherence, and stemness properties of tumor cells and causes poor survival in vivo. SOX11 and NGN2 are the downstream targets of miR-211 and negatively regulate miR-211-mediated TNBC brain metastasis in vitro and in vivo. Most importantly, high miR-211 is correlated with poor survival and brain metastasis in TNBC patients. Our findings suggest that miR-211 may be used as an indicator for TNBC brain metastasis.
- Published
- 2021