1. Prenatal prediction of postnatal survival in fetuses with congenital diaphragmatic hernia using MRI: lung volume measurement, signal intensity ratio, and effect of experience
- Author
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Van Huynh, Vivien Dütemeyer, Véronique Houfflin-Debarge, Elisa Bevilacqua, Alexandra Benachi, Jacques Jani, Anne-Gaël Cordier, Camille Olivier, Mieke Cannie, Pauline Verpillat, Supporting clinical sciences, Radiology, and Clinical sciences
- Subjects
Congenital diaphragmatic hernia ,fetal lung signal intensity ratios ,Ultrasonography, Prenatal ,03 medical and health sciences ,Fetus ,0302 clinical medicine ,Pregnancy ,030225 pediatrics ,Obstetrics and Gynaecology ,Humans ,Medicine ,Lung volumes ,Lung ,fetoscopic endoluminal tracheal occlusion ,030219 obstetrics & reproductive medicine ,Receiver operating characteristic ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Standard error ,operator’s experience ,Radiology Nuclear Medicine and imaging ,Pediatrics, Perinatology and Child Health ,Cohort ,Female ,Signal intensity ,Hernias, Diaphragmatic, Congenital ,Lung Volume Measurements ,business ,Nuclear medicine - Abstract
Objective: To evaluate various signal intensity ratios in isolated congenital diaphragmatic hernia (CDH) and to compare their potential in predicting survival with that of the observed-to-expected (O/E) ratio of total fetal lung volume (TFLV) using magnetic resonance imaging (MRI) measurements. Our second objective was to evaluate the impact of operator's experience in comparing the prediction of postnatal survival by O/E-TFLV.Methods: In 75 conservatively managed CDH fetuses and in 50 who underwent fetoscopic endoluminal tracheal occlusion (FETO), the fetal lung-to-amniotic fluid, lung-to-liver, lung-to-muscle, lung-to-spinal fluid signal intensity ratios, respectively LAFSIR, LLSIR, LMSIR, and LSFSIR, were measured, as was O/E-TFLV. Receiver operating characteristic (ROC) curves were constructed and used to compare the various signal intensity ratios with O/E-TFLV in the prediction of postnatal survival. In 72 MRI lung volumes assessed by the referring radiologists in Paris and Lille and secondarily by our expert radiologist in Brussels (M.M.C.) using the same MRI examinations, ROC curves were constructed and used to compare the value of O/E-TFLV determined by the two centers in the prediction of postnatal survival.Results: In the total cohort of CDH fetuses, O/E-TFLV and LLSIR were predictive of postnatal survival whereas in the conservatively managed group O/E-TFLV, LLSIR, and LMSIR predicted postnatal survival. O/E-TFLV predicted postnatal survival far better than the signal intensity ratios: area under the ROC curve for prediction by O/E-TFLV in the total cohort was 0.866 (p
- Published
- 2020