1. Disruptive Mood Dysregulation Disorder: Symptomatic and Syndromic Thresholds and Diagnostic Operationalization
- Author
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Iná S. Santos, Daniel S. Pine, Tiago N. Munhoz, Alicia Matijasevich, Luis Augusto Rohde, Aluísio J D Barros, Paola Paganella Laporte, Ellen Leibenluft, and Giovanni Abrahão Salum
- Subjects
Adolescent ,Irritability ,Disease cluster ,Article ,03 medical and health sciences ,0302 clinical medicine ,Prevalence ,Developmental and Educational Psychology ,medicine ,Humans ,0501 psychology and cognitive sciences ,Irritable Mood ,Problem Behavior ,Operationalization ,Disruptive mood dysregulation disorder ,Mood Disorders ,business.industry ,05 social sciences ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Attention Deficit and Disruptive Behavior Disorders ,Normative ,Early adolescents ,medicine.symptom ,Birth cohort ,business ,Developmental psychopathology ,030217 neurology & neurosurgery ,050104 developmental & child psychology ,Clinical psychology ,Psychopathology - Abstract
ObjectiveThe aim of this study is to identify the most appropriate threshold for Disruptive Mood Dysregulation Disorder (DMDD) diagnosis and the impact of potential changes in diagnostic rules on prevalence levels in the community.MethodTrained psychologists evaluated 3,562 pre-adolescents/early adolescents from the 2004 Pelotas Birth Cohort with the Development and Well-Being Behavior Assessment (DAWBA). The clinical threshold was assessed in three stages: symptomatic, syndromic and clinical operationalization. The symptomatic threshold identified the response category in each DAWBA item which separates normative misbehavior from a clinical indicator. The syndromic threshold identified the number of irritable mood and outbursts needed to capture pre-adolescents/early adolescents with high symptom levels. Clinical operationalization compared the impact of AND/OR rules for combining irritable mood and outbursts on impairment and levels of psychopathology.ResultsAt the symptomatic threshold, most irritable mood items were normative in their lowest response categories and clinically significant in their highest response categories. For outbursts some indicated a symptom even when present at only a mild level, while others did not indicate symptoms at any level. At the syndromic level, a combination of 2 out of 7 irritable mood and 3 out of 8 outburst indicators accurately captured a cluster of individuals with high level of symptoms. Analysis combining irritable mood and outbursts delineated non-overlapping aspects of DMDD, providing support for the OR rule in clinical operationalization. The best DMDD criteria resulted in a prevalence of 3%.ConclusionResults provide information for initiatives aiming to provide data-driven and clinically oriented operationalized criteria for DMDD.
- Published
- 2020