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Spontaneous dissection of the internal carotid artery is rarely submitted to surgery. We report a case successfully operated on with complete restoration of the cerebral blood flow. A 43-year-old male was admitted to our hospital 10 days after an episode of amaurosis fugax of the left eye, left sided headache and paresis of the right arm of a few hours duration. A diagnosis of dissection of the left internal carotid artery was made by duplex and triplex ultrasound examination and was confirmed by cerebral arteriography in contrast to magnetic resonance angiography which was misleading. Due to the slow arterial flow from the right to the left cerebral hemisphere through only the posterior communicating arteries we envisaged the possibility of a cerebral infarction if the dissection were to be extended. For this reason a surgical procedure was performed by excising the dissected segment and inserting a venous graft for the re-establishment of the arterial flow. Surgical treatment of spontaneous internal carotid dissection should be considered very carefully when the clinical and laboratory findings suggest the possibility of an impending stroke.

Secondary aortoenteric fistula (SAF) is a rare but fatal complication of reconstructive aortoiliac surgery. The prevention, diagnosis and treatment of this complication remains a challenging problem in everyday practice. Nine cases of secondary aortoduodenal fistulae during the period of 1980 to 1992 are presented. Their main symptom was bleeding of the upper gastrointestinal tract. The mean time interval since the aortic surgical procedure was 32 months. Removal of the old graft and closure of the duodenal defect was the first stage of the operative procedure. One patient underwent replacement of the old graft, with a new graft, while in the remaining three patients extranatomical bypass was not necessary because of satisfactory circulation in the lower extremities. In five patients extranatomical revascularization of the lower limbs was performed postoperatively at various intervals. Three patients died postoperatively. Follow-up of the remaining patients ranged from one month to 8 years. Bleeding of the upper gastrointestinal tract in patients with a history of intrabdominal reconstructive vascular surgery must raise severe suspicion as to the certainty of existance of SAF unless the diagnostic procedure, mainly exploratory laparotomy, excludes this possibility.

To determine the long-term results of aortofemoral grafts using the profunda femoris artery as an outflow vessel and to determine the factors affecting the outcome of these procedures.Prospective study.From 1980 to 1993, 224 profundoplasties were performed as an adjunctive outflow procedure of aortofemoral grafts in 180 patients. There were 167 men and 13 women with a mean age of 63.7 years. Severe claudication was the indication for operation in 147 limbs (65.6%), and critical ischemia in 77 (34.4%). Good runoff was present in 159 limbs (71%), while poor run-off in 65 (29%). Profundoplasty was extended distally in 67 cases (29.9%), while in the remaining 157 (70.1%) it was limited to the proximal portion of the artery. Arterial and venous patches were used alternatively for the profundoplasty.The 30-day mortality was 1.6% and the 5-year and 9-year survival rate was 69.7% and 49.1% respectively. Primary graft patency was 87.2% in 5 years and 78.5% in 9 years, while secondary graft patency was 90.1% in 5 years and 81.4% in 9 years. Limb salvage rate was 92.7% in 5 years and 87.6% in 9 years. There were four factors which were predictive of inferior longterm results namely; critical ischemia, poor run-off, extended profundoplasty and vein patch used for the profundoplasty.Angioplasty of the profunda femoris artery is a durable outflow procedure for aortofemoral graft surgery, when the above mentioned risk factors are absent; however when they do exist, the use of arterial patch for profundoplasty may improve the prognosis.

This study was designed in order to determine the diagnostic accuracy in imaging of the extracranial arteries by using magnetic resonance angiography (MRA), digital subtraction angiography (DSA), B-mode duplex ultrasonic examination (DUE) in comparison with the surgical and histological findings of the specimen removed after endarterectomy. The degree of stenosis of the arterial lumen of the surgical specimen was compared with the imaging findings of MRA, DSA and DUE: a) the degree of agreement of stenosis with histologic findings was found in 89% of cases for MRA, in 93% for DSA and 88% for DUE; b) the correlation of morphology of the plaque showed agreement in 91% of the cases with MRA, in 94% with DSA and 87% with DUE; c) the constitution of the plaque was in agreement with DUE findings in 96% of cases. There is no significant difference between the three methods, as far as the estimation of degree of carotid stenosis and morphology of the atheromatous plaque in the carotid arteries. MRA findings are similar with those of DSA and DUE with a high sensitivity and specificity concerning the constitution of the plaque. The combination of MRA and DUE provides all the necessary information concerning the extracranial segments of the cerebral arteries for the preoperative evaluation of patients with carotid disease.

A retrospective analysis comparing the three-dimensional time-of-flight MR angiography, MR imaging and transfemoral digital substraction angiography (DSA) in cases of carotid artery dissection was made. During a 2-year period, 12 cases (11 males and 1 female), aged between 16 and 60 years, were submitted to our Hospital with the symptoms of TIA, stroke or cranial nerve palsies and the suspicion of carotid dissection. Transfemoral angiograms were done in other Institutions, while the MRI and MRA were performed in our diagnostic center. Blind interpretation of MR and angiography images was made by two independent radiologists. MR angiography in combination with MR imaging was more accurate than conventional angiography in the diagnosis of carotid artery dissection. Respective sensitivity and specificity were 100% and 100% for MRI with MRA and 91.6% and 100% for conventional angiography. From the analysis of this small series, we can conclude that MR angiography in combination with MR imaging is a reliable noninvasive method for use in diagnosis of extracranial internal carotid artery dissection.

Mesenteric venous thrombosis is a rather rare condition posing diagnostic problems and very often with an obscure etiology. Recently, various coagulation deficiencies were found as the main etiologic factor. A case of a 75-year-old man with acute abdomen is presented. Exploratory laparotomy revealed a 250 cm necrosis of the small intestine. Patient was successfully treated by resecting the entire involved segment of the bowel. After a complete coagulation profile examination, deficiencies of protein C and anti-thrombin III were found and were considered as the main cause of the disease. In cases with known coagulation deficiencies the presence of an acute abdomen should raise suspicion of mesenteric venous thrombosis.

The co-existence of abnormalities of the inferior vena cava (IVC) and abdominal aortic aneurysm (AAA) is a rare condition but with surgical significance. With the development of various imaging technics and the routine use of computerized tomography for the examination of the abdomen and/or the investigation of AAA these venous abnormalities can be disclosed. A male patient with AAA and left sided IVC is presented.

A rare case of obstruction of the right ureter due to encagement between the right iliofemoral and right limb of an aorto-bilateral femoral Dacron graft is described. Patient was managed successfully by ureterolysis, removal of the occluded right iliofemoral graft, omentoplasty and placement of a pig tail catheter along the right ureter.

Six cases of arterial aneurysms, due to "Behçet's disease" located in various arteries are presented. Surgical reconstruction included: Resection of the lesions and replacement with corresponding grafts with satisfactory results. In spite of the macroscopic similarity of the aneurysms found in "Behçet's disease" as compared to those of mycotic origin, the presence of any microorganism could not be detected in various cultures or pathological specimens. Meticulous diagnosis on the nature of the aneurysm, close follow-up and careful postoperative anticoagulant treatment, is imperative for satisfactory immediate and late results.

The development of ultrasonic diagnostic imaging technics has recently been a competitive diagnostic method in cerebral arteriography. Many vascular surgeons, based on the high specificity and sensitivity of the ultrasonic imaging technics in carotid artery disease, have been performing carotid endarterectomy without arteriography with satisfactory results. In the last four years we have performed in our Department 62 carotid endarterectomies on 57 patients without using cerebral arteriography. In this paper diagnostic ultrasonic imaging and transcranial Doppler technics are presented and the immediate results of carotid endarterectomy in the above series of patients are reported. From our and other authors' experience it is concluded that carotid endarterectomy in patients with carotid artery disease is a safe procedure. Larger series of patients are needed with a longer follow-up in order that carotid endarterectomy without arteriography be accepted by the medical profession as a safe procedure.

Patients with chronic inflammatory bowel disease, particularly ulcerative colitis, have a greater thrombotic tendency. An effective management of a patient with established ulcerative colitis complicated with acute arterial occlusion of the right lower extremity and inferior vena cava thrombosis is presented. The episodes of thrombosis usually occur in the active phase of the disease. It is suggested that in patients with diseases such as UC, predisposing to thrombosis, the identification of abnormalities in the coagulation profile may predict those particularly at risk.

The incidence of deep venous thrombosis (DVT) coexistent in patients suffering from superficial venous thrombosis (SVT) has not been well documented. In a series of 57 consecutive patients with SVT of the lower extremities treated in our Department in the last five years without any obvious clinical signs of co-existing DVT, an ascending phlebographic study was performed. Co-existent DVT was disclosed in 19.6% of the patients. There was no correlation between the location or the length of thrombus and the co-existence of DVT. Patients in whom SVT developed in existing varicose veins were younger in age and the incidence of co-existence of DVT was lower. Our findings show that SVT does not always have a benign course. The disclosure of a high incidence of co-existing DVT in our series suggests the necessity of the examination of the deep venous system in all the cases of SVT by using ultrasonic technics, triplex and preferably of the ascending phlebography. The disclosure of DVT in those cases makes the application of anticoagulant treatment mandatory.

The authors developed a method for studying the whole arterial system, except for the coronary arteries, by means of ultrasonic techniques. It was based on the conception of the generalized nature of atherosclerosis presuming the existence of some specific types of the process which may be classified into 5 categories (according to DeBakey) depending on the main focus of distribution of the disease. The method was named pan-arterial ultrasonography. It includes a series of ultrasonic examinations performed by means of Doppler's ultrasonic scanning apparatus operating in B-regimen with various transducers for determining the arterial blood flow and imaging the various arterial segments. The authors examined successfully 716 patients by the method.

Rupture of abdominal aortic aneurysms (AAA) is a life-threatening condition and a leading cause of death in various countries. In spite of increased awareness of most physicians for an early diagnosis of the rupture, the performance of surgery in an early stage and special care in the Intensive Care Unit, postoperative mortality is still high in most medical centers as well as in our Clinic. Two series of patients operated in our Clinic during the last 17 years are analysed. The applied surgical technics are presented and morbidity and mortality are analysed. A distinction between the general mortality was made based on all the inhospital deaths and the postoperative mortality rate including only the deaths after the operation during the postoperative period. Among the other conclusions it is also stressed that a real improvement in the mortality rate depends on elective surgery of all the disclosed AAA larger than 4 cm in diameter.

Based on the concept of the generalized character of atherosclerosis which tends to assume characteristic patterns that may be classified by a predominant site of distribution of the disease within five major categories according to DeBakey, we have developed the examination of the whole arterial system, except the coronary arteries, by using ultrasonic technics which have coined panarterial ultrasonography (PU). This includes a series of ultrasonic examinations by using the Doppler ultrasonic and B-mode duplex or triplex scan apparatus with various probes for the detection of arterial flow and imaging of the various arterial segments. During the last years 716 patients were submitted to PU. The indications for and the findings resulting from the application of PU are presented.

The current indications to and long-term results of the femoropopliteal by-passes are analysed. The absolute indication is critical ischaemia with rest pain or trophic change i.e. ulcers and gangrene. The most important factor influencing the long-term results is the nature of the graft per se. The indications, arteriographic run-off, site of anastomosis, earlier femoropopliteal operations all exert a major influence on the late results, particularly prosthetic grafts are used. The results indicate the need for more prospective studies with careful monitoring of different variants in order to better understand the role of the femoropopliteal by-pass in the palliation of infra-inguinal atherosclerotic occlusive disease.

Venous thrombosis in childhood is an extremely rare condition. The etiologic factors in childhood are different than in the adult. Generalized infection seems to play the main etiologic role, and for this reason antibiotic treatment is usually necessary. Anticoagulant treatment is mandatory; however its application presents many difficulties. The administration of calcium-heparin subcutaneously for a long time is feasible, well-controlled, without side effects and highly effective. The authors therefore strongly recommended this anticoagulant treatment in childhood.

A group of ten female patients suffering from telengiectasia of the lower limbs was treated with Daflon 500 mg administered orally. The results obtained are presented and discussed.

A postoperative arteriovenous fistula of the upper thyroidal pedicle was detected 14 years after thyroidectomy. Treatment in this rare case was by elective surgical excision of the fistula.

A 62-year-old male had repeated episodes of aortic bifurcation occlusion by malignant masses of the same histologic type as the previously excised adenocarcinoma of the ascending colon. In spite of an extensive investigation of the lungs, heart and aorta no trace of the origin and the route of dissemination of the carcinomatous masses was found. Severe suspicion arises of massive malignant direct invasion of the aorta from the local recurrence of the tumor of the descending colon excised 3 years previously.

Two cases of acute abdomen operated on twice and biopsy specimens confirmed are presented. The diagnosis of a systemic necrotizing vasculitis group of polyarteritis nodosa was established. The syndrome affects predominantly males between the second and forth decade of life. The gastrointestinal tract is involved in approximately 50% of the cases. While a negative laparotomy may be considered as a surgical pit-fall, nevertheless, it is the only way of establishing the diagnosis and treating the complications of the disease in some of the cases.

During the 3-year period, 1983-86, 194 procedures for acute arterial occlusion were performed in our Clinic. In 43 cases following revascularization procedures, decompression fasciotomy of the leg for a developed or impending compartment syndrome was performed. Of these, three fasciotomies were done as a prophylactic procedure, before the development of the syndrome. Adequate and early fasciotomy should be considered by the vascular surgeon in every case of embolectomy when the ischemic time is greater than 6 hours, when the patient is young without sufficient collateral circulation, the history of acute arterial occlusion is precipitous, the patient is hypotensive and the back-flow is inadequate intra-operatively, despite the passage of the Fogarty's catheter down to the malleolus. Skin closure after fasciotomy has to be done early, mainly with approximation of the skin edges, or to cover early the exposed viable muscles with a free split-thickness autogenous skin graft. This was done in our series between the 8th and 14th postoperative days. In the case of muscle necrosis of the anterior compartment, skin coverage of the cavity has to be done later, after 2-3 weeks, as in some of our patients.

The measurement of DBP and the arteriography of the hand have been used for the estimation of digital arterial circulation and for the disclosure of occlusive processes of the digital and palmar arteries in vascular and, mainly, in arterial disorders of the hands. However, both methods have some limitations; the first might give normal values in the presence of occlusion of digital or palmar arteries while the second is an invasive technic, it cannot be repeated and is followed by a low morbidity. The technic that we are introducing namely the digital arterial flow tracing (DAFT) is a non-invasive method which discloses, with a high accuracy, the occlusive processes of the digital arteries and it could replace to some extent especially in the study of Raynaud's syndrome, hand arteriography. Further experience is required for the refinement of the method and for the study of the palmar arteries.

During a nine-year period, 201 profundoplasties were performed on 152 patients; of these, 83 were simple and the remaining 132 combined with other inflow or outflow by-pass procedures. Immediate postoperative results were satisfactory whereas late results of 63 simple profundoplasties carried a patency rate of 78% and a limb salvage of 70% was detected eight years postoperatively. Profundoplasty alone or in combination with proximal or distal angioplastic procedures is a very effective method for the revascularization of ischemic lower extremities.

Although the earliest possible embolectomy is still correlated with best rates of limb salvage, we consider, as do most other authors, that the only critical criterion for operability must be the viability of the ischemic limb. Even in the presence of gangrene of the foot relief of arterial occlusion is recommended in order to secure a more distal amputation. Arterial embolectomy seems to be a simple surgical procedure; however, in the presence of atherosclerotic arteries or in the cases of acute arterial thrombosis the operative procedure needs considerable experience in vascular surgical techniques to secure a successful outcome. Finally, the prevention and early treatment of the revascularization syndrome together with appropriate cardiopulmonary management in a strict intensive-care unit can improve the mortality significantly in cases of acute arterial occlusion of the extremities.

Complement activation in the plasma of patients with severe atherosclerosis (arterial occlusive or aneurysmatic disease) was investigated in this study. The effects of angiography and reconstructive arterial surgery (RAS) were also assessed. Atherosclerosis was not found to be associated with systemic complement activation. Angiography resulted in high levels of C3 breakdown products. Surgery caused a significant degree of systemic complement activation in both patients with atherosclerosis and controls. Post-operative levels of C3 breakdown products were significantly higher in atheromatic patients than in controls, most likely due to the insertion of dacron arterial prostheses in the first group.

One hundred and seventy-five diabetic patients belonging to the same cohort were investigated. They were all inhabitants of a suburb of Athens and were initially identified during a diabetes detection drive conducted 11 years earlier. The study comprised a full physical examination, answering of a detailed questionnaire--with emphasis on signs of intermittent claudication (IC)--and a 12 lead ECG (analyzed according to the Minnesota code). It was shown that clinical signs of peripheral occlusive arterial disease were significantly associated to male sex, increased duration of diabetes, type of treatment and major ECG signs of coronary heart disease, while increased age, current smoking and existence ease, while increased age, current smoking and existence of hypertension were not significantly associated to POAD.

A case is reported of torsion of an ovarian cystadenoma in a 101-year-old woman. The tumor was removed surgically. The noteworthy features of the case were the rarity of this complication in such an aged woman, the presence of clinical and radiological signs that made the correct diagnosis possible before operation, and the remarkable tolerance to surgery displayed by the centenarian patient.