1. Myocardial mechanics in dilated cardiomyopathy: prognostic value of left ventricular torsion and strain
- Author
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Sebastian J. Buss, Norbert Frey, Oliver Bruder, Hugo A. Katus, Andreas Schuster, Marco Ochs, Nisha Arenja, Thomas A. Fritz, Florian Andre, Johannes Riffel, Evangelos Giannitsis, Andreas Ochs, Christian Galuschky, and Heiko Mahrholdt
- Subjects
Cardiomyopathy, Dilated ,medicine.medical_specialty ,Cardiac magnetic resonance ,medicine.medical_treatment ,Dilated cardiomyopathy ,Contrast Media ,Magnetic Resonance Imaging, Cine ,Gadolinium ,Ventricular Function, Left ,Sudden cardiac death ,Strain ,Predictive Value of Tests ,Internal medicine ,medicine ,Clinical endpoint ,Humans ,Diseases of the circulatory (Cardiovascular) system ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,LV torsion ,Retrospective Studies ,Angiology ,Heart transplantation ,Univariate analysis ,Ejection fraction ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Research ,Stroke Volume ,Magnetic resonance imaging ,medicine.disease ,musculoskeletal system ,Prognosis ,RC666-701 ,Cardiology ,cardiovascular system ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Data on the prognostic value of left ventricular (LV) morphological and functional parameters including LV rotation in patients with dilated cardiomyopathy (DCM) using cardiovascular magnetic resonance (CMR) are currently scarce. In this study, we assessed the prognostic value of global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS) and LV torsion using CMR feature tracking (FT). Methods CMR was performed in 350 DCM patients and 70 healthy subjects across 5 different European CMR Centers. Myocardial strain parameters were retrospectively assessed from conventional balanced steady-state free precession cine images applying FT. A combined primary endpoint (cardiac death, heart transplantation, aborted sudden cardiac death) was defined for the assessment of clinical outcome. Results GLS, GCS, GRS and LV torsion were significantly lower in DCM patients than in healthy subjects (all p Conclusion LV strain assessed with CMR FT has a high prognostic value in patients with DCM, surpassing routine and dedicated functional parameters. Thus, CMR strain imaging may contribute to the improvement of risk stratification in DCM.
- Published
- 2021