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When analyzing medical utilization or other health care-related measurements across provider panels, case mix adjustment is required because "illness burden" is often unevenly distributed across these patient populations. This article develops the rationale for case mix adjustment and walks readers through the case mix adjustment process using the Johns Hopkins Ambulatory Care Group (ACG) Case-Mix System as a model. The ACG system is a population-oriented patient classification tool based on diagnoses assigned by providers and found in payors' data systems. The system categorizes patients according to illness burden. It does not categorize visits, encounters, or episodes. ACGs adjust for case mix differences in the analysis of ambulatory, laboratory, pharmacy, and total health care service delivery.

Since the original observation and description of the various forms of Bleomycin (BLM), numerous articles have appeared dealing with the activity on mammalian cells and its possible clinical use. The present review on this very important compound, although not very comprehensive, deals with the important characteristics; such as the action of DNA and cells, and its chromosome breaking effects. The manner in which the minute detail of the action of BLM on cells has helped to implement in vivo chemotherapeutic regimes, is also discussed.