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3 results on '"Monica Dors"'

1. The DNA sequence and analysis of human chromosome 14

Author

Roland Heilig, Ralph Eckenberg, Jean-Louis Petit, Núria Fonknechten, Corinne Da Silva, Laurence Cattolico, Michaël Levy, Valérie Barbe, Véronique de Berardinis, Abel Ureta-Vidal, Eric Pelletier, Virginie Vico, Véronique Anthouard, Lee Rowen, Anup Madan, Shizhen Qin, Hui Sun, Hui Du, Kymberlie Pepin, François Artiguenave, Catherine Robert, Corinne Cruaud, Thomas Brüls, Olivier Jaillon, Lucie Friedlander, Gaelle Samson, Philippe Brottier, Susan Cure, Béatrice Ségurens, Franck Anière, Sylvie Samain, Hervé Crespeau, Nissa Abbasi, Nathalie Aiach, Didier Boscus, Rachel Dickhoff, Monica Dors, Ivan Dubois, Cynthia Friedman, Michel Gouyvenoux, Rose James, Anuradha Madan, Barbara Mairey–Estrada, Sophie Mangenot, Nathalie Martins, Manuela Ménard, Sophie Oztas, Amber Ratcliffe, Tristan Shaffer, Barbara Trask, Benoit Vacherie, Chadia Bellemere, Caroline Belser, Marielle Besnard-Gonnet, Delphine Bartol–Mavel, Magali Boutard, Stéphanie Briez-Silla, Stephane Combette, Virginie Dufossé-Laurent, Carolyne Ferron, Christophe Lechaplais, Claudine Louesse, Delphine Muselet, Ghislaine Magdelenat, Emilie Pateau, Emmanuelle Petit, Peggy Sirvain-Trukniewicz, Arnaud Trybou, Nathalie Vega-Czarny, Elodie Bataille, Elodie Bluet, Isabelle Bordelais, Maria Dubois, Corinne Dumont, Thomas Guérin, Sébastien Haffray, Rachid Hammadi, Jacqueline Muanga, Virginie Pellouin, Dominique Robert, Edith Wunderle, Gilbert Gauguet, Alice Roy, Laurent Sainte-Marthe, Jean Verdier, Claude Verdier-Discala, LaDeana Hillier, Lucinda Fulton, John McPherson, Fumihiko Matsuda, Richard Wilson, Claude Scarpelli, Gábor Gyapay, Patrick Wincker, William Saurin, Francis Quétier, Robert Waterston, Leroy Hood, and Jean Weissenbach

Subjects
Chromosomes, Human, Pair 14, Base Composition, Multidisciplinary, Molecular Sequence Data, Immunity, Reproducibility of Results, Genomics, Sequence Analysis, DNA, Physical Chromosome Mapping, DNA, Mitochondrial, DNA, Ribosomal, Synteny, Mice, Open Reading Frames, Genes, Animals, Humans, Chromosomes, Artificial, CpG Islands, 5' Untranslated Regions, Pseudogenes, Microsatellite Repeats
Abstract

Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located. The finished sequence of human chromosome 14 comprises 87,410,661 base pairs, representing 100% of its euchromatic portion, in a single continuous segment covering the entire long arm with no gaps. Two loci of crucial importance for the immune system, as well as more than 60 disease genes, have been localized so far on chromosome 14. We identified 1,050 genes and gene fragments, and 393 pseudogenes. On the basis of comparisons with other vertebrate genomes, we estimate that more than 96% of the chromosome 14 genes have been annotated. From an analysis of the CpG island occurrences, we estimate that 70% of these annotated genes are complete at their 5' end.

Published
2003

2. A physical map of the human genome

Author

Anuradha Madan, S. Naylor, Kami Dixon, Wonhee Jang, John Douglas Mcpherson, Asao Fujiyama, Simon G. Gregory, Jacquelyn R. Idol, Takashi Sasaki, David Haussler, Hong Seok Park, Jun Kudoh, Ai Shintani, Erica Sodergren, Barbara J. Trask, Norma J. Nowak, Gerald Nyakatura, Gregory D. Schuler, Shinsei Minoshima, Raluca Yonescu, J. Harley Gorrell, Roland Heilig, Vivian G. Cheung, Steve Scherer, Kazunori Shibuya, Hsiu Chuan Chen, Olivia Velasquez, Scot Kennedy, Leroy Hood, Richard Reinhardt, Lucía Ramírez, Richard M. Myers, Atsushi Toyoda, Tetsushi Yada, Nobuyoshi Shimizu, Eric D. Green, Dawn Garcia, Owen T. McCann, Kate Montgomery, Asif T. Chinwalla, Elaine R. Mardis, Peter Seranski, Valerie Maduro, W. James Kent, Cynthia Friedman, Kazutoyo Osoegawa, Carol Scott, Juliane Ramser, Marco A. Marra, Caryn Wagner-McPherson, William B. Barbazuk, Thomas Reid, Mandeep Sekhon, Lee Rowen, Nancy E. Stone, Richard A. Gibbs, Lisa French, Trevor Hawkins, J. de Jong, Jin Shang, Tamara A. Kucaba, Robert H. Waterston, Adam Whittaker, Jeremy Schmutz, Richard K. Wilson, Kristine M. Wylie, Masahira Hattori, Atsushi Shimizu, Ilan R. Kirsch, Jean Weissenbach, Céline Hoff, Julie R. Korenberg, Markus Schilhabel, Sanja Rogic, David R. Bentley, Shuichi Asakawa, Paul E. Tabor, Terrence S. Furey, Kerstin P. Clerc-Blankenburg, Raju Kucherlapati, Joseph J. Catanese, Shizhen Qin, Annemarie Poustka, Suzanne Emerling, Reiner Siebert, Brigitte Schlegelberger, Hans Lehrach, Monica Dors, Thomas Brüls, Hillary Massa, R Evans, Steven J.M. Jones, Gernot Gloeckner, Elbert Branscomb, Andrew Dunham, Jane L. Holden, Xiao Ning Chen, Ashley Miller, Jan Fang Cheng, André Rosenthal, John W. Wallis, Eunice Lee, Gaiping Wen, Sean Humphray, Carol Soderlund, Robert S. Fulton, Yoshiyuki Sakaki, David R. Cox, Norman A. Doggett, Kazuhiko Kawasaki, Anne S. Olsen, Graeme Bethel, and LaDeana W. Hillier

Subjects
Genetics, Cancer genome sequencing, Whole genome sequencing, Chromosomes, Artificial, Bacterial, Multidisciplinary, Contig, Genome, Human, Computational biology, Genome project, Biology, ENCODE, DNA Fingerprinting, Genome, Chimpanzee genome project, Contig Mapping, Gene Duplication, Humans, Cloning, Molecular, In Situ Hybridization, Fluorescence, Repetitive Sequences, Nucleic Acid, Reference genome
Abstract

The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.

Published
2001

3. Analysis of the DNA sequence and duplication history of human chromosome 15

Author

Sandra Stewart, Amardeep Kaur, Evan Mauceli, Kerri Topham, Harindra Arachchi, Brian Birditt, Jerome Naylor, Toby Bloom, Sarah Young, Anup Madan, Reinhard Engels, Manuel Garber, Sabrina M. Stone, Anuradha Madan, Amber L Ratcliffe, Ryan Nesbitt, Amr Abouelleil, Keith O'Neill, Scott Bloom, Katherine M. B. Sneddon, Dascena Vincent, Lester Dorris, Steven Rounsley, Jennifer L. Hall, Michael Fitzgerald, David B. Jaffe, Grace Hensley, Gary Gearin, Devin P. Locke, Asha Kamat, Ericka M. Johnson, Jonathan Butler, Sinéad B. O'Leary, Jeremy Burke, Lida Baradarani, Jean L. Chang, Kurt DeArellano, Michael Kamal, Andrew Zimmer, Annie Lui, Eric S. Lander, Charles A. Whittaker, Monica Dors, Chad Nusbaum, David DeCaprio, Chinnappa D. Kodira, Leroy Hood, Robert Nicol, Ted Sharpe, Evan E. Eichler, Nissa Abbasi, Christina A. Cuomo, Glen Munson, Mark L. Borowsky, Shunguang Wang, Michael C. Zody, Shizhen Qin, Charlien Jones, Peter Fleetwood, Xinwei She, Pendexter Macdonald, Ken Dewar, April Cook, Xiaoping Yang, Bruce W. Birren, Jessica Fahey, Cynthia Friedman, Carrie Sougnez, and Lee Rowen

Subjects
Molecular Sequence Data, Biology, Synteny, Evolution, Molecular, Chromosome 16, Chromosome 19, Gene Duplication, Animals, Humans, Conserved Sequence, Phylogeny, Segmental duplication, Genetics, Chromosome 7 (human), Chromosomes, Human, Pair 15, Multidisciplinary, Polymorphism, Genetic, Genome, Human, Sequence Analysis, DNA, Macaca mulatta, Chromosome 17 (human), Chromosome 4, Genes, Haplotypes, Multigene Family, Chromosome 21, Chromosome 22
Abstract

Here we present a finished sequence of human chromosome 15, together with a high-quality gene catalogue. As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplication, we have carried out a detailed analysis of the duplication structure of the chromosome. Segmental duplications in chromosome 15 are largely clustered in two regions, on proximal and distal 15q; the proximal region is notable because recombination among the segmental duplications can result in deletions causing Prader-Willi and Angelman syndromes. Sequence analysis shows that the proximal and distal regions of 15q share extensive ancient similarity. Using a simple approach, we have been able to reconstruct many of the events by which the current duplication structure arose. We find that most of the intrachromosomal duplications seem to share a common ancestry. Finally, we demonstrate that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes; this may explain a significant fraction of the gaps remaining in the human genome.

Published
2005

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