1. Implications of differential age distribution of disease-associated meningococcal lineages for vaccine development
- Author
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Brehony, Carina, Trotter, Caroline L., Ramsay, Mary E., Chandra, Manosree, Jolley, Keith A., van der Ende, Arie, Carion, Françoise, Berthelsen, Lene, Hoffmann, Steen, Harðardóttir, Hjördís, Vazquez, Julio A., Murphy, Karen, Toropainen, Maija, Caniça, Manuela, Ferreira, Eugenia, Diggle, Mathew, Edwards, Giles F., Taha, Muhamed-Kheir, Stefanelli, Paola, Kriz, Paula, Gray, Steve J., Fox, Andrew J., Jacobsson, Susanne, Claus, Heike, Vogel, Ulrich, Tzanakaki, Georgina, Heuberger, Sigrid, Caugant, Dominique A., Frosch, Matthias, Maiden, Martin C. J., Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, Department of Zoology [Oxford], University of Oxford [Oxford], University of Cambridge [UK] (CAM), Public Health England [London], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Institut Scientifique de Santé Publique [Belgique] - Scientific Institute of Public Health [Belgium] (WIV-ISP), Réseau International des Instituts Pasteur (RIIP), Statens Serum Institut [Copenhagen], Landspitali National University Hospital of Iceland, Meningococcal Reference Laboratory [Madrid], Irish Meningococcal and Meningitis Reference Laboratory, National Institute for Health and Welfare [Helsinki], National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (NRL-AMR-HAI), Department of Infectious Diseases, Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), The Scottish Haemophilus, Legionella, Meningococcus, and Pneumococcus Reference Laboratory, Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae (CNR), Institut Pasteur [Paris], Department of Infectious, Parasitic and Immune-Mediated Diseases [Rome], Istituto Superiore di Sanita [Rome], National Institute of Public Health [Prague], Manchester Royal Infirmary, University of Manchester [Manchester], Örebro University Hospital [Örebro, Sweden], Institut für Hygiene und Mikrobiologie [Würzburg], National Meningitis Reference Laboratory, National School of Public Health Athens, Institute for Medical Microbiology and Hygiene [Graz], Norwegian Institute of Public Health [Oslo] (NIPH), This publication made use of the Neisseria Multi Locus Sequence Typing website (http://pubmlst.org/neisseria) developed by Keith Jolley and sited at the University of Oxford. The development of this site has been funded by the Wellcome Trust and the European Union., University of Oxford, Institut Pasteur [Paris] (IP), and Istituto Superiore di Sanità (ISS)
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Adult ,MESH: Sequence Analysis, DNA ,Adolescent ,Meningococcal Vaccines ,Meningitis, Meningococcal ,Neisseria meningitidis ,Neisseria meningitidis, Serogroup B ,MESH: Base Sequence ,MESH: Neisseria meningitidis ,Young Adult ,Age Distribution ,MESH: Child ,MESH: Neisseria meningitidis, Serogroup B ,MESH: Bacterial Capsules ,Humans ,ddc:610 ,Child ,MESH: Age Distribution ,Bacterial Capsules ,MESH: Adolescent ,Vaccines ,Antigens, Bacterial ,MESH: Humans ,Base Sequence ,MESH: Child, Preschool ,MESH: Meningitis, Meningococcal ,Infant ,MESH: Adult ,Sequence Analysis, DNA ,MESH: Infant ,MESH: Multilocus Sequence Typing ,MESH: Young Adult ,Child, Preschool ,[SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology ,MESH: Antigens, Bacterial ,Multilocus Sequence Typing - Abstract
International audience; New vaccines targeting meningococci expressing serogroup B polysaccharide have been developed, with some being licensed in Europe. Coverage depends on the distribution of disease-associated genotypes, which may vary by age. It is well established that a small number of hyperinvasive lineages account for most disease, and these lineages are associated with particular antigens, including vaccine candidates. A collection of 4,048 representative meningococcal disease isolates from 18 European countries, collected over a 3-year period, were characterized by multilocus sequence typing (MLST). Age data were available for 3,147 isolates. The proportions of hyperinvasive lineages, identified as particular clonal complexes (ccs) by MLST, differed among age groups. Subjects 25-year-olds were more likely to experience disease due to less common ccs and unassigned STs. Younger and older subjects were vulnerable to a more diverse set of genotypes, indicating the more clonal nature of genotypes affecting adolescents and young adults. Knowledge of temporal and spatial diversity and the dynamics of meningococcal populations is essential for disease control by vaccines, as coverage is lineage specific. The nonrandom age distribution of hyperinvasive lineages has consequences for the design and implementation of vaccines, as different variants, or perhaps targets, may be required for different age groups.
- Published
- 2014
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